Fostamatinib (disodium hexahydrate)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.0739601
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0655065
ELL2 elongation factor, RNA polymerase II, 2 0.0566522
NDRG1 N-myc downstream regulated 1 0.0447775
FN1 fibronectin 1 0.0403309
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0369031
FNDC3B fibronectin type III domain containing 3B 0.036827
NGLY1 N-glycanase 1 0.0327604
SEPTIN9 septin 9 0.0305525
IGFBP3 insulin-like growth factor binding protein 3 0.0257454
PDE10A phosphodiesterase 10A 0.0244668
CD109 CD109 molecule 0.0228129
MSN moesin 0.0227141
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0225414
AXL AXL receptor tyrosine kinase 0.0221351
TNS1 tensin 1 0.0220027
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0218853
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.021515
HPCAL1 hippocalcin-like 1 0.0210132
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0208673
UBA6 ubiquitin-like modifier activating enzyme 6 0.0207206
FLNB filamin B, beta 0.0203351
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0202873
RUNX1 runt-related transcription factor 1 0.0189283
SBF2 SET binding factor 2 0.0170661
USP3 ubiquitin specific peptidase 3 0.016649
PRELID2 PRELI domain containing 2 0.0166282
SHB Src homology 2 domain containing adaptor protein B 0.0158707
VEGFA vascular endothelial growth factor A 0.0156386
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0153012
TENM2 teneurin transmembrane protein 2 0.0147812
RNF24 ring finger protein 24 0.0145865
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0144821
JARID2 jumonji, AT rich interactive domain 2 0.0139504
ZNF292 zinc finger protein 292 0.0138517
BHLHE40 basic helix-loop-helix family, member e40 0.0138102
NAMPT nicotinamide phosphoribosyltransferase 0.0136951
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0136456
SETD5 SET domain containing 5 0.0132115
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0123285
FOSL1 FOS-like antigen 1 0.0122984
ZMIZ1 zinc finger, MIZ-type containing 1 0.0121935
YEATS2 YEATS domain containing 2 0.0121462
ABLIM3 actin binding LIM protein family, member 3 0.0121203
RAB8B RAB8B, member RAS oncogene family 0.011672
DOT1L DOT1-like histone H3K79 methyltransferase 0.011573
ARF4 ADP-ribosylation factor 4 0.0114753
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.0112666
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0110795
RNF145 ring finger protein 145 0.0108438
PCBP3 poly(rC) binding protein 3 0.0104397
HELZ helicase with zinc finger 0.0104141
IRS2 insulin receptor substrate 2 0.0103746
LIMS1 LIM and senescent cell antigen-like domains 1 0.0103577
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 0.0100449
PLAUR plasminogen activator, urokinase receptor 0.00998209
MEF2A myocyte enhancer factor 2A 0.00989709
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00988163
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.00985804
ERRFI1 ERBB receptor feedback inhibitor 1 0.00982127
H1-4 H1.4 linker histone, cluster member 0.00977658
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.00976964
PLEC plectin 0.00962253
PPARD peroxisome proliferator-activated receptor delta 0.00958586
SRP54 signal recognition particle 54kDa 0.00958463
KLF10 Kruppel-like factor 10 0.00957695
SPATS2L spermatogenesis associated, serine-rich 2-like 0.00937931
SUCO SUN domain containing ossification factor 0.00935491
MXI1 MAX interactor 1, dimerization protein 0.00935385
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.00921977
SDK1 sidekick cell adhesion molecule 1 0.00920605
SP3 Sp3 transcription factor 0.00910378
ARHGAP21 Rho GTPase activating protein 21 0.00909699
MXRA7 matrix-remodelling associated 7 0.00906029
FNIP1 folliculin interacting protein 1 0.00897708
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.00897516
CEMIP cell migration inducing protein, hyaluronan binding 0.00891367
CRTC3 CREB regulated transcription coactivator 3 0.00882627
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.00880338
TRAM2 translocation associated membrane protein 2 0.00877593
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00871185
PDGFB platelet-derived growth factor beta polypeptide 0.00860728
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.00858318
TET3 tet methylcytosine dioxygenase 3 0.00856763
CHD1L chromodomain helicase DNA binding protein 1-like 0.00855356
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.008514
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.00849437
ESYT2 extended synaptotagmin-like protein 2 0.00848882
HILPDA hypoxia inducible lipid droplet-associated 0.00845502
DEPP1 DEPP autophagy regulator 1 0.00829995
NECTIN2 nectin cell adhesion molecule 2 0.00816249
SIAH1 siah E3 ubiquitin protein ligase 1 0.0081612
DLG1 discs, large homolog 1 (Drosophila) 0.0081471
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.00813393
STC1 stanniocalcin 1 0.00807059
SEC24A SEC24 family member A 0.0079676
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.00795723
TMEM51 transmembrane protein 51 0.00794828
ETV6 ets variant 6 0.00788255
TMF1 TATA element modulatory factor 1 0.00780192

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.474001
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.389033
TMSB10 thymosin beta 10 -0.204802
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.177167
ENO1 enolase 1, (alpha) -0.143105
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.138692
MT2A metallothionein 2A -0.11895
UBC ubiquitin C -0.0992707
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0915366
ASPH aspartate beta-hydroxylase -0.0883084
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0880732
TPT1 tumor protein, translationally-controlled 1 -0.0874997
LDHA lactate dehydrogenase A -0.0829088
CD44 CD44 molecule (Indian blood group) -0.0805116
AHNAK AHNAK nucleoprotein -0.0751177
RPS27A ribosomal protein S27a -0.0748998
LOC112694756 uncharaterized LOC112694756 -0.0731338
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.064933
CANX calnexin -0.0613459
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0573859
RPL23 ribosomal protein L23 -0.0565373
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0541384
RPLP1 ribosomal protein, large, P1 -0.0535061
RPS6 ribosomal protein S6 -0.0488554
PKM pyruvate kinase, muscle -0.0439411
RPL12 ribosomal protein L12 -0.0433371
EEF2 eukaryotic translation elongation factor 2 -0.0429416
TM4SF1 transmembrane 4 L six family member 1 -0.0428186
PDIA3 protein disulfide isomerase family A, member 3 -0.0406534
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0394957
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0373196
JUN jun proto-oncogene -0.0372474
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0366546
RPL35A ribosomal protein L35a -0.0365575
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0364606
RPS8 ribosomal protein S8 -0.0363851
PCBP2 poly(rC) binding protein 2 -0.0356801
PTMA prothymosin, alpha -0.0354711
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0352593
CALU calumenin -0.0346847
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0342338
EIF1 eukaryotic translation initiation factor 1 -0.0322341
NAP1L1 nucleosome assembly protein 1-like 1 -0.0320926
EXT1 exostosin glycosyltransferase 1 -0.031419
GNAS GNAS complex locus -0.0309922
RPS3 ribosomal protein S3 -0.0308916
FTL ferritin, light polypeptide -0.0308806
IER3 immediate early response 3 -0.0305601
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0297458
RPL19 ribosomal protein L19 -0.0291273
RAD21 RAD21 homolog (S. pombe) -0.0290015
APP amyloid beta (A4) precursor protein -0.0289598
AKAP12 A kinase (PRKA) anchor protein 12 -0.0286981
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0284429
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0281954
YBX1 Y box binding protein 1 -0.0280111
HMGB2 high mobility group box 2 -0.027889
RAI14 retinoic acid induced 14 -0.0276827
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0274999
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.027279
RPS19 ribosomal protein S19 -0.0272148
RPLP2 ribosomal protein, large, P2 -0.0271427
PDIA4 protein disulfide isomerase family A, member 4 -0.0268894
HDLBP high density lipoprotein binding protein -0.02648
MT1X metallothionein 1X -0.0264285
RPS13 ribosomal protein S13 -0.0264284
RPS24 ribosomal protein S24 -0.0262027
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0261518
KPNB1 karyopherin (importin) beta 1 -0.0256866
RACK1 receptor for activated C kinase 1 -0.0256602
LOX lysyl oxidase -0.0255019
RPS16 ribosomal protein S16 -0.0254969
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0252997
RPL8 ribosomal protein L8 -0.0252461
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0250634
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0250601
LAMB3 laminin, beta 3 -0.0250599
RPS20 ribosomal protein S20 -0.0249181
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0248996
RPL15 ribosomal protein L15 -0.0247456
GLG1 golgi glycoprotein 1 -0.0247377
ZFAND3 zinc finger, AN1-type domain 3 -0.0246148
RPL31 ribosomal protein L31 -0.0244874
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0243989
RPL9 ribosomal protein L9 -0.0243641
NAV1 neuron navigator 1 -0.0242233
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0239087
ANXA2 annexin A2 -0.0236252
CCND1 cyclin D1 -0.0235551
SFPQ splicing factor proline/glutamine-rich -0.0235238
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0232919
ACTN4 actinin, alpha 4 -0.0232322
VDAC1 voltage-dependent anion channel 1 -0.0229966
EMP1 epithelial membrane protein 1 -0.0229965
RAB7A RAB7A, member RAS oncogene family -0.0228812
EEF1G eukaryotic translation elongation factor 1 gamma -0.0228246
RPS4X ribosomal protein S4, X-linked -0.0228035
MORF4L2 mortality factor 4 like 2 -0.0226746
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0226057
COL6A1 collagen, type VI, alpha 1 -0.0225623