Folic acid_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.129062
EFNA5 ephrin-A5 0.0944498
MAML2 mastermind-like 2 (Drosophila) 0.0919868
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0808912
RUNX1 runt-related transcription factor 1 0.0790263
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0741413
MUC4 mucin 4, cell surface associated 0.0739666
RAD51B RAD51 paralog B 0.0698103
SVIL supervillin 0.0627445
FNDC3B fibronectin type III domain containing 3B 0.0606719
IL1RAP interleukin 1 receptor accessory protein 0.0588146
SMAD3 SMAD family member 3 0.0560816
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0553827
MUC16 mucin 16, cell surface associated 0.0546948
ARHGAP26 Rho GTPase activating protein 26 0.0532995
SMYD3 SET and MYND domain containing 3 0.0505539
FHIT fragile histidine triad 0.0503866
FOSL1 FOS-like antigen 1 0.0495749
LPP LIM domain containing preferred translocation partner in lipoma 0.0473389
SAMD12 sterile alpha motif domain containing 12 0.0459663
MACF1 microtubule-actin crosslinking factor 1 0.0459327
DLG1 discs, large homolog 1 (Drosophila) 0.0458943
SEPTIN9 septin 9 0.0443101
TGM2 transglutaminase 2 0.0439673
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0426107
NRP1 neuropilin 1 0.0423035
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0418447
CLMN calmin (calponin-like, transmembrane) 0.0416213
NDRG1 N-myc downstream regulated 1 0.0414982
TRIO trio Rho guanine nucleotide exchange factor 0.0405125
ETV6 ets variant 6 0.0401321
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0397574
EXOC4 exocyst complex component 4 0.0385357
SLC35F3 solute carrier family 35, member F3 0.0382384
MACC1 metastasis associated in colon cancer 1 0.0378865
EGR1 early growth response 1 0.0349114
MT2A metallothionein 2A 0.0347027
NRIP1 nuclear receptor interacting protein 1 0.0332344
OSMR oncostatin M receptor 0.0331615
TBC1D5 TBC1 domain family, member 5 0.0320168
TAPBP TAP binding protein (tapasin) 0.0319493
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0319163
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.030949
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0301095
TRAPPC9 trafficking protein particle complex 9 0.0296285
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0293006
RPL35A ribosomal protein L35a 0.0292111
BCL2L1 BCL2-like 1 0.0291528
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0287249
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0287126
CCNL1 cyclin L1 0.0283293
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0282205
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0281564
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0281422
MAML3 mastermind-like 3 (Drosophila) 0.0279278
ATXN1 ataxin 1 0.0278281
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0275808
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0275802
AFAP1 actin filament associated protein 1 0.0273124
PRELID2 PRELI domain containing 2 0.0271357
EZR ezrin 0.0269488
RPLP1 ribosomal protein, large, P1 0.0267073
BACE2 beta-site APP-cleaving enzyme 2 0.0266898
RORA RAR-related orphan receptor A 0.0266211
LAMA4 laminin, alpha 4 0.0263336
BICC1 BicC family RNA binding protein 1 0.0261736
ESYT2 extended synaptotagmin-like protein 2 0.025925
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0258347
ZBTB20 zinc finger and BTB domain containing 20 0.0255755
CNKSR3 CNKSR family member 3 0.0255272
SLTM SAFB-like, transcription modulator 0.0254624
PICALM phosphatidylinositol binding clathrin assembly protein 0.0252335
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0251141
RPS19 ribosomal protein S19 0.0245912
CD44 CD44 molecule (Indian blood group) 0.0245858
DOCK1 dedicator of cytokinesis 1 0.024527
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0244045
DST dystonin 0.0242953
AFDN afadin, adherens junction formation factor 0.0242395
YEATS2 YEATS domain containing 2 0.0238677
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.0235292
NFIB nuclear factor I/B 0.023104
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0230757
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0230272
MX1 MX dynamin-like GTPase 1 0.0230175
WWOX WW domain containing oxidoreductase 0.0229024
MPRIP myosin phosphatase Rho interacting protein 0.0228502
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0228212
PTK2 protein tyrosine kinase 2 0.0227622
VMP1 vacuole membrane protein 1 0.022735
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0226272
PATJ PATJ crumbs cell polarity complex component 0.0222254
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0222247
MKI67 marker of proliferation Ki-67 0.0221447
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0217327
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0216935
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0215711
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0214377
MYOF myoferlin 0.0210193
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0209733

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.164265
TPT1 tumor protein, translationally-controlled 1 -0.144928
KRT17 keratin 17, type I -0.104659
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.100425
UBC ubiquitin C -0.0982419
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0901342
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0868717
MYO6 myosin VI -0.0850648
TMSB4X thymosin beta 4, X-linked -0.0843434
DSCAM Down syndrome cell adhesion molecule -0.0730759
CANX calnexin -0.0724377
RPS27A ribosomal protein S27a -0.0720544
TMSB10 thymosin beta 10 -0.0645375
CALR calreticulin -0.0615805
AHNAK AHNAK nucleoprotein -0.0586599
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0575598
LMO7 LIM domain 7 -0.0547135
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0526988
ACTG1 actin gamma 1 -0.0519352
TM4SF1 transmembrane 4 L six family member 1 -0.050975
B2M beta-2-microglobulin -0.0499127
DSG2 desmoglein 2 -0.0454371
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0419761
TOP2A topoisomerase (DNA) II alpha 170kDa -0.04191
RPL23 ribosomal protein L23 -0.0417332
LAMB3 laminin, beta 3 -0.0416019
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0398379
KDM3A lysine (K)-specific demethylase 3A -0.0391126
KRT18 keratin 18, type I -0.0388665
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0383292
EMP1 epithelial membrane protein 1 -0.0374359
OGA O-GlcNAcase -0.0372096
RAD21 RAD21 homolog (S. pombe) -0.0371761
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0368651
GOLGB1 golgin B1 -0.0366126
RPS8 ribosomal protein S8 -0.0361995
TPM4 tropomyosin 4 -0.0343292
KRT7 keratin 7, type II -0.0342654
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0332833
SPAG9 sperm associated antigen 9 -0.0324646
EEF1G eukaryotic translation elongation factor 1 gamma -0.0323355
HLA-B major histocompatibility complex, class I, B -0.0322271
COPB1 coatomer protein complex, subunit beta 1 -0.0310608
HLA-E major histocompatibility complex, class I, E -0.0307798
HMGA1 high mobility group AT-hook 1 -0.0305511
TMF1 TATA element modulatory factor 1 -0.0302727
TRA2A transformer 2 alpha homolog (Drosophila) -0.0297686
EPCAM epithelial cell adhesion molecule -0.0295684
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.029549
PDLIM5 PDZ and LIM domain 5 -0.0288192
ERBIN erbb2 interacting protein -0.0286683
WSB1 WD repeat and SOCS box containing 1 -0.0285404
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0282984
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0279978
INTS6 integrator complex subunit 6 -0.027841
RPS24 ribosomal protein S24 -0.0276267
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0274057
HDLBP high density lipoprotein binding protein -0.0273695
FNBP4 formin binding protein 4 -0.0273477
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.027182
IFIH1 interferon induced with helicase C domain 1 -0.0264757
GOLGA4 golgin A4 -0.0262436
BZW1 basic leucine zipper and W2 domains 1 -0.0261082
RPS3 ribosomal protein S3 -0.0258742
KTN1 kinectin 1 (kinesin receptor) -0.0258502
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0256038
PDIA3 protein disulfide isomerase family A, member 3 -0.0254385
TFG TRK-fused gene -0.0253799
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0252834
RBM25 RNA binding motif protein 25 -0.0252817
PCBP2 poly(rC) binding protein 2 -0.0252294
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0250161
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.024915
HMGB2 high mobility group box 2 -0.0247024
FBXO11 F-box protein 11 -0.0236514
KIF5B kinesin family member 5B -0.0233847
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0229284
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0228764
EIF1 eukaryotic translation initiation factor 1 -0.0228607
KLF5 Kruppel-like factor 5 (intestinal) -0.0227746
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0227481
CD2AP CD2-associated protein -0.022698
RPS6 ribosomal protein S6 -0.022697
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0226321
YTHDC1 YTH domain containing 1 -0.022308
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0221297
LDHA lactate dehydrogenase A -0.0220783
VIM vimentin -0.0220699
SOX4 SRY (sex determining region Y)-box 4 -0.0220669
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0220056
H3-3B H3.3 histone B -0.0219461
PLK2 polo-like kinase 2 -0.0219402
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0217657
JUN jun proto-oncogene -0.0216483
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0214142
FN1 fibronectin 1 -0.0212861
SEC31A SEC31 homolog A (S. cerevisiae) -0.0212199
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0212176
HLA-C major histocompatibility complex, class I, C -0.0211752
UGCG UDP-glucose ceramide glucosyltransferase -0.0209477