| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.146823 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0830962 |
| TMEM165 | transmembrane protein 165 | 0.0659764 |
| NDRG1 | N-myc downstream regulated 1 | 0.0653817 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0581303 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0532787 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0503896 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0484667 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0465909 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0443471 |
| PTMA | prothymosin, alpha | 0.0415338 |
| MT2A | metallothionein 2A | 0.0370013 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0367748 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0356693 |
| FAM13A | family with sequence similarity 13, member A | 0.0333232 |
| CCNL1 | cyclin L1 | 0.032272 |
| TOM1L1 | target of myb1 (chicken)-like 1 | 0.0320155 |
| ZNF292 | zinc finger protein 292 | 0.0319214 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0318122 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0313381 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0309485 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0305037 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0304665 |
| GRB7 | growth factor receptor-bound protein 7 | 0.0301786 |
| VMP1 | vacuole membrane protein 1 | 0.0299037 |
| ACTG1 | actin gamma 1 | 0.0281529 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0280385 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0273008 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0270704 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0270078 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.0269667 |
| RPL19 | ribosomal protein L19 | 0.0266344 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0264123 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0252849 |
| FBXO32 | F-box protein 32 | 0.0250714 |
| USP53 | ubiquitin specific peptidase 53 | 0.0242875 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0239496 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0239174 |
| FOXO3 | forkhead box O3 | 0.02304 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0228633 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0224482 |
| RTN4 | reticulon 4 | 0.022429 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0221773 |
| DSCAM | Down syndrome cell adhesion molecule | 0.022137 |
| TPD52 | tumor protein D52 | 0.0217723 |
| STXBP1 | syntaxin binding protein 1 | 0.0217664 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0212676 |
| PRELID2 | PRELI domain containing 2 | 0.0211106 |
| LDLR | low density lipoprotein receptor | 0.0210036 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0209993 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0209208 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0208899 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0207573 |
| YEATS2 | YEATS domain containing 2 | 0.0202561 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0201237 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0201055 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | 0.0200798 |
| TMEM123 | transmembrane protein 123 | 0.0200603 |
| FDPS | farnesyl diphosphate synthase | 0.0195616 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0194892 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0194729 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0187333 |
| RPS3 | ribosomal protein S3 | 0.0178008 |
| AREG | amphiregulin | 0.0177861 |
| ANXA2 | annexin A2 | 0.0176325 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0171386 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0168947 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0167735 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0166448 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.016244 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0161647 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0158064 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0157119 |
| SETD5 | SET domain containing 5 | 0.0156803 |
| WASL | Wiskott-Aldrich syndrome-like | 0.0153829 |
| BBX | bobby sox homolog (Drosophila) | 0.0153277 |
| ECT2 | epithelial cell transforming 2 | 0.0152743 |
| CDCP1 | CUB domain containing protein 1 | 0.0152488 |
| ENO1 | enolase 1, (alpha) | 0.015132 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0150127 |
| SBF2 | SET binding factor 2 | 0.0149743 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.014696 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0146331 |
| INSIG1 | insulin induced gene 1 | 0.0145785 |
| CCNI | cyclin I | 0.014558 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0145334 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0144536 |
| CENPF | centromere protein F, 350/400kDa | 0.0144376 |
| WASF2 | WAS protein family, member 2 | 0.0144299 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0144163 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0143935 |
| RASA2 | RAS p21 protein activator 2 | 0.0142568 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0140419 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.014023 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0139988 |
| RESF1 | retroelement silencing factor 1 | 0.013943 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0139233 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0139062 |
| ZNF395 | zinc finger protein 395 | 0.0138337 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0138223 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDK12 | cyclin-dependent kinase 12 | -0.100836 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0882231 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0865535 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.0793333 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0671936 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0641165 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0596565 |
| ASPH | aspartate beta-hydroxylase | -0.0586579 |
| NTN4 | netrin 4 | -0.0571805 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.0544206 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0529476 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0492073 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0472239 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0421191 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0420322 |
| PTK2 | protein tyrosine kinase 2 | -0.0417913 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0413492 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0413354 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0397164 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0382502 |
| ENAH | enabled homolog (Drosophila) | -0.0361376 |
| CCND1 | cyclin D1 | -0.0360865 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0356109 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0352435 |
| CLTC | clathrin, heavy chain (Hc) | -0.0330738 |
| GLCCI1 | glucocorticoid induced 1 | -0.0326477 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0326047 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0324906 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0321969 |
| CEP250 | centrosomal protein 250kDa | -0.0302591 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0301105 |
| LASP1 | LIM and SH3 protein 1 | -0.0296243 |
| SMYD3 | SET and MYND domain containing 3 | -0.0294506 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0294406 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0294245 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0288907 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0288783 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0279385 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | -0.0275643 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0273236 |
| MED13L | mediator complex subunit 13-like | -0.0272218 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0270116 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0269184 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0266228 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0266185 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0266026 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.026228 |
| APP | amyloid beta (A4) precursor protein | -0.0262108 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0261307 |
| INTS6 | integrator complex subunit 6 | -0.0259343 |
| SEPTIN9 | septin 9 | -0.0259013 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.025729 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.024655 |
| GRHL2 | grainyhead-like 2 (Drosophila) | -0.0245084 |
| POTEF | POTE ankyrin domain family, member F | -0.0244565 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0241093 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0239299 |
| RPL23 | ribosomal protein L23 | -0.0230389 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0229878 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.0229434 |
| MYOF | myoferlin | -0.0229045 |
| AHR | aryl hydrocarbon receptor | -0.0222436 |
| NRP1 | neuropilin 1 | -0.0219275 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0219118 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | -0.0218305 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0217528 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0217283 |
| STXBP4 | syntaxin binding protein 4 | -0.0215282 |
| DUSP16 | dual specificity phosphatase 16 | -0.0212074 |
| TMSB4X | thymosin beta 4, X-linked | -0.0209356 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.0208363 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.02056 |
| INSR | insulin receptor | -0.0204467 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0204323 |
| VCP | valosin containing protein | -0.0201512 |
| ARF1 | ADP-ribosylation factor 1 | -0.0200554 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0196211 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0195264 |
| CUX1 | cut-like homeobox 1 | -0.0195154 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0191815 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0190633 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0190554 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0187768 |
| NFIA | nuclear factor I/A | -0.0183183 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0183046 |
| PLEC | plectin | -0.0181347 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.018115 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0180082 |
| OLA1 | Obg-like ATPase 1 | -0.0179124 |
| PHF20L1 | PHD finger protein 20-like 1 | -0.0177434 |
| ZNF207 | zinc finger protein 207 | -0.0177328 |
| COBL | cordon-bleu WH2 repeat protein | -0.01772 |
| LRRC59 | leucine rich repeat containing 59 | -0.0175176 |
| EFNA5 | ephrin-A5 | -0.0174271 |
| FASN | fatty acid synthase | -0.0172265 |
| PRKCA | protein kinase C, alpha | -0.0170572 |
| SETX | senataxin | -0.0170228 |
| RTF2 | replication termination factor 2 | -0.0170177 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0170124 |
| SP100 | SP100 nuclear antigen | -0.0170101 |
