Folic acid_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Folic acid_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TP63 tumor protein p63 0.120105
PSD3 pleckstrin and Sec7 domain containing 3 0.0870556
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0720809
BCAR3 breast cancer anti-estrogen resistance 3 0.0630781
DST dystonin 0.0605349
H1-0 H1.0 linker histone 0.0533216
RAD51B RAD51 paralog B 0.052785
FMNL2 formin-like 2 0.0516092
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0490873
DPYD dihydropyrimidine dehydrogenase 0.0486346
VCL vinculin 0.0456256
CD44 CD44 molecule (Indian blood group) 0.0449227
PTK2 protein tyrosine kinase 2 0.0424226
WWTR1 WW domain containing transcription regulator 1 0.0405795
ADGRG6 adhesion G protein-coupled receptor G6 0.040526
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0377845
MKI67 marker of proliferation Ki-67 0.0372497
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0342017
ERRFI1 ERBB receptor feedback inhibitor 1 0.0333885
RUNX1 runt-related transcription factor 1 0.0318674
FAF1 Fas (TNFRSF6) associated factor 1 0.0307321
RNF213 ring finger protein 213 0.029408
SPIDR scaffolding protein involved in DNA repair 0.0293421
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0291793
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.029154
VMP1 vacuole membrane protein 1 0.0291219
SPAG9 sperm associated antigen 9 0.0284511
PRELID2 PRELI domain containing 2 0.0281495
ECT2 epithelial cell transforming 2 0.0280288
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0279991
DPH6 diphthamine biosynthesis 6 0.0279495
BIRC3 baculoviral IAP repeat containing 3 0.027785
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0277103
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0274869
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.026346
CEP128 centrosomal protein 128kDa 0.0261493
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0257093
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0253213
DIAPH3 diaphanous-related formin 3 0.0251642
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0250014
CAPRIN2 caprin family member 2 0.0247983
RAB27B RAB27B, member RAS oncogene family 0.0240638
CMIP c-Maf inducing protein 0.0237453
BIRC2 baculoviral IAP repeat containing 2 0.0237376
SMYD3 SET and MYND domain containing 3 0.0237062
ZBTB38 zinc finger and BTB domain containing 38 0.0234911
RIGI RNA sensor RIG-I 0.02308
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0226679
SDCCAG8 serologically defined colon cancer antigen 8 0.022649
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0226072
TRIP12 thyroid hormone receptor interactor 12 0.0225284
SP100 SP100 nuclear antigen 0.0219511
SRPK2 SRSF protein kinase 2 0.02183
SMC4 structural maintenance of chromosomes 4 0.0212917
IFIH1 interferon induced with helicase C domain 1 0.0212515
CDK6 cyclin-dependent kinase 6 0.0212231
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0209788
RTTN rotatin 0.0208082
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0207628
CFAP299 cilia and flagella associated protein 299 0.0206589
EXOC6B exocyst complex component 6B 0.0204142
WARS1 tryptophanyl-tRNA synthetase 1 0.0202451
TPRG1 tumor protein p63 regulated 1 0.0200237
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0200035
BMERB1 bMERB domain containing 1 0.0196566
ZNF644 zinc finger protein 644 0.0195193
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0193817
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0193024
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0190859
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0190709
EXOC4 exocyst complex component 4 0.0190021
SMAD3 SMAD family member 3 0.0189831
PARD3 par-3 family cell polarity regulator 0.0188562
MYH9 myosin, heavy chain 9, non-muscle 0.0185706
DNAH14 dynein, axonemal, heavy chain 14 0.0184874
ANLN anillin, actin binding protein 0.0184521
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0184395
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0183958
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0180304
METTL15 methyltransferase like 15 0.0179737
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0179626
USP9X ubiquitin specific peptidase 9, X-linked 0.0179335
FOXP1 forkhead box P1 0.0179227
USP12 ubiquitin specific peptidase 12 0.0176136
RRM2 ribonucleotide reductase M2 0.0175221
THSD4 thrombospondin, type I, domain containing 4 0.0174491
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0172753
SVIL supervillin 0.017268
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0172133
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0170777
AHNAK AHNAK nucleoprotein 0.0170742
CNOT1 CCR4-NOT transcription complex, subunit 1 0.016925
TAS2R14 taste receptor, type 2, member 14 0.016843
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0167442
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0167014
RSRC1 arginine/serine-rich coiled-coil 1 0.0166656
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0165574
ZNFX1 zinc finger, NFX1-type containing 1 0.0164173
BRWD3 bromodomain and WD repeat domain containing 3 0.0163357
COL6A3 collagen, type VI, alpha 3 0.0162771

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.329474
VIM vimentin -0.262818
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.134083
RPS6 ribosomal protein S6 -0.0906041
TMSB10 thymosin beta 10 -0.0873213
RPS8 ribosomal protein S8 -0.0863651
PTMA prothymosin, alpha -0.0821576
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0816042
FTL ferritin, light polypeptide -0.0716351
RPS19 ribosomal protein S19 -0.0585251
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0580619
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0580078
MT2A metallothionein 2A -0.0569938
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0556152
RPL37A ribosomal protein L37a -0.05465
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0518442
HMGA1 high mobility group AT-hook 1 -0.0484998
RPL12 ribosomal protein L12 -0.0482568
RPL35A ribosomal protein L35a -0.0470915
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0440876
RPL37 ribosomal protein L37 -0.0440565
KTN1 kinectin 1 (kinesin receptor) -0.0429433
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0422439
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.04209
CANX calnexin -0.0420088
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0417401
RPL31 ribosomal protein L31 -0.0414797
RACK1 receptor for activated C kinase 1 -0.0404299
FTH1 ferritin, heavy polypeptide 1 -0.040213
RPS23 ribosomal protein S23 -0.0392104
RPL36 ribosomal protein L36 -0.0387351
LDHA lactate dehydrogenase A -0.0363323
RPS25 ribosomal protein S25 -0.0363018
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0346105
RPL26 ribosomal protein L26 -0.0340739
RPS12 ribosomal protein S12 -0.0336043
RPS3 ribosomal protein S3 -0.0327509
TPT1 tumor protein, translationally-controlled 1 -0.0326607
CALR calreticulin -0.032575
LOC112694756 uncharaterized LOC112694756 -0.0322568
RPL36A ribosomal protein L36a -0.0322323
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0319439
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0317487
RPL23 ribosomal protein L23 -0.0317479
CSMD3 CUB and Sushi multiple domains 3 -0.0315172
RPS14 ribosomal protein S14 -0.0307736
EEF1G eukaryotic translation elongation factor 1 gamma -0.0304502
RAI1 retinoic acid induced 1 -0.0299898
POTEF POTE ankyrin domain family, member F -0.0296839
RPL19 ribosomal protein L19 -0.0295883
PDIA3 protein disulfide isomerase family A, member 3 -0.0294857
HLA-B major histocompatibility complex, class I, B -0.0290635
RPLP1 ribosomal protein, large, P1 -0.0290548
ENO2 enolase 2 (gamma, neuronal) -0.0287427
RPS13 ribosomal protein S13 -0.0283464
GOLGA4 golgin A4 -0.027828
TMEM123 transmembrane protein 123 -0.0274238
RPL35 ribosomal protein L35 -0.0274047
RPS27 ribosomal protein S27 -0.0269031
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0267875
TTC3 tetratricopeptide repeat domain 3 -0.0267207
RPS29 ribosomal protein S29 -0.0264848
RPS16 ribosomal protein S16 -0.0263973
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0261358
RPLP2 ribosomal protein, large, P2 -0.0260629
EIF1 eukaryotic translation initiation factor 1 -0.0258663
EPHA4 EPH receptor A4 -0.0256264
RPL5 ribosomal protein L5 -0.0255648
LMAN1 lectin, mannose-binding, 1 -0.0250696
LOXL2 lysyl oxidase-like 2 -0.0246576
EGR1 early growth response 1 -0.024469
PGK1 phosphoglycerate kinase 1 -0.0242777
EEF2 eukaryotic translation elongation factor 2 -0.0239044
RPL11 ribosomal protein L11 -0.0238609
PLIN2 perilipin 2 -0.0237666
RPS27A ribosomal protein S27a -0.0236982
WSB1 WD repeat and SOCS box containing 1 -0.023486
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0234085
RPL34 ribosomal protein L34 -0.0231069
TXNIP thioredoxin interacting protein -0.0230662
RPL8 ribosomal protein L8 -0.0230269
ANGPTL4 angiopoietin-like 4 -0.0225424
GARS1 glycyl-tRNA synthetase 1 -0.0224888
SLK STE20-like kinase -0.0224143
RPL27A ribosomal protein L27a -0.022195
SDK1 sidekick cell adhesion molecule 1 -0.0219283
SLC38A2 solute carrier family 38, member 2 -0.0218968
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0217705
RPL7A ribosomal protein L7a -0.0217545
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0216613
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0215413
RPS24 ribosomal protein S24 -0.021316
UBC ubiquitin C -0.0209544
MYOF myoferlin -0.0207976
EFNA5 ephrin-A5 -0.0207586
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0203371
RPL9 ribosomal protein L9 -0.0202189
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0200463
RPL27 ribosomal protein L27 -0.0199378
SRRM2 serine/arginine repetitive matrix 2 -0.0198449