Fostamatinib (disodium hexahydrate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.170086
PTMA prothymosin, alpha 0.136424
STC1 stanniocalcin 1 0.115593
MT2A metallothionein 2A 0.113475
NDRG1 N-myc downstream regulated 1 0.105741
FAM13A family with sequence similarity 13, member A 0.104348
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.098878
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0981384
COL6A3 collagen, type VI, alpha 3 0.0937588
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0902287
TIMP3 TIMP metallopeptidase inhibitor 3 0.0887196
ENO1 enolase 1, (alpha) 0.0874945
FTL ferritin, light polypeptide 0.0853651
TGFBI transforming growth factor, beta-induced, 68kDa 0.0835553
NAV2 neuron navigator 2 0.0794414
B2M beta-2-microglobulin 0.0735928
AKAP12 A kinase (PRKA) anchor protein 12 0.0715851
PLAUR plasminogen activator, urokinase receptor 0.0646233
ANXA2 annexin A2 0.0640604
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0624001
CENPF centromere protein F, 350/400kDa 0.0615614
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0604111
NLGN1 neuroligin 1 0.0596374
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0593412
PGK1 phosphoglycerate kinase 1 0.0573791
ZNF395 zinc finger protein 395 0.0572665
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0572492
TMSB10 thymosin beta 10 0.0562016
SDK1 sidekick cell adhesion molecule 1 0.0549888
MKI67 marker of proliferation Ki-67 0.0547243
LIMS1 LIM and senescent cell antigen-like domains 1 0.0532705
CXCL8 chemokine (C-X-C motif) ligand 8 0.0511986
NAP1L1 nucleosome assembly protein 1-like 1 0.0508048
RPL37A ribosomal protein L37a 0.0492941
MXI1 MAX interactor 1, dimerization protein 0.0490073
RAI1 retinoic acid induced 1 0.0482166
KTN1 kinectin 1 (kinesin receptor) 0.0479394
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0475127
PDE4D phosphodiesterase 4D, cAMP-specific 0.046801
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0463566
EGFR epidermal growth factor receptor 0.0444412
TRIO trio Rho guanine nucleotide exchange factor 0.0443378
SEPTIN7 septin 7 0.0433589
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0417304
RPS8 ribosomal protein S8 0.041104
LMNA lamin A/C 0.040705
ASPH aspartate beta-hydroxylase 0.0403668
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0393067
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0384228
ZNF292 zinc finger protein 292 0.0374346
NAV1 neuron navigator 1 0.0369717
RPS3 ribosomal protein S3 0.0368883
ANLN anillin, actin binding protein 0.0358442
EIF1 eukaryotic translation initiation factor 1 0.035673
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0356108
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0353066
HILPDA hypoxia inducible lipid droplet-associated 0.0349433
DTNA dystrobrevin, alpha 0.0348813
LOXL2 lysyl oxidase-like 2 0.0346445
PRELID2 PRELI domain containing 2 0.0344972
RACK1 receptor for activated C kinase 1 0.0341803
RPS12 ribosomal protein S12 0.0341483
KMT2E lysine (K)-specific methyltransferase 2E 0.0337144
DGKD diacylglycerol kinase, delta 130kDa 0.0330305
CCDC88A coiled-coil domain containing 88A 0.0329446
GYS1 glycogen synthase 1 (muscle) 0.0328792
CEMIP cell migration inducing protein, hyaluronan binding 0.0328555
RPLP2 ribosomal protein, large, P2 0.0322675
STXBP1 syntaxin binding protein 1 0.0319272
CLEC1B C-type lectin domain family 1, member B 0.031816
CENPE centromere protein E, 312kDa 0.0317697
DDIT4 DNA-damage-inducible transcript 4 0.0316535
ZMYND8 zinc finger, MYND-type containing 8 0.0316033
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.031146
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0311432
HLA-B major histocompatibility complex, class I, B 0.0307293
NFE2L1 nuclear factor, erythroid 2-like 1 0.030652
GNAS GNAS complex locus 0.0299977
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0298977
SEC61G Sec61 gamma subunit 0.0295427
UGCG UDP-glucose ceramide glucosyltransferase 0.0290781
ERRFI1 ERBB receptor feedback inhibitor 1 0.0288114
RPL37 ribosomal protein L37 0.0287921
FSCN1 fascin actin-bundling protein 1 0.0287425
MMP12 matrix metallopeptidase 12 0.028656
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0286395
BACE2 beta-site APP-cleaving enzyme 2 0.0284797
SMC4 structural maintenance of chromosomes 4 0.0281139
INHBA inhibin, beta A 0.0280239
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.027908
SFXN1 sideroflexin 1 0.0278424
TRA2A transformer 2 alpha homolog (Drosophila) 0.0274104
RPS19 ribosomal protein S19 0.0273506
RPS2 ribosomal protein S2 0.026656
SGO2 shugoshin 2 0.0266313
MAP2K1 mitogen-activated protein kinase kinase 1 0.0266026
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0265165
TNIP1 TNFAIP3 interacting protein 1 0.0263124
NIPBL Nipped-B homolog (Drosophila) 0.0261284
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0261224

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0923697
EXT1 exostosin glycosyltransferase 1 -0.0866004
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0763946
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0705563
EGR1 early growth response 1 -0.0645083
KYNU kynureninase -0.0635145
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0595058
LOC112694756 uncharaterized LOC112694756 -0.0488741
PDLIM5 PDZ and LIM domain 5 -0.0476442
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0458082
FNDC3B fibronectin type III domain containing 3B -0.0447497
OSMR oncostatin M receptor -0.0446417
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0436253
ZCCHC7 zinc finger, CCHC domain containing 7 -0.042262
ANKRD17 ankyrin repeat domain 17 -0.0419395
NALF1 NALCN channel auxiliary factor 1 -0.0407361
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0401172
VMP1 vacuole membrane protein 1 -0.0400541
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0396671
VCL vinculin -0.0377661
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0376541
MON2 MON2 homolog (S. cerevisiae) -0.0369816
CREB5 cAMP responsive element binding protein 5 -0.0359434
HDAC9 histone deacetylase 9 -0.0358299
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0342871
AKAP9 A kinase (PRKA) anchor protein 9 -0.0338701
ACTN1 actinin, alpha 1 -0.0321196
GLIS3 GLIS family zinc finger 3 -0.0309121
TRIP12 thyroid hormone receptor interactor 12 -0.0304357
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0299237
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0299166
SCFD2 sec1 family domain containing 2 -0.0295786
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0293934
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0292996
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0276864
TSC22D2 TSC22 domain family, member 2 -0.0276826
ZNF432 zinc finger protein 432 -0.0273578
IARS1 isoleucyl-tRNA synthetase 1 -0.027259
RAB7A RAB7A, member RAS oncogene family -0.0272228
COPA coatomer protein complex, subunit alpha -0.0271714
ATM ATM serine/threonine kinase -0.0261055
USP15 ubiquitin specific peptidase 15 -0.0260648
NABP1 nucleic acid binding protein 1 -0.0260524
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.025956
PICALM phosphatidylinositol binding clathrin assembly protein -0.0259096
TNNC1 troponin C type 1 (slow) -0.025517
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0249344
GSK3B glycogen synthase kinase 3 beta -0.0244133
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.0241648
NPC1 Niemann-Pick disease, type C1 -0.0241049
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0240573
AHRR aryl-hydrocarbon receptor repressor -0.0239951
PHF14 PHD finger protein 14 -0.0239366
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0230932
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0228888
COG6 component of oligomeric golgi complex 6 -0.0228461
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0227967
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0225178
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0223307
CDK12 cyclin-dependent kinase 12 -0.0222804
SMC5 structural maintenance of chromosomes 5 -0.0222367
WWTR1 WW domain containing transcription regulator 1 -0.0221663
SETX senataxin -0.0218662
JMJD1C jumonji domain containing 1C -0.0217456
TTC17 tetratricopeptide repeat domain 17 -0.0216805
GOLGB1 golgin B1 -0.0215024
DGKI diacylglycerol kinase, iota -0.0213001
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0211929
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0207372
FBXO11 F-box protein 11 -0.0206305
GARS1 glycyl-tRNA synthetase 1 -0.0201666
SPAG9 sperm associated antigen 9 -0.0200209
TXNRD1 thioredoxin reductase 1 -0.0200041
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0199849
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0199806
TJP1 tight junction protein 1 -0.0198144
MB21D2 Mab-21 domain containing 2 -0.019805
VEGFA vascular endothelial growth factor A -0.0196443
RNF216 ring finger protein 216 -0.0194566
UBAP2 ubiquitin associated protein 2 -0.0194
SLC39A9 solute carrier family 39, member 9 -0.0192027
FNDC3A fibronectin type III domain containing 3A -0.0189704
ZNF207 zinc finger protein 207 -0.0188189
STK17A serine/threonine kinase 17a -0.0187418
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0186545
BLZF1 basic leucine zipper nuclear factor 1 -0.0185528
PALLD palladin, cytoskeletal associated protein -0.0184966
NFX1 nuclear transcription factor, X-box binding 1 -0.0184342
ATF6 activating transcription factor 6 -0.0182732
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0182722
LENG8 leukocyte receptor cluster (LRC) member 8 -0.0181503
FHL2 four and a half LIM domains 2 -0.0180911
LPP LIM domain containing preferred translocation partner in lipoma -0.0179253
BRD2 bromodomain containing 2 -0.0179057
SON SON DNA binding protein -0.0178298
ZFAND3 zinc finger, AN1-type domain 3 -0.0178217
GPATCH2L G patch domain containing 2-like -0.0177994
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0177535
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -0.0177408
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0176128