Fostamatinib (disodium hexahydrate)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.100384
NGLY1 N-glycanase 1 0.0443887
CAMTA1 calmodulin binding transcription activator 1 0.0353771
ARRDC3 arrestin domain containing 3 0.0324028
TMEM165 transmembrane protein 165 0.0310247
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0286858
NCKAP1 NCK-associated protein 1 0.0285046
NAMPT nicotinamide phosphoribosyltransferase 0.0280862
OGA O-GlcNAcase 0.0277245
PUM2 pumilio RNA-binding family member 2 0.027094
ZC3H11A zinc finger CCCH-type containing 11A 0.0254719
FNIP1 folliculin interacting protein 1 0.0246613
HELZ helicase with zinc finger 0.0245135
RICTOR RPTOR independent companion of MTOR, complex 2 0.0242484
RNF145 ring finger protein 145 0.0234343
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0233495
ANKRD10 ankyrin repeat domain 10 0.0233397
SUCO SUN domain containing ossification factor 0.0231927
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0230785
UBA6 ubiquitin-like modifier activating enzyme 6 0.0227
MXI1 MAX interactor 1, dimerization protein 0.022229
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0218152
ATP13A3 ATPase type 13A3 0.0215136
ZFC3H1 zinc finger, C3H1-type containing 0.0214767
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0213603
SRP54 signal recognition particle 54kDa 0.0208456
ERRFI1 ERBB receptor feedback inhibitor 1 0.0202151
HOOK2 hook microtubule-tethering protein 2 0.0198255
YEATS2 YEATS domain containing 2 0.019656
TPD52 tumor protein D52 0.0193399
H1-0 H1.0 linker histone 0.0190006
ANO6 anoctamin 6 0.0187443
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0187243
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0183424
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0182484
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.018232
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0182183
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0181679
ADAM17 ADAM metallopeptidase domain 17 0.0180379
BRWD1 bromodomain and WD repeat domain containing 1 0.0179216
CES1 carboxylesterase 1 0.0179125
HDLBP high density lipoprotein binding protein 0.0177112
SLMAP sarcolemma associated protein 0.0176398
BRWD3 bromodomain and WD repeat domain containing 3 0.0175815
SEPTIN2 septin 2 0.0174189
PDE8A phosphodiesterase 8A 0.0173143
HYOU1 hypoxia up-regulated 1 0.0172748
CYLD cylindromatosis (turban tumor syndrome) 0.0171075
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0169317
PAPOLA poly(A) polymerase alpha 0.0167164
NDE1 nudE neurodevelopment protein 1 0.0165022
UVRAG UV radiation resistance associated 0.0164773
GCLC glutamate-cysteine ligase, catalytic subunit 0.0164482
KDM6A lysine (K)-specific demethylase 6A 0.0163156
KCMF1 potassium channel modulatory factor 1 0.0162126
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0161394
ATG14 autophagy related 14 0.016109
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0160115
TM9SF2 transmembrane 9 superfamily member 2 0.0159097
ARL8B ADP-ribosylation factor-like 8B 0.0157049
TMEM39A transmembrane protein 39A 0.0156887
SEC31A SEC31 homolog A (S. cerevisiae) 0.0156827
MYH9 myosin, heavy chain 9, non-muscle 0.0154914
MACF1 microtubule-actin crosslinking factor 1 0.014742
USP9X ubiquitin specific peptidase 9, X-linked 0.0146925
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0143775
MARF1 meiosis regulator and mRNA stability factor 1 0.0141037
BIRC6 baculoviral IAP repeat containing 6 0.0139791
KMT2E lysine (K)-specific methyltransferase 2E 0.0139514
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0138069
UBE2O ubiquitin-conjugating enzyme E2O 0.013801
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0137753
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0135887
GIGYF2 GRB10 interacting GYF protein 2 0.0135454
ZFR zinc finger RNA binding protein 0.0133464
NEK7 NIMA-related kinase 7 0.0133252
EIF4B eukaryotic translation initiation factor 4B 0.0132268
CCNY cyclin Y 0.0131879
PDIA6 protein disulfide isomerase family A, member 6 0.0131832
CTTN cortactin 0.0131815
KLC1 kinesin light chain 1 0.0131695
TOP1 topoisomerase (DNA) I 0.0130509
CSNK1A1 casein kinase 1, alpha 1 0.0129171
NBAS neuroblastoma amplified sequence 0.0129004
USP3 ubiquitin specific peptidase 3 0.0127751
ZBTB1 zinc finger and BTB domain containing 1 0.0127051
TMF1 TATA element modulatory factor 1 0.0126362
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0126287
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0125035
INSIG2 insulin induced gene 2 0.0123263
NPTN neuroplastin 0.0122741
RBM26 RNA binding motif protein 26 0.012274
GRB10 growth factor receptor-bound protein 10 0.012243
SLC35F5 solute carrier family 35, member F5 0.0120146
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0118934
ECT2 epithelial cell transforming 2 0.0118872
YAP1 Yes-associated protein 1 0.0118174
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0118103
ADGRG7 adhesion G protein-coupled receptor G7 0.0117863
SEC23A Sec23 homolog A (S. cerevisiae) 0.011761

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.580719
TMSB10 thymosin beta 10 -0.184922
MT2A metallothionein 2A -0.179239
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.113948
EGR1 early growth response 1 -0.0949047
LOC112694756 uncharaterized LOC112694756 -0.0925111
FTL ferritin, light polypeptide -0.0885302
TPT1 tumor protein, translationally-controlled 1 -0.0870559
TXNRD1 thioredoxin reductase 1 -0.0843386
RPLP1 ribosomal protein, large, P1 -0.0819144
RPL35A ribosomal protein L35a -0.0796586
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0750276
PKM pyruvate kinase, muscle -0.064829
S100A10 S100 calcium binding protein A10 -0.0645289
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0638711
SEC61G Sec61 gamma subunit -0.0635549
CST3 cystatin C -0.061697
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0611842
ACTG1 actin gamma 1 -0.0548559
LDHA lactate dehydrogenase A -0.0543795
RPS3 ribosomal protein S3 -0.0535115
FTH1 ferritin, heavy polypeptide 1 -0.0521466
MCL1 myeloid cell leukemia 1 -0.050515
RPS8 ribosomal protein S8 -0.0476967
RPS6 ribosomal protein S6 -0.0474275
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0462577
RPL37A ribosomal protein L37a -0.0458802
RPS25 ribosomal protein S25 -0.0451512
RPL31 ribosomal protein L31 -0.0448522
OSMR oncostatin M receptor -0.0438015
SLC38A1 solute carrier family 38, member 1 -0.0435472
RPL34 ribosomal protein L34 -0.0431364
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0430315
EIF1 eukaryotic translation initiation factor 1 -0.0427836
AREG amphiregulin -0.0426233
RPS23 ribosomal protein S23 -0.0426207
RPS24 ribosomal protein S24 -0.0425562
RPL11 ribosomal protein L11 -0.0419915
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0414323
PTMA prothymosin, alpha -0.0408521
CAV1 caveolin 1, caveolae protein, 22kDa -0.0401267
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0399703
BLZF1 basic leucine zipper nuclear factor 1 -0.0398291
B2M beta-2-microglobulin -0.0397398
ENO1 enolase 1, (alpha) -0.0393097
RPL12 ribosomal protein L12 -0.0377115
S100A11 S100 calcium binding protein A11 -0.037601
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0369263
INTS6 integrator complex subunit 6 -0.0368356
RPL19 ribosomal protein L19 -0.0366856
RPS19 ribosomal protein S19 -0.036662
RPLP0 ribosomal protein, large, P0 -0.036651
RPL23 ribosomal protein L23 -0.0364631
MT1X metallothionein 1X -0.0361759
RPS29 ribosomal protein S29 -0.0358182
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0355101
HLA-B major histocompatibility complex, class I, B -0.0353349
IFI6 interferon, alpha-inducible protein 6 -0.0347745
NABP1 nucleic acid binding protein 1 -0.0346304
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0344751
ANKRD12 ankyrin repeat domain 12 -0.0341577
AKR1C1 aldo-keto reductase family 1, member C1 -0.033902
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0331607
RPLP2 ribosomal protein, large, P2 -0.0326155
RPS27A ribosomal protein S27a -0.0325269
MCTP1 multiple C2 domains, transmembrane 1 -0.0324156
S100A9 S100 calcium binding protein A9 -0.0323884
RPL37 ribosomal protein L37 -0.0321379
RPS27 ribosomal protein S27 -0.0321372
MYO1E myosin IE -0.0321332
RPL30 ribosomal protein L30 -0.0321168
STC1 stanniocalcin 1 -0.0316202
RPS21 ribosomal protein S21 -0.0315375
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0313042
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0313025
CCND1 cyclin D1 -0.0311836
BTG1 B-cell translocation gene 1, anti-proliferative -0.0305315
IER3 immediate early response 3 -0.0305306
NDRG1 N-myc downstream regulated 1 -0.0298532
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0295229
VCL vinculin -0.0287707
S100P S100 calcium binding protein P -0.0285207
RPS12 ribosomal protein S12 -0.0284228
RPL8 ribosomal protein L8 -0.0283046
RPL36 ribosomal protein L36 -0.0278941
CIB1 calcium and integrin binding 1 (calmyrin) -0.0277854
UBC ubiquitin C -0.0277721
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0277549
EFNA5 ephrin-A5 -0.027371
RPL5 ribosomal protein L5 -0.0269371
RPS14 ribosomal protein S14 -0.0267423
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0265516
THSD4 thrombospondin, type I, domain containing 4 -0.0262409
ANXA2 annexin A2 -0.0260971
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0260217
IGFBP3 insulin-like growth factor binding protein 3 -0.0258456
RAB7A RAB7A, member RAS oncogene family -0.0257677
RPS17 ribosomal protein S17 -0.0257368
AGO2 argonaute RISC catalytic component 2 -0.0254085
KRT7 keratin 7, type II -0.024954