| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.166289 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.12836 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.1095 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.106382 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.103056 |
| RPS12 | ribosomal protein S12 | 0.0904165 |
| RPS6 | ribosomal protein S6 | 0.0842678 |
| PRELID2 | PRELI domain containing 2 | 0.0836569 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0802313 |
| RPLP1 | ribosomal protein, large, P1 | 0.078652 |
| RPS8 | ribosomal protein S8 | 0.0769739 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.075388 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0729507 |
| RPS3 | ribosomal protein S3 | 0.072456 |
| RPS19 | ribosomal protein S19 | 0.0694795 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0691273 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0680809 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0642574 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0638513 |
| PLAC8 | placenta-specific 8 | 0.0637094 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0633207 |
| EREG | epiregulin | 0.0623005 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0617479 |
| RPL4 | ribosomal protein L4 | 0.0591935 |
| ZNF292 | zinc finger protein 292 | 0.0590724 |
| RPL37A | ribosomal protein L37a | 0.0578044 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0545085 |
| RPL34 | ribosomal protein L34 | 0.0527655 |
| CALB1 | calbindin 1, 28kDa | 0.0525265 |
| FOXO1 | forkhead box O1 | 0.0522339 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0502185 |
| RPS17 | ribosomal protein S17 | 0.0487131 |
| RPS2 | ribosomal protein S2 | 0.0483944 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.0473917 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0470861 |
| RPL26 | ribosomal protein L26 | 0.0460441 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0455397 |
| RNF145 | ring finger protein 145 | 0.0454464 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0452371 |
| PGK1 | phosphoglycerate kinase 1 | 0.0450877 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 0.0428888 |
| ACTG1 | actin gamma 1 | 0.042665 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0424657 |
| RPS27A | ribosomal protein S27a | 0.0420257 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0418487 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0417019 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0416073 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0413294 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0412817 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0403159 |
| FRMD5 | FERM domain containing 5 | 0.0402533 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0400428 |
| NFIA | nuclear factor I/A | 0.0399619 |
| PDE8A | phosphodiesterase 8A | 0.0398741 |
| ABHD17C | abhydrolase domain containing 17C | 0.0391955 |
| MED13L | mediator complex subunit 13-like | 0.0390058 |
| USP3 | ubiquitin specific peptidase 3 | 0.038627 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0384306 |
| RPL12 | ribosomal protein L12 | 0.0379526 |
| FAM13A | family with sequence similarity 13, member A | 0.0376007 |
| ENO1 | enolase 1, (alpha) | 0.0373794 |
| RACK1 | receptor for activated C kinase 1 | 0.0371914 |
| RPLP0 | ribosomal protein, large, P0 | 0.036892 |
| AUTS2 | autism susceptibility candidate 2 | 0.0359569 |
| MYO6 | myosin VI | 0.0358923 |
| JMJD1C | jumonji domain containing 1C | 0.0358356 |
| RPL18 | ribosomal protein L18 | 0.0358312 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0357695 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0357238 |
| RPL11 | ribosomal protein L11 | 0.0356112 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.035384 |
| MKI67 | marker of proliferation Ki-67 | 0.0348762 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.034661 |
| CDC42SE2 | CDC42 small effector 2 | 0.034658 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0346139 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0344941 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0344316 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0340834 |
| TMSB10 | thymosin beta 10 | 0.0340197 |
| CD2AP | CD2-associated protein | 0.0337105 |
| WWC1 | WW and C2 domain containing 1 | 0.0337053 |
| RPL32 | ribosomal protein L32 | 0.0329119 |
| OGA | O-GlcNAcase | 0.0328589 |
| RPS23 | ribosomal protein S23 | 0.0327908 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0326541 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0322563 |
| YBX3 | Y box binding protein 3 | 0.0320297 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.032029 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0319881 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0315884 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0314298 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0309901 |
| LIMA1 | LIM domain and actin binding 1 | 0.0309608 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0307665 |
| GOLGA4 | golgin A4 | 0.0306463 |
| KIF5B | kinesin family member 5B | 0.0305184 |
| TCF12 | transcription factor 12 | 0.0304941 |
| CDK19 | cyclin-dependent kinase 19 | 0.0303798 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0303493 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0302207 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.141091 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.106667 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0974444 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0866676 |
| MYO1E | myosin IE | -0.0735652 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0703611 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0607635 |
| TJP1 | tight junction protein 1 | -0.0539555 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0521532 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0515539 |
| OXSR1 | oxidative stress responsive 1 | -0.0505414 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0505372 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0492757 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0473792 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0447116 |
| SLC38A2 | solute carrier family 38, member 2 | -0.043576 |
| EGR1 | early growth response 1 | -0.0434104 |
| SP100 | SP100 nuclear antigen | -0.0423217 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0414442 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0393021 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0391979 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.0382544 |
| UBAP2 | ubiquitin associated protein 2 | -0.037078 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.036323 |
| MX1 | MX dynamin-like GTPase 1 | -0.0356786 |
| RIGI | RNA sensor RIG-I | -0.0350703 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0344114 |
| CTBP2 | C-terminal binding protein 2 | -0.0342591 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | -0.0326524 |
| SQSTM1 | sequestosome 1 | -0.0321337 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.031841 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0314348 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0307571 |
| BRD2 | bromodomain containing 2 | -0.03051 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.0303062 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0296113 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0292377 |
| INTS6 | integrator complex subunit 6 | -0.0288406 |
| FAT1 | FAT atypical cadherin 1 | -0.0287536 |
| MYOF | myoferlin | -0.0286319 |
| POTEF | POTE ankyrin domain family, member F | -0.027394 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0273206 |
| TC2N | tandem C2 domains, nuclear | -0.027319 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0271336 |
| CLDN4 | claudin 4 | -0.0269361 |
| PLSCR1 | phospholipid scramblase 1 | -0.0265401 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0258477 |
| LAMA4 | laminin, alpha 4 | -0.0249233 |
| FBXO11 | F-box protein 11 | -0.0247027 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0240189 |
| ATP10B | ATPase, class V, type 10B | -0.0238204 |
| RNF213 | ring finger protein 213 | -0.023699 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0230594 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0229979 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0227419 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0226235 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.022586 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0225285 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0220726 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0216846 |
| MYO5B | myosin VB | -0.0215337 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0214012 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0212971 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0211816 |
| SPON1 | spondin 1, extracellular matrix protein | -0.0210676 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0206261 |
| INO80 | INO80 complex subunit | -0.0204861 |
| ATF6 | activating transcription factor 6 | -0.0204707 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0203565 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0202942 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0201453 |
| ADIPOR2 | adiponectin receptor 2 | -0.0201034 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | -0.0198263 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0196184 |
| PSEN1 | presenilin 1 | -0.0194432 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0192225 |
| NABP1 | nucleic acid binding protein 1 | -0.0186074 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0184551 |
| PITPNB | phosphatidylinositol transfer protein, beta | -0.0183707 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0183247 |
| MX2 | MX dynamin-like GTPase 2 | -0.018151 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.0179833 |
| SPINK13 | serine peptidase inhibitor, Kazal type 13 (putative) | -0.0179832 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0176518 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0175657 |
| TRIM69 | tripartite motif containing 69 | -0.0174309 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0173318 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | -0.0173112 |
| VCL | vinculin | -0.0173008 |
| DIAPH1 | diaphanous-related formin 1 | -0.0172182 |
| IRF1 | interferon regulatory factor 1 | -0.0171659 |
| GATAD2A | GATA zinc finger domain containing 2A | -0.0171567 |
| MORF4L2 | mortality factor 4 like 2 | -0.0170286 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0169898 |
| NLRC5 | NLR family, CARD domain containing 5 | -0.0167336 |
| ZNF207 | zinc finger protein 207 | -0.0167141 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0166571 |
| ARF4 | ADP-ribosylation factor 4 | -0.0165079 |
| CCDC138 | coiled-coil domain containing 138 | -0.0163538 |
| SYNJ2 | synaptojanin 2 | -0.0163024 |
