Folic acid_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.0890715
ASPH aspartate beta-hydroxylase 0.0889251
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0843578
TMEM178B transmembrane protein 178B 0.068394
CD44 CD44 molecule (Indian blood group) 0.0659678
NRP1 neuropilin 1 0.0657366
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0652689
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.063298
FHIT fragile histidine triad 0.0625488
HDAC9 histone deacetylase 9 0.0620516
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0606315
SMAD3 SMAD family member 3 0.0601199
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0596277
FNDC3B fibronectin type III domain containing 3B 0.0592799
NPAS2 neuronal PAS domain protein 2 0.0588751
FAM20C family with sequence similarity 20, member C 0.0572354
EXT1 exostosin glycosyltransferase 1 0.0518963
WWTR1 WW domain containing transcription regulator 1 0.048295
MYH9 myosin, heavy chain 9, non-muscle 0.047704
JARID2 jumonji, AT rich interactive domain 2 0.0469921
FN1 fibronectin 1 0.0450755
NRIP1 nuclear receptor interacting protein 1 0.0446394
COL5A1 collagen, type V, alpha 1 0.0414374
SVIL supervillin 0.0400403
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0383654
PTK2 protein tyrosine kinase 2 0.0382332
FLNB filamin B, beta 0.0380328
ATXN1 ataxin 1 0.0366826
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0366008
EXOC4 exocyst complex component 4 0.035281
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0344025
ZBTB38 zinc finger and BTB domain containing 38 0.0342983
MSN moesin 0.0336576
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.03331
LPP LIM domain containing preferred translocation partner in lipoma 0.0332636
SLIT2 slit homolog 2 (Drosophila) 0.0329126
HMGA2 high mobility group AT-hook 2 0.0321754
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0320875
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0320037
DST dystonin 0.0317441
SETBP1 SET binding protein 1 0.0316641
LRMDA leucine rich melanocyte differentiation associated 0.0314924
TGM2 transglutaminase 2 0.0312587
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0308893
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0307876
RUNX1 runt-related transcription factor 1 0.0302653
FNIP1 folliculin interacting protein 1 0.0300938
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0297159
LOXL2 lysyl oxidase-like 2 0.029315
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0290169
KDM4C lysine (K)-specific demethylase 4C 0.0277946
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0276932
HPCAL1 hippocalcin-like 1 0.0270575
RAD51B RAD51 paralog B 0.0269341
AFAP1 actin filament associated protein 1 0.0268753
IL6ST interleukin 6 signal transducer 0.0266684
PTPRM protein tyrosine phosphatase, receptor type, M 0.0262076
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0258592
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0257254
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0252555
NAV1 neuron navigator 1 0.0250605
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0250373
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0247362
SMYD3 SET and MYND domain containing 3 0.0246115
IGFBP3 insulin-like growth factor binding protein 3 0.0244239
USP34 ubiquitin specific peptidase 34 0.0238244
FAT1 FAT atypical cadherin 1 0.0232933
ZBTB20 zinc finger and BTB domain containing 20 0.0232779
MCL1 myeloid cell leukemia 1 0.0232126
BBS9 Bardet-Biedl syndrome 9 0.0231954
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0229781
ZNF638 zinc finger protein 638 0.0224145
DLG1 discs, large homolog 1 (Drosophila) 0.0223327
USP9X ubiquitin specific peptidase 9, X-linked 0.0221503
TRIO trio Rho guanine nucleotide exchange factor 0.0220807
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0219663
SP100 SP100 nuclear antigen 0.0218254
AHNAK AHNAK nucleoprotein 0.0217386
MED13L mediator complex subunit 13-like 0.0216061
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0211851
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0210493
EXOC6B exocyst complex component 6B 0.0210434
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0208682
SH3PXD2A SH3 and PX domains 2A 0.0208066
SUMF1 sulfatase modifying factor 1 0.0205655
ADAM12 ADAM metallopeptidase domain 12 0.0204482
COL7A1 collagen, type VII, alpha 1 0.0200917
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0200561
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0200218
MTSS1 metastasis suppressor 1 0.0196283
MBD5 methyl-CpG binding domain protein 5 0.0195786
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0195067
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0193656
ZNF644 zinc finger protein 644 0.0193182
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0189893
CLIC4 chloride intracellular channel 4 0.0189387
ZHX2 zinc fingers and homeoboxes 2 0.0189348
EGFR epidermal growth factor receptor 0.0186969
TRIP12 thyroid hormone receptor interactor 12 0.0186233
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0186031

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.309505
HLA-B major histocompatibility complex, class I, B -0.132073
B2M beta-2-microglobulin -0.118411
FTL ferritin, light polypeptide -0.0956778
COL1A2 collagen, type I, alpha 2 -0.0891208
COL1A1 collagen, type I, alpha 1 -0.085844
TMSB10 thymosin beta 10 -0.0843957
MT2A metallothionein 2A -0.08215
IFI6 interferon, alpha-inducible protein 6 -0.0764039
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0658739
STC1 stanniocalcin 1 -0.0646627
PTMA prothymosin, alpha -0.0575965
TPT1 tumor protein, translationally-controlled 1 -0.0541975
INHBA inhibin, beta A -0.0531863
TFPI2 tissue factor pathway inhibitor 2 -0.0463192
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0419722
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0416624
TPM4 tropomyosin 4 -0.0415415
GOLGA4 golgin A4 -0.0410741
RRBP1 ribosome binding protein 1 -0.0408979
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0393102
HLA-C major histocompatibility complex, class I, C -0.0387869
IER3 immediate early response 3 -0.0364208
RPL35A ribosomal protein L35a -0.0359215
HLA-A major histocompatibility complex, class I, A -0.0347331
RPS6 ribosomal protein S6 -0.0346688
COL6A2 collagen, type VI, alpha 2 -0.0344496
RPS8 ribosomal protein S8 -0.0337627
IFITM3 interferon induced transmembrane protein 3 -0.0332673
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0329186
PGK1 phosphoglycerate kinase 1 -0.0325537
RPLP1 ribosomal protein, large, P1 -0.0324891
ACTG1 actin gamma 1 -0.0302837
GNAS GNAS complex locus -0.0297185
CAVIN1 caveolae associated protein 1 -0.0293478
TIMP3 TIMP metallopeptidase inhibitor 3 -0.029072
CALR calreticulin -0.0290499
S100A6 S100 calcium binding protein A6 -0.0286455
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0281076
IFI16 interferon, gamma-inducible protein 16 -0.0280177
RPL11 ribosomal protein L11 -0.0272049
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0267235
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0265392
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0263635
SEPTIN7 septin 7 -0.025877
IFIH1 interferon induced with helicase C domain 1 -0.0254879
EIF1 eukaryotic translation initiation factor 1 -0.0250912
RPS21 ribosomal protein S21 -0.0248585
LOC102724023 ES1 protein homolog, mitochondrial -0.0246796
RPL37A ribosomal protein L37a -0.02434
ARL4C ADP-ribosylation factor-like 4C -0.0241015
S100A9 S100 calcium binding protein A9 -0.0240454
COL6A1 collagen, type VI, alpha 1 -0.0238927
RPS19 ribosomal protein S19 -0.0238624
SEC61G Sec61 gamma subunit -0.0237886
TIMP1 TIMP metallopeptidase inhibitor 1 -0.02309
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0224849
RSAD2 radical S-adenosyl methionine domain containing 2 -0.022146
IL1B interleukin 1, beta -0.0220315
RPL31 ribosomal protein L31 -0.0217435
RPL34 ribosomal protein L34 -0.021184
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0210701
VDAC1 voltage-dependent anion channel 1 -0.0209367
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.020921
RPS24 ribosomal protein S24 -0.0208145
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0207592
LMNA lamin A/C -0.0206854
RPL32 ribosomal protein L32 -0.0201096
S100A10 S100 calcium binding protein A10 -0.0200118
FAM162A family with sequence similarity 162, member A -0.0197951
CD63 CD63 molecule -0.0196509
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0195636
ALCAM activated leukocyte cell adhesion molecule -0.0195559
RPS13 ribosomal protein S13 -0.0195193
LDHA lactate dehydrogenase A -0.0192375
CBX3 chromobox homolog 3 -0.0192292
TGFBI transforming growth factor, beta-induced, 68kDa -0.0191165
GCC2 GRIP and coiled-coil domain containing 2 -0.0190033
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0188075
PFN1 profilin 1 -0.0184966
RPL26 ribosomal protein L26 -0.0181252
RPS12 ribosomal protein S12 -0.0180768
POU2F2 POU class 2 homeobox 2 -0.0180358
SMC4 structural maintenance of chromosomes 4 -0.0179026
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0178105
CENPF centromere protein F, 350/400kDa -0.0178004
RPLP2 ribosomal protein, large, P2 -0.0173761
RAB2A RAB2A, member RAS oncogene family -0.0173756
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0167989
LMAN1 lectin, mannose-binding, 1 -0.016688
EGR1 early growth response 1 -0.0166208
TPI1 triosephosphate isomerase 1 -0.0165749
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0164309
RPS29 ribosomal protein S29 -0.01643
RPS16 ribosomal protein S16 -0.0163223
IFITM1 interferon induced transmembrane protein 1 -0.0162894
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0159835
RPS27A ribosomal protein S27a -0.0158712
PDIA3 protein disulfide isomerase family A, member 3 -0.0157353
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0155989