Folic acid_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.219469
GRAMD1B GRAM domain containing 1B 0.17074
TXNRD1 thioredoxin reductase 1 0.11085
GDA guanine deaminase 0.10514
NAMPT nicotinamide phosphoribosyltransferase 0.103051
COL8A1 collagen, type VIII, alpha 1 0.097125
SPTBN1 spectrin, beta, non-erythrocytic 1 0.093107
PDE10A phosphodiesterase 10A 0.0782072
ASPH aspartate beta-hydroxylase 0.0709096
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0636976
EFNA5 ephrin-A5 0.0617629
NEK7 NIMA-related kinase 7 0.0570122
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0543606
DOCK4 dedicator of cytokinesis 4 0.0541442
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0519451
PM20D1 peptidase M20 domain containing 1 0.0505917
TRIO trio Rho guanine nucleotide exchange factor 0.0483465
EZR ezrin 0.0482616
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0478047
RAB3B RAB3B, member RAS oncogene family 0.0476102
ELL2 elongation factor, RNA polymerase II, 2 0.0441652
BCAR3 breast cancer anti-estrogen resistance 3 0.0424542
ESYT2 extended synaptotagmin-like protein 2 0.0417598
NT5C2 5'-nucleotidase, cytosolic II 0.0405845
KYNU kynureninase 0.0404584
TBXT T-box transcription factor T 0.0403334
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0397353
NRCAM neuronal cell adhesion molecule 0.0396311
OGA O-GlcNAcase 0.0393848
SAMD4A sterile alpha motif domain containing 4A 0.038419
COL5A2 collagen, type V, alpha 2 0.0371293
TFPI2 tissue factor pathway inhibitor 2 0.0369281
DISP1 dispatched homolog 1 (Drosophila) 0.0364523
FLNB filamin B, beta 0.0361531
RPLP1 ribosomal protein, large, P1 0.0356541
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0355738
CXCL8 chemokine (C-X-C motif) ligand 8 0.035311
RPH3AL rabphilin 3A-like (without C2 domains) 0.0352487
MFF mitochondrial fission factor 0.0347322
BDNF brain-derived neurotrophic factor 0.0346496
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0346299
MCL1 myeloid cell leukemia 1 0.0312957
WWTR1 WW domain containing transcription regulator 1 0.0305979
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0302766
AHNAK AHNAK nucleoprotein 0.029911
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0290727
IGF1R insulin-like growth factor 1 receptor 0.0289085
DST dystonin 0.0288157
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0278731
TM4SF1 transmembrane 4 L six family member 1 0.0275066
PDE4D phosphodiesterase 4D, cAMP-specific 0.0269453
PTGR1 prostaglandin reductase 1 0.0264422
TGFBI transforming growth factor, beta-induced, 68kDa 0.0262186
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.02607
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0258662
DGKD diacylglycerol kinase, delta 130kDa 0.0258594
AVL9 AVL9 homolog (S. cerevisiase) 0.0254258
PYGL phosphorylase, glycogen, liver 0.0253194
RTN4 reticulon 4 0.024847
CFLAR CASP8 and FADD-like apoptosis regulator 0.0248318
ANKRD28 ankyrin repeat domain 28 0.0247408
MYOF myoferlin 0.0246524
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0244416
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0240901
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0240705
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.023834
SLF1 SMC5-SMC6 complex localization factor 1 0.0231243
INHBA inhibin, beta A 0.022612
MALT1 MALT1 paracaspase 0.0223385
ARHGAP29 Rho GTPase activating protein 29 0.0221789
ZBTB38 zinc finger and BTB domain containing 38 0.0221044
COL4A5 collagen, type IV, alpha 5 0.0217489
ALPK2 alpha-kinase 2 0.0216159
ZEB2 zinc finger E-box binding homeobox 2 0.0214081
AGFG1 ArfGAP with FG repeats 1 0.0210467
UNC5D unc-5 homolog D (C. elegans) 0.0208748
TMX4 thioredoxin-related transmembrane protein 4 0.0208118
NCAM1 neural cell adhesion molecule 1 0.0207394
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0206498
OSMR oncostatin M receptor 0.0205448
RPL35A ribosomal protein L35a 0.0205023
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0204808
MKI67 marker of proliferation Ki-67 0.0202627
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0200327
TBC1D5 TBC1 domain family, member 5 0.0197767
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0196973
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0194279
HSPA8 heat shock 70kDa protein 8 0.0193213
DOCK5 dedicator of cytokinesis 5 0.0192892
SSH2 slingshot protein phosphatase 2 0.0192438
NFE2L2 nuclear factor, erythroid 2-like 2 0.0191535
RTN1 reticulon 1 0.0189562
NPAS2 neuronal PAS domain protein 2 0.0189333
RPL19 ribosomal protein L19 0.0187833
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0187071
PRKN parkin RBR E3 ubiquitin protein ligase 0.018652
PHIP pleckstrin homology domain interacting protein 0.0186433
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0185553
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0183109
TNPO1 transportin 1 0.0182066

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.238228
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.16738
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0829817
CDH13 cadherin 13 -0.0820669
FN1 fibronectin 1 -0.076658
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0614797
IGFBP3 insulin-like growth factor binding protein 3 -0.0560147
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0515876
VIM vimentin -0.0500226
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0495245
AUTS2 autism susceptibility candidate 2 -0.0470781
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0437473
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0437052
NCKAP5 NCK-associated protein 5 -0.0436528
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0420679
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0378413
RPS6 ribosomal protein S6 -0.0377854
WARS1 tryptophanyl-tRNA synthetase 1 -0.036472
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0355192
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0346146
RAD51B RAD51 paralog B -0.0341877
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0340559
TPT1 tumor protein, translationally-controlled 1 -0.0323922
NALF1 NALCN channel auxiliary factor 1 -0.0321976
SMOC1 SPARC related modular calcium binding 1 -0.0319141
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0313757
SOX6 SRY (sex determining region Y)-box 6 -0.0313407
LAMA5 laminin, alpha 5 -0.0311788
MARCHF1 membrane associated ring-CH-type finger 1 -0.0300334
RPS8 ribosomal protein S8 -0.0299499
DNER delta/notch-like EGF repeat containing -0.0297114
RPS12 ribosomal protein S12 -0.0290455
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.028741
SMAD2 SMAD family member 2 -0.0287401
DENND1A DENN/MADD domain containing 1A -0.0284776
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0282399
PDIA3 protein disulfide isomerase family A, member 3 -0.0279503
LSAMP limbic system-associated membrane protein -0.0276836
GRB10 growth factor receptor-bound protein 10 -0.0267615
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0263132
IARS1 isoleucyl-tRNA synthetase 1 -0.0262592
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0261701
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0258298
CTBP2 C-terminal binding protein 2 -0.0255652
CHD1 chromodomain helicase DNA binding protein 1 -0.0249031
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0245703
MORF4L2 mortality factor 4 like 2 -0.0235455
SLC38A2 solute carrier family 38, member 2 -0.0231432
IRS2 insulin receptor substrate 2 -0.0230563
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0225681
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0223296
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0222385
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -0.0218578
RPS24 ribosomal protein S24 -0.0216332
VCL vinculin -0.0211717
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0210856
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0210687
INTS6 integrator complex subunit 6 -0.020964
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0209563
LAMB1 laminin, beta 1 -0.020855
COPA coatomer protein complex, subunit alpha -0.0207655
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0207584
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0207422
PTPRD protein tyrosine phosphatase, receptor type, D -0.0206613
FNIP1 folliculin interacting protein 1 -0.0205987
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0202623
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0201665
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0200716
XYLT1 xylosyltransferase I -0.0194031
UBAP2 ubiquitin associated protein 2 -0.019378
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0193535
P3H2 prolyl 3-hydroxylase 2 -0.0191854
ZMIZ1 zinc finger, MIZ-type containing 1 -0.018764
SCFD1 sec1 family domain containing 1 -0.01862
SLC16A6 solute carrier family 16, member 6 -0.0183257
PDIA6 protein disulfide isomerase family A, member 6 -0.0182527
NRXN3 neurexin 3 -0.0181922
EGR1 early growth response 1 -0.0179564
NAP1L1 nucleosome assembly protein 1-like 1 -0.0178648
WSB1 WD repeat and SOCS box containing 1 -0.0177502
CAMTA1 calmodulin binding transcription activator 1 -0.0177334
SOX9 SRY (sex determining region Y)-box 9 -0.0175755
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0175486
KIF16B kinesin family member 16B -0.0173939
ASTN2 astrotactin 2 -0.0172099
PFN1 profilin 1 -0.0172087
CLTC clathrin, heavy chain (Hc) -0.0171731
TTC28 tetratricopeptide repeat domain 28 -0.0171414
ADGRD1 adhesion G protein-coupled receptor D1 -0.0169831
CLU clusterin -0.0168229
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0166946
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0165812
IFI16 interferon, gamma-inducible protein 16 -0.0164348
PGM3 phosphoglucomutase 3 -0.0163093
GPC6 glypican 6 -0.0161123
RPS3 ribosomal protein S3 -0.0160577
KAT6B K(lysine) acetyltransferase 6B -0.0160512
RPL9 ribosomal protein L9 -0.0160476
ZFHX3 zinc finger homeobox 3 -0.0160063
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0159721