Folic acid_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

140 genes differentially expressed following the Folic acid_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INHBA inhibin, beta A 0.174254
IGF2 insulin-like growth factor 2 0.171078
PDE4D phosphodiesterase 4D, cAMP-specific 0.165677
EXT1 exostosin glycosyltransferase 1 0.142491
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.119015
RORA RAR-related orphan receptor A 0.108456
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0993443
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0935125
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0934992
NALF1 NALCN channel auxiliary factor 1 0.0904751
CDH13 cadherin 13 0.0903689
DST dystonin 0.0876513
SAMD4A sterile alpha motif domain containing 4A 0.0815386
PSD3 pleckstrin and Sec7 domain containing 3 0.0792125
ERRFI1 ERBB receptor feedback inhibitor 1 0.0771064
FLNB filamin B, beta 0.0760236
PUM2 pumilio RNA-binding family member 2 0.074147
PDE10A phosphodiesterase 10A 0.0711797
CLTC clathrin, heavy chain (Hc) 0.0692357
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0599728
PALLD palladin, cytoskeletal associated protein 0.0588662
YAP1 Yes-associated protein 1 0.058576
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0555475
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0550229
MAML3 mastermind-like 3 (Drosophila) 0.0526282
STC1 stanniocalcin 1 0.050905
DSPP dentin sialophosphoprotein 0.0495315
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0478322
NLGN1 neuroligin 1 0.0456568
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0439609
KMT2C lysine (K)-specific methyltransferase 2C 0.042852
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0416076
EGR1 early growth response 1 0.0398108
RAP1B RAP1B, member of RAS oncogene family 0.0382896
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0341579
RUNX1 runt-related transcription factor 1 0.0340888
CELF1 CUGBP, Elav-like family member 1 0.0340209
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0336835
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0327415
VCL vinculin 0.0325996
KDM3A lysine (K)-specific demethylase 3A 0.031827
PTK2 protein tyrosine kinase 2 0.0311004
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0301397
FRMD4A FERM domain containing 4A 0.029629
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0294615
ALCAM activated leukocyte cell adhesion molecule 0.0291972
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0291118
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0290753
PLAUR plasminogen activator, urokinase receptor 0.0285427
PTPRG protein tyrosine phosphatase, receptor type, G 0.0281144
TENT5A terminal nucleotidyltransferase 5A 0.0275697
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0272392
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0257534
ASPH aspartate beta-hydroxylase 0.024883
BRD2 bromodomain containing 2 0.0242602
PRRC2C proline-rich coiled-coil 2C 0.0235743
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0234047
INTS6 integrator complex subunit 6 0.0218556
ZBTB20 zinc finger and BTB domain containing 20 0.0217159
NAMPT nicotinamide phosphoribosyltransferase 0.0206337
MARCHF6 membrane associated ring-CH-type finger 6 0.0204007
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.020215
PDLIM5 PDZ and LIM domain 5 0.018254
KMT2E lysine (K)-specific methyltransferase 2E 0.0181025
WAC WW domain containing adaptor with coiled-coil 0.0151253
ITGAV integrin, alpha V 0.0142507
IQGAP1 IQ motif containing GTPase activating protein 1 0.0138942
PCBP3 poly(rC) binding protein 3 0.0138571
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0132815
EIF1 eukaryotic translation initiation factor 1 0.00990361
GPC6 glypican 6 0.00812777
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.00713308
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.00668617
RAD51B RAD51 paralog B 0.00517657
AK1 adenylate kinase 1 0.00429066
EFNA5 ephrin-A5 0.00308108
LDHA lactate dehydrogenase A 0.0030063
AHNAK AHNAK nucleoprotein 0.00228007
GSE1 Gse1 coiled-coil protein 1.38032E-4

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.218554
TMSB10 thymosin beta 10 -0.158142
EGFR epidermal growth factor receptor -0.156128
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.129049
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.12387
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.120893
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.101615
LPP LIM domain containing preferred translocation partner in lipoma -0.0994231
AKAP12 A kinase (PRKA) anchor protein 12 -0.0972695
MT2A metallothionein 2A -0.0955329
RPS6 ribosomal protein S6 -0.0909552
ANXA2 annexin A2 -0.0869689
THSD4 thrombospondin, type I, domain containing 4 -0.0683631
RPL23 ribosomal protein L23 -0.0672332
DSCAM Down syndrome cell adhesion molecule -0.0654225
UBC ubiquitin C -0.0635049
VIM vimentin -0.061102
LMO7 LIM domain 7 -0.0603109
SMYD3 SET and MYND domain containing 3 -0.0589167
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0573608
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0571811
FMNL2 formin-like 2 -0.0569752
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.054945
RPS27A ribosomal protein S27a -0.0543784
COL6A3 collagen, type VI, alpha 3 -0.0540515
FN1 fibronectin 1 -0.0456687
MYO10 myosin X -0.0456417
FNDC3B fibronectin type III domain containing 3B -0.0422392
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0414231
ACTN4 actinin, alpha 4 -0.0409787
ENO1 enolase 1, (alpha) -0.0402852
JMJD1C jumonji domain containing 1C -0.0376226
SMAD3 SMAD family member 3 -0.0368155
RPS3 ribosomal protein S3 -0.031863
IGF1R insulin-like growth factor 1 receptor -0.0302537
CCNI cyclin I -0.0288451
PARD3 par-3 family cell polarity regulator -0.0284387
PRKCA protein kinase C, alpha -0.0277667
RPS12 ribosomal protein S12 -0.0269698
RLF rearranged L-myc fusion -0.0252419
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0249204
IGFBP3 insulin-like growth factor binding protein 3 -0.0246801
CD44 CD44 molecule (Indian blood group) -0.023179
NUP58 nucleoporin 58 -0.0231751
RTN4 reticulon 4 -0.0204979
GOLGB1 golgin B1 -0.0176458
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0175756
HMGA2 high mobility group AT-hook 2 -0.0171329
MYO1E myosin IE -0.0169221
PGK1 phosphoglycerate kinase 1 -0.0154104
ZNF292 zinc finger protein 292 -0.013276
TPT1 tumor protein, translationally-controlled 1 -0.0126368
MED13L mediator complex subunit 13-like -0.0114615
PRELID2 PRELI domain containing 2 -0.00911572
ANKRD11 ankyrin repeat domain 11 -0.00880743
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.00774907
NDRG1 N-myc downstream regulated 1 -0.00620707
PKM pyruvate kinase, muscle -0.0055845
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.00461588
TRIO trio Rho guanine nucleotide exchange factor -0.00201588
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.00201242