Fostamatinib (disodium hexahydrate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
C3 complement component 3 0.155669
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.144166
FNDC3B fibronectin type III domain containing 3B 0.130418
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0816907
ERRFI1 ERBB receptor feedback inhibitor 1 0.0685193
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0568421
DDIT4 DNA-damage-inducible transcript 4 0.0491536
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0486374
LRMDA leucine rich melanocyte differentiation associated 0.047637
ELL2 elongation factor, RNA polymerase II, 2 0.0469592
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0466875
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0445098
VEGFA vascular endothelial growth factor A 0.0440545
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0388944
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0373414
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0368424
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0368369
AFDN afadin, adherens junction formation factor 0.0367195
ZNF292 zinc finger protein 292 0.0363813
MYH9 myosin, heavy chain 9, non-muscle 0.0346202
TNS1 tensin 1 0.0346156
MXI1 MAX interactor 1, dimerization protein 0.0343589
PTBP3 polypyrimidine tract binding protein 3 0.0340549
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0337397
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0328802
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0325897
FMNL2 formin-like 2 0.0324265
MBNL3 muscleblind-like splicing regulator 3 0.0322875
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0319933
CDK19 cyclin-dependent kinase 19 0.0319856
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0316649
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0304739
DTNA dystrobrevin, alpha 0.0303673
HELZ helicase with zinc finger 0.0293899
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0292426
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0284011
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0278929
KIF1B kinesin family member 1B 0.0277865
CAMTA1 calmodulin binding transcription activator 1 0.0271849
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0270861
INSIG2 insulin induced gene 2 0.0270764
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0259963
WNK1 WNK lysine deficient protein kinase 1 0.0258558
RAB6A RAB6A, member RAS oncogene family 0.0253987
PTPRM protein tyrosine phosphatase, receptor type, M 0.0253376
YAP1 Yes-associated protein 1 0.0252541
PRELID2 PRELI domain containing 2 0.0252153
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0250502
SESTD1 SEC14 and spectrin domains 1 0.0249283
KMT2C lysine (K)-specific methyltransferase 2C 0.0246502
RPL3 ribosomal protein L3 0.0241914
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0240514
KDM7A lysine (K)-specific demethylase 7A 0.0239669
PUM2 pumilio RNA-binding family member 2 0.0237742
NDRG1 N-myc downstream regulated 1 0.0236748
CCNL1 cyclin L1 0.0236335
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0236258
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0234068
MTUS1 microtubule associated tumor suppressor 1 0.0233812
WDFY2 WD repeat and FYVE domain containing 2 0.0231923
FAM13A family with sequence similarity 13, member A 0.0229991
DSCAM Down syndrome cell adhesion molecule 0.0226812
RB1CC1 RB1-inducible coiled-coil 1 0.0225732
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0225243
MACF1 microtubule-actin crosslinking factor 1 0.0222585
GRK3 G protein-coupled receptor kinase 3 0.0222513
PDE8A phosphodiesterase 8A 0.0220613
CLASP1 cytoplasmic linker associated protein 1 0.0219516
QKI QKI, KH domain containing, RNA binding 0.0218547
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0217981
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0215484
EIF4B eukaryotic translation initiation factor 4B 0.0215472
FBXO42 F-box protein 42 0.0215288
DENND4A DENN/MADD domain containing 4A 0.0214053
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0213827
LRRC1 leucine rich repeat containing 1 0.0210475
BHLHE40 basic helix-loop-helix family, member e40 0.0209044
FNIP1 folliculin interacting protein 1 0.0208955
RICTOR RPTOR independent companion of MTOR, complex 2 0.0207738
USP47 ubiquitin specific peptidase 47 0.0207291
MSI2 musashi RNA-binding protein 2 0.0203654
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0203521
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.020149
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0198451
HLF hepatic leukemia factor 0.019809
FLNB filamin B, beta 0.0197822
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0197224
PIAS2 protein inhibitor of activated STAT, 2 0.0197087
KRT8 keratin 8, type II 0.019654
KTN1 kinectin 1 (kinesin receptor) 0.0196516
ESYT2 extended synaptotagmin-like protein 2 0.0195613
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0193063
CCNY cyclin Y 0.0189219
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0185895
MAN1A1 mannosidase, alpha, class 1A, member 1 0.018557
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0183452
LYZ lysozyme 0.0181672
WAC WW domain containing adaptor with coiled-coil 0.0181124
MTSS1 metastasis suppressor 1 0.017867
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0177971

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.230867
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.193487
MT2A metallothionein 2A -0.120783
TPT1 tumor protein, translationally-controlled 1 -0.106966
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0850834
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0779688
RPL11 ribosomal protein L11 -0.077535
VCL vinculin -0.0751051
RPLP1 ribosomal protein, large, P1 -0.0739905
RPL35A ribosomal protein L35a -0.0739052
EGR1 early growth response 1 -0.0725114
TMSB10 thymosin beta 10 -0.0687072
AKAP12 A kinase (PRKA) anchor protein 12 -0.0668327
ITGAV integrin, alpha V -0.0651241
RPS24 ribosomal protein S24 -0.0639206
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0638362
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0568273
RPL23 ribosomal protein L23 -0.0567318
LOC112694756 uncharaterized LOC112694756 -0.0555583
RPL31 ribosomal protein L31 -0.0549599
GPC6 glypican 6 -0.0524557
DLC1 DLC1 Rho GTPase activating protein -0.0521874
RPL34 ribosomal protein L34 -0.0489197
FTL ferritin, light polypeptide -0.0482033
EHBP1 EH domain binding protein 1 -0.0481224
SLC38A2 solute carrier family 38, member 2 -0.0469215
NKD1 naked cuticle homolog 1 (Drosophila) -0.0467183
APOA2 apolipoprotein A-II -0.0460522
RPS6 ribosomal protein S6 -0.0446482
FN1 fibronectin 1 -0.0440902
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0399868
DNAH17 dynein, axonemal, heavy chain 17 -0.0397027
BCL2L1 BCL2-like 1 -0.0394538
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0390905
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0385334
RRBP1 ribosome binding protein 1 -0.0379574
RPLP2 ribosomal protein, large, P2 -0.0378467
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0371015
A2M alpha-2-macroglobulin -0.0369638
PTCHD4 patched domain containing 4 -0.0364771
LMCD1 LIM and cysteine-rich domains 1 -0.036215
FBF1 Fas (TNFRSF6) binding factor 1 -0.0346592
RPL38 ribosomal protein L38 -0.0345104
HMGA1 high mobility group AT-hook 1 -0.0341758
GPC3 glypican 3 -0.0339841
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0337148
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0337102
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0333697
IER3 immediate early response 3 -0.0333079
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0327191
RPS19 ribosomal protein S19 -0.0327155
EXT1 exostosin glycosyltransferase 1 -0.0326161
IGFBP1 insulin-like growth factor binding protein 1 -0.032057
FOXP1 forkhead box P1 -0.031909
FAM107B family with sequence similarity 107, member B -0.0302947
RPLP0 ribosomal protein, large, P0 -0.0296769
RPL37A ribosomal protein L37a -0.0289884
RPL26 ribosomal protein L26 -0.0285644
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0276599
RPS8 ribosomal protein S8 -0.0271711
RPS29 ribosomal protein S29 -0.0266813
CP ceruloplasmin (ferroxidase) -0.026559
PAWR PRKC, apoptosis, WT1, regulator -0.0265545
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0263873
RPS27A ribosomal protein S27a -0.0262223
MYO1E myosin IE -0.0259535
RPL30 ribosomal protein L30 -0.0258446
RPL19 ribosomal protein L19 -0.0256153
RPL12 ribosomal protein L12 -0.0255795
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0254757
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0253449
RPS20 ribosomal protein S20 -0.0251564
RPS23 ribosomal protein S23 -0.025131
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0248696
RIGI RNA sensor RIG-I -0.0247789
KLF6 Kruppel-like factor 6 -0.0246863
RPL5 ribosomal protein L5 -0.024672
GNAS GNAS complex locus -0.0245211
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0243068
VMP1 vacuole membrane protein 1 -0.0242495
BPTF bromodomain PHD finger transcription factor -0.024077
MAPK8 mitogen-activated protein kinase 8 -0.0238166
UGDH UDP-glucose 6-dehydrogenase -0.0237625
PDLIM5 PDZ and LIM domain 5 -0.0237303
UBASH3B ubiquitin associated and SH3 domain containing B -0.0236969
TXNRD1 thioredoxin reductase 1 -0.0235658
RPS14 ribosomal protein S14 -0.023535
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0234201
KPNB1 karyopherin (importin) beta 1 -0.0234056
ENAH enabled homolog (Drosophila) -0.0232632
ZBTB20 zinc finger and BTB domain containing 20 -0.0232363
APOB apolipoprotein B -0.0230334
PTPRK protein tyrosine phosphatase, receptor type, K -0.0229149
NPAS2 neuronal PAS domain protein 2 -0.0226306
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0224002
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.022349
IFITM1 interferon induced transmembrane protein 1 -0.0223147
ISG15 ISG15 ubiquitin-like modifier -0.0221258
FAT1 FAT atypical cadherin 1 -0.0219456
RPS16 ribosomal protein S16 -0.0218486