Folic acid_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.16266
MYO10 myosin X 0.0839598
GLIS3 GLIS family zinc finger 3 0.0682438
NALF1 NALCN channel auxiliary factor 1 0.0646888
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0639129
NAV1 neuron navigator 1 0.0613474
RUNX1 runt-related transcription factor 1 0.0599742
JARID2 jumonji, AT rich interactive domain 2 0.059288
LOX lysyl oxidase 0.0592545
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.056682
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0541406
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0531618
COL6A3 collagen, type VI, alpha 3 0.0482693
NDRG1 N-myc downstream regulated 1 0.0475721
ATP13A3 ATPase type 13A3 0.047496
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0472943
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0469966
EXT1 exostosin glycosyltransferase 1 0.0424357
MCL1 myeloid cell leukemia 1 0.0423979
TRIO trio Rho guanine nucleotide exchange factor 0.0423231
MSN moesin 0.0417772
NOTCH2 notch 2 0.0405289
FN1 fibronectin 1 0.0395155
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0385895
FNDC3B fibronectin type III domain containing 3B 0.0384605
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0374475
ZSWIM6 zinc finger, SWIM-type containing 6 0.0374068
EGFR epidermal growth factor receptor 0.0358346
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0348604
VEGFA vascular endothelial growth factor A 0.0340381
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0337625
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.033382
EEF2 eukaryotic translation elongation factor 2 0.033041
INTS6 integrator complex subunit 6 0.0325511
TNS1 tensin 1 0.0315989
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0310727
ADGRB3 adhesion G protein-coupled receptor B3 0.0310051
VCL vinculin 0.0309141
COL6A1 collagen, type VI, alpha 1 0.0307933
ANO6 anoctamin 6 0.030565
ANTXR2 anthrax toxin receptor 2 0.0304438
ARHGAP21 Rho GTPase activating protein 21 0.0302936
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0296866
MYH9 myosin, heavy chain 9, non-muscle 0.0284991
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0284865
PDLIM5 PDZ and LIM domain 5 0.0277712
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0275354
FRMD6 FERM domain containing 6 0.027481
POTEF POTE ankyrin domain family, member F 0.0264
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0259597
VEGFC vascular endothelial growth factor C 0.0259106
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0253969
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0252666
SEPTIN9 septin 9 0.0247823
FNDC3A fibronectin type III domain containing 3A 0.0246535
OXR1 oxidation resistance 1 0.0245647
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0244528
ANKRD28 ankyrin repeat domain 28 0.0242773
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0240236
SLIT2 slit homolog 2 (Drosophila) 0.023999
MBD5 methyl-CpG binding domain protein 5 0.0239534
WWTR1 WW domain containing transcription regulator 1 0.0238708
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0236449
EPAS1 endothelial PAS domain protein 1 0.0235354
PICALM phosphatidylinositol binding clathrin assembly protein 0.0233837
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0228457
MAML2 mastermind-like 2 (Drosophila) 0.0227938
VMP1 vacuole membrane protein 1 0.0222384
SPRED1 sprouty-related, EVH1 domain containing 1 0.0221628
KDM4C lysine (K)-specific demethylase 4C 0.0216549
PLS3 plastin 3 0.021301
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0212979
LTBP1 latent transforming growth factor beta binding protein 1 0.0210956
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0199092
DST dystonin 0.0199071
FAM219A family with sequence similarity 219, member A 0.019636
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0195701
PRELID2 PRELI domain containing 2 0.0194528
CD44 CD44 molecule (Indian blood group) 0.0193586
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0193516
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0193191
AMOTL1 angiomotin like 1 0.0191729
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0190914
FER fer (fps/fes related) tyrosine kinase 0.019009
KLF12 Kruppel-like factor 12 0.0189658
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0188842
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0188831
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0187485
SOD2 superoxide dismutase 2, mitochondrial 0.0185532
RCOR1 REST corepressor 1 0.0181231
HDAC9 histone deacetylase 9 0.0179542
WDFY3 WD repeat and FYVE domain containing 3 0.0175521
MAML3 mastermind-like 3 (Drosophila) 0.0174961
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0174812
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0173448
SH3RF1 SH3 domain containing ring finger 1 0.0167358
NUMB numb homolog (Drosophila) 0.0166226
ZEB2 zinc finger E-box binding homeobox 2 0.016609
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0165753
CYTH3 cytohesin 3 0.0165635

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.231818
INHBA inhibin, beta A -0.225175
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.174329
COL1A1 collagen, type I, alpha 1 -0.173533
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.166393
TPT1 tumor protein, translationally-controlled 1 -0.124421
GREM1 gremlin 1, DAN family BMP antagonist -0.104781
MMP1 matrix metallopeptidase 1 -0.103235
PTMA prothymosin, alpha -0.0857736
CAVIN1 caveolae associated protein 1 -0.0786193
HLA-B major histocompatibility complex, class I, B -0.0776016
RPS6 ribosomal protein S6 -0.0722072
TMSB10 thymosin beta 10 -0.0708122
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0657256
FTL ferritin, light polypeptide -0.0639288
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.061092
CALR calreticulin -0.0606833
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0600532
B2M beta-2-microglobulin -0.053922
COL1A2 collagen, type I, alpha 2 -0.0525308
RPS8 ribosomal protein S8 -0.0507188
RPS24 ribosomal protein S24 -0.0504964
CANX calnexin -0.0498395
RPL23 ribosomal protein L23 -0.0495478
PDE4D phosphodiesterase 4D, cAMP-specific -0.0480014
RPL35A ribosomal protein L35a -0.0470563
RPL34 ribosomal protein L34 -0.0464842
WSB1 WD repeat and SOCS box containing 1 -0.0439503
MT2A metallothionein 2A -0.0437002
EIF1 eukaryotic translation initiation factor 1 -0.0420475
PGK1 phosphoglycerate kinase 1 -0.0416101
TPM4 tropomyosin 4 -0.0407498
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0397225
IER3 immediate early response 3 -0.0396663
ACTG1 actin gamma 1 -0.0390271
RPL12 ribosomal protein L12 -0.038886
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0352364
RPL9 ribosomal protein L9 -0.0344767
RPS13 ribosomal protein S13 -0.0340639
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0337416
S100A6 S100 calcium binding protein A6 -0.0337337
RPS27A ribosomal protein S27a -0.0336366
TFPI2 tissue factor pathway inhibitor 2 -0.0330491
PDIA3 protein disulfide isomerase family A, member 3 -0.0325393
AHNAK AHNAK nucleoprotein -0.032447
CALU calumenin -0.0320631
ALCAM activated leukocyte cell adhesion molecule -0.031292
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0307941
RPS12 ribosomal protein S12 -0.0301485
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0295157
NAMPT nicotinamide phosphoribosyltransferase -0.0292107
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0287376
RPL26 ribosomal protein L26 -0.0286853
RPS19 ribosomal protein S19 -0.0284463
GOLGA4 golgin A4 -0.0281338
TM4SF1 transmembrane 4 L six family member 1 -0.0276545
AKAP12 A kinase (PRKA) anchor protein 12 -0.0276089
PRKG1 protein kinase, cGMP-dependent, type I -0.0274249
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0267458
RPLP1 ribosomal protein, large, P1 -0.0266092
COL3A1 collagen, type III, alpha 1 -0.0264966
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0262118
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0260869
AFF4 AF4/FMR2 family, member 4 -0.0260493
RPL31 ribosomal protein L31 -0.0260359
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0258406
RPL38 ribosomal protein L38 -0.0258086
RRBP1 ribosome binding protein 1 -0.0256383
RPLP0 ribosomal protein, large, P0 -0.0255894
VDAC1 voltage-dependent anion channel 1 -0.0255667
RPL11 ribosomal protein L11 -0.0254648
GARS1 glycyl-tRNA synthetase 1 -0.0254404
RPL37A ribosomal protein L37a -0.0252092
GCC2 GRIP and coiled-coil domain containing 2 -0.0251136
YME1L1 YME1-like 1 ATPase -0.0249648
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0247947
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 -0.0243486
PRSS23 protease, serine, 23 -0.0241197
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0239995
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0239786
ZNF292 zinc finger protein 292 -0.0239012
TXNRD1 thioredoxin reductase 1 -0.0237814
TPI1 triosephosphate isomerase 1 -0.0236906
CD63 CD63 molecule -0.0236242
LAMB3 laminin, beta 3 -0.0235939
S100A10 S100 calcium binding protein A10 -0.0234312
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0233101
RPL37 ribosomal protein L37 -0.0231331
RPS25 ribosomal protein S25 -0.023024
NAP1L1 nucleosome assembly protein 1-like 1 -0.0226924
TMSB4X thymosin beta 4, X-linked -0.0225933
BZW1 basic leucine zipper and W2 domains 1 -0.0224412
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0223301
RPL19 ribosomal protein L19 -0.0222514
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.021899
RAD21 RAD21 homolog (S. pombe) -0.0218398
RPS3 ribosomal protein S3 -0.0218386
KPNB1 karyopherin (importin) beta 1 -0.0218055
ANKRD11 ankyrin repeat domain 11 -0.0218002
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0216933