Fostamatinib (disodium hexahydrate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOS1 son of sevenless homolog 1 (Drosophila) 0.0418342
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0272703
NRG1 neuregulin 1 0.0240519
COL3A1 collagen, type III, alpha 1 0.0227801
CD36 CD36 molecule (thrombospondin receptor) 0.0226792
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0204088
RUNX1 runt-related transcription factor 1 0.0191009
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0187009
PTPRD protein tyrosine phosphatase, receptor type, D 0.0182917
SMAD3 SMAD family member 3 0.0181162
COL1A1 collagen, type I, alpha 1 0.017804
RO60 Ro60, Y RNA binding protein 0.0176797
BIRC2 baculoviral IAP repeat containing 2 0.0172869
AOPEP aminopeptidase O (putative) 0.017134
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0170811
CADM2 cell adhesion molecule 2 0.0167452
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0166234
SBF2 SET binding factor 2 0.0158016
RPL6 ribosomal protein L6 0.0156675
H1-4 H1.4 linker histone, cluster member 0.0155761
ZFAND3 zinc finger, AN1-type domain 3 0.0154201
ADGRG6 adhesion G protein-coupled receptor G6 0.0148763
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0148056
GPC5 glypican 5 0.0146733
AHR aryl hydrocarbon receptor 0.0145417
NAP1L1 nucleosome assembly protein 1-like 1 0.014449
PCBP3 poly(rC) binding protein 3 0.0143928
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0143895
EIF4B eukaryotic translation initiation factor 4B 0.0143
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0141754
TENT5A terminal nucleotidyltransferase 5A 0.0139464
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0136992
RPL4 ribosomal protein L4 0.0135963
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0135619
SPAG9 sperm associated antigen 9 0.0134798
TCERG1 transcription elongation regulator 1 0.0134792
DST dystonin 0.0134048
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0132434
SEC23A Sec23 homolog A (S. cerevisiae) 0.0131805
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0131197
AQR aquarius intron-binding spliceosomal factor 0.0130927
NCKAP1 NCK-associated protein 1 0.0130644
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0130627
SH3RF1 SH3 domain containing ring finger 1 0.0129586
MBD5 methyl-CpG binding domain protein 5 0.0129445
ITPRID2 ITPR interacting domain containing 2 0.0128552
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0127185
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0126279
CDK19 cyclin-dependent kinase 19 0.0124979
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0124624
SEPTIN9 septin 9 0.0123198
TERF2 telomeric repeat binding factor 2 0.0122644
BABAM2 BRISC and BRCA1 A complex member 2 0.0122216
FUBP3 far upstream element (FUSE) binding protein 3 0.0122168
MTUS1 microtubule associated tumor suppressor 1 0.0121312
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0120975
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0120657
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0119822
ELP2 elongator acetyltransferase complex subunit 2 0.0119622
DNAH14 dynein, axonemal, heavy chain 14 0.0119359
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0118984
CAB39 calcium binding protein 39 0.0118002
SRP9 signal recognition particle 9kDa 0.0117939
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.01177
WDPCP WD repeat containing planar cell polarity effector 0.0116983
RAD51B RAD51 paralog B 0.0115877
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0115848
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0113919
NRIP1 nuclear receptor interacting protein 1 0.0112361
RPTOR regulatory associated protein of MTOR, complex 1 0.0112268
SPG11 spastic paraplegia 11 (autosomal recessive) 0.0111787
FBXO32 F-box protein 32 0.0110722
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0109998
CAMLG calcium modulating ligand 0.0109753
RIC1 RAB6A GEF complex partner 1 0.0109395
RBM5 RNA binding motif protein 5 0.0109243
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0109166
RFC3 replication factor C (activator 1) 3, 38kDa 0.0107629
PLAT plasminogen activator, tissue 0.0107402
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0106906
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0106862
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0106739
AFDN afadin, adherens junction formation factor 0.0106699
CDC27 cell division cycle 27 0.0106577
SSH1 slingshot protein phosphatase 1 0.0105885
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0105215
DYM dymeclin 0.0104963
ANKRD36 ankyrin repeat domain 36 0.0104161
CEP95 centrosomal protein 95kDa 0.0102688
UBA6 ubiquitin-like modifier activating enzyme 6 0.010261
BCLAF1 BCL2-associated transcription factor 1 0.0102452
FLNB filamin B, beta 0.0102141
SLAIN2 SLAIN motif family, member 2 0.0102018
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.0101725
ARHGAP9 Rho GTPase activating protein 9 0.0101468
MATR3 matrin 3 0.0101255
VMP1 vacuole membrane protein 1 0.01005
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0100181
BRCA1 breast cancer 1, early onset 0.00999631
CRCP CGRP receptor component 0.00990287

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.394368
IGF2 insulin-like growth factor 2 -0.34219
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196467
VCL vinculin -0.0940326
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0842521
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0813182
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0755459
RPL23 ribosomal protein L23 -0.0616153
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0528044
TLE4 transducin-like enhancer of split 4 -0.0521181
NDRG1 N-myc downstream regulated 1 -0.0498311
RPL35A ribosomal protein L35a -0.0435556
EGR1 early growth response 1 -0.0434115
WDR45B WD repeat domain 45B -0.0427358
HELZ helicase with zinc finger -0.0416996
RAB7A RAB7A, member RAS oncogene family -0.0415611
VIM vimentin -0.0396223
MAP1B microtubule-associated protein 1B -0.0384541
TRIB2 tribbles pseudokinase 2 -0.0372866
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0370586
FMN1 formin 1 -0.0357992
LOC112694756 uncharaterized LOC112694756 -0.0352872
KDM3A lysine (K)-specific demethylase 3A -0.03512
EEF2 eukaryotic translation elongation factor 2 -0.0349675
HILPDA hypoxia inducible lipid droplet-associated -0.0349008
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0348068
AKAP12 A kinase (PRKA) anchor protein 12 -0.0346726
RPLP1 ribosomal protein, large, P1 -0.0334423
ACTG1 actin gamma 1 -0.033119
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.032807
MED13 mediator complex subunit 13 -0.0320789
NALF1 NALCN channel auxiliary factor 1 -0.03174
AFF4 AF4/FMR2 family, member 4 -0.0308772
KDM5B lysine (K)-specific demethylase 5B -0.030764
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0305261
RARA retinoic acid receptor, alpha -0.0275624
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0274324
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0271291
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0270968
RPS24 ribosomal protein S24 -0.026971
IER3 immediate early response 3 -0.0265517
POTEF POTE ankyrin domain family, member F -0.026495
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0257342
PKM pyruvate kinase, muscle -0.0257016
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0255024
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0252118
RPS6 ribosomal protein S6 -0.0249073
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0246362
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0244483
RYBP RING1 and YY1 binding protein -0.0241832
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0237181
CALR calreticulin -0.0234518
FBXO11 F-box protein 11 -0.0233287
ZNF148 zinc finger protein 148 -0.0233154
TOB1 transducer of ERBB2, 1 -0.0233002
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0232226
FOXO3 forkhead box O3 -0.0231996
RPL19 ribosomal protein L19 -0.0231119
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.023078
ARF1 ADP-ribosylation factor 1 -0.0227288
IGFBP3 insulin-like growth factor binding protein 3 -0.0225786
HIP1 huntingtin interacting protein 1 -0.0224717
SOX9 SRY (sex determining region Y)-box 9 -0.0223928
ZNF292 zinc finger protein 292 -0.0221545
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0220816
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0220596
KIAA1217 KIAA1217 -0.0213587
CANX calnexin -0.0213428
TAOK1 TAO kinase 1 -0.0213224
FNDC3A fibronectin type III domain containing 3A -0.0210431
VEGFA vascular endothelial growth factor A -0.0209575
S100A6 S100 calcium binding protein A6 -0.0209467
QKI QKI, KH domain containing, RNA binding -0.0207131
SEPTIN7 septin 7 -0.0204174
TPM4 tropomyosin 4 -0.0202919
RPL38 ribosomal protein L38 -0.0202765
PCM1 pericentriolar material 1 -0.0201646
FAM162A family with sequence similarity 162, member A -0.0201053
KMT2E lysine (K)-specific methyltransferase 2E -0.0200349
FTL ferritin, light polypeptide -0.0199493
RPL28 ribosomal protein L28 -0.0191613
RBM39 RNA binding motif protein 39 -0.0187295
AUTS2 autism susceptibility candidate 2 -0.0186947
NUP58 nucleoporin 58 -0.018685
SLIT2 slit homolog 2 (Drosophila) -0.0186422
PCDH10 protocadherin 10 -0.0184006
PRKCA protein kinase C, alpha -0.018356
RPS23 ribosomal protein S23 -0.0179409
KPNB1 karyopherin (importin) beta 1 -0.0178945
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0178
SOD2 superoxide dismutase 2, mitochondrial -0.0177026
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.017697
LAMA5 laminin, alpha 5 -0.0176366
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0175908
YBX1 Y box binding protein 1 -0.0175624
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.017545
NPEPPS aminopeptidase puromycin sensitive -0.0174947
PFN1 profilin 1 -0.0172708
FTH1 ferritin, heavy polypeptide 1 -0.0172676
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0172642