Folic acid_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) 0.2225
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.106017
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.105294
EGFR epidermal growth factor receptor 0.104547
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.103854
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0942364
FAT1 FAT atypical cadherin 1 0.0829787
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0785032
EEF2 eukaryotic translation elongation factor 2 0.0696048
EZR ezrin 0.0687337
RAD51B RAD51 paralog B 0.0661316
CCSER1 coiled-coil serine-rich protein 1 0.0617442
FHIT fragile histidine triad 0.0529106
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0522256
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0449436
ZNRF3 zinc and ring finger 3 0.0449316
EXOC4 exocyst complex component 4 0.0443609
HILPDA hypoxia inducible lipid droplet-associated 0.0436242
MTUS1 microtubule associated tumor suppressor 1 0.043498
KITLG KIT ligand 0.0434384
AXIN2 axin 2 0.0432758
TBC1D5 TBC1 domain family, member 5 0.0431858
FAM3C family with sequence similarity 3, member C 0.0404524
EDAR ectodysplasin A receptor 0.040343
ATXN1 ataxin 1 0.03922
PDE4D phosphodiesterase 4D, cAMP-specific 0.0387118
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0385387
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.038443
SPRED2 sprouty-related, EVH1 domain containing 2 0.0357854
EVA1C eva-1 homolog C (C. elegans) 0.0356291
TMSB10 thymosin beta 10 0.0349459
ATL2 atlastin GTPase 2 0.0338679
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0325556
BCL2L1 BCL2-like 1 0.032416
OXR1 oxidation resistance 1 0.0319727
FTH1 ferritin, heavy polypeptide 1 0.0317785
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0316561
GDF15 growth differentiation factor 15 0.0315728
SPATA13 spermatogenesis associated 13 0.0314057
NCEH1 neutral cholesterol ester hydrolase 1 0.0311334
ACTN4 actinin, alpha 4 0.0308133
WWOX WW domain containing oxidoreductase 0.0306702
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0306468
FOSL1 FOS-like antigen 1 0.029069
NT5DC3 5'-nucleotidase domain containing 3 0.0288342
TENM3 teneurin transmembrane protein 3 0.0283773
PRKN parkin RBR E3 ubiquitin protein ligase 0.0279782
OSBPL10 oxysterol binding protein-like 10 0.0279434
EPHA2 EPH receptor A2 0.0270346
RPL3 ribosomal protein L3 0.0266069
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0259303
SLC30A10 solute carrier family 30, member 10 0.0250021
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0247952
NTSR1 neurotensin receptor 1 (high affinity) 0.0247256
RNF43 ring finger protein 43 0.0246312
SAMD5 sterile alpha motif domain containing 5 0.0244468
IGSF9B immunoglobulin superfamily, member 9B 0.0244061
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0242767
FER fer (fps/fes related) tyrosine kinase 0.0238534
SHB Src homology 2 domain containing adaptor protein B 0.0237896
DUSP4 dual specificity phosphatase 4 0.0236199
VMP1 vacuole membrane protein 1 0.0235056
PHF14 PHD finger protein 14 0.0233176
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0230049
MCL1 myeloid cell leukemia 1 0.022832
SMYD3 SET and MYND domain containing 3 0.022335
TRAPPC9 trafficking protein particle complex 9 0.0220701
HDAC4 histone deacetylase 4 0.0216864
IGFBP3 insulin-like growth factor binding protein 3 0.0215636
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0207077
DPY19L1 dpy-19-like 1 (C. elegans) 0.0202397
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0201269
KDM6B lysine (K)-specific demethylase 6B 0.0201241
EIF4B eukaryotic translation initiation factor 4B 0.0200113
SERINC5 serine incorporator 5 0.0195723
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.019423
FTL ferritin, light polypeptide 0.0194158
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.0194083
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0192336
BAMBI BMP and activin membrane-bound inhibitor 0.0191807
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.019147
FBXL17 F-box and leucine-rich repeat protein 17 0.0188629
GPHN gephyrin 0.0187629
PARD3B par-3 family cell polarity regulator beta 0.0186606
KLF12 Kruppel-like factor 12 0.0185518
DOCK5 dedicator of cytokinesis 5 0.0185406
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0183416
POTEF POTE ankyrin domain family, member F 0.0183076
RANBP9 RAN binding protein 9 0.0182526
RREB1 ras responsive element binding protein 1 0.0181817
TXNIP thioredoxin interacting protein 0.0181773
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.018143
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0180244
RABGAP1L RAB GTPase activating protein 1-like 0.0179341
RGS6 regulator of G-protein signaling 6 0.0179076
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0177436
ZFP36L1 ZFP36 ring finger protein-like 1 0.0172306
EMP1 epithelial membrane protein 1 0.0169167
FHL2 four and a half LIM domains 2 0.0168918
TNRC18 trinucleotide repeat containing 18 0.0165197

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.0994483
AREG amphiregulin -0.0915607
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0813366
FERMT1 fermitin family member 1 -0.0808703
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0743837
RPS2 ribosomal protein S2 -0.0722592
PTMA prothymosin, alpha -0.0704357
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0701728
LAMB3 laminin, beta 3 -0.0691806
GOLGA4 golgin A4 -0.0679922
HSPA8 heat shock 70kDa protein 8 -0.0656757
IER3 immediate early response 3 -0.0646959
TPT1 tumor protein, translationally-controlled 1 -0.0597825
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0568132
RPS6 ribosomal protein S6 -0.0555716
LDHA lactate dehydrogenase A -0.0531441
RPS8 ribosomal protein S8 -0.0520032
RPL26 ribosomal protein L26 -0.0517066
HDAC2 histone deacetylase 2 -0.0487324
PRRC2C proline-rich coiled-coil 2C -0.0478528
DSPP dentin sialophosphoprotein -0.0453274
RPS24 ribosomal protein S24 -0.044842
RBM25 RNA binding motif protein 25 -0.0445733
SETD5 SET domain containing 5 -0.0431086
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0427928
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.04259
NCOR1 nuclear receptor corepressor 1 -0.041738
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0408847
ZFAND3 zinc finger, AN1-type domain 3 -0.0404657
LOC102724023 ES1 protein homolog, mitochondrial -0.0399242
RPS29 ribosomal protein S29 -0.039758
LAMA4 laminin, alpha 4 -0.039515
MACF1 microtubule-actin crosslinking factor 1 -0.0387994
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0385903
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0379626
KMT2C lysine (K)-specific methyltransferase 2C -0.0377284
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0376534
RPS3 ribosomal protein S3 -0.037554
EREG epiregulin -0.0370497
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0369583
RPL11 ribosomal protein L11 -0.0355715
RPL32 ribosomal protein L32 -0.0346124
CD9 CD9 molecule -0.0338069
RPL9 ribosomal protein L9 -0.0337097
KTN1 kinectin 1 (kinesin receptor) -0.0334525
PDE4B phosphodiesterase 4B, cAMP-specific -0.0333476
KDM3A lysine (K)-specific demethylase 3A -0.0330808
CLTC clathrin, heavy chain (Hc) -0.0329009
PNISR PNN-interacting serine/arginine-rich protein -0.0328009
MTAP methylthioadenosine phosphorylase -0.0326912
RPS27A ribosomal protein S27a -0.0325899
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0322696
CSNK1A1 casein kinase 1, alpha 1 -0.0318042
KDM6A lysine (K)-specific demethylase 6A -0.0315784
LMO7 LIM domain 7 -0.0312514
RPLP2 ribosomal protein, large, P2 -0.0311395
GSK3B glycogen synthase kinase 3 beta -0.030919
CDC73 cell division cycle 73 -0.0308434
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.030811
MKI67 marker of proliferation Ki-67 -0.0306454
RSL1D1 ribosomal L1 domain containing 1 -0.0304985
CD44 CD44 molecule (Indian blood group) -0.0304242
RPL7 ribosomal protein L7 -0.030412
NCKAP1 NCK-associated protein 1 -0.0302322
PLAUR plasminogen activator, urokinase receptor -0.0299971
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0288088
ANXA1 annexin A1 -0.0278838
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0278056
AHNAK AHNAK nucleoprotein -0.0277677
BIRC3 baculoviral IAP repeat containing 3 -0.027618
NUP58 nucleoporin 58 -0.0276082
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0275283
KMT2E lysine (K)-specific methyltransferase 2E -0.0272862
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.027213
RBM39 RNA binding motif protein 39 -0.0270115
UBE3C ubiquitin protein ligase E3C -0.0268497
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0266951
SEPTIN7 septin 7 -0.0261497
BBX bobby sox homolog (Drosophila) -0.0258675
GLG1 golgi glycoprotein 1 -0.0258248
RAB1A RAB1A, member RAS oncogene family -0.0257802
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0256328
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0255854
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0254086
SPAG9 sperm associated antigen 9 -0.0253994
TPR translocated promoter region, nuclear basket protein -0.0253692
GARS1 glycyl-tRNA synthetase 1 -0.0252985
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0252496
TRIO trio Rho guanine nucleotide exchange factor -0.0250271
SET SET nuclear proto-oncogene -0.0249242
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0248781
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0247767
PUM1 pumilio RNA-binding family member 1 -0.0246702
UBE2K ubiquitin-conjugating enzyme E2K -0.0246662
FBXO11 F-box protein 11 -0.024554
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0241528
BIRC6 baculoviral IAP repeat containing 6 -0.0240687
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0239636
RLF rearranged L-myc fusion -0.0239141
ZMYM2 zinc finger, MYM-type 2 -0.0238623