Folic acid_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UBC ubiquitin C 0.174547
FTH1 ferritin, heavy polypeptide 1 0.16249
AHNAK AHNAK nucleoprotein 0.10687
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.103161
EEF2 eukaryotic translation elongation factor 2 0.0869763
RPS27A ribosomal protein S27a 0.0744668
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0658166
IFRD1 interferon-related developmental regulator 1 0.06531
TMSB10 thymosin beta 10 0.0643691
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0635545
ZBTB20 zinc finger and BTB domain containing 20 0.0581328
PCBP2 poly(rC) binding protein 2 0.0566114
ZMYND8 zinc finger, MYND-type containing 8 0.0553828
JUN jun proto-oncogene 0.054218
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0497131
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.049396
KRT8 keratin 8, type II 0.0472619
EZR ezrin 0.0469128
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0456947
EXOC4 exocyst complex component 4 0.0450388
ETV6 ets variant 6 0.0412404
FAT1 FAT atypical cadherin 1 0.040559
PCLO piccolo presynaptic cytomatrix protein 0.0403114
CADPS Ca++-dependent secretion activator 0.0397737
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0388182
PLSCR1 phospholipid scramblase 1 0.0385619
BPTF bromodomain PHD finger transcription factor 0.0385061
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0382624
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0374739
PRELID2 PRELI domain containing 2 0.0373252
ENO1 enolase 1, (alpha) 0.0369469
RIGI RNA sensor RIG-I 0.0350023
NRP1 neuropilin 1 0.0343185
EIF4A2 eukaryotic translation initiation factor 4A2 0.0341699
PDIA4 protein disulfide isomerase family A, member 4 0.033722
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0336143
OGA O-GlcNAcase 0.0323574
PKM pyruvate kinase, muscle 0.0323509
SPDYA speedy/RINGO cell cycle regulator family member A 0.0321159
SP100 SP100 nuclear antigen 0.0316193
CEP95 centrosomal protein 95kDa 0.0314065
EHBP1 EH domain binding protein 1 0.03122
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0311889
FLNA filamin A, alpha 0.0309126
ITGB4 integrin, beta 4 0.0307473
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.030603
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0304699
TIMP2 TIMP metallopeptidase inhibitor 2 0.0301834
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0296786
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0292899
APLP2 amyloid beta (A4) precursor-like protein 2 0.0286952
MYO18A myosin XVIIIA 0.0285529
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0285338
RNF213 ring finger protein 213 0.0281868
RAD51B RAD51 paralog B 0.027927
ATXN1 ataxin 1 0.0277748
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0277664
LOC112694756 uncharaterized LOC112694756 0.0277199
POTEF POTE ankyrin domain family, member F 0.027665
ACTN4 actinin, alpha 4 0.0274218
EIF4B eukaryotic translation initiation factor 4B 0.0272482
TM9SF4 transmembrane 9 superfamily protein member 4 0.0271562
TRAPPC9 trafficking protein particle complex 9 0.0269613
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0268865
RNF43 ring finger protein 43 0.0266468
HDAC4 histone deacetylase 4 0.0261511
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0259643
NEBL nebulette 0.0259154
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0258827
TXNIP thioredoxin interacting protein 0.0251301
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0249414
NCOR2 nuclear receptor corepressor 2 0.0249119
AMOTL2 angiomotin like 2 0.0245225
PTPRK protein tyrosine phosphatase, receptor type, K 0.024232
SMAD3 SMAD family member 3 0.0239977
CTNND1 catenin (cadherin-associated protein), delta 1 0.0232736
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.023177
UBASH3B ubiquitin associated and SH3 domain containing B 0.0228099
OSBPL10 oxysterol binding protein-like 10 0.0228072
PARP9 poly (ADP-ribose) polymerase family, member 9 0.0224594
KIAA1217 KIAA1217 0.0220359
PRKCE protein kinase C, epsilon 0.0218915
ANO1 anoctamin 1, calcium activated chloride channel 0.0218404
ZNF609 zinc finger protein 609 0.0217275
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0216664
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0213676
HSPA1B heat shock 70kDa protein 1B 0.0213066
TNRC18 trinucleotide repeat containing 18 0.0209231
CANX calnexin 0.0208842
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0208299
MCL1 myeloid cell leukemia 1 0.0206737
ZYX zyxin 0.0206239
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0205375
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0205216
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0203796
PARD3B par-3 family cell polarity regulator beta 0.0199404
KIAA1191 KIAA1191 0.0196273
ATXN7L1 ataxin 7-like 1 0.0196005
KDM4C lysine (K)-specific demethylase 4C 0.0195846
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0194394

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.148113
GOLGA4 golgin A4 -0.0915643
RPS2 ribosomal protein S2 -0.0915498
RPS6 ribosomal protein S6 -0.0897816
RBM39 RNA binding motif protein 39 -0.0889194
FTL ferritin, light polypeptide -0.0873377
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0737901
MKI67 marker of proliferation Ki-67 -0.0710273
MACC1 metastasis associated in colon cancer 1 -0.0705618
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0588205
RPS21 ribosomal protein S21 -0.057635
RPL12 ribosomal protein L12 -0.0558171
KRT18 keratin 18, type I -0.0532934
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0530514
WWC1 WW and C2 domain containing 1 -0.0525928
TRA2A transformer 2 alpha homolog (Drosophila) -0.0521298
RPL32 ribosomal protein L32 -0.0518964
PTMA prothymosin, alpha -0.0506478
SNX9 sorting nexin 9 -0.0502643
MATR3 matrin 3 -0.0501348
CCND1 cyclin D1 -0.0500579
TSC22D2 TSC22 domain family, member 2 -0.049926
RPS13 ribosomal protein S13 -0.0483524
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0481745
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0457059
RPL19 ribosomal protein L19 -0.0456344
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0449137
KMT2E lysine (K)-specific methyltransferase 2E -0.0448796
EIF1 eukaryotic translation initiation factor 1 -0.0446142
RYBP RING1 and YY1 binding protein -0.0444012
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0440596
RPL35A ribosomal protein L35a -0.0433963
UBQLN1 ubiquilin 1 -0.0430275
SPAG9 sperm associated antigen 9 -0.0424726
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.042424
CKAP5 cytoskeleton associated protein 5 -0.0419678
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0419577
KRT19 keratin 19, type I -0.041951
RAB1A RAB1A, member RAS oncogene family -0.0412657
RPS19 ribosomal protein S19 -0.0404743
ITCH itchy E3 ubiquitin protein ligase -0.0400118
OXR1 oxidation resistance 1 -0.0398173
MAPK8 mitogen-activated protein kinase 8 -0.038678
NAMPT nicotinamide phosphoribosyltransferase -0.0384987
DSPP dentin sialophosphoprotein -0.0383473
RPL38 ribosomal protein L38 -0.0383191
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0383111
CCNL1 cyclin L1 -0.0371056
PLAUR plasminogen activator, urokinase receptor -0.0368476
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0368464
SDK1 sidekick cell adhesion molecule 1 -0.0365747
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0361903
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0361673
CAPRIN1 cell cycle associated protein 1 -0.0354908
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0354322
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0352086
MYOF myoferlin -0.0351958
ZNF292 zinc finger protein 292 -0.0350852
RPLP1 ribosomal protein, large, P1 -0.0349951
RPS25 ribosomal protein S25 -0.03493
CENPF centromere protein F, 350/400kDa -0.0348998
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0346977
RPLP2 ribosomal protein, large, P2 -0.0345513
GOLT1B golgi transport 1B -0.0342688
XRN2 5'-3' exoribonuclease 2 -0.034252
SETD5 SET domain containing 5 -0.0341313
TMSB4X thymosin beta 4, X-linked -0.0340998
EDN1 endothelin 1 -0.0337917
TCERG1 transcription elongation regulator 1 -0.033407
U2SURP U2 snRNP-associated SURP domain containing -0.0332353
XPO1 exportin 1 -0.0331203
ANLN anillin, actin binding protein -0.0329941
CBX3 chromobox homolog 3 -0.0329511
KAT6A K(lysine) acetyltransferase 6A -0.0326079
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.0325355
CST3 cystatin C -0.0325223
CLTC clathrin, heavy chain (Hc) -0.0324362
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0323957
AKAP12 A kinase (PRKA) anchor protein 12 -0.032264
NIPBL Nipped-B homolog (Drosophila) -0.0321121
RPL37 ribosomal protein L37 -0.031991
ANKRD12 ankyrin repeat domain 12 -0.031788
FMR1 fragile X mental retardation 1 -0.0317214
H3-3B H3.3 histone B -0.0316938
TMEM123 transmembrane protein 123 -0.0315869
FRMD5 FERM domain containing 5 -0.0314444
CLINT1 clathrin interactor 1 -0.0311197
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0306407
RNF149 ring finger protein 149 -0.0302976
RPLP0 ribosomal protein, large, P0 -0.0302046
SMC4 structural maintenance of chromosomes 4 -0.0301502
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0300991
RPL11 ribosomal protein L11 -0.0300531
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0298192
SCAF11 SR-related CTD-associated factor 11 -0.0294908
CELF1 CUGBP, Elav-like family member 1 -0.0294333
ZNF706 zinc finger protein 706 -0.0292535
PDS5A PDS5 cohesin associated factor A -0.0292018
SEPTIN2 septin 2 -0.0290672
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0286789