| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CCL2 | chemokine (C-C motif) ligand 2 | 0.118723 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.100503 |
| B2M | beta-2-microglobulin | 0.0955273 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0877861 |
| PTMA | prothymosin, alpha | 0.0860065 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.077181 |
| FTL | ferritin, light polypeptide | 0.0682551 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0652872 |
| CD44 | CD44 molecule (Indian blood group) | 0.059276 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0553653 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.054132 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0534218 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.0502142 |
| VIM | vimentin | 0.0496558 |
| G0S2 | G0/G1 switch 2 | 0.0492298 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0491719 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0487774 |
| MT2A | metallothionein 2A | 0.048745 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0482171 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0459828 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0445624 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.044071 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0419597 |
| RPS8 | ribosomal protein S8 | 0.0402017 |
| TPM3 | tropomyosin 3 | 0.0400783 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0373312 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0372414 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0371697 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0359961 |
| MSN | moesin | 0.0355127 |
| CA12 | carbonic anhydrase XII | 0.0344536 |
| FMNL2 | formin-like 2 | 0.0339994 |
| CADM1 | cell adhesion molecule 1 | 0.0337867 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0337623 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0335359 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0332352 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0325709 |
| RPL37A | ribosomal protein L37a | 0.0324308 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0324093 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0322162 |
| FAM13A | family with sequence similarity 13, member A | 0.0321333 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0315696 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0312156 |
| GOLGA4 | golgin A4 | 0.0310882 |
| IRS2 | insulin receptor substrate 2 | 0.0307091 |
| PAX8 | paired box 8 | 0.0305063 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.030175 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0301495 |
| NCKAP1 | NCK-associated protein 1 | 0.0299285 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0292322 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0292179 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0290682 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0290327 |
| ZNF706 | zinc finger protein 706 | 0.0289887 |
| CENPF | centromere protein F, 350/400kDa | 0.0289784 |
| DSTN | destrin (actin depolymerizing factor) | 0.0279075 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0277811 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0277124 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0275799 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0271416 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0268045 |
| RPS6 | ribosomal protein S6 | 0.02675 |
| RPS2 | ribosomal protein S2 | 0.0265424 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0259115 |
| RPLP2 | ribosomal protein, large, P2 | 0.0256459 |
| LMNA | lamin A/C | 0.0255715 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0246145 |
| SRGN | serglycin | 0.0246067 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0245313 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0243617 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0240235 |
| OGA | O-GlcNAcase | 0.0240032 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0239073 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0236542 |
| RPS27A | ribosomal protein S27a | 0.0234131 |
| NAV2 | neuron navigator 2 | 0.0233908 |
| CALR | calreticulin | 0.0233811 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0233414 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0228527 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0227532 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0226725 |
| WASL | Wiskott-Aldrich syndrome-like | 0.022643 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.022588 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0224595 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0223566 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0223085 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0223059 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0221882 |
| HDGF | hepatoma-derived growth factor | 0.0219665 |
| CD70 | CD70 molecule | 0.0219274 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0217424 |
| RPL7A | ribosomal protein L7a | 0.0214582 |
| ACTG1 | actin gamma 1 | 0.0213508 |
| RPS17 | ribosomal protein S17 | 0.0212768 |
| RNF220 | ring finger protein 220 | 0.0212154 |
| PRDX1 | peroxiredoxin 1 | 0.0210207 |
| XPO1 | exportin 1 | 0.020851 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0208023 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0207958 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0207599 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.141288 |
| FRMD4A | FERM domain containing 4A | -0.118728 |
| GLIS3 | GLIS family zinc finger 3 | -0.0747959 |
| TXNRD1 | thioredoxin reductase 1 | -0.0584101 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0506579 |
| VCL | vinculin | -0.0462616 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0459972 |
| PALLD | palladin, cytoskeletal associated protein | -0.0458206 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.044966 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0428941 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.042893 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0426685 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0411139 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0410691 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0400105 |
| OSMR | oncostatin M receptor | -0.0399983 |
| CTSD | cathepsin D | -0.0388752 |
| TMSB10 | thymosin beta 10 | -0.0386636 |
| ASPH | aspartate beta-hydroxylase | -0.0356528 |
| CP | ceruloplasmin (ferroxidase) | -0.0352232 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0350954 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0350471 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0340589 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0331592 |
| SCFD2 | sec1 family domain containing 2 | -0.0326442 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0314588 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0310467 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0301659 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0298303 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0292431 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0280183 |
| RPL35A | ribosomal protein L35a | -0.0278084 |
| MAP1B | microtubule-associated protein 1B | -0.0272763 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0271988 |
| POTEF | POTE ankyrin domain family, member F | -0.0264471 |
| EFNA5 | ephrin-A5 | -0.0258645 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0258337 |
| FAT1 | FAT atypical cadherin 1 | -0.0255588 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0249615 |
| LDHA | lactate dehydrogenase A | -0.0249566 |
| UBAP2 | ubiquitin associated protein 2 | -0.0248545 |
| MSR1 | macrophage scavenger receptor 1 | -0.0248227 |
| CANX | calnexin | -0.024578 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0244961 |
| PLIN2 | perilipin 2 | -0.0238798 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0238252 |
| EGR1 | early growth response 1 | -0.0236883 |
| PRKCA | protein kinase C, alpha | -0.023474 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0234241 |
| EHBP1 | EH domain binding protein 1 | -0.023223 |
| GDI2 | GDP dissociation inhibitor 2 | -0.0230945 |
| SETX | senataxin | -0.0226402 |
| ARF1 | ADP-ribosylation factor 1 | -0.0223411 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0219469 |
| SP100 | SP100 nuclear antigen | -0.0217219 |
| PTH2R | parathyroid hormone 2 receptor | -0.021647 |
| PKM | pyruvate kinase, muscle | -0.0215931 |
| ZNF644 | zinc finger protein 644 | -0.0213219 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0211605 |
| KYNU | kynureninase | -0.021103 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0209918 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0208533 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0207122 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0205781 |
| MYO1E | myosin IE | -0.0205387 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0200941 |
| RRBP1 | ribosome binding protein 1 | -0.0200502 |
| GPC6 | glypican 6 | -0.0200438 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0199895 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0197475 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0195911 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0195328 |
| LIMA1 | LIM domain and actin binding 1 | -0.0195256 |
| TUSC3 | tumor suppressor candidate 3 | -0.0195212 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0194941 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0194867 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0193541 |
| TAPBP | TAP binding protein (tapasin) | -0.0192808 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0191944 |
| TPM4 | tropomyosin 4 | -0.0191726 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0190955 |
| INTS6 | integrator complex subunit 6 | -0.0190071 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0189103 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0183544 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.017625 |
| NUP98 | nucleoporin 98kDa | -0.0175228 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0174541 |
| RNF213 | ring finger protein 213 | -0.017323 |
| TOB1 | transducer of ERBB2, 1 | -0.0172608 |
| RAB10 | RAB10, member RAS oncogene family | -0.0169532 |
| ATF6 | activating transcription factor 6 | -0.0169136 |
| EGFR | epidermal growth factor receptor | -0.016834 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0167977 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0167934 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0167667 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.016659 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0165071 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.016268 |
| SYNPO | synaptopodin | -0.0162409 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -0.0161433 |
