Folic acid_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.173209
FNDC3B fibronectin type III domain containing 3B 0.130434
NRG3 neuregulin 3 0.109542
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.103315
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0693768
RUNX1 runt-related transcription factor 1 0.0580954
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.055225
FRMD5 FERM domain containing 5 0.054743
HDAC9 histone deacetylase 9 0.0498571
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.046892
FMNL2 formin-like 2 0.0464654
DST dystonin 0.0463749
FRMD4A FERM domain containing 4A 0.0412343
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0368478
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0356552
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0344088
IGFBP3 insulin-like growth factor binding protein 3 0.0337277
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0328334
LINGO2 leucine rich repeat and Ig domain containing 2 0.0324267
SMAD3 SMAD family member 3 0.0316167
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0315249
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0313639
WWTR1 WW domain containing transcription regulator 1 0.0305848
OSBPL10 oxysterol binding protein-like 10 0.0300544
PRELID2 PRELI domain containing 2 0.0296388
ANKRD28 ankyrin repeat domain 28 0.029297
NOTCH2 notch 2 0.029075
TXNRD1 thioredoxin reductase 1 0.0288935
IGF1R insulin-like growth factor 1 receptor 0.0288451
TRIO trio Rho guanine nucleotide exchange factor 0.0271917
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0264014
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0255446
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0251828
PTPRG protein tyrosine phosphatase, receptor type, G 0.0249865
PTK2 protein tyrosine kinase 2 0.02473
SVIL supervillin 0.0247226
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.024666
NPAS2 neuronal PAS domain protein 2 0.0245315
FHIT fragile histidine triad 0.0244361
MSN moesin 0.0233534
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0228815
LRMDA leucine rich melanocyte differentiation associated 0.0228505
LEF1 lymphoid enhancer-binding factor 1 0.0221173
UBASH3B ubiquitin associated and SH3 domain containing B 0.0220287
BACE2 beta-site APP-cleaving enzyme 2 0.0218554
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.021342
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0210932
KDM4C lysine (K)-specific demethylase 4C 0.020955
CNKSR3 CNKSR family member 3 0.0209003
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0207636
JMJD1C jumonji domain containing 1C 0.0205433
ETV6 ets variant 6 0.0202378
RASAL2 RAS protein activator like 2 0.020162
FBXL17 F-box and leucine-rich repeat protein 17 0.0199806
RABGAP1L RAB GTPase activating protein 1-like 0.0199577
INPP5F inositol polyphosphate-5-phosphatase F 0.0198006
MED13L mediator complex subunit 13-like 0.0197855
SPRED1 sprouty-related, EVH1 domain containing 1 0.0196831
IL1RAP interleukin 1 receptor accessory protein 0.0196225
FNIP1 folliculin interacting protein 1 0.0195866
TBC1D5 TBC1 domain family, member 5 0.0194653
AFDN afadin, adherens junction formation factor 0.0191601
TENM3 teneurin transmembrane protein 3 0.0188394
RNF145 ring finger protein 145 0.018835
VMP1 vacuole membrane protein 1 0.0187101
RAD51B RAD51 paralog B 0.0186845
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0186544
CORO1C coronin, actin binding protein, 1C 0.0183587
TUSC3 tumor suppressor candidate 3 0.0181647
EP300 E1A binding protein p300 0.0180021
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0179437
FER fer (fps/fes related) tyrosine kinase 0.0178756
LPP LIM domain containing preferred translocation partner in lipoma 0.0178525
YEATS2 YEATS domain containing 2 0.0178236
SOX6 SRY (sex determining region Y)-box 6 0.0176823
OGA O-GlcNAcase 0.0176399
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0176238
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0176196
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0174001
RPL3 ribosomal protein L3 0.0173427
PRKCSH protein kinase C substrate 80K-H 0.0172719
FLNA filamin A, alpha 0.0172673
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0172297
FLNB filamin B, beta 0.0171575
MYH9 myosin, heavy chain 9, non-muscle 0.0166266
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0166098
TRIP12 thyroid hormone receptor interactor 12 0.016438
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0164249
ARB2A ARB2 cotranscriptional regulator A 0.0161549
ITCH itchy E3 ubiquitin protein ligase 0.0160868
PLSCR1 phospholipid scramblase 1 0.0160078
GSK3B glycogen synthase kinase 3 beta 0.0159448
AMOTL1 angiomotin like 1 0.0159189
FAM3C family with sequence similarity 3, member C 0.0158928
NCKAP1 NCK-associated protein 1 0.0158796
OPHN1 oligophrenin 1 0.0156642
KLC1 kinesin light chain 1 0.0155351
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0155242
MCL1 myeloid cell leukemia 1 0.0151586
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0150886

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.288005
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12642
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.115676
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.11174
RPS3 ribosomal protein S3 -0.0889077
PTMA prothymosin, alpha -0.0785077
RPS6 ribosomal protein S6 -0.0696057
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0677389
RPL35A ribosomal protein L35a -0.065519
FTL ferritin, light polypeptide -0.0651815
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0647987
TMSB10 thymosin beta 10 -0.0642195
RPL23 ribosomal protein L23 -0.0630512
MT2A metallothionein 2A -0.0585297
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0547317
TPT1 tumor protein, translationally-controlled 1 -0.0539015
RPLP1 ribosomal protein, large, P1 -0.0531127
IFI6 interferon, alpha-inducible protein 6 -0.0529835
B2M beta-2-microglobulin -0.048875
RPS8 ribosomal protein S8 -0.0467841
NLGN1 neuroligin 1 -0.0461561
PGK1 phosphoglycerate kinase 1 -0.0435452
CENPF centromere protein F, 350/400kDa -0.0432804
NAP1L1 nucleosome assembly protein 1-like 1 -0.0423269
RPL34 ribosomal protein L34 -0.0416211
S100A9 S100 calcium binding protein A9 -0.0407836
RPL31 ribosomal protein L31 -0.0405985
RPL12 ribosomal protein L12 -0.0405133
ACTG1 actin gamma 1 -0.0394536
RPLP2 ribosomal protein, large, P2 -0.0392327
EIF1 eukaryotic translation initiation factor 1 -0.0389556
RPS24 ribosomal protein S24 -0.0385684
LDHA lactate dehydrogenase A -0.0373272
RPL37A ribosomal protein L37a -0.0367903
RPS12 ribosomal protein S12 -0.0363078
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0362656
RPS21 ribosomal protein S21 -0.0360447
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0350941
HLA-B major histocompatibility complex, class I, B -0.0348162
VDAC1 voltage-dependent anion channel 1 -0.0346511
RPL11 ribosomal protein L11 -0.0342349
RPS13 ribosomal protein S13 -0.0341851
RPS14 ribosomal protein S14 -0.0338154
RACK1 receptor for activated C kinase 1 -0.0338067
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0335821
RPL32 ribosomal protein L32 -0.0332958
RPL19 ribosomal protein L19 -0.0321807
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0320442
RPS23 ribosomal protein S23 -0.0314577
RPS27A ribosomal protein S27a -0.0307837
TPI1 triosephosphate isomerase 1 -0.0304844
RPS19 ribosomal protein S19 -0.0297882
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0297372
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0292041
RPL36A ribosomal protein L36a -0.0290563
FN1 fibronectin 1 -0.0288779
RPL38 ribosomal protein L38 -0.0283619
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0282988
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0280463
RPS16 ribosomal protein S16 -0.0276463
LITAF lipopolysaccharide-induced TNF factor -0.0274584
GOLGA4 golgin A4 -0.0270384
RPL9 ribosomal protein L9 -0.026857
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0262507
RPS29 ribosomal protein S29 -0.0256717
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0255953
RPL37 ribosomal protein L37 -0.0255439
RAB7A RAB7A, member RAS oncogene family -0.0253959
ENO1 enolase 1, (alpha) -0.024962
SQSTM1 sequestosome 1 -0.0249379
RPL36 ribosomal protein L36 -0.0247928
CBX3 chromobox homolog 3 -0.0246891
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0246766
IFI16 interferon, gamma-inducible protein 16 -0.024211
CTSD cathepsin D -0.0240411
LMNA lamin A/C -0.0236948
RPLP0 ribosomal protein, large, P0 -0.0233844
RPS4X ribosomal protein S4, X-linked -0.0230763
IFITM3 interferon induced transmembrane protein 3 -0.0226566
SMC4 structural maintenance of chromosomes 4 -0.0225254
SFTPA2 surfactant protein A2 -0.0222519
RPS17 ribosomal protein S17 -0.0220927
S100A10 S100 calcium binding protein A10 -0.0219288
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0218542
HMGA1 high mobility group AT-hook 1 -0.0218412
RPL27 ribosomal protein L27 -0.0215287
TKT transketolase -0.0215286
RPL28 ribosomal protein L28 -0.0211166
PMEL premelanosome protein -0.0209815
RPL26 ribosomal protein L26 -0.0208978
RPL27A ribosomal protein L27a -0.0206289
HSPB1 heat shock 27kDa protein 1 -0.0202334
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0200406
TPM4 tropomyosin 4 -0.0200371
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0200259
PRAME preferentially expressed antigen in melanoma -0.01983
RPL30 ribosomal protein L30 -0.0196748
RPL35 ribosomal protein L35 -0.0196276
RPS15 ribosomal protein S15 -0.0195657
S100A6 S100 calcium binding protein A6 -0.0194908