Folic acid_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.19472
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.184095
CEMIP cell migration inducing protein, hyaluronan binding 0.170855
SPTBN1 spectrin, beta, non-erythrocytic 1 0.133248
GMDS GDP-mannose 4,6-dehydratase 0.110179
NALF1 NALCN channel auxiliary factor 1 0.0932892
ANXA2 annexin A2 0.072902
LDHA lactate dehydrogenase A 0.0707074
KRT8 keratin 8, type II 0.064673
H1-0 H1.0 linker histone 0.0645854
PKM pyruvate kinase, muscle 0.0623908
SMYD3 SET and MYND domain containing 3 0.0623777
EREG epiregulin 0.0574211
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0557462
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0554516
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0553409
LMO7 LIM domain 7 0.0543316
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0541845
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0524991
LPP LIM domain containing preferred translocation partner in lipoma 0.0518022
PSD3 pleckstrin and Sec7 domain containing 3 0.0517193
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0502916
KLF5 Kruppel-like factor 5 (intestinal) 0.0496255
ALCAM activated leukocyte cell adhesion molecule 0.0494595
MYH9 myosin, heavy chain 9, non-muscle 0.0490516
ARL15 ADP-ribosylation factor-like 15 0.0468331
PELI1 pellino E3 ubiquitin protein ligase 1 0.0462836
HSPA8 heat shock 70kDa protein 8 0.0462794
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0458465
TRIM2 tripartite motif containing 2 0.0457572
SERINC5 serine incorporator 5 0.045262
KRT18 keratin 18, type I 0.0452091
PDZD8 PDZ domain containing 8 0.0449778
NDRG1 N-myc downstream regulated 1 0.0442431
EZR ezrin 0.044096
MYOF myoferlin 0.0432809
NEBL nebulette 0.042941
FHL2 four and a half LIM domains 2 0.0426569
TPM4 tropomyosin 4 0.0425188
SHROOM3 shroom family member 3 0.0415225
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0407287
ARHGAP32 Rho GTPase activating protein 32 0.0406246
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0405359
MED13L mediator complex subunit 13-like 0.0396885
SAMD12 sterile alpha motif domain containing 12 0.0396849
NFIA nuclear factor I/A 0.0391337
PRSS3 protease, serine, 3 0.038958
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0388378
RPL3 ribosomal protein L3 0.0380581
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0377786
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0371079
EHBP1 EH domain binding protein 1 0.0366209
USP6NL USP6 N-terminal like 0.0356124
PARD3B par-3 family cell polarity regulator beta 0.0355144
MBNL2 muscleblind-like splicing regulator 2 0.0351803
UBE2H ubiquitin-conjugating enzyme E2H 0.0348405
NRXN3 neurexin 3 0.0346424
CEMIP2 cell migration inducing hyaluronidase 2 0.0344791
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0344348
ASPH aspartate beta-hydroxylase 0.033852
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0333525
ARHGAP26 Rho GTPase activating protein 26 0.0330106
ABHD17C abhydrolase domain containing 17C 0.0327007
MUC13 mucin 13, cell surface associated 0.0326042
ONECUT3 one cut homeobox 3 0.0325186
SAMD5 sterile alpha motif domain containing 5 0.0325039
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0324131
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0323448
FTL ferritin, light polypeptide 0.0322002
CTBP2 C-terminal binding protein 2 0.0320224
APP amyloid beta (A4) precursor protein 0.0319696
ITPRID2 ITPR interacting domain containing 2 0.0318069
MPRIP myosin phosphatase Rho interacting protein 0.0316611
SPRED1 sprouty-related, EVH1 domain containing 1 0.0313244
ZFAND3 zinc finger, AN1-type domain 3 0.0309538
TBC1D22A TBC1 domain family, member 22A 0.0303336
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0302612
BCL2L1 BCL2-like 1 0.0298719
MACF1 microtubule-actin crosslinking factor 1 0.0297279
FRYL FRY-like 0.0297109
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0296722
PTPRG protein tyrosine phosphatase, receptor type, G 0.0295864
FOXP1 forkhead box P1 0.0295222
CLTC clathrin, heavy chain (Hc) 0.0294581
FHIT fragile histidine triad 0.0290444
ADGRA3 adhesion G protein-coupled receptor A3 0.0287446
AHNAK AHNAK nucleoprotein 0.0285935
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0284886
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0280362
EEF2 eukaryotic translation elongation factor 2 0.0278507
MAML3 mastermind-like 3 (Drosophila) 0.0276755
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0275839
CADPS Ca++-dependent secretion activator 0.0273386
ARHGAP6 Rho GTPase activating protein 6 0.0272909
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0272466
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0271803
GPSM2 G-protein signaling modulator 2 0.0270668
UBC ubiquitin C 0.0268107
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.026474
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0263922

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.186271
RPS6 ribosomal protein S6 -0.115631
PTMA prothymosin, alpha -0.105333
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0832396
LOC102724023 ES1 protein homolog, mitochondrial -0.0546191
NPSR1 neuropeptide S receptor 1 -0.053221
MUC6 mucin 6, oligomeric mucus/gel-forming -0.052342
SOX4 SRY (sex determining region Y)-box 4 -0.0515732
TFF3 trefoil factor 3 (intestinal) -0.0482288
S100A6 S100 calcium binding protein A6 -0.0438518
RPS19 ribosomal protein S19 -0.0434023
RPL18 ribosomal protein L18 -0.0420001
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0393492
RPL34 ribosomal protein L34 -0.0356172
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0349125
GCC2 GRIP and coiled-coil domain containing 2 -0.0342427
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0340401
RPS8 ribosomal protein S8 -0.0337701
RPLP1 ribosomal protein, large, P1 -0.0336382
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0335616
RPS21 ribosomal protein S21 -0.0319147
HMGA1 high mobility group AT-hook 1 -0.0314032
HMGB1 high mobility group box 1 -0.0309254
GPHN gephyrin -0.0305082
ANTXR2 anthrax toxin receptor 2 -0.0298892
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.02978
CBX3 chromobox homolog 3 -0.0297705
GTF2A2 general transcription factor IIA, 2, 12kDa -0.0286339
RPL36 ribosomal protein L36 -0.0281901
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0280715
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0271373
TXNIP thioredoxin interacting protein -0.0266386
RBM25 RNA binding motif protein 25 -0.0265913
TFF1 trefoil factor 1 -0.0262844
RPL12 ribosomal protein L12 -0.0258511
PNISR PNN-interacting serine/arginine-rich protein -0.0243483
GTF2IRD1 GTF2I repeat domain containing 1 -0.0239521
SCAF11 SR-related CTD-associated factor 11 -0.023778
RPLP2 ribosomal protein, large, P2 -0.0237299
CANX calnexin -0.0234921
YBX3 Y box binding protein 3 -0.0232672
MYL12B myosin, light chain 12B, regulatory -0.0232427
TPT1 tumor protein, translationally-controlled 1 -0.0230045
PFN1 profilin 1 -0.0228855
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0227364
S100A14 S100 calcium binding protein A14 -0.0227248
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.022487
RPS27A ribosomal protein S27a -0.0224005
MT1X metallothionein 1X -0.0220165
ZNF638 zinc finger protein 638 -0.0217815
ZBTB7A zinc finger and BTB domain containing 7A -0.0216635
S100A9 S100 calcium binding protein A9 -0.0211794
IFI27 interferon, alpha-inducible protein 27 -0.0209737
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0208604
NRN1 neuritin 1 -0.0207118
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0206519
LMNA lamin A/C -0.020383
RPL8 ribosomal protein L8 -0.0202782
LAMA4 laminin, alpha 4 -0.0202778
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0199778
INSIG1 insulin induced gene 1 -0.0197744
PABPN1 poly(A) binding protein, nuclear 1 -0.0193164
BSG basigin (Ok blood group) -0.0192965
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0192148
RPS14 ribosomal protein S14 -0.0191837
ATXN1 ataxin 1 -0.0190178
CES2 carboxylesterase 2 -0.0188291
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0188016
PHGR1 proline/histidine/glycine-rich 1 -0.0185311
ASTN2 astrotactin 2 -0.018407
RPL32 ribosomal protein L32 -0.0180782
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0174094
FBXO11 F-box protein 11 -0.0170711
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0170468
RPL37A ribosomal protein L37a -0.0166292
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0166153
RPS25 ribosomal protein S25 -0.0165781
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0165632
RPL23 ribosomal protein L23 -0.0164163
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0163736
BPTF bromodomain PHD finger transcription factor -0.0163222
EPCAM epithelial cell adhesion molecule -0.0161828
CNRIP1 cannabinoid receptor interacting protein 1 -0.0161397
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0161209
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0161181
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.016087
BMP4 bone morphogenetic protein 4 -0.0160284
KRT19 keratin 19, type I -0.0159966
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0159215
RPL21 ribosomal protein L21 -0.0158784
RPL35A ribosomal protein L35a -0.0156809
RPL36AL ribosomal protein L36a-like -0.0154806
CD9 CD9 molecule -0.0152837
SRSF11 serine/arginine-rich splicing factor 11 -0.0149917
NDUFA4 NDUFA4, mitochondrial complex associated -0.0148923
CCNI cyclin I -0.01459
DSCAM Down syndrome cell adhesion molecule -0.0144787
SEC62 SEC62 homolog (S. cerevisiae) -0.0144537
RPS16 ribosomal protein S16 -0.0142656
KLK10 kallikrein-related peptidase 10 -0.014222