| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.133943 |
| NDRG1 | N-myc downstream regulated 1 | 0.082328 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.072592 |
| ACTG1 | actin gamma 1 | 0.0602749 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0558527 |
| CA12 | carbonic anhydrase XII | 0.053765 |
| FA2H | fatty acid 2-hydroxylase | 0.04816 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0443714 |
| FAM13A | family with sequence similarity 13, member A | 0.0432814 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0413695 |
| RPS6 | ribosomal protein S6 | 0.0376168 |
| PTMA | prothymosin, alpha | 0.0374179 |
| AXL | AXL receptor tyrosine kinase | 0.0357636 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0349929 |
| USP3 | ubiquitin specific peptidase 3 | 0.0321775 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0318506 |
| B2M | beta-2-microglobulin | 0.0317105 |
| FTL | ferritin, light polypeptide | 0.030837 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0297302 |
| HELZ | helicase with zinc finger | 0.0283767 |
| ZNF292 | zinc finger protein 292 | 0.0281155 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0264982 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0255789 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.025295 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0248754 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0242544 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0241903 |
| SRGN | serglycin | 0.0233677 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0229165 |
| HIP1 | huntingtin interacting protein 1 | 0.0225653 |
| FOSL1 | FOS-like antigen 1 | 0.0225193 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.0224013 |
| SETD5 | SET domain containing 5 | 0.0222521 |
| GOLGA4 | golgin A4 | 0.022152 |
| RPS2 | ribosomal protein S2 | 0.0220809 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0218495 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0217062 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0211581 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0206294 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0204465 |
| FLNB | filamin B, beta | 0.0202583 |
| SFXN1 | sideroflexin 1 | 0.0202482 |
| TPD52 | tumor protein D52 | 0.0200307 |
| RNF24 | ring finger protein 24 | 0.0199335 |
| H1-4 | H1.4 linker histone, cluster member | 0.0194309 |
| NGLY1 | N-glycanase 1 | 0.0188996 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0186698 |
| CDCA2 | cell division cycle associated 2 | 0.0185023 |
| RPL37A | ribosomal protein L37a | 0.0183366 |
| RPS19 | ribosomal protein S19 | 0.0179177 |
| YEATS2 | YEATS domain containing 2 | 0.0176919 |
| VEGFA | vascular endothelial growth factor A | 0.017606 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0174251 |
| ANXA4 | annexin A4 | 0.017278 |
| ANGPTL4 | angiopoietin-like 4 | 0.0170684 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0170181 |
| LMNA | lamin A/C | 0.0168435 |
| LOXL2 | lysyl oxidase-like 2 | 0.0166982 |
| MT2A | metallothionein 2A | 0.0166301 |
| HPCAL1 | hippocalcin-like 1 | 0.0165194 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0164802 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0164094 |
| RPS8 | ribosomal protein S8 | 0.0163552 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0161214 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0161145 |
| LAMB3 | laminin, beta 3 | 0.0161049 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0161016 |
| TMF1 | TATA element modulatory factor 1 | 0.0159921 |
| ZFP36 | ZFP36 ring finger protein | 0.0157098 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0156808 |
| MSN | moesin | 0.0152954 |
| TNS1 | tensin 1 | 0.0151822 |
| WBP11 | WW domain binding protein 11 | 0.0149065 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0148272 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0148134 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0146753 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0145839 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0145709 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0145306 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.014529 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0144784 |
| NUP58 | nucleoporin 58 | 0.0143446 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0142564 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0141819 |
| ADAR | adenosine deaminase, RNA-specific | 0.0141719 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0141614 |
| KLF10 | Kruppel-like factor 10 | 0.0141308 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.013819 |
| HNRNPLL | heterogeneous nuclear ribonucleoprotein L-like | 0.013395 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0133731 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | 0.0133435 |
| ANKRD11 | ankyrin repeat domain 11 | 0.013332 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0132918 |
| SRP54 | signal recognition particle 54kDa | 0.0131619 |
| PGM2L1 | phosphoglucomutase 2-like 1 | 0.0130128 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0128725 |
| RPL6 | ribosomal protein L6 | 0.0127802 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0127463 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.012697 |
| PDCD5 | programmed cell death 5 | 0.0126725 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.215596 |
| KYNU | kynureninase | -0.155029 |
| TMSB10 | thymosin beta 10 | -0.148938 |
| PDE10A | phosphodiesterase 10A | -0.140815 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.130037 |
| UBC | ubiquitin C | -0.128889 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.102506 |
| VCL | vinculin | -0.0962027 |
| OSMR | oncostatin M receptor | -0.0937261 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0902191 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0885579 |
| EFNA5 | ephrin-A5 | -0.084552 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0783452 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0724426 |
| RPS27A | ribosomal protein S27a | -0.0715404 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0701961 |
| VMP1 | vacuole membrane protein 1 | -0.0691887 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0690346 |
| LDHA | lactate dehydrogenase A | -0.068244 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0680026 |
| TXNRD1 | thioredoxin reductase 1 | -0.0673553 |
| ASPH | aspartate beta-hydroxylase | -0.0663324 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0662454 |
| EGFR | epidermal growth factor receptor | -0.0652929 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0651914 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0630818 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0622932 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0605628 |
| AHNAK | AHNAK nucleoprotein | -0.0588507 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0577095 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0567958 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0560273 |
| ANXA2 | annexin A2 | -0.0558551 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0552966 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0541693 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0539154 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0524186 |
| RPL23 | ribosomal protein L23 | -0.0520372 |
| VIM | vimentin | -0.051691 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0514219 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0510267 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0500329 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0499756 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0497414 |
| ENO1 | enolase 1, (alpha) | -0.049522 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0486863 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0464251 |
| DOCK4 | dedicator of cytokinesis 4 | -0.045602 |
| EHBP1 | EH domain binding protein 1 | -0.0447678 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0447033 |
| CANX | calnexin | -0.0443355 |
| PCBP2 | poly(rC) binding protein 2 | -0.0442232 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0442165 |
| MT1X | metallothionein 1X | -0.0438798 |
| DUSP16 | dual specificity phosphatase 16 | -0.0434586 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0432539 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0432072 |
| TPM1 | tropomyosin 1 (alpha) | -0.0425872 |
| GLIS3 | GLIS family zinc finger 3 | -0.0423472 |
| GOLGB1 | golgin B1 | -0.041948 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0419299 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0410637 |
| SP100 | SP100 nuclear antigen | -0.0404732 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0404385 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0399191 |
| PKM | pyruvate kinase, muscle | -0.0398575 |
| ACTN4 | actinin, alpha 4 | -0.0395252 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.039194 |
| RHCG | Rh family, C glycoprotein | -0.0377942 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0377909 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0377613 |
| RSPO3 | R-spondin 3 | -0.0376704 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0374713 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.036811 |
| BICC1 | BicC family RNA binding protein 1 | -0.0364973 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0362522 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0362251 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0357834 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0357494 |
| USP34 | ubiquitin specific peptidase 34 | -0.0355533 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0355223 |
| PALLD | palladin, cytoskeletal associated protein | -0.0355101 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0354442 |
| GRAMD1B | GRAM domain containing 1B | -0.0352223 |
| RAB10 | RAB10, member RAS oncogene family | -0.0350567 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0348567 |
| NTN4 | netrin 4 | -0.034589 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.034577 |
| LMO7 | LIM domain 7 | -0.0345018 |
| APP | amyloid beta (A4) precursor protein | -0.0344905 |
| MYO9A | myosin IXA | -0.0342441 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0337774 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0337373 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0336548 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0336168 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0332497 |
| BPTF | bromodomain PHD finger transcription factor | -0.0330674 |
| DST | dystonin | -0.0330534 |
| RIGI | RNA sensor RIG-I | -0.0330094 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.0327076 |
