Folic acid_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.0938452
MYO1E myosin IE 0.0851657
PDE4D phosphodiesterase 4D, cAMP-specific 0.0700577
TXNRD1 thioredoxin reductase 1 0.0657122
SPTBN1 spectrin, beta, non-erythrocytic 1 0.057771
PTPRG protein tyrosine phosphatase, receptor type, G 0.0556707
PKP2 plakophilin 2 0.0521734
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0519589
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0509203
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0507318
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0440954
PARD3B par-3 family cell polarity regulator beta 0.0402774
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0401721
EXT1 exostosin glycosyltransferase 1 0.0393535
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0383908
PRELID2 PRELI domain containing 2 0.0381889
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0379326
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0366885
RPL3 ribosomal protein L3 0.0362262
CCSER1 coiled-coil serine-rich protein 1 0.0361334
EEF2 eukaryotic translation elongation factor 2 0.0355161
CEMIP cell migration inducing protein, hyaluronan binding 0.0345245
RIMKLB ribosomal modification protein rimK-like family member B 0.0321419
WWC1 WW and C2 domain containing 1 0.0312079
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0310861
PCBP2 poly(rC) binding protein 2 0.0309703
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0306392
VCL vinculin 0.0306057
ARHGAP26 Rho GTPase activating protein 26 0.030364
LPP LIM domain containing preferred translocation partner in lipoma 0.0302935
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0299846
ASPH aspartate beta-hydroxylase 0.0285351
ATXN1 ataxin 1 0.0285155
WWOX WW domain containing oxidoreductase 0.0278749
FOXP1 forkhead box P1 0.0275995
RNF145 ring finger protein 145 0.0274997
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0273369
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0272726
ARL15 ADP-ribosylation factor-like 15 0.027267
DUSP4 dual specificity phosphatase 4 0.0268894
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0268481
SAMD5 sterile alpha motif domain containing 5 0.0267351
LMO7 LIM domain 7 0.0261677
SFPQ splicing factor proline/glutamine-rich 0.026121
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0253717
ABHD17C abhydrolase domain containing 17C 0.0251224
RNF43 ring finger protein 43 0.024755
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0244231
PDZD8 PDZ domain containing 8 0.0244214
TC2N tandem C2 domains, nuclear 0.0243934
EPS8 epidermal growth factor receptor pathway substrate 8 0.0242226
SERINC5 serine incorporator 5 0.0241735
DST dystonin 0.0240265
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0238184
SMYD3 SET and MYND domain containing 3 0.0237234
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0236539
RNF213 ring finger protein 213 0.0235636
EXOC4 exocyst complex component 4 0.023477
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0233671
PRSS3 protease, serine, 3 0.0232021
RPL13A ribosomal protein L13a 0.0231274
EXOC6B exocyst complex component 6B 0.023007
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0225591
MYH9 myosin, heavy chain 9, non-muscle 0.0223587
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0223232
ZSWIM6 zinc finger, SWIM-type containing 6 0.022185
ARHGAP42 Rho GTPase activating protein 42 0.0221844
LGALS12 lectin, galactoside-binding, soluble, 12 0.0218552
WNK1 WNK lysine deficient protein kinase 1 0.0216038
CAPRIN2 caprin family member 2 0.0214228
FBXL17 F-box and leucine-rich repeat protein 17 0.0214191
RAD51B RAD51 paralog B 0.021243
TMEM45B transmembrane protein 45B 0.0209488
MUC13 mucin 13, cell surface associated 0.0207935
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0207158
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.02058
TRIM2 tripartite motif containing 2 0.0205119
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0205065
SH3RF2 SH3 domain containing ring finger 2 0.0203093
SHB Src homology 2 domain containing adaptor protein B 0.0196703
SHROOM3 shroom family member 3 0.0196387
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0194666
FHIT fragile histidine triad 0.0190292
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0190185
RPL5 ribosomal protein L5 0.0189348
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0188593
FOXO1 forkhead box O1 0.0188177
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0186433
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0184107
EFNB2 ephrin-B2 0.0182939
RPL21 ribosomal protein L21 0.0182809
AKAP13 A kinase (PRKA) anchor protein 13 0.0182278
MKI67 marker of proliferation Ki-67 0.0181836
ANKRD11 ankyrin repeat domain 11 0.0180924
SPON1 spondin 1, extracellular matrix protein 0.0180109
NHSL1 NHS-like 1 0.0177017
MAST4 microtubule associated serine/threonine kinase family member 4 0.0176839
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0175482
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0175271
BCAS3 breast carcinoma amplified sequence 3 0.0174532

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.338641
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.133
RPS6 ribosomal protein S6 -0.103532
PTMA prothymosin, alpha -0.100275
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0914958
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0892966
RPS8 ribosomal protein S8 -0.0825456
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0735911
RPL34 ribosomal protein L34 -0.0725492
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0723024
HLA-B major histocompatibility complex, class I, B -0.0715593
GOLGA4 golgin A4 -0.0663107
RPL26 ribosomal protein L26 -0.0658136
RPL31 ribosomal protein L31 -0.0637039
RPLP0 ribosomal protein, large, P0 -0.0632924
KRT18 keratin 18, type I -0.0596308
RPS12 ribosomal protein S12 -0.0594428
RPS24 ribosomal protein S24 -0.0590602
RPL37A ribosomal protein L37a -0.0587307
CALB1 calbindin 1, 28kDa -0.0572952
RPLP1 ribosomal protein, large, P1 -0.0562437
RPL35A ribosomal protein L35a -0.0542457
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.053675
THSD4 thrombospondin, type I, domain containing 4 -0.0533546
RRBP1 ribosome binding protein 1 -0.0522086
CANX calnexin -0.0521105
PDIA3 protein disulfide isomerase family A, member 3 -0.0515105
F3 coagulation factor III (thromboplastin, tissue factor) -0.0505855
S100A6 S100 calcium binding protein A6 -0.0505317
DSPP dentin sialophosphoprotein -0.0499786
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0493021
TMSB10 thymosin beta 10 -0.0478431
DSG2 desmoglein 2 -0.0471393
IFI6 interferon, alpha-inducible protein 6 -0.0471293
RPS27A ribosomal protein S27a -0.0469796
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0456585
RPS25 ribosomal protein S25 -0.045459
TSPAN8 tetraspanin 8 -0.045169
GMDS GDP-mannose 4,6-dehydratase -0.0442352
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0437804
PERP PERP, TP53 apoptosis effector -0.0433974
KRT19 keratin 19, type I -0.0424176
RPL37 ribosomal protein L37 -0.0404559
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0403306
RPS3 ribosomal protein S3 -0.0399235
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0398506
RPL11 ribosomal protein L11 -0.0398407
ACTG1 actin gamma 1 -0.0393132
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0383549
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0380773
NPSR1 neuropeptide S receptor 1 -0.0380111
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0379098
LDHA lactate dehydrogenase A -0.0378845
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0377376
CALU calumenin -0.0375949
SEC31A SEC31 homolog A (S. cerevisiae) -0.0370367
RPL27A ribosomal protein L27a -0.036651
RACK1 receptor for activated C kinase 1 -0.0360021
RAB1A RAB1A, member RAS oncogene family -0.035992
RPS13 ribosomal protein S13 -0.0349492
TPM4 tropomyosin 4 -0.0347946
RPL9 ribosomal protein L9 -0.0346339
KLF5 Kruppel-like factor 5 (intestinal) -0.0342528
LAMB3 laminin, beta 3 -0.033657
HDLBP high density lipoprotein binding protein -0.0333405
EPCAM epithelial cell adhesion molecule -0.0328076
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0324135
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.031534
NAP1L1 nucleosome assembly protein 1-like 1 -0.0315156
RSL1D1 ribosomal L1 domain containing 1 -0.0310659
ESYT2 extended synaptotagmin-like protein 2 -0.0307342
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0306387
GCC2 GRIP and coiled-coil domain containing 2 -0.0301202
MYH14 myosin, heavy chain 14, non-muscle -0.0300967
ANXA2 annexin A2 -0.0300424
AGR2 anterior gradient 2 -0.0296687
AOPEP aminopeptidase O (putative) -0.0288891
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0288492
CD2AP CD2-associated protein -0.0288018
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0287526
RPL12 ribosomal protein L12 -0.0284311
RPS21 ribosomal protein S21 -0.0283417
PGK1 phosphoglycerate kinase 1 -0.0282384
EIF5B eukaryotic translation initiation factor 5B -0.0281833
FERMT1 fermitin family member 1 -0.0279838
S100A10 S100 calcium binding protein A10 -0.0278626
RPS14 ribosomal protein S14 -0.027361
RBM25 RNA binding motif protein 25 -0.0271938
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0271664
RPL36A ribosomal protein L36a -0.0269463
INHBA inhibin, beta A -0.0267544
MORF4L2 mortality factor 4 like 2 -0.0267401
BIRC6 baculoviral IAP repeat containing 6 -0.0266283
ISG15 ISG15 ubiquitin-like modifier -0.0265815
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0261358
PTPRR protein tyrosine phosphatase, receptor type, R -0.0261235
LAMA4 laminin, alpha 4 -0.025976
GNAS GNAS complex locus -0.0258459
RPL38 ribosomal protein L38 -0.025816
SLK STE20-like kinase -0.0257492