| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.177413 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.174929 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.169667 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.123228 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0884159 |
| RPS8 | ribosomal protein S8 | 0.0787048 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0765446 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0658526 |
| PGK1 | phosphoglycerate kinase 1 | 0.0641521 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0632346 |
| RPL37A | ribosomal protein L37a | 0.0612943 |
| RPS3 | ribosomal protein S3 | 0.0609441 |
| RPS6 | ribosomal protein S6 | 0.0580629 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0573843 |
| S100A10 | S100 calcium binding protein A10 | 0.0564439 |
| ENO1 | enolase 1, (alpha) | 0.0545067 |
| RPS12 | ribosomal protein S12 | 0.0537227 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0534128 |
| ZNF292 | zinc finger protein 292 | 0.0531433 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0525499 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0501795 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0501088 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0497378 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.049163 |
| RPL26 | ribosomal protein L26 | 0.0480769 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0476752 |
| PRELID2 | PRELI domain containing 2 | 0.0469051 |
| RPS2 | ribosomal protein S2 | 0.0464695 |
| RPS27A | ribosomal protein S27a | 0.0425511 |
| RPS19 | ribosomal protein S19 | 0.0424997 |
| RPLP2 | ribosomal protein, large, P2 | 0.0423622 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0423001 |
| B2M | beta-2-microglobulin | 0.0405093 |
| RPL18 | ribosomal protein L18 | 0.0401738 |
| RPL4 | ribosomal protein L4 | 0.0392787 |
| RUNX1 | runt-related transcription factor 1 | 0.0392376 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0387595 |
| RPLP0 | ribosomal protein, large, P0 | 0.0385778 |
| RPL11 | ribosomal protein L11 | 0.038228 |
| RPS29 | ribosomal protein S29 | 0.0376329 |
| H1-4 | H1.4 linker histone, cluster member | 0.0374984 |
| MT2A | metallothionein 2A | 0.0372067 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0365526 |
| RPL31 | ribosomal protein L31 | 0.0357464 |
| ATF4 | activating transcription factor 4 | 0.0357075 |
| RPL36 | ribosomal protein L36 | 0.0355196 |
| HELZ | helicase with zinc finger | 0.0354227 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.035206 |
| OGA | O-GlcNAcase | 0.0352003 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0351121 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0350512 |
| RPL12 | ribosomal protein L12 | 0.0348987 |
| SFXN1 | sideroflexin 1 | 0.0348209 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0344649 |
| SEPTIN7 | septin 7 | 0.0342255 |
| SET | SET nuclear proto-oncogene | 0.0340565 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0337535 |
| RPL34 | ribosomal protein L34 | 0.0337036 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0335941 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0332632 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0322964 |
| FTL | ferritin, light polypeptide | 0.0322875 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.031763 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.031672 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0315256 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0310825 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0310797 |
| RACK1 | receptor for activated C kinase 1 | 0.0301126 |
| KIAA1217 | KIAA1217 | 0.0298859 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0298195 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0286182 |
| TMEM263 | transmembrane protein 263 | 0.0285 |
| RPLP1 | ribosomal protein, large, P1 | 0.0284308 |
| S100A9 | S100 calcium binding protein A9 | 0.0283666 |
| RPL19 | ribosomal protein L19 | 0.028052 |
| RPS17 | ribosomal protein S17 | 0.0278138 |
| RPL9 | ribosomal protein L9 | 0.0270337 |
| RPL7A | ribosomal protein L7a | 0.0267195 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0264532 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0260548 |
| RPL23 | ribosomal protein L23 | 0.0259133 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0258961 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0258772 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0255247 |
| FAM162A | family with sequence similarity 162, member A | 0.025495 |
| RRM2 | ribonucleotide reductase M2 | 0.0253897 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0250639 |
| RPS21 | ribosomal protein S21 | 0.0249328 |
| GNAS | GNAS complex locus | 0.0249036 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0248297 |
| RNF24 | ring finger protein 24 | 0.0246262 |
| RPL32 | ribosomal protein L32 | 0.0245598 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0245264 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.024517 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0242262 |
| FDPS | farnesyl diphosphate synthase | 0.0241453 |
| RPL35A | ribosomal protein L35a | 0.0240613 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0240238 |
| GOLGA4 | golgin A4 | 0.0240036 |
| RPL5 | ribosomal protein L5 | 0.0236121 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | -0.287785 |
| EGR1 | early growth response 1 | -0.11767 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0935748 |
| EZR | ezrin | -0.0853968 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0789942 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0648475 |
| ARF4 | ADP-ribosylation factor 4 | -0.0629529 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0608287 |
| NDRG1 | N-myc downstream regulated 1 | -0.0580869 |
| TENM3 | teneurin transmembrane protein 3 | -0.0571986 |
| POTEF | POTE ankyrin domain family, member F | -0.0554381 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.054309 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0521399 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0520056 |
| TXNRD1 | thioredoxin reductase 1 | -0.0511649 |
| SERINC5 | serine incorporator 5 | -0.049989 |
| ERBIN | erbb2 interacting protein | -0.0499372 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0493945 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0486305 |
| MCL1 | myeloid cell leukemia 1 | -0.0440398 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0435275 |
| AHNAK | AHNAK nucleoprotein | -0.0433561 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0419274 |
| RHOA | ras homolog family member A | -0.0408999 |
| EGFR | epidermal growth factor receptor | -0.0405705 |
| HMGA1 | high mobility group AT-hook 1 | -0.0405279 |
| HDLBP | high density lipoprotein binding protein | -0.0399793 |
| SCFD2 | sec1 family domain containing 2 | -0.0399085 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0394433 |
| JUN | jun proto-oncogene | -0.037911 |
| RNF213 | ring finger protein 213 | -0.0378985 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0363545 |
| PKM | pyruvate kinase, muscle | -0.0351603 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0351142 |
| VCL | vinculin | -0.0347105 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0344276 |
| ZNF207 | zinc finger protein 207 | -0.0340252 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0339011 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.03263 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.0318929 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0318668 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0315939 |
| SETX | senataxin | -0.0314569 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0311294 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0307029 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0306832 |
| SFPQ | splicing factor proline/glutamine-rich | -0.029789 |
| UBAP2 | ubiquitin associated protein 2 | -0.0296373 |
| ACTN4 | actinin, alpha 4 | -0.0294729 |
| VEGFA | vascular endothelial growth factor A | -0.0294077 |
| BPTF | bromodomain PHD finger transcription factor | -0.0289932 |
| ZNF638 | zinc finger protein 638 | -0.0288434 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0279947 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0274694 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.02739 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0273654 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0272151 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0270747 |
| CUL3 | cullin 3 | -0.0269205 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0268422 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0267505 |
| SQSTM1 | sequestosome 1 | -0.026602 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0265873 |
| FLNB | filamin B, beta | -0.0263405 |
| ARF1 | ADP-ribosylation factor 1 | -0.0263264 |
| NF1 | neurofibromin 1 | -0.0263096 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0262511 |
| PKP4 | plakophilin 4 | -0.0260743 |
| TCF12 | transcription factor 12 | -0.0260669 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0258237 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0256957 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0256917 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0254312 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0252056 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0251968 |
| MORF4L2 | mortality factor 4 like 2 | -0.0250356 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0249885 |
| BRD2 | bromodomain containing 2 | -0.0249437 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0248193 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0247071 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0244132 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0243777 |
| NSD1 | nuclear receptor binding SET domain protein 1 | -0.0241639 |
| FNBP4 | formin binding protein 4 | -0.0241156 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.024003 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0236689 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0235746 |
| SUMF1 | sulfatase modifying factor 1 | -0.0233262 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | -0.0229674 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0229174 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0227929 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0227479 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0224462 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0222368 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0222038 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0221611 |
| GSPT1 | G1 to S phase transition 1 | -0.0220875 |
| APP | amyloid beta (A4) precursor protein | -0.0220792 |
| KLF12 | Kruppel-like factor 12 | -0.0220598 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0218798 |
