Folic acid_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.185967
SAMD4A sterile alpha motif domain containing 4A 0.156892
EFNA5 ephrin-A5 0.120362
TRIO trio Rho guanine nucleotide exchange factor 0.109556
LPP LIM domain containing preferred translocation partner in lipoma 0.108481
LIMCH1 LIM and calponin homology domains 1 0.0887219
FNDC3B fibronectin type III domain containing 3B 0.0874352
EXT1 exostosin glycosyltransferase 1 0.0826226
GRB10 growth factor receptor-bound protein 10 0.0738565
NAV2 neuron navigator 2 0.0702611
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.069417
LMO7 LIM domain 7 0.0597313
PTK2 protein tyrosine kinase 2 0.0579221
ERBIN erbb2 interacting protein 0.0552919
ZSWIM6 zinc finger, SWIM-type containing 6 0.0520484
MYH9 myosin, heavy chain 9, non-muscle 0.0514347
AHNAK AHNAK nucleoprotein 0.0479398
SMAD3 SMAD family member 3 0.0470122
LAMC2 laminin, gamma 2 0.0449653
ERRFI1 ERBB receptor feedback inhibitor 1 0.0436045
ELL2 elongation factor, RNA polymerase II, 2 0.0429324
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0423701
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0416569
ATXN1 ataxin 1 0.0414325
RUNX1 runt-related transcription factor 1 0.0403694
MACF1 microtubule-actin crosslinking factor 1 0.0400396
AKAP13 A kinase (PRKA) anchor protein 13 0.03903
MYO5B myosin VB 0.0389762
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0383047
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0375367
MYO6 myosin VI 0.0373739
ASPH aspartate beta-hydroxylase 0.0371581
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0365615
FHIT fragile histidine triad 0.0363966
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0363585
DTNA dystrobrevin, alpha 0.0354399
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0341317
OCLN occludin 0.0338351
FBXO32 F-box protein 32 0.0336835
NRIP1 nuclear receptor interacting protein 1 0.0333144
RASAL2 RAS protein activator like 2 0.0330537
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0328258
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0327521
RAD51B RAD51 paralog B 0.0320959
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0320752
ATP11A ATPase, class VI, type 11A 0.031962
MAML2 mastermind-like 2 (Drosophila) 0.0313299
PLEC plectin 0.0311746
EGFR epidermal growth factor receptor 0.0305599
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.030507
FLNB filamin B, beta 0.030095
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0299325
DST dystonin 0.0298115
VCL vinculin 0.0297019
ETV6 ets variant 6 0.0291576
FNIP1 folliculin interacting protein 1 0.0290762
PRKCA protein kinase C, alpha 0.0290279
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0290225
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0288898
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0287933
SH3RF1 SH3 domain containing ring finger 1 0.0287484
ARHGAP5 Rho GTPase activating protein 5 0.0285783
PATJ PATJ crumbs cell polarity complex component 0.0284823
DUSP10 dual specificity phosphatase 10 0.0282014
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0281356
ANO6 anoctamin 6 0.0280377
ZBTB20 zinc finger and BTB domain containing 20 0.0278572
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0278533
PGBD5 piggyBac transposable element derived 5 0.0277304
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0276648
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0275075
ARHGAP20 Rho GTPase activating protein 20 0.0272245
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0270365
PPARD peroxisome proliferator-activated receptor delta 0.0269475
SVIL supervillin 0.0264742
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.02637
MYO1E myosin IE 0.0261043
CAB39 calcium binding protein 39 0.0259179
PICALM phosphatidylinositol binding clathrin assembly protein 0.0257727
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0257607
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0251785
PDLIM5 PDZ and LIM domain 5 0.0251421
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.025116
SMYD3 SET and MYND domain containing 3 0.0249861
DOCK5 dedicator of cytokinesis 5 0.024896
MACC1 metastasis associated in colon cancer 1 0.0248291
GLS2 glutaminase 2 (liver, mitochondrial) 0.0247593
MCTP2 multiple C2 domains, transmembrane 2 0.024696
SAMD12 sterile alpha motif domain containing 12 0.0245056
RBM47 RNA binding motif protein 47 0.0240726
PLSCR1 phospholipid scramblase 1 0.0239827
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0239325
NF1 neurofibromin 1 0.0237682
RNF213 ring finger protein 213 0.0236024
VGLL3 vestigial-like family member 3 0.0235524
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0234245
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0233331
BTBD9 BTB (POZ) domain containing 9 0.0231985
FER fer (fps/fes related) tyrosine kinase 0.0229458
SBF2 SET binding factor 2 0.0229385

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.237407
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.195814
PTMA prothymosin, alpha -0.165835
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0998452
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0984356
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0952138
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0891089
TMSB10 thymosin beta 10 -0.0885244
ACTG1 actin gamma 1 -0.0772812
S100A6 S100 calcium binding protein A6 -0.0738366
TPT1 tumor protein, translationally-controlled 1 -0.0722177
RPL35A ribosomal protein L35a -0.0651397
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0619152
EIF1 eukaryotic translation initiation factor 1 -0.061478
RPS6 ribosomal protein S6 -0.0609007
RPS8 ribosomal protein S8 -0.0581651
RPLP1 ribosomal protein, large, P1 -0.0577933
MT2A metallothionein 2A -0.0552364
HMGA1 high mobility group AT-hook 1 -0.0534121
POTEF POTE ankyrin domain family, member F -0.0529681
RPL23 ribosomal protein L23 -0.0503806
RPL34 ribosomal protein L34 -0.0503357
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0490959
RPS19 ribosomal protein S19 -0.0476984
RPL8 ribosomal protein L8 -0.0452142
RPL9 ribosomal protein L9 -0.0450367
RPS3 ribosomal protein S3 -0.0449091
S100A10 S100 calcium binding protein A10 -0.0428142
RPS23 ribosomal protein S23 -0.0424047
SLC38A1 solute carrier family 38, member 1 -0.0423391
RPLP2 ribosomal protein, large, P2 -0.0421508
RPS29 ribosomal protein S29 -0.0409938
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0396636
RPL37A ribosomal protein L37a -0.0379315
FN1 fibronectin 1 -0.0376111
RPS13 ribosomal protein S13 -0.0366795
ISG15 ISG15 ubiquitin-like modifier -0.0365604
TMSB4X thymosin beta 4, X-linked -0.0363243
VIM vimentin -0.0360886
RACK1 receptor for activated C kinase 1 -0.0355697
RPL12 ribosomal protein L12 -0.035555
RPS12 ribosomal protein S12 -0.0354893
CALR calreticulin -0.0353426
RPLP0 ribosomal protein, large, P0 -0.0343142
RBM25 RNA binding motif protein 25 -0.0333125
RAD21 RAD21 homolog (S. pombe) -0.0326458
S100A9 S100 calcium binding protein A9 -0.0324617
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0322368
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0319254
RPL11 ribosomal protein L11 -0.0318431
IFITM3 interferon induced transmembrane protein 3 -0.0315437
G0S2 G0/G1 switch 2 -0.0304386
DSTN destrin (actin depolymerizing factor) -0.0299393
RPL32 ribosomal protein L32 -0.0298913
RPS14 ribosomal protein S14 -0.0297225
HMGB2 high mobility group box 2 -0.0297162
RPS27A ribosomal protein S27a -0.0294819
RPL5 ribosomal protein L5 -0.0293593
RPS25 ribosomal protein S25 -0.0288849
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.028562
RPS27 ribosomal protein S27 -0.0282216
RPL19 ribosomal protein L19 -0.0280528
UQCRB ubiquinol-cytochrome c reductase binding protein -0.028026
GNAS GNAS complex locus -0.0276422
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0275278
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0273902
RPL37 ribosomal protein L37 -0.0270062
NAP1L1 nucleosome assembly protein 1-like 1 -0.0269317
LMNA lamin A/C -0.0260164
EPCAM epithelial cell adhesion molecule -0.0258985
RPL31 ribosomal protein L31 -0.025896
IFI27 interferon, alpha-inducible protein 27 -0.0257293
GOLGA4 golgin A4 -0.0256934
CSTB cystatin B (stefin B) -0.025148
YBX1 Y box binding protein 1 -0.0250879
GARS1 glycyl-tRNA synthetase 1 -0.0247584
RPL7 ribosomal protein L7 -0.0245043
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0243619
RPL15 ribosomal protein L15 -0.024276
TPM4 tropomyosin 4 -0.0242612
RPL36 ribosomal protein L36 -0.0242226
FTH1 ferritin, heavy polypeptide 1 -0.0239357
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0237274
IFITM1 interferon induced transmembrane protein 1 -0.0235676
RPL30 ribosomal protein L30 -0.023414
FAM162A family with sequence similarity 162, member A -0.0234082
HLA-B major histocompatibility complex, class I, B -0.0233061
H3-3B H3.3 histone B -0.0231984
CANX calnexin -0.0226799
EEF2 eukaryotic translation elongation factor 2 -0.0226355
RPL26 ribosomal protein L26 -0.0224058
B2M beta-2-microglobulin -0.022198
RPL36A ribosomal protein L36a -0.0218648
C15ORF48 chromosome 15 open reading frame 48 -0.0216054
CD63 CD63 molecule -0.0215199
RPS10 ribosomal protein S10 -0.0213591
KTN1 kinectin 1 (kinesin receptor) -0.0211824
RPS16 ribosomal protein S16 -0.0210796
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0210368
HLA-A major histocompatibility complex, class I, A -0.0208976