Folic acid_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.0923844
WWOX WW domain containing oxidoreductase 0.0749287
FTL ferritin, light polypeptide 0.0746742
RPL35A ribosomal protein L35a 0.0730474
TNS3 tensin 3 0.0681964
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0648623
RUNX1 runt-related transcription factor 1 0.0634606
HDAC4 histone deacetylase 4 0.051566
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0494553
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0494479
YAP1 Yes-associated protein 1 0.0489358
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0479899
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0467809
ZNRF3 zinc and ring finger 3 0.0461761
SYT1 synaptotagmin I 0.0452072
MYH9 myosin, heavy chain 9, non-muscle 0.0448851
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0441866
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0440223
MSI2 musashi RNA-binding protein 2 0.041068
RPS19 ribosomal protein S19 0.041025
VMP1 vacuole membrane protein 1 0.0402798
RAD51B RAD51 paralog B 0.0395016
POTEF POTE ankyrin domain family, member F 0.0370806
TRA2B transformer 2 beta homolog (Drosophila) 0.0368605
SMYD3 SET and MYND domain containing 3 0.0355613
SEPTIN9 septin 9 0.0337459
ACTN4 actinin, alpha 4 0.0335896
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.03333
WNK1 WNK lysine deficient protein kinase 1 0.0332255
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0327568
RPL31 ribosomal protein L31 0.0323164
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0320565
RPL37A ribosomal protein L37a 0.0317502
AOPEP aminopeptidase O (putative) 0.0314374
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0308275
INTS6 integrator complex subunit 6 0.0307028
COBL cordon-bleu WH2 repeat protein 0.0305479
CEMIP cell migration inducing protein, hyaluronan binding 0.0304137
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0303924
MTCL1 microtubule crosslinking factor 1 0.0303311
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0302023
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0294164
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0293732
RPLP1 ribosomal protein, large, P1 0.029294
ETNK1 ethanolamine kinase 1 0.0288619
GMDS GDP-mannose 4,6-dehydratase 0.0288328
RPL28 ribosomal protein L28 0.0284923
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0275648
CEMIP2 cell migration inducing hyaluronidase 2 0.0275376
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0273951
ATP5F1B ATP synthase F1 subunit beta 0.0273461
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.0270707
CD46 CD46 molecule, complement regulatory protein 0.0268273
MBNL1 muscleblind-like splicing regulator 1 0.0265614
EXOC4 exocyst complex component 4 0.0262864
FAT1 FAT atypical cadherin 1 0.0261368
SMAD3 SMAD family member 3 0.0256713
SFPQ splicing factor proline/glutamine-rich 0.0256175
USP9X ubiquitin specific peptidase 9, X-linked 0.0254409
MCC mutated in colorectal cancers 0.0254054
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0253488
BRD2 bromodomain containing 2 0.0250681
SPATA13 spermatogenesis associated 13 0.0249452
RPL3 ribosomal protein L3 0.024891
RPS23 ribosomal protein S23 0.0248041
PKM pyruvate kinase, muscle 0.024279
RPLP2 ribosomal protein, large, P2 0.0239142
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0237071
H1-2 H1.2 linker histone, cluster member 0.0236299
GPHN gephyrin 0.0231583
ATXN1 ataxin 1 0.0231251
MCL1 myeloid cell leukemia 1 0.0230244
TBC1D5 TBC1 domain family, member 5 0.0228142
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0227938
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0226025
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0220025
PCBP2 poly(rC) binding protein 2 0.0218861
WDR43 WD repeat domain 43 0.0217821
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0216812
FNDC3B fibronectin type III domain containing 3B 0.0216776
IGF1R insulin-like growth factor 1 receptor 0.0216283
FHIT fragile histidine triad 0.0214481
RPS11 ribosomal protein S11 0.0213881
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0213069
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0212633
PDE4D phosphodiesterase 4D, cAMP-specific 0.0212046
PUM2 pumilio RNA-binding family member 2 0.0211719
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0210605
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0210589
GSE1 Gse1 coiled-coil protein 0.0208978
RBM26 RNA binding motif protein 26 0.0208016
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0207578
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0207481
RPS29 ribosomal protein S29 0.0207295
SRRM2 serine/arginine repetitive matrix 2 0.0203216
AXIN2 axin 2 0.020161
H1-4 H1.4 linker histone, cluster member 0.0201198
MYO1D myosin ID 0.0199494
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0198946
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0196485

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.123815
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0850324
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0576612
TMSB4X thymosin beta 4, X-linked -0.054416
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0502562
RPS24 ribosomal protein S24 -0.0481104
TPT1 tumor protein, translationally-controlled 1 -0.0432458
TPM4 tropomyosin 4 -0.0418113
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0396744
ANO1 anoctamin 1, calcium activated chloride channel -0.0388416
VCL vinculin -0.0375692
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0347233
RAD21 RAD21 homolog (S. pombe) -0.0340917
KRT18 keratin 18, type I -0.0337142
EPCAM epithelial cell adhesion molecule -0.0334225
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0329258
CANX calnexin -0.0318915
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0308502
PERP PERP, TP53 apoptosis effector -0.0302787
RSL1D1 ribosomal L1 domain containing 1 -0.0278473
ZBTB20 zinc finger and BTB domain containing 20 -0.0275076
EGR1 early growth response 1 -0.0272871
NAP1L1 nucleosome assembly protein 1-like 1 -0.0272732
DUSP6 dual specificity phosphatase 6 -0.0270793
KRT8 keratin 8, type II -0.0263603
H3-3B H3.3 histone B -0.0255707
CBX3 chromobox homolog 3 -0.0250888
AHNAK AHNAK nucleoprotein -0.0247482
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0245484
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.024156
LDHA lactate dehydrogenase A -0.0240733
SLC38A2 solute carrier family 38, member 2 -0.0239418
RPL26 ribosomal protein L26 -0.0239227
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0237675
KLF5 Kruppel-like factor 5 (intestinal) -0.0237001
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0234007
LOC102724023 ES1 protein homolog, mitochondrial -0.0230535
PGK1 phosphoglycerate kinase 1 -0.0229285
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0223843
RPS6 ribosomal protein S6 -0.0220691
GCC2 GRIP and coiled-coil domain containing 2 -0.0219753
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0213036
YBX3 Y box binding protein 3 -0.0212313
MYL12B myosin, light chain 12B, regulatory -0.021213
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.020904
LAMA4 laminin, alpha 4 -0.0207448
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0207092
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0201801
MRPS6 mitochondrial ribosomal protein S6 -0.0201142
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0196618
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0192417
TXNIP thioredoxin interacting protein -0.019014
NIPSNAP2 nipsnap homolog 2 -0.0189858
PTMA prothymosin, alpha -0.0186669
GARS1 glycyl-tRNA synthetase 1 -0.0186642
TM4SF1 transmembrane 4 L six family member 1 -0.0185791
BZW1 basic leucine zipper and W2 domains 1 -0.0185684
HMGB2 high mobility group box 2 -0.0184723
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0183594
RPL18 ribosomal protein L18 -0.0181754
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.018169
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0181506
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0176614
NPAS2 neuronal PAS domain protein 2 -0.0175457
SOX4 SRY (sex determining region Y)-box 4 -0.0175196
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0175122
PDGFA platelet-derived growth factor alpha polypeptide -0.0173801
CCND1 cyclin D1 -0.0173504
ZFR zinc finger RNA binding protein -0.0171293
ACTG1 actin gamma 1 -0.0171144
RPLP0 ribosomal protein, large, P0 -0.0170178
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.01674
EMP1 epithelial membrane protein 1 -0.0163971
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0161874
MORF4L2 mortality factor 4 like 2 -0.0160713
SSB Sjogren syndrome antigen B (autoantigen La) -0.0157614
KLF6 Kruppel-like factor 6 -0.0154252
ZNF33A zinc finger protein 33A -0.0153773
ANXA3 annexin A3 -0.014963
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0149409
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -0.0148468
KIZ kizuna centrosomal protein -0.0148346
RACK1 receptor for activated C kinase 1 -0.0146519
NACA nascent polypeptide-associated complex alpha subunit -0.0146465
SRP72 signal recognition particle 72kDa -0.0145391
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0145301
CSDE1 cold shock domain containing E1, RNA-binding -0.0144265
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0141546
COPB1 coatomer protein complex, subunit beta 1 -0.0141459
CCDC47 coiled-coil domain containing 47 -0.0140569
RPS27A ribosomal protein S27a -0.0140029
KDM3A lysine (K)-specific demethylase 3A -0.0139362
S100A10 S100 calcium binding protein A10 -0.0138274
THRAP3 thyroid hormone receptor associated protein 3 -0.0136637
CAVIN1 caveolae associated protein 1 -0.0136313
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0136192
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0136097
SMC4 structural maintenance of chromosomes 4 -0.0135574
S100A4 S100 calcium binding protein A4 -0.0135298
RPS12 ribosomal protein S12 -0.0135295