Fostamatinib (disodium hexahydrate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.219867
VIM vimentin 0.069272
FTL ferritin, light polypeptide 0.044464
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0433437
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0426438
RPS12 ribosomal protein S12 0.0349218
CPOX coproporphyrinogen oxidase 0.0316962
RPS3 ribosomal protein S3 0.0307663
PTMA prothymosin, alpha 0.0307504
EIF1 eukaryotic translation initiation factor 1 0.0273841
RPS8 ribosomal protein S8 0.0254809
RPS2 ribosomal protein S2 0.0245905
RPS19 ribosomal protein S19 0.0240161
ZBTB20 zinc finger and BTB domain containing 20 0.0231
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0222341
RPL37A ribosomal protein L37a 0.0219011
ZNF292 zinc finger protein 292 0.0204783
KLHL24 kelch-like family member 24 0.0200917
RPL12 ribosomal protein L12 0.0200877
RPS6 ribosomal protein S6 0.0198395
RB1CC1 RB1-inducible coiled-coil 1 0.0198342
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0193561
ATP5F1B ATP synthase F1 subunit beta 0.0189535
CXADR coxsackie virus and adenovirus receptor 0.0189006
CNRIP1 cannabinoid receptor interacting protein 1 0.0184257
CCNL1 cyclin L1 0.0182812
RPLP2 ribosomal protein, large, P2 0.0180137
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0177876
RACK1 receptor for activated C kinase 1 0.0177481
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0171119
BIRC2 baculoviral IAP repeat containing 2 0.0165963
RPS23 ribosomal protein S23 0.0165944
RPL11 ribosomal protein L11 0.0164427
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.016437
ARRDC3 arrestin domain containing 3 0.0163721
TMEM41B transmembrane protein 41B 0.0162564
RPLP1 ribosomal protein, large, P1 0.0162056
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0161487
PNISR PNN-interacting serine/arginine-rich protein 0.0159922
RPL19 ribosomal protein L19 0.0157829
KDM3A lysine (K)-specific demethylase 3A 0.0156937
ELF2 E74-like factor 2 (ets domain transcription factor) 0.015137
HLA-A major histocompatibility complex, class I, A 0.015053
RPL34 ribosomal protein L34 0.0150421
CDK19 cyclin-dependent kinase 19 0.0147291
RPL26 ribosomal protein L26 0.0147266
RPS29 ribosomal protein S29 0.0146627
BRWD3 bromodomain and WD repeat domain containing 3 0.0143494
BTG3 BTG family, member 3 0.0141387
RPS27A ribosomal protein S27a 0.0141148
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0139874
EDN1 endothelin 1 0.0138159
FTH1 ferritin, heavy polypeptide 1 0.0134823
AKAP9 A kinase (PRKA) anchor protein 9 0.0133152
RPL36 ribosomal protein L36 0.0132699
THOC1 THO complex 1 0.0132014
FBXL20 F-box and leucine-rich repeat protein 20 0.013178
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0130707
UBA6 ubiquitin-like modifier activating enzyme 6 0.0129599
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0128298
RPS16 ribosomal protein S16 0.0124982
ERRFI1 ERBB receptor feedback inhibitor 1 0.0123095
RPS27 ribosomal protein S27 0.0122579
ARL5B ADP-ribosylation factor-like 5B 0.0120463
NKTR natural killer cell triggering receptor 0.0120371
RPS14 ribosomal protein S14 0.0120361
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0120042
RPL5 ribosomal protein L5 0.0119656
PREPL prolyl endopeptidase-like 0.0118123
ARHGAP12 Rho GTPase activating protein 12 0.0116238
RPL32 ribosomal protein L32 0.0115533
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0114911
EEF2 eukaryotic translation elongation factor 2 0.0112327
RPL18 ribosomal protein L18 0.0112255
RPL23 ribosomal protein L23 0.0112156
RPL4 ribosomal protein L4 0.0111915
RPL8 ribosomal protein L8 0.0111841
TM7SF3 transmembrane 7 superfamily member 3 0.0111787
KIF3A kinesin family member 3A 0.0109787
ACBD3 acyl-CoA binding domain containing 3 0.0109143
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.0108819
OGA O-GlcNAcase 0.0106031
RPS13 ribosomal protein S13 0.0106012
RPL9 ribosomal protein L9 0.0105592
CAMTA1 calmodulin binding transcription activator 1 0.0105582
OXR1 oxidation resistance 1 0.0105553
RPL6 ribosomal protein L6 0.0105549
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.010495
USP3 ubiquitin specific peptidase 3 0.010443
KTN1 kinectin 1 (kinesin receptor) 0.010428
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0103469
ELP2 elongator acetyltransferase complex subunit 2 0.0103035
PER1 period circadian clock 1 0.0102159
RPS15 ribosomal protein S15 0.0101944
RNF145 ring finger protein 145 0.0101714
TMEM39A transmembrane protein 39A 0.0101451
KMT2E lysine (K)-specific methyltransferase 2E 0.0100792
MXI1 MAX interactor 1, dimerization protein 0.0100481
THOC2 THO complex 2 0.0100479
ATP5F1E ATP synthase F1 subunit epsilon 0.0099866

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.28483
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.251115
PDE4D phosphodiesterase 4D, cAMP-specific -0.13544
HMGA2 high mobility group AT-hook 2 -0.121606
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.113948
PCDH7 protocadherin 7 -0.10788
MMP12 matrix metallopeptidase 12 -0.1069
DST dystonin -0.097514
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0940078
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0918497
YAP1 Yes-associated protein 1 -0.0792708
EHBP1 EH domain binding protein 1 -0.0770645
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0759365
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0670466
ZNF804A zinc finger protein 804A -0.0666957
DPYD dihydropyrimidine dehydrogenase -0.0656277
NHSL1 NHS-like 1 -0.0628672
RAB7A RAB7A, member RAS oncogene family -0.0627534
RASAL2 RAS protein activator like 2 -0.0617532
CELF2 CUGBP, Elav-like family member 2 -0.0574257
ASPH aspartate beta-hydroxylase -0.0563831
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0534616
JMJD1C jumonji domain containing 1C -0.0530613
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0529389
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0512527
ADIPOR2 adiponectin receptor 2 -0.0506042
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0497298
TENM3 teneurin transmembrane protein 3 -0.0496565
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0487724
MSRB3 methionine sulfoxide reductase B3 -0.0482687
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0475716
TAS2R14 taste receptor, type 2, member 14 -0.0461508
RIMS2 regulating synaptic membrane exocytosis 2 -0.0458025
DLC1 DLC1 Rho GTPase activating protein -0.0454774
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0451994
PDGFC platelet derived growth factor C -0.044842
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0443063
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0429429
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0425375
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0420318
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0419396
NEBL nebulette -0.0417952
EGR1 early growth response 1 -0.0405209
AHNAK AHNAK nucleoprotein -0.0402075
BCHE butyrylcholinesterase -0.0399528
CMIP c-Maf inducing protein -0.0396174
INTS6 integrator complex subunit 6 -0.0391425
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0387084
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0382736
MACF1 microtubule-actin crosslinking factor 1 -0.0379527
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0377919
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0373702
ZFAND3 zinc finger, AN1-type domain 3 -0.0373126
USP34 ubiquitin specific peptidase 34 -0.037277
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0372167
EDARADD EDAR-associated death domain -0.0369177
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0361771
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0359177
LPP LIM domain containing preferred translocation partner in lipoma -0.0353838
ERBIN erbb2 interacting protein -0.0352748
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0348323
SLC38A2 solute carrier family 38, member 2 -0.0348067
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0347029
ADGRG6 adhesion G protein-coupled receptor G6 -0.0346704
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0339343
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0338278
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0327852
CUX1 cut-like homeobox 1 -0.032719
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.032142
CANX calnexin -0.0319678
MTAP methylthioadenosine phosphorylase -0.0317914
ANKRD17 ankyrin repeat domain 17 -0.0310878
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0309915
TRIO trio Rho guanine nucleotide exchange factor -0.0305971
EXOC4 exocyst complex component 4 -0.0301093
NAV3 neuron navigator 3 -0.0299364
CSMD3 CUB and Sushi multiple domains 3 -0.0298874
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0291028
FNDC3B fibronectin type III domain containing 3B -0.0288683
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0287657
COMMD10 COMM domain containing 10 -0.0280626
RAB10 RAB10, member RAS oncogene family -0.027911
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0277608
SMC4 structural maintenance of chromosomes 4 -0.027672
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0276438
NABP1 nucleic acid binding protein 1 -0.0274794
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.0274011
DOCK1 dedicator of cytokinesis 1 -0.027364
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.026992
ANXA1 annexin A1 -0.0266762
ANKRD28 ankyrin repeat domain 28 -0.0266207
SETX senataxin -0.0265035
CALR calreticulin -0.026334
HDAC9 histone deacetylase 9 -0.0262025
LMO7 LIM domain 7 -0.0261798
CCND1 cyclin D1 -0.0260592
AFF4 AF4/FMR2 family, member 4 -0.0258575
RABGAP1L RAB GTPase activating protein 1-like -0.0258146
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0256418
ETV6 ets variant 6 -0.0256204