Fostamatinib (disodium hexahydrate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.115521
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0723884
LEF1 lymphoid enhancer-binding factor 1 0.0620368
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0603712
CDC73 cell division cycle 73 0.0506511
IFI16 interferon, gamma-inducible protein 16 0.0476461
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0412818
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0343735
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0335579
SPRED1 sprouty-related, EVH1 domain containing 1 0.0328926
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0319947
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0313211
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0312287
KMT2E lysine (K)-specific methyltransferase 2E 0.0295218
TMEM178B transmembrane protein 178B 0.0286147
A2M alpha-2-macroglobulin 0.0280803
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0276407
BIRC2 baculoviral IAP repeat containing 2 0.0261116
AHR aryl hydrocarbon receptor 0.0240187
HELZ helicase with zinc finger 0.023829
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.023641
IL6ST interleukin 6 signal transducer 0.023621
EPS8 epidermal growth factor receptor pathway substrate 8 0.0232332
ZNF292 zinc finger protein 292 0.0230009
FN1 fibronectin 1 0.0228878
PRELID2 PRELI domain containing 2 0.0222513
RNF145 ring finger protein 145 0.022224
TNNC1 troponin C type 1 (slow) 0.020967
ARRDC3 arrestin domain containing 3 0.0208636
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0207906
PXMP2 peroxisomal membrane protein 2, 22kDa 0.0206391
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0203854
NEK7 NIMA-related kinase 7 0.0203452
RAD21 RAD21 homolog (S. pombe) 0.0200936
IL1RAP interleukin 1 receptor accessory protein 0.0193768
RBM33 RNA binding motif protein 33 0.019366
PI15 peptidase inhibitor 15 0.0188599
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0184386
KDM3A lysine (K)-specific demethylase 3A 0.017271
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0171264
FOXJ3 forkhead box J3 0.0167632
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0164054
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0161763
ZNF608 zinc finger protein 608 0.0159721
SUCO SUN domain containing ossification factor 0.015852
APP amyloid beta (A4) precursor protein 0.0156337
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0155208
GTF2I general transcription factor IIi 0.0154743
FBXO7 F-box protein 7 0.0150391
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.01502
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0147329
TOP2B topoisomerase (DNA) II beta 180kDa 0.0146613
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0146548
CHIC2 cysteine-rich hydrophobic domain 2 0.0143932
NUP58 nucleoporin 58 0.0143873
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0142916
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0142356
ATP13A3 ATPase type 13A3 0.0141681
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0139667
KLHDC10 kelch domain containing 10 0.0137919
MRTFA myocardin related transcription factor A 0.0137778
ETNK1 ethanolamine kinase 1 0.0132749
KDM1A lysine (K)-specific demethylase 1A 0.013195
NCKAP1 NCK-associated protein 1 0.0131873
RAD23B RAD23 homolog B (S. cerevisiae) 0.0130595
DICER1 dicer 1, ribonuclease type III 0.0130127
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0129009
CHSY1 chondroitin sulfate synthase 1 0.0128754
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0128701
VGLL4 vestigial-like family member 4 0.0128515
ICAM1 intercellular adhesion molecule 1 0.0128333
MARCHF6 membrane associated ring-CH-type finger 6 0.0125109
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0124846
USP3 ubiquitin specific peptidase 3 0.0123565
CAPRIN1 cell cycle associated protein 1 0.0123459
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.012336
ETV6 ets variant 6 0.0122423
STRN3 striatin, calmodulin binding protein 3 0.0121778
PGK1 phosphoglycerate kinase 1 0.0121769
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0121353
RICTOR RPTOR independent companion of MTOR, complex 2 0.0120554
LAMP2 lysosomal-associated membrane protein 2 0.0118681
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0118378
SERINC1 serine incorporator 1 0.011774
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0117072
MT1X metallothionein 1X 0.0115448
H1-4 H1.4 linker histone, cluster member 0.011507
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.0114956
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0114867
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0114832
RIPK4 receptor-interacting serine-threonine kinase 4 0.0114156
CRYBG1 crystallin beta-gamma domain containing 1 0.0113652
ARL15 ADP-ribosylation factor-like 15 0.0113612
UBA2 ubiquitin-like modifier activating enzyme 2 0.0113064
AFDN afadin, adherens junction formation factor 0.0112901
MED13L mediator complex subunit 13-like 0.0111568
ZNF277 zinc finger protein 277 0.0110162
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0109967
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.010973
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0109641

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.385667
VIM vimentin -0.234689
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.139468
TMSB10 thymosin beta 10 -0.125254
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.124613
HLA-B major histocompatibility complex, class I, B -0.122971
IGFBP3 insulin-like growth factor binding protein 3 -0.119929
NLGN1 neuroligin 1 -0.118961
IGFBP5 insulin-like growth factor binding protein 5 -0.110333
VGF VGF nerve growth factor inducible -0.10911
GPC6 glypican 6 -0.108669
NDRG1 N-myc downstream regulated 1 -0.107955
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0966281
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0896061
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0851236
GDF15 growth differentiation factor 15 -0.0846793
HILPDA hypoxia inducible lipid droplet-associated -0.0842313
FTL ferritin, light polypeptide -0.0802033
EGR1 early growth response 1 -0.07976
PTMA prothymosin, alpha -0.0795305
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0779529
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0717674
PTK2 protein tyrosine kinase 2 -0.0686641
CALD1 caldesmon 1 -0.0671398
PDIA3 protein disulfide isomerase family A, member 3 -0.0635688
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0617644
CALR calreticulin -0.0608243
RPL35A ribosomal protein L35a -0.0608204
S100A6 S100 calcium binding protein A6 -0.0595721
RPLP1 ribosomal protein, large, P1 -0.059397
ENO1 enolase 1, (alpha) -0.0593775
RPS8 ribosomal protein S8 -0.0587164
CUX1 cut-like homeobox 1 -0.0578075
RPL37A ribosomal protein L37a -0.0558207
ACTG1 actin gamma 1 -0.0548893
PKM pyruvate kinase, muscle -0.0546103
ENO2 enolase 2 (gamma, neuronal) -0.0537488
RPS6 ribosomal protein S6 -0.0524496
CALU calumenin -0.0522664
TBC1D22A TBC1 domain family, member 22A -0.0519927
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0518953
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0495843
PTCHD4 patched domain containing 4 -0.04936
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0484219
VDAC1 voltage-dependent anion channel 1 -0.0476548
NPAS2 neuronal PAS domain protein 2 -0.0467793
AKAP12 A kinase (PRKA) anchor protein 12 -0.0462029
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0453476
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0448323
AKAP9 A kinase (PRKA) anchor protein 9 -0.0437489
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0420581
TRIM2 tripartite motif containing 2 -0.0417947
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0413155
MAML3 mastermind-like 3 (Drosophila) -0.0410584
ADM adrenomedullin -0.040982
RPS19 ribosomal protein S19 -0.0398821
CTSD cathepsin D -0.0396231
POTEF POTE ankyrin domain family, member F -0.0394015
RPLP2 ribosomal protein, large, P2 -0.0392021
BACE2 beta-site APP-cleaving enzyme 2 -0.0386876
KDM2A lysine (K)-specific demethylase 2A -0.038295
ZMIZ1 zinc finger, MIZ-type containing 1 -0.037949
TAGLN2 transgelin 2 -0.0379273
S100A9 S100 calcium binding protein A9 -0.0378425
SFTPA2 surfactant protein A2 -0.0378362
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0376672
PARVB parvin, beta -0.0375495
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0374461
MYO1E myosin IE -0.0373594
MRPS6 mitochondrial ribosomal protein S6 -0.0371804
CABIN1 calcineurin binding protein 1 -0.0370546
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0370077
TPT1 tumor protein, translationally-controlled 1 -0.0369523
KTN1 kinectin 1 (kinesin receptor) -0.036684
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0360843
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0359869
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0358503
RPS13 ribosomal protein S13 -0.0353972
RPL31 ribosomal protein L31 -0.0353523
PLIN2 perilipin 2 -0.0350806
KDM5B lysine (K)-specific demethylase 5B -0.0344947
PTPRM protein tyrosine phosphatase, receptor type, M -0.0344622
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0342926
PTPRD protein tyrosine phosphatase, receptor type, D -0.0342212
RPL9 ribosomal protein L9 -0.0342009
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0341782
TLE4 transducin-like enhancer of split 4 -0.0341269
HSPG2 heparan sulfate proteoglycan 2 -0.0339543
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0339043
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0338691
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0337582
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0333933
FUS FUS RNA binding protein -0.032662
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0325797
LDHA lactate dehydrogenase A -0.0325152
LMNA lamin A/C -0.0324258
LOC112694756 uncharaterized LOC112694756 -0.0323634
HSPB1 heat shock 27kDa protein 1 -0.0323469
IFITM3 interferon induced transmembrane protein 3 -0.0320254
IFI6 interferon, alpha-inducible protein 6 -0.0318229