Folic acid_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.138195
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.127092
VCL vinculin 0.0647981
DST dystonin 0.0643764
FN1 fibronectin 1 0.0639372
SMAD3 SMAD family member 3 0.0618871
MYH9 myosin, heavy chain 9, non-muscle 0.055306
VMP1 vacuole membrane protein 1 0.0532488
HDAC9 histone deacetylase 9 0.0426628
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0419145
KYNU kynureninase 0.0404715
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0385413
NAV2 neuron navigator 2 0.0384199
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0374361
DUSP10 dual specificity phosphatase 10 0.0359664
FNDC3B fibronectin type III domain containing 3B 0.0354413
MYOF myoferlin 0.0342915
FNIP1 folliculin interacting protein 1 0.0322539
TRIO trio Rho guanine nucleotide exchange factor 0.0321325
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0319075
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0311966
AGTPBP1 ATP/GTP binding protein 1 0.0308652
NABP1 nucleic acid binding protein 1 0.029791
COL6A3 collagen, type VI, alpha 3 0.0291052
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0286091
ATXN1 ataxin 1 0.027982
ELL2 elongation factor, RNA polymerase II, 2 0.0278583
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0271685
PPARD peroxisome proliferator-activated receptor delta 0.0267361
AHNAK AHNAK nucleoprotein 0.0264297
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0261454
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0259867
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0256838
NRIP1 nuclear receptor interacting protein 1 0.0254508
RNF213 ring finger protein 213 0.0251843
JMJD1C jumonji domain containing 1C 0.0251544
MSN moesin 0.0249124
BICC1 BicC family RNA binding protein 1 0.024675
USP9X ubiquitin specific peptidase 9, X-linked 0.0242639
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0242082
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0241119
WTAP Wilms tumor 1 associated protein 0.0237813
SP100 SP100 nuclear antigen 0.0233311
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0231801
FMNL2 formin-like 2 0.0231135
AHR aryl hydrocarbon receptor 0.0227642
THBS1 thrombospondin 1 0.0226984
ARRDC3 arrestin domain containing 3 0.0226105
OGA O-GlcNAcase 0.0223754
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0219491
TENT5A terminal nucleotidyltransferase 5A 0.0218223
MKI67 marker of proliferation Ki-67 0.0215399
NOTCH2 notch 2 0.0215077
SLC38A2 solute carrier family 38, member 2 0.0213022
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0207857
SPAG9 sperm associated antigen 9 0.0206134
EXT1 exostosin glycosyltransferase 1 0.0205101
LAMP2 lysosomal-associated membrane protein 2 0.0203399
RB1CC1 RB1-inducible coiled-coil 1 0.0201486
RND3 Rho family GTPase 3 0.0196519
ZBTB38 zinc finger and BTB domain containing 38 0.0195666
PALLD palladin, cytoskeletal associated protein 0.01928
CORO1C coronin, actin binding protein, 1C 0.0191167
EPAS1 endothelial PAS domain protein 1 0.0190942
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0189269
FTH1 ferritin, heavy polypeptide 1 0.0185233
FLNB filamin B, beta 0.018441
KIAA1217 KIAA1217 0.0182244
CTNND1 catenin (cadherin-associated protein), delta 1 0.018084
SOX9 SRY (sex determining region Y)-box 9 0.0180766
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0180698
ANXA2 annexin A2 0.0180109
APP amyloid beta (A4) precursor protein 0.0179615
BCAR3 breast cancer anti-estrogen resistance 3 0.0176979
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0172767
RIGI RNA sensor RIG-I 0.0169074
PCLO piccolo presynaptic cytomatrix protein 0.016468
FOXO3 forkhead box O3 0.0162294
PRELID2 PRELI domain containing 2 0.0160653
RUNX1 runt-related transcription factor 1 0.0160246
COL8A1 collagen, type VIII, alpha 1 0.0159739
PRKCSH protein kinase C substrate 80K-H 0.0157916
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0157592
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0155428
LPP LIM domain containing preferred translocation partner in lipoma 0.0152551
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0151229
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0150332
ACTN4 actinin, alpha 4 0.0150096
FLNA filamin A, alpha 0.0148322
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.014832
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0147784
RASEF RAS and EF-hand domain containing 0.0147425
PUM2 pumilio RNA-binding family member 2 0.0145148
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0143935
NEK7 NIMA-related kinase 7 0.0143008
XPO1 exportin 1 0.0140131
TRIP12 thyroid hormone receptor interactor 12 0.0139997
ARFGEF3 ARFGEF family member 3 0.0139536
FRMD5 FERM domain containing 5 0.0138196
FHL2 four and a half LIM domains 2 0.0137199

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.190642
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0851915
HLA-B major histocompatibility complex, class I, B -0.0798275
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0717681
TPT1 tumor protein, translationally-controlled 1 -0.0676254
IGFBP3 insulin-like growth factor binding protein 3 -0.0656582
MT2A metallothionein 2A -0.0632376
FTL ferritin, light polypeptide -0.0588422
TMSB10 thymosin beta 10 -0.0542764
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0508526
RPS12 ribosomal protein S12 -0.0474669
RPS6 ribosomal protein S6 -0.0464679
FRMD4A FERM domain containing 4A -0.0459001
RPS8 ribosomal protein S8 -0.0449441
NAP1L1 nucleosome assembly protein 1-like 1 -0.0422453
CDH13 cadherin 13 -0.0417413
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0411125
PTMA prothymosin, alpha -0.0402951
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0376668
GOLGA4 golgin A4 -0.0370239
AKAP12 A kinase (PRKA) anchor protein 12 -0.0363498
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0349705
HLA-A major histocompatibility complex, class I, A -0.0347122
RPS24 ribosomal protein S24 -0.0346287
RPL37A ribosomal protein L37a -0.0342458
EIF1 eukaryotic translation initiation factor 1 -0.0341705
AFF3 AF4/FMR2 family, member 3 -0.0336956
FRMPD4 FERM and PDZ domain containing 4 -0.0333931
RPL23 ribosomal protein L23 -0.0323369
B2M beta-2-microglobulin -0.0305877
CALR calreticulin -0.0304675
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0293505
IER3 immediate early response 3 -0.029125
RPS13 ribosomal protein S13 -0.0285642
RPS23 ribosomal protein S23 -0.0284209
RPL9 ribosomal protein L9 -0.0278123
WSB1 WD repeat and SOCS box containing 1 -0.0251531
PTPRK protein tyrosine phosphatase, receptor type, K -0.0246842
HMGA1 high mobility group AT-hook 1 -0.024452
RPL36A ribosomal protein L36a -0.0244454
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0240967
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0239216
RPL35A ribosomal protein L35a -0.0237251
LDHA lactate dehydrogenase A -0.0236318
SOX5 SRY (sex determining region Y)-box 5 -0.0233232
RPL37 ribosomal protein L37 -0.0232171
SLC38A1 solute carrier family 38, member 1 -0.0229797
RPLP2 ribosomal protein, large, P2 -0.0228141
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0226769
CTSD cathepsin D -0.0226138
RPS3 ribosomal protein S3 -0.0223482
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0223196
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0222231
RPL26 ribosomal protein L26 -0.0219209
TTC3 tetratricopeptide repeat domain 3 -0.0218866
ZMYND8 zinc finger, MYND-type containing 8 -0.021538
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0215012
TMEM132D transmembrane protein 132D -0.0213564
RPL19 ribosomal protein L19 -0.021216
PLIN2 perilipin 2 -0.0210961
RAI14 retinoic acid induced 14 -0.0210073
RPL11 ribosomal protein L11 -0.0209203
RPL27A ribosomal protein L27a -0.0206183
RPS10 ribosomal protein S10 -0.020557
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0205478
BASP1 brain abundant, membrane attached signal protein 1 -0.0204885
GNAS GNAS complex locus -0.0204621
IARS1 isoleucyl-tRNA synthetase 1 -0.0204083
BTG1 B-cell translocation gene 1, anti-proliferative -0.0202508
EFNA5 ephrin-A5 -0.0199195
PGK1 phosphoglycerate kinase 1 -0.0198276
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.019695
RPL12 ribosomal protein L12 -0.0195304
PTEN phosphatase and tensin homolog -0.0193224
NDRG1 N-myc downstream regulated 1 -0.0192001
RPL34 ribosomal protein L34 -0.0191505
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0190734
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0190672
DIAPH2 diaphanous-related formin 2 -0.0190502
AFF4 AF4/FMR2 family, member 4 -0.018709
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0182555
RPL31 ribosomal protein L31 -0.0180976
TMSB4X thymosin beta 4, X-linked -0.0180538
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0179369
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0179235
BNC2 basonuclin 2 -0.0178862
PRRC2C proline-rich coiled-coil 2C -0.0177858
RPLP1 ribosomal protein, large, P1 -0.0177455
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0177146
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0176998
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.01763
ZBTB20 zinc finger and BTB domain containing 20 -0.0176036
QKI QKI, KH domain containing, RNA binding -0.017485
RHOBTB3 Rho-related BTB domain containing 3 -0.0174766
RACK1 receptor for activated C kinase 1 -0.0173048
USP34 ubiquitin specific peptidase 34 -0.0172432
HLA-E major histocompatibility complex, class I, E -0.0172015
ENO2 enolase 2 (gamma, neuronal) -0.0168653
TCEAL9 transcription elongation factor A like 9 -0.0168539
RPS19 ribosomal protein S19 -0.0168497