| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.113099 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0622216 |
| GPC6 | glypican 6 | 0.044989 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0449519 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0423783 |
| STC1 | stanniocalcin 1 | 0.0413266 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0396071 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0382471 |
| NDRG1 | N-myc downstream regulated 1 | 0.0375425 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0372501 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0370689 |
| SBF2 | SET binding factor 2 | 0.0368236 |
| PRELID2 | PRELI domain containing 2 | 0.0348254 |
| FLNB | filamin B, beta | 0.0348162 |
| SQSTM1 | sequestosome 1 | 0.0339825 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.033913 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0330345 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0323961 |
| SETD5 | SET domain containing 5 | 0.0308976 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0302116 |
| AUTS2 | autism susceptibility candidate 2 | 0.0298388 |
| ATP13A3 | ATPase type 13A3 | 0.0283169 |
| OGA | O-GlcNAcase | 0.027456 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0272318 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0268126 |
| FBN1 | fibrillin 1 | 0.0263117 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0259428 |
| FNIP1 | folliculin interacting protein 1 | 0.0256939 |
| FMNL2 | formin-like 2 | 0.0255408 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.02543 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0252909 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0252363 |
| HELZ | helicase with zinc finger | 0.0250036 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0246485 |
| OPTN | optineurin | 0.0245834 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0237287 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0233688 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0231583 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0228298 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0225263 |
| UBC | ubiquitin C | 0.021976 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0218139 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0216951 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0216325 |
| DTNA | dystrobrevin, alpha | 0.021413 |
| ATXN1 | ataxin 1 | 0.0211554 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0210693 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0210604 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0210053 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0209586 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0209465 |
| SEPTIN9 | septin 9 | 0.0206332 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0205741 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0202329 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0201881 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0201287 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0199217 |
| WTAP | Wilms tumor 1 associated protein | 0.0199099 |
| ARRDC3 | arrestin domain containing 3 | 0.0198881 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0196595 |
| C1D | C1D nuclear receptor corepressor | 0.0195998 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0195006 |
| NGLY1 | N-glycanase 1 | 0.0194837 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0194507 |
| ARFGEF3 | ARFGEF family member 3 | 0.0191163 |
| TMOD1 | tropomodulin 1 | 0.0188782 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0188315 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.0186271 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0183599 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.018262 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0177121 |
| FOSL1 | FOS-like antigen 1 | 0.0176399 |
| ANK2 | ankyrin 2, neuronal | 0.017462 |
| NAV2 | neuron navigator 2 | 0.0174358 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0171938 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 0.0169809 |
| CLU | clusterin | 0.0169741 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0169283 |
| KIFAP3 | kinesin-associated protein 3 | 0.0168005 |
| KIAA1217 | KIAA1217 | 0.0167731 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0166112 |
| FAM219A | family with sequence similarity 219, member A | 0.0165695 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0164721 |
| CDK18 | cyclin-dependent kinase 18 | 0.0164602 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0164527 |
| MEF2A | myocyte enhancer factor 2A | 0.0164157 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0163681 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0162107 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0161439 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | 0.0160659 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0159272 |
| YEATS2 | YEATS domain containing 2 | 0.0157811 |
| PCGF5 | polycomb group ring finger 5 | 0.0157369 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.015683 |
| MT2A | metallothionein 2A | 0.0154906 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0153657 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0152644 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0151648 |
| LRRC49 | leucine rich repeat containing 49 | 0.0150476 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0150449 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.31988 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.258897 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.162618 |
| TMSB10 | thymosin beta 10 | -0.153806 |
| CDH13 | cadherin 13 | -0.130481 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.130089 |
| FN1 | fibronectin 1 | -0.112149 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0986943 |
| MAP1B | microtubule-associated protein 1B | -0.0984051 |
| COL5A1 | collagen, type V, alpha 1 | -0.0979511 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0978887 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0943309 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0875606 |
| TPM4 | tropomyosin 4 | -0.0852972 |
| AHNAK | AHNAK nucleoprotein | -0.0828673 |
| CANX | calnexin | -0.077355 |
| LOX | lysyl oxidase | -0.0773533 |
| PLAT | plasminogen activator, tissue | -0.0729576 |
| PODXL | podocalyxin-like | -0.070213 |
| S100A6 | S100 calcium binding protein A6 | -0.0699989 |
| S100A10 | S100 calcium binding protein A10 | -0.067593 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0625582 |
| PRSS23 | protease, serine, 23 | -0.0614752 |
| CSTB | cystatin B (stefin B) | -0.0606953 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0606797 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0588528 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0575018 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0574331 |
| ASPH | aspartate beta-hydroxylase | -0.057117 |
| SUCNR1 | succinate receptor 1 | -0.0546733 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0509739 |
| NAV1 | neuron navigator 1 | -0.0505961 |
| EGFR | epidermal growth factor receptor | -0.0496227 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0466231 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0456807 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0451836 |
| LDHA | lactate dehydrogenase A | -0.0440984 |
| LMNA | lamin A/C | -0.0440416 |
| CCND1 | cyclin D1 | -0.0437525 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0431315 |
| RRBP1 | ribosome binding protein 1 | -0.0426971 |
| RIGI | RNA sensor RIG-I | -0.0424912 |
| CAVIN1 | caveolae associated protein 1 | -0.0424228 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0422557 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0421505 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0417433 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0410765 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0402488 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0399821 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0397788 |
| CALR | calreticulin | -0.0397098 |
| TMSB4X | thymosin beta 4, X-linked | -0.039429 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0379414 |
| TAGLN2 | transgelin 2 | -0.0374785 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0373199 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0366101 |
| LRRC17 | leucine rich repeat containing 17 | -0.0360638 |
| EFNA5 | ephrin-A5 | -0.0360606 |
| DCLK2 | doublecortin-like kinase 2 | -0.0357715 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0356265 |
| SEPTIN7 | septin 7 | -0.0351441 |
| PLXNA2 | plexin A2 | -0.0351432 |
| HLA-B | major histocompatibility complex, class I, B | -0.0349133 |
| CENPF | centromere protein F, 350/400kDa | -0.0347897 |
| PKM | pyruvate kinase, muscle | -0.0346587 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0344497 |
| S100A11 | S100 calcium binding protein A11 | -0.033751 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0335673 |
| IL7R | interleukin 7 receptor | -0.0332434 |
| THBS2 | thrombospondin 2 | -0.0332363 |
| CYTH3 | cytohesin 3 | -0.0328896 |
| S100A4 | S100 calcium binding protein A4 | -0.0324035 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0320121 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.031859 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0318284 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0314514 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0313106 |
| MX2 | MX dynamin-like GTPase 2 | -0.0312144 |
| TPM1 | tropomyosin 1 (alpha) | -0.0308571 |
| COL5A2 | collagen, type V, alpha 2 | -0.0305723 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0302541 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0300413 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0291755 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0290433 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0289837 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0286906 |
| FRMD4A | FERM domain containing 4A | -0.0283071 |
| FSTL1 | follistatin-like 1 | -0.0280553 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0277615 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0274524 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0272169 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0266133 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0262773 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0255713 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0255622 |
| ENO1 | enolase 1, (alpha) | -0.0252272 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0251939 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0250787 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0250579 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0241363 |
