Folic acid_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.203711
PKM pyruvate kinase, muscle 0.105407
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.086944
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0774729
PDE4B phosphodiesterase 4B, cAMP-specific 0.0622825
ADAM10 ADAM metallopeptidase domain 10 0.0600045
EGFR epidermal growth factor receptor 0.0590349
FOXP1 forkhead box P1 0.0553907
SMYD3 SET and MYND domain containing 3 0.0553006
PDGFC platelet derived growth factor C 0.0545734
SSBP2 single-stranded DNA binding protein 2 0.0530976
ZBTB20 zinc finger and BTB domain containing 20 0.0518986
NPAS2 neuronal PAS domain protein 2 0.0503961
TJP1 tight junction protein 1 0.0473503
PTPRG protein tyrosine phosphatase, receptor type, G 0.0463374
POTEF POTE ankyrin domain family, member F 0.0419508
EXT1 exostosin glycosyltransferase 1 0.0416504
GLI3 GLI family zinc finger 3 0.0410011
USP34 ubiquitin specific peptidase 34 0.0406963
CAMTA1 calmodulin binding transcription activator 1 0.0397734
FER fer (fps/fes related) tyrosine kinase 0.0392881
HDAC9 histone deacetylase 9 0.039114
MACROD2 MACRO domain containing 2 0.0383373
MED13L mediator complex subunit 13-like 0.0370885
ZFAND3 zinc finger, AN1-type domain 3 0.0369429
METTL15 methyltransferase like 15 0.036516
PCBP2 poly(rC) binding protein 2 0.0354288
PTK2 protein tyrosine kinase 2 0.0338373
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0336415
VIM vimentin 0.0334959
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0323671
MBD5 methyl-CpG binding domain protein 5 0.0321941
EFNA5 ephrin-A5 0.0321674
BBS9 Bardet-Biedl syndrome 9 0.0316525
TMEM65 transmembrane protein 65 0.03158
PYGB phosphorylase, glycogen; brain 0.0310531
RPL3 ribosomal protein L3 0.0299615
TCF12 transcription factor 12 0.0294234
RBM39 RNA binding motif protein 39 0.0293841
FAM193A family with sequence similarity 193, member A 0.0292488
MEF2A myocyte enhancer factor 2A 0.0288729
N4BP2L2 NEDD4 binding protein 2-like 2 0.0284744
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0284599
GLI2 GLI family zinc finger 2 0.0279409
ZNF608 zinc finger protein 608 0.0278825
RHOA ras homolog family member A 0.0270843
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0260486
PICALM phosphatidylinositol binding clathrin assembly protein 0.0260265
RSRC1 arginine/serine-rich coiled-coil 1 0.0258701
BIRC6 baculoviral IAP repeat containing 6 0.0256057
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0254062
RABGAP1L RAB GTPase activating protein 1-like 0.0252746
EML4 echinoderm microtubule associated protein like 4 0.0245079
SOX6 SRY (sex determining region Y)-box 6 0.0233349
SFPQ splicing factor proline/glutamine-rich 0.0231586
PRELID2 PRELI domain containing 2 0.0231275
TMEM117 transmembrane protein 117 0.0230991
WNK1 WNK lysine deficient protein kinase 1 0.0230927
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0229207
TBC1D22A TBC1 domain family, member 22A 0.0228689
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0226912
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0225741
ADAM9 ADAM metallopeptidase domain 9 0.0225482
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0224191
RPS29 ribosomal protein S29 0.0222573
PDE10A phosphodiesterase 10A 0.0221905
RAD51B RAD51 paralog B 0.0221401
ASPH aspartate beta-hydroxylase 0.0221258
SENP6 SUMO1/sentrin specific peptidase 6 0.0218675
ATP9B ATPase, class II, type 9B 0.0217879
CEP112 centrosomal protein 112kDa 0.0215458
KDM6A lysine (K)-specific demethylase 6A 0.0214217
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0213327
ARL15 ADP-ribosylation factor-like 15 0.0212438
ITCH itchy E3 ubiquitin protein ligase 0.0211529
NDRG1 N-myc downstream regulated 1 0.0210188
DENND4A DENN/MADD domain containing 4A 0.0207715
TBC1D5 TBC1 domain family, member 5 0.0207133
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0206576
ZMYND8 zinc finger, MYND-type containing 8 0.0205767
PCNX1 pecanex 1 0.0205406
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0205405
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0204051
GLS2 glutaminase 2 (liver, mitochondrial) 0.0203999
BTBD9 BTB (POZ) domain containing 9 0.0201627
SPRED2 sprouty-related, EVH1 domain containing 2 0.0201331
MYO5C myosin VC 0.020121
JMJD1C jumonji domain containing 1C 0.0200364
HDAC8 histone deacetylase 8 0.0199194
IGF1R insulin-like growth factor 1 receptor 0.0196531
BCAS3 breast carcinoma amplified sequence 3 0.0196205
GSK3B glycogen synthase kinase 3 beta 0.019573
SS18 synovial sarcoma translocation, chromosome 18 0.0194905
DOCK3 dedicator of cytokinesis 3 0.0194358
QKI QKI, KH domain containing, RNA binding 0.0193733
NF1 neurofibromin 1 0.0192219
KDM4C lysine (K)-specific demethylase 4C 0.018673
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0186234
RPS25 ribosomal protein S25 0.018559
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0185222

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.156115
TPT1 tumor protein, translationally-controlled 1 -0.110272
NAP1L1 nucleosome assembly protein 1-like 1 -0.0791916
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0771749
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.063164
ACTG1 actin gamma 1 -0.0605999
TMSB4X thymosin beta 4, X-linked -0.0576861
BMP10 bone morphogenetic protein 10 -0.0477191
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0472515
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0453563
MYOF myoferlin -0.0453495
S100A4 S100 calcium binding protein A4 -0.0453041
RPLP0 ribosomal protein, large, P0 -0.0409628
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0408488
MKI67 marker of proliferation Ki-67 -0.0395287
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.039503
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0389966
RPL34 ribosomal protein L34 -0.0375763
RPL26 ribosomal protein L26 -0.0366656
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0362217
RPS24 ribosomal protein S24 -0.0357948
CENPF centromere protein F, 350/400kDa -0.0353349
NAV2 neuron navigator 2 -0.0348933
MYL12B myosin, light chain 12B, regulatory -0.0331703
DUSP6 dual specificity phosphatase 6 -0.0331031
WSB1 WD repeat and SOCS box containing 1 -0.0322206
RPL35A ribosomal protein L35a -0.0314408
EBNA1BP2 EBNA1 binding protein 2 -0.030881
RPL12 ribosomal protein L12 -0.0299711
KPNB1 karyopherin (importin) beta 1 -0.0299386
HSPB1 heat shock 27kDa protein 1 -0.0294016
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0289362
RPS6 ribosomal protein S6 -0.0288825
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0288803
ANXA1 annexin A1 -0.0284611
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0284427
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0282136
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0281986
RRBP1 ribosome binding protein 1 -0.0281001
CCND1 cyclin D1 -0.0271314
EVI5 ecotropic viral integration site 5 -0.0267609
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0267371
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0265797
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0261713
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0260896
KIF5B kinesin family member 5B -0.0260485
RSL1D1 ribosomal L1 domain containing 1 -0.0251589
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0249139
S100A6 S100 calcium binding protein A6 -0.0245728
BZW1 basic leucine zipper and W2 domains 1 -0.0239786
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0238118
KDM3A lysine (K)-specific demethylase 3A -0.0236447
BCOR BCL6 corepressor -0.0231323
SET SET nuclear proto-oncogene -0.0226405
RPL5 ribosomal protein L5 -0.02205
RAD21 RAD21 homolog (S. pombe) -0.0218663
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0217713
SMC4 structural maintenance of chromosomes 4 -0.0217167
LMAN1 lectin, mannose-binding, 1 -0.0216484
RPL4 ribosomal protein L4 -0.0216069
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0215433
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0213301
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0212589
RPLP1 ribosomal protein, large, P1 -0.0211793
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0204271
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.020329
NT5C2 5'-nucleotidase, cytosolic II -0.020183
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0199173
GNAS GNAS complex locus -0.0198731
ZC3H13 zinc finger CCCH-type containing 13 -0.019824
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0196883
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0196522
RPS4X ribosomal protein S4, X-linked -0.019613
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0192154
RPS21 ribosomal protein S21 -0.0191132
CCNI cyclin I -0.0189476
SEC24D SEC24 family member D -0.0187144
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0187118
CSDE1 cold shock domain containing E1, RNA-binding -0.0186907
CKAP2 cytoskeleton associated protein 2 -0.0184636
SMC3 structural maintenance of chromosomes 3 -0.0182951
ZNF106 zinc finger protein 106 -0.0182495
DLG1 discs, large homolog 1 (Drosophila) -0.0181126
IFI16 interferon, gamma-inducible protein 16 -0.0180629
ZNF638 zinc finger protein 638 -0.0180252
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0180195
ZFP36L1 ZFP36 ring finger protein-like 1 -0.017882
RPL8 ribosomal protein L8 -0.0172498
HMGB1 high mobility group box 1 -0.0170387
CDK12 cyclin-dependent kinase 12 -0.0170315
RPL11 ribosomal protein L11 -0.0169491
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0169405
LMNA lamin A/C -0.0168379
HJURP Holliday junction recognition protein -0.0167033
RPS8 ribosomal protein S8 -0.0166466
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0166119
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0164343
SEPTIN7 septin 7 -0.0163926
PTPRF protein tyrosine phosphatase, receptor type, F -0.0162019
ECT2 epithelial cell transforming 2 -0.0161473