Fostamatinib (disodium hexahydrate)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.112828
ATP13A3 ATPase type 13A3 0.0792978
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0540871
TRIO trio Rho guanine nucleotide exchange factor 0.0504738
SMAD3 SMAD family member 3 0.0342873
KLF7 Kruppel-like factor 7 (ubiquitous) 0.032911
WWTR1 WW domain containing transcription regulator 1 0.0321055
ELL2 elongation factor, RNA polymerase II, 2 0.0305364
ZNF292 zinc finger protein 292 0.0287955
KMT2E lysine (K)-specific methyltransferase 2E 0.0280593
PDE10A phosphodiesterase 10A 0.0279338
ARRDC3 arrestin domain containing 3 0.0278683
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0270353
UBA6 ubiquitin-like modifier activating enzyme 6 0.0263384
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0255329
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0235188
PRELID2 PRELI domain containing 2 0.0234614
TNIP1 TNFAIP3 interacting protein 1 0.0234565
RICTOR RPTOR independent companion of MTOR, complex 2 0.0232895
RASA2 RAS p21 protein activator 2 0.0222578
GRB10 growth factor receptor-bound protein 10 0.0221629
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.022037
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0218997
ANTXR2 anthrax toxin receptor 2 0.0213415
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0203006
DPYSL3 dihydropyrimidinase-like 3 0.0200598
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0196089
CD44 CD44 molecule (Indian blood group) 0.019402
ADAM17 ADAM metallopeptidase domain 17 0.0191536
VEGFC vascular endothelial growth factor C 0.018909
ERRFI1 ERBB receptor feedback inhibitor 1 0.0188388
TMEM165 transmembrane protein 165 0.0188368
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0187774
ARHGAP29 Rho GTPase activating protein 29 0.0186946
ESYT2 extended synaptotagmin-like protein 2 0.018444
AXL AXL receptor tyrosine kinase 0.018368
KDM7A lysine (K)-specific demethylase 7A 0.018086
GOLGA4 golgin A4 0.0178075
RUNX1 runt-related transcription factor 1 0.0175319
TIMP3 TIMP metallopeptidase inhibitor 3 0.0172104
CAMTA1 calmodulin binding transcription activator 1 0.0171435
RNF145 ring finger protein 145 0.0171109
SBF2 SET binding factor 2 0.0170051
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0167331
MSN moesin 0.0165387
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0163406
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0159785
FOSL1 FOS-like antigen 1 0.0157272
RNF24 ring finger protein 24 0.0153856
SPAG9 sperm associated antigen 9 0.0152466
TMEM39A transmembrane protein 39A 0.0151816
ZNF148 zinc finger protein 148 0.0151336
MYH9 myosin, heavy chain 9, non-muscle 0.0148482
PLAUR plasminogen activator, urokinase receptor 0.0148164
PTBP2 polypyrimidine tract binding protein 2 0.0145695
PTK2 protein tyrosine kinase 2 0.0144079
TSC22D2 TSC22 domain family, member 2 0.0143693
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0140824
TFG TRK-fused gene 0.014025
SHB Src homology 2 domain containing adaptor protein B 0.0139505
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0139116
SKIC3 SKI3 subunit of superkiller complex 0.0138758
FAR1 fatty acyl CoA reductase 1 0.0138195
TRAM2 translocation associated membrane protein 2 0.0135237
HAS2 hyaluronan synthase 2 0.0134826
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0133955
USP3 ubiquitin specific peptidase 3 0.0130914
H1-4 H1.4 linker histone, cluster member 0.0130143
DLG1 discs, large homolog 1 (Drosophila) 0.0129551
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0128563
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0128026
USP24 ubiquitin specific peptidase 24 0.0127362
RPL3 ribosomal protein L3 0.0127289
MAP1B microtubule-associated protein 1B 0.0127278
LRRC8C leucine rich repeat containing 8 family, member C 0.0127211
SQLE squalene epoxidase 0.0127047
FAM13A family with sequence similarity 13, member A 0.0126616
FMNL2 formin-like 2 0.0126545
CCNL1 cyclin L1 0.0125903
ADAM9 ADAM metallopeptidase domain 9 0.0125853
FXR1 fragile X mental retardation, autosomal homolog 1 0.0125832
HELZ helicase with zinc finger 0.0125329
YEATS2 YEATS domain containing 2 0.0123615
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.012359
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0123269
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0123072
PDE8A phosphodiesterase 8A 0.0122508
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0121128
AFAP1 actin filament associated protein 1 0.0121059
RAB8B RAB8B, member RAS oncogene family 0.0120623
SNX4 sorting nexin 4 0.0120423
ANKH ANKH inorganic pyrophosphate transport regulator 0.0120344
BCLAF1 BCL2-associated transcription factor 1 0.0120172
SUCO SUN domain containing ossification factor 0.0119473
NOTCH2 notch 2 0.0118858
ECPAS Ecm29 proteasome adaptor and scaffold 0.0118326
NFE2L1 nuclear factor, erythroid 2-like 1 0.0117731
GRID1 glutamate receptor, ionotropic, delta 1 0.011747
NAV2 neuron navigator 2 0.0115751
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.0115458

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.272742
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.218964
IGFBP3 insulin-like growth factor binding protein 3 -0.199623
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175515
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.165204
COL1A1 collagen, type I, alpha 1 -0.145906
TMSB10 thymosin beta 10 -0.140062
IER3 immediate early response 3 -0.131243
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.12148
RPL35A ribosomal protein L35a -0.121194
COL1A2 collagen, type I, alpha 2 -0.112933
FTL ferritin, light polypeptide -0.0990947
CDH13 cadherin 13 -0.0918506
RPS8 ribosomal protein S8 -0.0913389
PTMA prothymosin, alpha -0.0905957
HLA-B major histocompatibility complex, class I, B -0.0827956
TPT1 tumor protein, translationally-controlled 1 -0.0817568
FN1 fibronectin 1 -0.0773397
MT2A metallothionein 2A -0.077237
NDRG1 N-myc downstream regulated 1 -0.0770783
TPM4 tropomyosin 4 -0.0763151
ENO1 enolase 1, (alpha) -0.0740437
RPS6 ribosomal protein S6 -0.0675736
CXCL8 chemokine (C-X-C motif) ligand 8 -0.066744
EXT1 exostosin glycosyltransferase 1 -0.0664634
CALR calreticulin -0.0655173
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.062759
FBN1 fibrillin 1 -0.0587427
ACTG1 actin gamma 1 -0.0513465
TGFBI transforming growth factor, beta-induced, 68kDa -0.0507951
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0504825
RPL11 ribosomal protein L11 -0.0491456
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0486571
S100A9 S100 calcium binding protein A9 -0.048173
RPL23 ribosomal protein L23 -0.0468034
MTDH metadherin -0.0466417
RPLP1 ribosomal protein, large, P1 -0.0466029
EIF1 eukaryotic translation initiation factor 1 -0.0463896
RPS13 ribosomal protein S13 -0.0461429
RPL37A ribosomal protein L37a -0.0450609
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0428644
RRBP1 ribosome binding protein 1 -0.0424495
RPL34 ribosomal protein L34 -0.0423194
RPS25 ribosomal protein S25 -0.0418519
CAVIN1 caveolae associated protein 1 -0.0417438
RPL28 ribosomal protein L28 -0.0413372
RPS24 ribosomal protein S24 -0.0410832
RPLP2 ribosomal protein, large, P2 -0.040714
RPL31 ribosomal protein L31 -0.0395795
RPL37 ribosomal protein L37 -0.0395489
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0394735
RPL26 ribosomal protein L26 -0.0388068
UBC ubiquitin C -0.0380955
COL6A1 collagen, type VI, alpha 1 -0.037989
LOX lysyl oxidase -0.0367671
RPS20 ribosomal protein S20 -0.0367622
LDHA lactate dehydrogenase A -0.0364574
GOLGB1 golgin B1 -0.0362896
RPS3 ribosomal protein S3 -0.035153
HM13 histocompatibility (minor) 13 -0.0351197
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0349486
RPS14 ribosomal protein S14 -0.0347645
CALU calumenin -0.0343001
F3 coagulation factor III (thromboplastin, tissue factor) -0.0342795
CADM1 cell adhesion molecule 1 -0.0340783
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0339265
CANX calnexin -0.0335257
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0335144
KPNB1 karyopherin (importin) beta 1 -0.0331534
VDAC1 voltage-dependent anion channel 1 -0.0329157
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0324336
COL3A1 collagen, type III, alpha 1 -0.0322587
EGR1 early growth response 1 -0.032132
RPS19 ribosomal protein S19 -0.0318296
RPL30 ribosomal protein L30 -0.0314673
ALCAM activated leukocyte cell adhesion molecule -0.0314281
RPS5 ribosomal protein S5 -0.0313776
RPL8 ribosomal protein L8 -0.0313021
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0306903
SQSTM1 sequestosome 1 -0.030659
SLC38A2 solute carrier family 38, member 2 -0.0306467
GNAS GNAS complex locus -0.0305255
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0299338
RPL9 ribosomal protein L9 -0.0296975
PKM pyruvate kinase, muscle -0.0294675
COL6A2 collagen, type VI, alpha 2 -0.029061
ENO2 enolase 2 (gamma, neuronal) -0.0290121
S100A10 S100 calcium binding protein A10 -0.0288717
RACK1 receptor for activated C kinase 1 -0.0286587
ADM adrenomedullin -0.0282694
SPDYA speedy/RINGO cell cycle regulator family member A -0.0281952
RPS27A ribosomal protein S27a -0.0277456
RPL38 ribosomal protein L38 -0.0276241
RPL5 ribosomal protein L5 -0.0273358
RPS21 ribosomal protein S21 -0.0273257
VCL vinculin -0.0270139
RPS11 ribosomal protein S11 -0.0269683
RPL36 ribosomal protein L36 -0.0269666
RPS29 ribosomal protein S29 -0.026694
SEC61G Sec61 gamma subunit -0.0266588