Folic acid_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMYD3 SET and MYND domain containing 3 0.0742146
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0695597
FNDC3B fibronectin type III domain containing 3B 0.0658326
FMNL2 formin-like 2 0.0621095
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0505823
SAMD4A sterile alpha motif domain containing 4A 0.0487539
OSMR oncostatin M receptor 0.0460649
TRIO trio Rho guanine nucleotide exchange factor 0.045947
SMAD3 SMAD family member 3 0.0454953
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0453568
ZBTB20 zinc finger and BTB domain containing 20 0.0405981
MED13L mediator complex subunit 13-like 0.0379166
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0376049
DPYD dihydropyrimidine dehydrogenase 0.0363645
VMP1 vacuole membrane protein 1 0.0361954
PICALM phosphatidylinositol binding clathrin assembly protein 0.0358727
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.035782
CD44 CD44 molecule (Indian blood group) 0.0356988
ZC3H12B zinc finger CCCH-type containing 12B 0.0356065
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0342488
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0334917
DERA deoxyribose-phosphate aldolase (putative) 0.0334336
TBC1D5 TBC1 domain family, member 5 0.0328678
TNRC6B trinucleotide repeat containing 6B 0.032838
GPHN gephyrin 0.0316101
PRKCA protein kinase C, alpha 0.0315955
ANO6 anoctamin 6 0.0315034
MACF1 microtubule-actin crosslinking factor 1 0.0313225
RAD51B RAD51 paralog B 0.0307113
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.029939
MBNL1 muscleblind-like splicing regulator 1 0.0297958
AFF4 AF4/FMR2 family, member 4 0.0293821
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0293552
DST dystonin 0.0285419
FAM3C family with sequence similarity 3, member C 0.0275878
PKM pyruvate kinase, muscle 0.0275548
BCAR3 breast cancer anti-estrogen resistance 3 0.0272858
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0263094
RANBP2 RAN binding protein 2 0.0261438
HSPA8 heat shock 70kDa protein 8 0.0261176
TTC28 tetratricopeptide repeat domain 28 0.0258947
CCDC91 coiled-coil domain containing 91 0.0257922
CPNE1 copine I 0.025779
JMJD1C jumonji domain containing 1C 0.0257393
STK24 serine/threonine kinase 24 0.025706
RORA RAR-related orphan receptor A 0.0255605
CUL5 cullin 5 0.0254243
TLK1 tousled-like kinase 1 0.0246806
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0243719
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0240879
WDR70 WD repeat domain 70 0.0239052
CAB39 calcium binding protein 39 0.0234599
NBEA neurobeachin 0.0232722
TXNIP thioredoxin interacting protein 0.023054
BTBD9 BTB (POZ) domain containing 9 0.0230076
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0229965
ARL15 ADP-ribosylation factor-like 15 0.0226836
BABAM2 BRISC and BRCA1 A complex member 2 0.0226171
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0222046
ZNF148 zinc finger protein 148 0.0221998
AHR aryl hydrocarbon receptor 0.0219935
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0219676
FBXL7 F-box and leucine-rich repeat protein 7 0.0219586
EXOC4 exocyst complex component 4 0.0217414
AHCTF1 AT hook containing transcription factor 1 0.0216906
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0216069
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.0215299
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0214894
PEAK1 pseudopodium-enriched atypical kinase 1 0.021433
MCL1 myeloid cell leukemia 1 0.0213259
HSPH1 heat shock 105kDa/110kDa protein 1 0.0213205
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0212461
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0211994
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0211892
PTK2 protein tyrosine kinase 2 0.0211674
GOLGA4 golgin A4 0.0210428
CKAP5 cytoskeleton associated protein 5 0.0208959
MYH9 myosin, heavy chain 9, non-muscle 0.0208941
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0208094
MBNL2 muscleblind-like splicing regulator 2 0.0206774
PRPF8 pre-mRNA processing factor 8 0.020596
KIF5B kinesin family member 5B 0.0204315
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.020358
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0202281
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0201667
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0201259
THBS1 thrombospondin 1 0.020074
FBXL17 F-box and leucine-rich repeat protein 17 0.0200644
SLMAP sarcolemma associated protein 0.0199438
KIAA1671 KIAA1671 0.019716
OXSR1 oxidative stress responsive 1 0.0196956
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0196593
AHNAK AHNAK nucleoprotein 0.019407
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0193745
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0193253
AFDN afadin, adherens junction formation factor 0.0192694
NGLY1 N-glycanase 1 0.019248
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0192305
SHB Src homology 2 domain containing adaptor protein B 0.0192011
NAMPT nicotinamide phosphoribosyltransferase 0.0189935

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196646
VIM vimentin -0.185191
TMSB10 thymosin beta 10 -0.132967
TPT1 tumor protein, translationally-controlled 1 -0.116836
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0617426
TM4SF1 transmembrane 4 L six family member 1 -0.0539818
PTMA prothymosin, alpha -0.0532729
LDHA lactate dehydrogenase A -0.0495331
MT2A metallothionein 2A -0.04933
RPLP1 ribosomal protein, large, P1 -0.0480833
GNAS GNAS complex locus -0.0470443
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0470132
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0456603
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0446196
RPL26 ribosomal protein L26 -0.0443245
HLA-C major histocompatibility complex, class I, C -0.0427785
B2M beta-2-microglobulin -0.0413439
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0412503
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0402578
BIRC3 baculoviral IAP repeat containing 3 -0.0398541
HILPDA hypoxia inducible lipid droplet-associated -0.0388242
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0377708
BASP1 brain abundant, membrane attached signal protein 1 -0.0375398
YBX3 Y box binding protein 3 -0.0369101
RPL35A ribosomal protein L35a -0.0364922
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0356401
S100A10 S100 calcium binding protein A10 -0.035163
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0348473
RPL37A ribosomal protein L37a -0.0346662
RPS13 ribosomal protein S13 -0.0341547
RIGI RNA sensor RIG-I -0.0341408
ANGPTL4 angiopoietin-like 4 -0.0326765
HLA-A major histocompatibility complex, class I, A -0.032259
HLA-B major histocompatibility complex, class I, B -0.0314011
IER3 immediate early response 3 -0.0312162
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0310247
FTL ferritin, light polypeptide -0.0308387
PURA purine-rich element binding protein A -0.0299736
RPS12 ribosomal protein S12 -0.028913
RPL31 ribosomal protein L31 -0.0285422
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0283535
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0280375
RPL19 ribosomal protein L19 -0.0280009
RPL12 ribosomal protein L12 -0.0273672
SPAG9 sperm associated antigen 9 -0.0270929
RPL23 ribosomal protein L23 -0.026916
EIF1 eukaryotic translation initiation factor 1 -0.0268829
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0268094
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0264931
SETD5 SET domain containing 5 -0.0259774
RPL34 ribosomal protein L34 -0.0257987
INTS6 integrator complex subunit 6 -0.0255535
RPS3 ribosomal protein S3 -0.0252155
ACTN1 actinin, alpha 1 -0.0249564
RPS21 ribosomal protein S21 -0.0249458
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0246715
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0245506
HLA-E major histocompatibility complex, class I, E -0.0245154
LMAN1 lectin, mannose-binding, 1 -0.0244554
PFN1 profilin 1 -0.0243442
RPLP2 ribosomal protein, large, P2 -0.0238835
RPL11 ribosomal protein L11 -0.0237103
SQSTM1 sequestosome 1 -0.0233781
LOC112694756 uncharaterized LOC112694756 -0.0232011
PLAUR plasminogen activator, urokinase receptor -0.0230079
RPS14 ribosomal protein S14 -0.022841
PDCD6IP programmed cell death 6 interacting protein -0.0225989
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0223583
PDE4D phosphodiesterase 4D, cAMP-specific -0.0222823
RPS25 ribosomal protein S25 -0.0219012
BZW1 basic leucine zipper and W2 domains 1 -0.0217733
MT1X metallothionein 1X -0.0216317
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0215205
CSDE1 cold shock domain containing E1, RNA-binding -0.021488
CBX3 chromobox homolog 3 -0.0213539
SDC4 syndecan 4 -0.0212462
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0212319
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0210586
RRBP1 ribosome binding protein 1 -0.0209972
RPS17 ribosomal protein S17 -0.0209449
CAVIN1 caveolae associated protein 1 -0.0209194
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.020862
GOLGA3 golgin A3 -0.0208188
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0205583
RPS8 ribosomal protein S8 -0.020509
NACA nascent polypeptide-associated complex alpha subunit -0.0204867
PRKCE protein kinase C, epsilon -0.0203486
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0202914
NDRG1 N-myc downstream regulated 1 -0.0202807
BTG1 B-cell translocation gene 1, anti-proliferative -0.0202338
LOC102724023 ES1 protein homolog, mitochondrial -0.0202287
SEC62 SEC62 homolog (S. cerevisiae) -0.0200752
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0200632
KPNB1 karyopherin (importin) beta 1 -0.0200549
HM13 histocompatibility (minor) 13 -0.0199227
IFITM3 interferon induced transmembrane protein 3 -0.0197696
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -0.0195005
NAP1L1 nucleosome assembly protein 1-like 1 -0.0194908
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0194587
RPS29 ribosomal protein S29 -0.0193988