Folic acid_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMC2 laminin, gamma 2 0.103146
RIGI RNA sensor RIG-I 0.100089
GRB10 growth factor receptor-bound protein 10 0.0795186
NDRG1 N-myc downstream regulated 1 0.0704474
MUC16 mucin 16, cell surface associated 0.0702029
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0641978
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0606616
PSD3 pleckstrin and Sec7 domain containing 3 0.0546065
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0541026
LMO7 LIM domain 7 0.046063
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0459854
DUSP5 dual specificity phosphatase 5 0.0458548
MYO1E myosin IE 0.0452201
CD44 CD44 molecule (Indian blood group) 0.0450328
TMPRSS4 transmembrane protease, serine 4 0.0446617
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.04407
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0437512
PLAU plasminogen activator, urokinase 0.0436295
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0431671
IRF6 interferon regulatory factor 6 0.0411946
MBNL2 muscleblind-like splicing regulator 2 0.0411291
MXD1 MAX dimerization protein 1 0.0407498
ESYT2 extended synaptotagmin-like protein 2 0.0406653
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0402352
MT2A metallothionein 2A 0.0401501
PTPRA protein tyrosine phosphatase, receptor type, A 0.0398923
TP53BP2 tumor protein p53 binding protein 2 0.0393344
NFIA nuclear factor I/A 0.0391778
SMAD3 SMAD family member 3 0.0385966
WDR7 WD repeat domain 7 0.0384086
PRKCA protein kinase C, alpha 0.0383351
METTL15 methyltransferase like 15 0.0382425
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0381206
TRIM44 tripartite motif containing 44 0.0376434
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.037296
EHBP1 EH domain binding protein 1 0.0371491
TGFB1 transforming growth factor, beta 1 0.0369383
LIMCH1 LIM and calponin homology domains 1 0.0368615
CALU calumenin 0.0367067
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0366226
PTPRK protein tyrosine phosphatase, receptor type, K 0.0358219
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0353495
MSI2 musashi RNA-binding protein 2 0.0350084
SLK STE20-like kinase 0.0349138
PTPRR protein tyrosine phosphatase, receptor type, R 0.0346851
FHIT fragile histidine triad 0.034503
MYO9B myosin IXB 0.03446
KIAA0232 KIAA0232 0.0342756
PKP4 plakophilin 4 0.0342475
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0330058
NEBL nebulette 0.0329934
WDR33 WD repeat domain 33 0.0328088
THSD4 thrombospondin, type I, domain containing 4 0.0325243
KDM4C lysine (K)-specific demethylase 4C 0.0325096
RORA RAR-related orphan receptor A 0.0320153
HDAC9 histone deacetylase 9 0.0319741
NME7 NME/NM23 family member 7 0.0317721
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0317674
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0316861
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0310516
SEC31A SEC31 homolog A (S. cerevisiae) 0.0310396
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0309378
TRAF3 TNF receptor-associated factor 3 0.0308024
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0306364
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0306213
GMDS GDP-mannose 4,6-dehydratase 0.0305482
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0304346
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.030314
KRT19 keratin 19, type I 0.0302466
CHD4 chromodomain helicase DNA binding protein 4 0.0301221
ZNF395 zinc finger protein 395 0.0301037
ICAM1 intercellular adhesion molecule 1 0.0300827
ARL5B ADP-ribosylation factor-like 5B 0.0300369
TMF1 TATA element modulatory factor 1 0.0299856
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0297798
SEC23B Sec23 homolog B (S. cerevisiae) 0.0297563
PLXNA2 plexin A2 0.0296347
BCL10 B-cell CLL/lymphoma 10 0.0296174
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0290683
PDLIM5 PDZ and LIM domain 5 0.0290582
NAV2 neuron navigator 2 0.0288887
BMAL2 basic helix-loop-helix ARNT like 2 0.0288237
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0287829
AK1 adenylate kinase 1 0.0285698
ANKRD11 ankyrin repeat domain 11 0.0284518
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0283592
TAS2R14 taste receptor, type 2, member 14 0.0281902
ADM adrenomedullin 0.0280428
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0279648
FNDC3B fibronectin type III domain containing 3B 0.0278897
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0278644
FRMD6 FERM domain containing 6 0.0277929
YTHDC1 YTH domain containing 1 0.0276444
MYOF myoferlin 0.027606
ENKUR enkurin, TRPC channel interacting protein 0.0275438
FHL2 four and a half LIM domains 2 0.0273827
CLU clusterin 0.0273654
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0273629
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0273126
LMAN2 lectin, mannose-binding 2 0.0272405

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.126495
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.094747
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0888916
FTL ferritin, light polypeptide -0.0843182
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0832551
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0826721
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0790373
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0725936
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0675674
H3-3B H3.3 histone B -0.0663104
TMSB10 thymosin beta 10 -0.0638705
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.061869
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0581777
IGFBP3 insulin-like growth factor binding protein 3 -0.0581038
SLC38A1 solute carrier family 38, member 1 -0.0580927
NAMPT nicotinamide phosphoribosyltransferase -0.057912
F3 coagulation factor III (thromboplastin, tissue factor) -0.0564611
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0562278
MED13L mediator complex subunit 13-like -0.0536295
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0520719
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.051172
ELL2 elongation factor, RNA polymerase II, 2 -0.0506556
RPS24 ribosomal protein S24 -0.0505346
DICER1 dicer 1, ribonuclease type III -0.0498681
PTMA prothymosin, alpha -0.0492034
RAB1A RAB1A, member RAS oncogene family -0.0485623
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0483335
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0477116
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0470156
NPTN neuroplastin -0.0467746
S100A6 S100 calcium binding protein A6 -0.0466695
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0465759
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0461566
GOLGA4 golgin A4 -0.0458262
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0440924
SRPK2 SRSF protein kinase 2 -0.0437951
DSCAM Down syndrome cell adhesion molecule -0.0437377
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0425782
MCTP1 multiple C2 domains, transmembrane 1 -0.0423198
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0417859
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0416252
KTN1 kinectin 1 (kinesin receptor) -0.0406771
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0406245
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0401585
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0398881
TPT1 tumor protein, translationally-controlled 1 -0.0396134
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0395912
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0394852
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0389661
RB1CC1 RB1-inducible coiled-coil 1 -0.0388998
TXNIP thioredoxin interacting protein -0.038804
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0386019
SNX9 sorting nexin 9 -0.0383667
GCLC glutamate-cysteine ligase, catalytic subunit -0.0377198
CD2AP CD2-associated protein -0.0376781
TRIO trio Rho guanine nucleotide exchange factor -0.0376375
KRT17 keratin 17, type I -0.0375329
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0374771
ACVR1 activin A receptor, type I -0.0373024
EXT1 exostosin glycosyltransferase 1 -0.0372592
MAST4 microtubule associated serine/threonine kinase family member 4 -0.037227
LPP LIM domain containing preferred translocation partner in lipoma -0.036982
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0365337
S100A10 S100 calcium binding protein A10 -0.0358212
FTH1 ferritin, heavy polypeptide 1 -0.0355851
CCNI cyclin I -0.0355584
RPL12 ribosomal protein L12 -0.0353485
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0350621
TMEM87A transmembrane protein 87A -0.0349181
OGA O-GlcNAcase -0.0348862
NALF1 NALCN channel auxiliary factor 1 -0.0347306
BPTF bromodomain PHD finger transcription factor -0.0346935
STC1 stanniocalcin 1 -0.0345922
ATOSA atos homolog A -0.0343225
BBX bobby sox homolog (Drosophila) -0.0343128
NPEPPS aminopeptidase puromycin sensitive -0.0342874
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0339998
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0334638
USP9X ubiquitin specific peptidase 9, X-linked -0.0334453
OSMR oncostatin M receptor -0.0333966
KDM6A lysine (K)-specific demethylase 6A -0.0325595
EXOC6B exocyst complex component 6B -0.0324668
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0322828
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0322183
NEK7 NIMA-related kinase 7 -0.0321443
TXNRD1 thioredoxin reductase 1 -0.0321338
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0317307
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0314607
SET SET nuclear proto-oncogene -0.0313629
KIF5B kinesin family member 5B -0.0313281
ERBIN erbb2 interacting protein -0.0310805
DLG1 discs, large homolog 1 (Drosophila) -0.0310485
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0305001
BASP1 brain abundant, membrane attached signal protein 1 -0.030384
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0302496
RPL35A ribosomal protein L35a -0.0302422
AKR1C2 aldo-keto reductase family 1, member C2 -0.0302168
RNF145 ring finger protein 145 -0.0300658
UBC ubiquitin C -0.0300631
HM13 histocompatibility (minor) 13 -0.0300156