Fostamatinib (disodium hexahydrate)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.170027
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.11349
MT2A metallothionein 2A 0.109817
UGCG UDP-glucose ceramide glucosyltransferase 0.0889617
RPS6 ribosomal protein S6 0.067369
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0615315
B2M beta-2-microglobulin 0.0606898
PTMA prothymosin, alpha 0.0571885
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0493819
FTH1 ferritin, heavy polypeptide 1 0.0478465
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0436304
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0406129
FOSL1 FOS-like antigen 1 0.0393119
RPLP2 ribosomal protein, large, P2 0.036707
SQSTM1 sequestosome 1 0.0359538
SET SET nuclear proto-oncogene 0.035482
RPS8 ribosomal protein S8 0.0349225
UBA6 ubiquitin-like modifier activating enzyme 6 0.0348713
RPL35A ribosomal protein L35a 0.0345959
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0338926
RPL12 ribosomal protein L12 0.0338031
GOLGA4 golgin A4 0.0329453
EIF1 eukaryotic translation initiation factor 1 0.0307473
IFI6 interferon, alpha-inducible protein 6 0.0292731
RND3 Rho family GTPase 3 0.0283429
NAP1L1 nucleosome assembly protein 1-like 1 0.0273922
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0263233
RPL23 ribosomal protein L23 0.0259798
DEK DEK proto-oncogene 0.0259154
ZFP36L1 ZFP36 ring finger protein-like 1 0.0251342
RPS12 ribosomal protein S12 0.0248993
RPL37A ribosomal protein L37a 0.0246159
KTN1 kinectin 1 (kinesin receptor) 0.024189
KMT2E lysine (K)-specific methyltransferase 2E 0.0240353
RPLP1 ribosomal protein, large, P1 0.0238838
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0237621
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0235444
RPS3 ribosomal protein S3 0.0234942
ZNF292 zinc finger protein 292 0.023397
RPL19 ribosomal protein L19 0.0232095
RPL11 ribosomal protein L11 0.0225807
RPL5 ribosomal protein L5 0.0220834
RPS19 ribosomal protein S19 0.0219622
ARRDC3 arrestin domain containing 3 0.0215635
RPL26 ribosomal protein L26 0.0214222
IFITM3 interferon induced transmembrane protein 3 0.0211451
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.020182
YBX1 Y box binding protein 1 0.0196416
RPS17 ribosomal protein S17 0.0195362
RPL31 ribosomal protein L31 0.0194444
HLA-A major histocompatibility complex, class I, A 0.0191509
VIM vimentin 0.0189687
RACK1 receptor for activated C kinase 1 0.018731
CCNL1 cyclin L1 0.018708
RPS2 ribosomal protein S2 0.0184545
RPL35 ribosomal protein L35 0.0184509
IRS2 insulin receptor substrate 2 0.0183907
ERRFI1 ERBB receptor feedback inhibitor 1 0.017755
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0176153
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0173732
UBC ubiquitin C 0.0172201
RPS14 ribosomal protein S14 0.0169051
PLIN2 perilipin 2 0.016692
MXI1 MAX interactor 1, dimerization protein 0.0165115
PNRC1 proline-rich nuclear receptor coactivator 1 0.0164251
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0162026
TPT1 tumor protein, translationally-controlled 1 0.0161551
RIOK3 RIO kinase 3 0.0155051
RPL7A ribosomal protein L7a 0.0151722
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0150943
PCBP2 poly(rC) binding protein 2 0.0150834
ANKRD33B ankyrin repeat domain 33B 0.0149632
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0149362
RPL32 ribosomal protein L32 0.0148202
RPL9 ribosomal protein L9 0.0148001
RYBP RING1 and YY1 binding protein 0.0147611
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0147517
HMGB2 high mobility group box 2 0.0147517
RPS23 ribosomal protein S23 0.0147247
HSPH1 heat shock 105kDa/110kDa protein 1 0.0147193
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0146065
TPR translocated promoter region, nuclear basket protein 0.0145936
RPS27 ribosomal protein S27 0.0144154
PNISR PNN-interacting serine/arginine-rich protein 0.0143744
TPM3 tropomyosin 3 0.0143716
RPS11 ribosomal protein S11 0.0143406
TMF1 TATA element modulatory factor 1 0.0142473
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0142285
TKT transketolase 0.014127
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0141153
BASP1 brain abundant, membrane attached signal protein 1 0.0140149
TFG TRK-fused gene 0.0139484
RPL30 ribosomal protein L30 0.0139315
RPL36 ribosomal protein L36 0.0138683
BHLHE40 basic helix-loop-helix family, member e40 0.0138367
RPS13 ribosomal protein S13 0.0138143
RPS27A ribosomal protein S27a 0.0137246
SEPTIN7 septin 7 0.0135136
RSRC2 arginine/serine-rich coiled-coil 2 0.0134844
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0133102

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.363006
NALF1 NALCN channel auxiliary factor 1 -0.331129
EXT1 exostosin glycosyltransferase 1 -0.230381
ABI3BP ABI family, member 3 (NESH) binding protein -0.187825
IGFBP3 insulin-like growth factor binding protein 3 -0.181787
GLIS3 GLIS family zinc finger 3 -0.150391
TRIO trio Rho guanine nucleotide exchange factor -0.14707
PHACTR1 phosphatase and actin regulator 1 -0.0945774
DLG1 discs, large homolog 1 (Drosophila) -0.0924388
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0907144
ERBIN erbb2 interacting protein -0.0868372
PLCB4 phospholipase C, beta 4 -0.0853799
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0835523
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.079926
CCBE1 collagen and calcium binding EGF domains 1 -0.0704138
F3 coagulation factor III (thromboplastin, tissue factor) -0.0698504
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0661692
DST dystonin -0.0610494
COL5A1 collagen, type V, alpha 1 -0.0604923
ZNF804A zinc finger protein 804A -0.0592185
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0573639
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0573366
RAI14 retinoic acid induced 14 -0.0562736
OSMR oncostatin M receptor -0.0518805
SAMD12 sterile alpha motif domain containing 12 -0.0509836
FLNB filamin B, beta -0.0505784
SLIT2 slit homolog 2 (Drosophila) -0.0501349
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0498896
AHNAK AHNAK nucleoprotein -0.0460071
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0458735
VEGFC vascular endothelial growth factor C -0.0458166
PTK2 protein tyrosine kinase 2 -0.0439844
MAP1B microtubule-associated protein 1B -0.0437716
LOX lysyl oxidase -0.0436658
PTPRG protein tyrosine phosphatase, receptor type, G -0.043609
FSTL1 follistatin-like 1 -0.0431235
SLC12A8 solute carrier family 12, member 8 -0.0424269
LYPD6B LY6/PLAUR domain containing 6B -0.0415591
LIMCH1 LIM and calponin homology domains 1 -0.041519
DIAPH3 diaphanous-related formin 3 -0.0409443
TGFB2 transforming growth factor, beta 2 -0.0409041
LPP LIM domain containing preferred translocation partner in lipoma -0.0407513
WNT5B wingless-type MMTV integration site family, member 5B -0.0397114
TMEM178B transmembrane protein 178B -0.0396833
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0393097
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0392382
TXNRD1 thioredoxin reductase 1 -0.0384036
PARD3B par-3 family cell polarity regulator beta -0.0383398
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0381261
POSTN periostin, osteoblast specific factor -0.0380851
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0368731
FOXP1 forkhead box P1 -0.0367216
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0366179
MAP4 microtubule-associated protein 4 -0.0359512
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0358039
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.035721
CCND1 cyclin D1 -0.0355519
DPYD dihydropyrimidine dehydrogenase -0.0351259
TENM3 teneurin transmembrane protein 3 -0.0348833
ASPH aspartate beta-hydroxylase -0.0344386
CAVIN1 caveolae associated protein 1 -0.0339191
IGFBP5 insulin-like growth factor binding protein 5 -0.0338507
SMYD3 SET and MYND domain containing 3 -0.0333786
TMSB4X thymosin beta 4, X-linked -0.0332679
PRRC2B proline-rich coiled-coil 2B -0.033205
PTPRF protein tyrosine phosphatase, receptor type, F -0.0330678
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0323263
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0320288
COL4A2 collagen, type IV, alpha 2 -0.0316521
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0313197
ZFAND3 zinc finger, AN1-type domain 3 -0.0307721
MAML2 mastermind-like 2 (Drosophila) -0.0306564
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0303221
NRG1 neuregulin 1 -0.0299092
MYLK myosin light chain kinase -0.0296072
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0294977
RASAL2 RAS protein activator like 2 -0.0292052
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0291377
NDRG1 N-myc downstream regulated 1 -0.0290233
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0287241
ZBTB20 zinc finger and BTB domain containing 20 -0.0281225
CUL4B cullin 4B -0.0280161
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0280071
SBF2 SET binding factor 2 -0.0274646
TNS3 tensin 3 -0.0270119
PRUNE2 prune homolog 2 (Drosophila) -0.0269503
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0268519
CAST calpastatin -0.0267776
CD44 CD44 molecule (Indian blood group) -0.0266879
FER fer (fps/fes related) tyrosine kinase -0.0265889
CTSD cathepsin D -0.0265865
FRMD4A FERM domain containing 4A -0.0265578
CDK6 cyclin-dependent kinase 6 -0.0264945
SULF1 sulfatase 1 -0.0263076
BMPER BMP binding endothelial regulator -0.0262393
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0260827
FAF1 Fas (TNFRSF6) associated factor 1 -0.0259963
LARP4B La ribonucleoprotein domain family, member 4B -0.0258323
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0257178
COL5A2 collagen, type V, alpha 2 -0.0256079