Folic acid_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in RKO cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Folic acid_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.157356
FLNB filamin B, beta 0.1273
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0956485
ZEB1 zinc finger E-box binding homeobox 1 0.0743782
MCL1 myeloid cell leukemia 1 0.0674
ELL2 elongation factor, RNA polymerase II, 2 0.0656146
EXT1 exostosin glycosyltransferase 1 0.0644412
PHC2 polyhomeotic homolog 2 (Drosophila) 0.056774
ARHGAP22 Rho GTPase activating protein 22 0.0561439
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0494447
EFNB2 ephrin-B2 0.048865
JMJD1C jumonji domain containing 1C 0.0481603
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.047499
C2CD2 C2 calcium-dependent domain containing 2 0.0458473
CREB5 cAMP responsive element binding protein 5 0.0446041
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.042955
SGMS2 sphingomyelin synthase 2 0.042864
IARS1 isoleucyl-tRNA synthetase 1 0.0426331
ASPH aspartate beta-hydroxylase 0.0423644
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.042067
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0411579
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0411058
AGO2 argonaute RISC catalytic component 2 0.0410054
PTBP2 polypyrimidine tract binding protein 2 0.0406874
ANTXR2 anthrax toxin receptor 2 0.0402262
MYH9 myosin, heavy chain 9, non-muscle 0.0385556
RB1CC1 RB1-inducible coiled-coil 1 0.0383597
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0375189
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0374774
POTEF POTE ankyrin domain family, member F 0.0373935
TXNRD1 thioredoxin reductase 1 0.0364436
CAPRIN2 caprin family member 2 0.0364422
AKAP12 A kinase (PRKA) anchor protein 12 0.0363082
RASA2 RAS p21 protein activator 2 0.0361754
TMEM156 transmembrane protein 156 0.034441
CHIC2 cysteine-rich hydrophobic domain 2 0.0336836
ZBTB38 zinc finger and BTB domain containing 38 0.0336092
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0335784
ANK2 ankyrin 2, neuronal 0.0333498
DST dystonin 0.0328448
CCDC91 coiled-coil domain containing 91 0.0324768
RPL3 ribosomal protein L3 0.0317239
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.031126
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.030995
AXL AXL receptor tyrosine kinase 0.0306617
FOSL1 FOS-like antigen 1 0.029549
PKM pyruvate kinase, muscle 0.0293561
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0290787
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0289545
JUN jun proto-oncogene 0.0286954
UPP1 uridine phosphorylase 1 0.0286413
ECPAS Ecm29 proteasome adaptor and scaffold 0.0284459
MAST4 microtubule associated serine/threonine kinase family member 4 0.0282525
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0282379
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0281258
RTN4 reticulon 4 0.0279662
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0275601
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0266786
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 0.0262793
GSE1 Gse1 coiled-coil protein 0.0261396
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0260899
EFL1 elongation factor like GTPase 1 0.0260625
CCNY cyclin Y 0.0260519
AOPEP aminopeptidase O (putative) 0.0259417
STC1 stanniocalcin 1 0.0252647
SPRED2 sprouty-related, EVH1 domain containing 2 0.0252249
ADTRP androgen-dependent TFPI-regulating protein 0.025137
FRMD4A FERM domain containing 4A 0.024951
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0245778
CORO1C coronin, actin binding protein, 1C 0.0244454
EXOC4 exocyst complex component 4 0.0243156
ADGRA3 adhesion G protein-coupled receptor A3 0.0239071
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0238408
FUBP3 far upstream element (FUSE) binding protein 3 0.02377
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0237237
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0234513
CTTNBP2NL CTTNBP2 N-terminal like 0.0231332
MDN1 MDN1, midasin homolog (yeast) 0.0228249
DOCK5 dedicator of cytokinesis 5 0.0222883
PBX3 pre-B-cell leukemia homeobox 3 0.0222146
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0221984
GATAD2B GATA zinc finger domain containing 2B 0.0221586
FAM241A family with sequence similarity 241 member A 0.0219532
DGKI diacylglycerol kinase, iota 0.0217982
FCHSD2 FCH and double SH3 domains 2 0.0217452
FLNA filamin A, alpha 0.0216177
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0214188
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0213043
TPD52 tumor protein D52 0.0212664
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0211281
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.0208466
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0204797
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 0.0203542
SPRY4 sprouty homolog 4 (Drosophila) 0.0202471
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0201023
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0200485
RNF169 ring finger protein 169 0.0199999
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0199585
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 0.019913
WDR37 WD repeat domain 37 0.0195323

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.15353
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.123097
TTR transthyretin -0.100412
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0983384
LPP LIM domain containing preferred translocation partner in lipoma -0.0780796
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0767227
TPT1 tumor protein, translationally-controlled 1 -0.0757881
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0747942
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0701688
NABP1 nucleic acid binding protein 1 -0.0686437
RAD21 RAD21 homolog (S. pombe) -0.0678687
PTMA prothymosin, alpha -0.0677465
DIAPH3 diaphanous-related formin 3 -0.0662423
HDAC9 histone deacetylase 9 -0.0654187
RPS8 ribosomal protein S8 -0.0624791
EIF1 eukaryotic translation initiation factor 1 -0.0614349
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0612468
ZFAND3 zinc finger, AN1-type domain 3 -0.0598537
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0588037
RPS3 ribosomal protein S3 -0.0577208
MYRFL myelin regulatory factor-like -0.056015
INTS6 integrator complex subunit 6 -0.0545873
RPL30 ribosomal protein L30 -0.052832
RPL23 ribosomal protein L23 -0.0520405
TRIO trio Rho guanine nucleotide exchange factor -0.0510305
RPL34 ribosomal protein L34 -0.050782
CANX calnexin -0.0484546
RPL19 ribosomal protein L19 -0.0476914
RPS25 ribosomal protein S25 -0.0474698
SP100 SP100 nuclear antigen -0.0452544
RPS12 ribosomal protein S12 -0.045172
RPL31 ribosomal protein L31 -0.0444199
RPL12 ribosomal protein L12 -0.0437115
RPS6 ribosomal protein S6 -0.0430358
PDIA3 protein disulfide isomerase family A, member 3 -0.0427137
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0426369
GARS1 glycyl-tRNA synthetase 1 -0.0425936
CALR calreticulin -0.0417219
PHF3 PHD finger protein 3 -0.0410303
NAP1L1 nucleosome assembly protein 1-like 1 -0.0400917
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0399818
RPS24 ribosomal protein S24 -0.0396084
MTAP methylthioadenosine phosphorylase -0.039572
PCNX4 pecanex 4 -0.0392326
GNAS GNAS complex locus -0.0391978
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0385402
RPS20 ribosomal protein S20 -0.0384295
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0379472
FRMD6 FERM domain containing 6 -0.037659
MT2A metallothionein 2A -0.0372956
RPL7 ribosomal protein L7 -0.0368381
MCTP1 multiple C2 domains, transmembrane 1 -0.0363192
RPS21 ribosomal protein S21 -0.0358193
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0353623
GPR75-ASB3 GPR75-ASB3 readthrough -0.0351981
CALD1 caldesmon 1 -0.0350653
FNDC3B fibronectin type III domain containing 3B -0.0349018
RPL26 ribosomal protein L26 -0.0347734
CELF1 CUGBP, Elav-like family member 1 -0.0347106
RPS15 ribosomal protein S15 -0.0341508
RPLP0 ribosomal protein, large, P0 -0.0338699
RPL9 ribosomal protein L9 -0.0337305
AEBP2 AE binding protein 2 -0.0336558
TMSB10 thymosin beta 10 -0.0335063
RPS16 ribosomal protein S16 -0.0331858
RPL37 ribosomal protein L37 -0.0331454
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0331007
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0326143
MSH4 mutS homolog 4 -0.0325215
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0323904
DLC1 DLC1 Rho GTPase activating protein -0.0323282
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0323196
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0314856
ENO2 enolase 2 (gamma, neuronal) -0.0314708
EGR1 early growth response 1 -0.0313749
RIGI RNA sensor RIG-I -0.0309619
RPL32 ribosomal protein L32 -0.0309017
LCORL ligand dependent nuclear receptor corepressor-like -0.0307966
SETD5 SET domain containing 5 -0.030604
SBF2 SET binding factor 2 -0.0304686
RPLP2 ribosomal protein, large, P2 -0.0302588
BNC2 basonuclin 2 -0.030157
SCFD1 sec1 family domain containing 1 -0.0300863
RACK1 receptor for activated C kinase 1 -0.029908
WNT2B wingless-type MMTV integration site family, member 2B -0.0298792
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0294314
RPL7A ribosomal protein L7a -0.0291696
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0289224
RHOA ras homolog family member A -0.0288172
FTL ferritin, light polypeptide -0.0287973
NRF1 nuclear respiratory factor 1 -0.028432
ZBTB20 zinc finger and BTB domain containing 20 -0.0283568
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0282812
NUP58 nucleoporin 58 -0.0281684
RPL5 ribosomal protein L5 -0.0281324
RPL37A ribosomal protein L37a -0.0278428
DENND1A DENN/MADD domain containing 1A -0.0278388
RPL11 ribosomal protein L11 -0.0275665
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0274802
WAC WW domain containing adaptor with coiled-coil -0.0271481