Folic acid_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.238825
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.15495
GRAMD1B GRAM domain containing 1B 0.131972
THSD4 thrombospondin, type I, domain containing 4 0.116287
MCL1 myeloid cell leukemia 1 0.0970793
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0963003
PDE4D phosphodiesterase 4D, cAMP-specific 0.0877906
PDE10A phosphodiesterase 10A 0.0758515
OSMR oncostatin M receptor 0.0746889
DOCK5 dedicator of cytokinesis 5 0.0726545
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0721873
ERRFI1 ERBB receptor feedback inhibitor 1 0.0687707
FMNL2 formin-like 2 0.0637019
AFF3 AF4/FMR2 family, member 3 0.0615723
IGF1R insulin-like growth factor 1 receptor 0.0575918
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0564756
RIMS2 regulating synaptic membrane exocytosis 2 0.0564556
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.055434
EXOC4 exocyst complex component 4 0.0542432
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.053571
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.052952
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.051674
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0492039
PRKCE protein kinase C, epsilon 0.0477807
ATP11A ATPase, class VI, type 11A 0.0476772
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0470119
YAP1 Yes-associated protein 1 0.0464885
RAD51B RAD51 paralog B 0.0454755
EXT1 exostosin glycosyltransferase 1 0.0452055
WWOX WW domain containing oxidoreductase 0.0434544
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0433406
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0433006
VMP1 vacuole membrane protein 1 0.0432603
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0428318
HMGA2 high mobility group AT-hook 2 0.0417303
PDLIM5 PDZ and LIM domain 5 0.0413408
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0413348
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0412874
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0407899
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0407559
PTK2 protein tyrosine kinase 2 0.0405429
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0396121
CDK17 cyclin-dependent kinase 17 0.039358
EML4 echinoderm microtubule associated protein like 4 0.0380578
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0380475
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.037149
YBX3 Y box binding protein 3 0.0370794
POTEF POTE ankyrin domain family, member F 0.0361129
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0356492
RABGAP1L RAB GTPase activating protein 1-like 0.0349371
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0345787
MACF1 microtubule-actin crosslinking factor 1 0.0344962
PRELID2 PRELI domain containing 2 0.0343322
FNDC3B fibronectin type III domain containing 3B 0.0337482
PRH1 proline-rich protein HaeIII subfamily 1 0.0328976
PYGL phosphorylase, glycogen, liver 0.0325048
VCL vinculin 0.0324096
ATXN1 ataxin 1 0.0320925
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0318277
CCNL1 cyclin L1 0.0308204
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0305935
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0298354
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0297609
WWTR1 WW domain containing transcription regulator 1 0.0296956
ELL2 elongation factor, RNA polymerase II, 2 0.0295052
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0294738
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0285623
MYH9 myosin, heavy chain 9, non-muscle 0.0284986
USP34 ubiquitin specific peptidase 34 0.0280335
ANO6 anoctamin 6 0.027949
SVIL supervillin 0.0275518
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0273355
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0272777
LATS2 large tumor suppressor kinase 2 0.0271252
ZSWIM6 zinc finger, SWIM-type containing 6 0.0270395
RICTOR RPTOR independent companion of MTOR, complex 2 0.0270342
BASP1 brain abundant, membrane attached signal protein 1 0.0270204
CMIP c-Maf inducing protein 0.0266831
TAS2R14 taste receptor, type 2, member 14 0.0266019
SPIDR scaffolding protein involved in DNA repair 0.026479
LPP LIM domain containing preferred translocation partner in lipoma 0.0263094
TRIP12 thyroid hormone receptor interactor 12 0.0258989
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0257463
CUX1 cut-like homeobox 1 0.0255855
NF1 neurofibromin 1 0.0253915
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0251941
CDCP1 CUB domain containing protein 1 0.0248837
SMYD3 SET and MYND domain containing 3 0.0244754
NLGN1 neuroligin 1 0.0243951
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0243789
RYR3 ryanodine receptor 3 0.0241105
JMJD1C jumonji domain containing 1C 0.0240148
RNF213 ring finger protein 213 0.0239636
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0238384
EPAS1 endothelial PAS domain protein 1 0.023815
TTC28 tetratricopeptide repeat domain 28 0.0237674
ITSN1 intersectin 1 (SH3 domain protein) 0.023728
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0234803
DNAH14 dynein, axonemal, heavy chain 14 0.0234466
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0234319

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.238073
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127928
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.12056
VIM vimentin -0.104674
PTMA prothymosin, alpha -0.104432
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0812749
TFPI2 tissue factor pathway inhibitor 2 -0.0781346
RPS8 ribosomal protein S8 -0.0707207
TMSB10 thymosin beta 10 -0.0698027
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.067945
RPL12 ribosomal protein L12 -0.0528435
RPL26 ribosomal protein L26 -0.0502775
TPT1 tumor protein, translationally-controlled 1 -0.0491889
NAP1L1 nucleosome assembly protein 1-like 1 -0.0490696
RPL35A ribosomal protein L35a -0.0487613
RPL23 ribosomal protein L23 -0.04872
RPL37A ribosomal protein L37a -0.0486107
RPLP1 ribosomal protein, large, P1 -0.0485528
RPS3 ribosomal protein S3 -0.046898
RPL37 ribosomal protein L37 -0.046637
MYL12B myosin, light chain 12B, regulatory -0.0465082
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0445697
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0434567
RPS21 ribosomal protein S21 -0.0423156
RPL34 ribosomal protein L34 -0.0413408
EIF1 eukaryotic translation initiation factor 1 -0.0402703
RPLP0 ribosomal protein, large, P0 -0.0392834
RPL19 ribosomal protein L19 -0.0385882
CANX calnexin -0.0384195
RPS27A ribosomal protein S27a -0.0381033
RPS27 ribosomal protein S27 -0.0373921
KDM3A lysine (K)-specific demethylase 3A -0.0366376
GOLGA4 golgin A4 -0.0352736
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0349265
RPS19 ribosomal protein S19 -0.0346353
RACK1 receptor for activated C kinase 1 -0.0340231
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0334437
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0331823
RPS24 ribosomal protein S24 -0.0328392
RPL11 ribosomal protein L11 -0.0324441
SRP72 signal recognition particle 72kDa -0.0321443
TPI1 triosephosphate isomerase 1 -0.0313239
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0308759
RPL31 ribosomal protein L31 -0.030595
LMAN1 lectin, mannose-binding, 1 -0.0305016
RPS15 ribosomal protein S15 -0.0302962
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0300766
FTL ferritin, light polypeptide -0.0298084
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0296666
VDAC1 voltage-dependent anion channel 1 -0.0295147
RPS6 ribosomal protein S6 -0.0294775
RPL32 ribosomal protein L32 -0.0293466
RPS4X ribosomal protein S4, X-linked -0.0286399
RPS29 ribosomal protein S29 -0.0283057
RPL38 ribosomal protein L38 -0.0281391
GARS1 glycyl-tRNA synthetase 1 -0.0277826
ZFR zinc finger RNA binding protein -0.0276608
PDIA4 protein disulfide isomerase family A, member 4 -0.0275486
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0273102
RPL5 ribosomal protein L5 -0.0271376
RPLP2 ribosomal protein, large, P2 -0.0271215
RPL8 ribosomal protein L8 -0.0267478
RPS12 ribosomal protein S12 -0.0265809
KPNB1 karyopherin (importin) beta 1 -0.0262723
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0261331
MT2A metallothionein 2A -0.0261196
PGK1 phosphoglycerate kinase 1 -0.0260395
ACTG1 actin gamma 1 -0.0259864
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0259257
KTN1 kinectin 1 (kinesin receptor) -0.0257306
CAVIN1 caveolae associated protein 1 -0.0257108
RPL9 ribosomal protein L9 -0.0256744
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0255049
WSB1 WD repeat and SOCS box containing 1 -0.0252855
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0250106
NACA nascent polypeptide-associated complex alpha subunit -0.0242702
RAD21 RAD21 homolog (S. pombe) -0.0240496
RSL1D1 ribosomal L1 domain containing 1 -0.0238724
UBB ubiquitin B -0.023749
RPS25 ribosomal protein S25 -0.0237416
PREPL prolyl endopeptidase-like -0.0237257
GNAS GNAS complex locus -0.0236013
LOC112694756 uncharaterized LOC112694756 -0.0235494
YBX1 Y box binding protein 1 -0.0233123
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0231754
RPL36 ribosomal protein L36 -0.0231205
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.022969
PHIP pleckstrin homology domain interacting protein -0.0228757
RAB1A RAB1A, member RAS oncogene family -0.0228526
LDHB lactate dehydrogenase B -0.0227318
RPL35 ribosomal protein L35 -0.0227272
SSB Sjogren syndrome antigen B (autoantigen La) -0.0226003
DEK DEK proto-oncogene -0.0225932
KIF5B kinesin family member 5B -0.022525
LDHA lactate dehydrogenase A -0.022197
SEPTIN7 septin 7 -0.0220812
RPL13A ribosomal protein L13a -0.0220742
CSDE1 cold shock domain containing E1, RNA-binding -0.0220085
BZW1 basic leucine zipper and W2 domains 1 -0.0218763
MORF4L2 mortality factor 4 like 2 -0.0218199