Folic acid_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.228989
FN1 fibronectin 1 0.205008
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.108668
NRG1 neuregulin 1 0.103105
TMEM156 transmembrane protein 156 0.0951826
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0868428
TRIO trio Rho guanine nucleotide exchange factor 0.0822934
NRP1 neuropilin 1 0.0818323
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0726491
PTK2 protein tyrosine kinase 2 0.071593
FNDC3B fibronectin type III domain containing 3B 0.0714233
HMGA2 high mobility group AT-hook 2 0.0710278
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0631829
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.062907
EXT1 exostosin glycosyltransferase 1 0.06164
DST dystonin 0.0606802
EFNA5 ephrin-A5 0.060291
GLIS3 GLIS family zinc finger 3 0.0571257
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0560551
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0546685
OSMR oncostatin M receptor 0.054198
LIMCH1 LIM and calponin homology domains 1 0.0539348
AHR aryl hydrocarbon receptor 0.0538961
LTBP1 latent transforming growth factor beta binding protein 1 0.0515401
GRB10 growth factor receptor-bound protein 10 0.0510752
NDRG1 N-myc downstream regulated 1 0.0508885
SMYD3 SET and MYND domain containing 3 0.0479225
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0477843
IL6ST interleukin 6 signal transducer 0.04743
MYH9 myosin, heavy chain 9, non-muscle 0.0467297
NPAS2 neuronal PAS domain protein 2 0.0467241
SPRED2 sprouty-related, EVH1 domain containing 2 0.0455826
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0453272
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0438543
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0429073
PDE4D phosphodiesterase 4D, cAMP-specific 0.0422799
AHNAK AHNAK nucleoprotein 0.0419284
SMAD3 SMAD family member 3 0.0418766
WWTR1 WW domain containing transcription regulator 1 0.0404186
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0401977
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0401967
PKM pyruvate kinase, muscle 0.0398764
FOXP1 forkhead box P1 0.0392201
VEGFC vascular endothelial growth factor C 0.0389769
SVIL supervillin 0.0387025
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0386741
CAB39 calcium binding protein 39 0.0385229
HIPK2 homeodomain interacting protein kinase 2 0.0364628
ATXN1 ataxin 1 0.0360333
ELL2 elongation factor, RNA polymerase II, 2 0.0355793
PHC2 polyhomeotic homolog 2 (Drosophila) 0.035423
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0350269
ANKRD11 ankyrin repeat domain 11 0.0348921
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0348703
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0348537
NRIP1 nuclear receptor interacting protein 1 0.0347498
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0332626
TOP1 topoisomerase (DNA) I 0.0331216
RABGAP1L RAB GTPase activating protein 1-like 0.0325894
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0325824
PRELID2 PRELI domain containing 2 0.0324459
RICTOR RPTOR independent companion of MTOR, complex 2 0.0323691
SYT1 synaptotagmin I 0.0315212
MBNL1 muscleblind-like splicing regulator 1 0.0312332
MBD5 methyl-CpG binding domain protein 5 0.0310214
GPC6 glypican 6 0.0310133
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0302128
PRKCA protein kinase C, alpha 0.0299842
MCTP2 multiple C2 domains, transmembrane 2 0.0299595
ZBTB20 zinc finger and BTB domain containing 20 0.0298812
LRMDA leucine rich melanocyte differentiation associated 0.0298075
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0296234
EPS8 epidermal growth factor receptor pathway substrate 8 0.0293807
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0290024
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0289515
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0288157
TMEM131 transmembrane protein 131 0.0286444
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0283392
JMJD1C jumonji domain containing 1C 0.0283019
TTC28 tetratricopeptide repeat domain 28 0.0280482
LCOR ligand dependent nuclear receptor corepressor 0.0278998
SEPTIN9 septin 9 0.0278967
RASAL2 RAS protein activator like 2 0.027861
CD44 CD44 molecule (Indian blood group) 0.0278005
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.027683
ETV1 ets variant 1 0.0274704
CAPN2 calpain 2, (m/II) large subunit 0.027264
ERRFI1 ERBB receptor feedback inhibitor 1 0.0272421
MAML2 mastermind-like 2 (Drosophila) 0.026951
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0265562
RAD51B RAD51 paralog B 0.025886
ACTN4 actinin, alpha 4 0.0253688
KDM4C lysine (K)-specific demethylase 4C 0.025285
EXOC4 exocyst complex component 4 0.0251364
FHIT fragile histidine triad 0.0250964
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0250421
DOCK5 dedicator of cytokinesis 5 0.0245116
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0244533
SPRED1 sprouty-related, EVH1 domain containing 1 0.0243172
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0241905

decreased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.246269
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.172228
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.077857
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0596131
SQSTM1 sequestosome 1 -0.0493915
MT2A metallothionein 2A -0.0489669
FTH1 ferritin, heavy polypeptide 1 -0.0430148
TMSB4X thymosin beta 4, X-linked -0.039223
FTL ferritin, light polypeptide -0.0327476
HLA-B major histocompatibility complex, class I, B -0.0316701
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0311585
TFPI2 tissue factor pathway inhibitor 2 -0.0311508
S100A6 S100 calcium binding protein A6 -0.0306034
LOC102724023 ES1 protein homolog, mitochondrial -0.0294991
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0278136
IFI6 interferon, alpha-inducible protein 6 -0.0246746
B2M beta-2-microglobulin -0.0244352
MRPS6 mitochondrial ribosomal protein S6 -0.0238292
TPT1 tumor protein, translationally-controlled 1 -0.0237173
IFI27 interferon, alpha-inducible protein 27 -0.0234667
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0230386
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0225851
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0223684
TMSB10 thymosin beta 10 -0.0214714
SOX4 SRY (sex determining region Y)-box 4 -0.0209442
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0202899
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0194347
HMGA1 high mobility group AT-hook 1 -0.0192417
CENPF centromere protein F, 350/400kDa -0.0191666
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0189261
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0187634
TOP2A topoisomerase (DNA) II alpha 170kDa -0.018735
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.018306
BASP1 brain abundant, membrane attached signal protein 1 -0.0178418
PLIN2 perilipin 2 -0.0178327
BZW1 basic leucine zipper and W2 domains 1 -0.0170251
ACBD3 acyl-CoA binding domain containing 3 -0.0165496
SPAG9 sperm associated antigen 9 -0.0162472
WSB1 WD repeat and SOCS box containing 1 -0.0155159
CP ceruloplasmin (ferroxidase) -0.0154886
IL6 interleukin 6 -0.0153441
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0153255
SOD2 superoxide dismutase 2, mitochondrial -0.0150071
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0148086
MT1X metallothionein 1X -0.0146919
ARF1 ADP-ribosylation factor 1 -0.0141704
HLA-A major histocompatibility complex, class I, A -0.0139678
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0133551
C15ORF48 chromosome 15 open reading frame 48 -0.0132729
LMNA lamin A/C -0.0129994
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0128086
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0126891
YBX3 Y box binding protein 3 -0.0126488
TPR translocated promoter region, nuclear basket protein -0.0125553
DUSP6 dual specificity phosphatase 6 -0.0125536
CALR calreticulin -0.0123
RND3 Rho family GTPase 3 -0.0121501
SON SON DNA binding protein -0.0121258
SRSF11 serine/arginine-rich splicing factor 11 -0.0121087
FBN1 fibrillin 1 -0.0119964
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0119292
SDCBP syndecan binding protein (syntenin) -0.0118761
RAD21 RAD21 homolog (S. pombe) -0.0118698
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0117855
KDM5B lysine (K)-specific demethylase 5B -0.0111738
RBM25 RNA binding motif protein 25 -0.0109473
NUCB2 nucleobindin 2 -0.0109444
UBXN4 UBX domain protein 4 -0.0107968
TM4SF1 transmembrane 4 L six family member 1 -0.0107964
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -0.0106399
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0104515
BIRC3 baculoviral IAP repeat containing 3 -0.010371
CBX3 chromobox homolog 3 -0.0103229
EIF1 eukaryotic translation initiation factor 1 -0.0101845
ZFP91 ZFP91 zinc finger protein -0.0100488
LAMB3 laminin, beta 3 -0.0100465
SEPTIN2 septin 2 -0.00997541
GOLGA4 golgin A4 -0.00977468
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.00973475
RAI14 retinoic acid induced 14 -0.00972538
BTG1 B-cell translocation gene 1, anti-proliferative -0.0097094
CCDC47 coiled-coil domain containing 47 -0.00943597
TUBA1C tubulin, alpha 1c -0.00940533
VIM vimentin -0.0093757
GLG1 golgi glycoprotein 1 -0.00936783
NCOA7 nuclear receptor coactivator 7 -0.00918242
DSTN destrin (actin depolymerizing factor) -0.00917569
PLAUR plasminogen activator, urokinase receptor -0.00913291
SREBF2 sterol regulatory element binding transcription factor 2 -0.00907028
RNMT RNA (guanine-7-) methyltransferase -0.00905249
SERBP1 SERPINE1 mRNA binding protein 1 -0.00892471
IGFBP3 insulin-like growth factor binding protein 3 -0.00891743
SEC61G Sec61 gamma subunit -0.00891725
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.00891043
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -0.00889084
BLZF1 basic leucine zipper nuclear factor 1 -0.00878383
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.00876454
ERLEC1 endoplasmic reticulum lectin 1 -0.00876034
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.00876006
INSIG1 insulin induced gene 1 -0.00873885