| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.21747 |
| FAM13A | family with sequence similarity 13, member A | 0.168752 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.149602 |
| VIM | vimentin | 0.124275 |
| PTMA | prothymosin, alpha | 0.108823 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.102323 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0948762 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0913014 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0733577 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0681492 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0680407 |
| FTL | ferritin, light polypeptide | 0.0639426 |
| PRELID2 | PRELI domain containing 2 | 0.0621238 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0620513 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0602937 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0600907 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0594364 |
| MT2A | metallothionein 2A | 0.0585343 |
| ZNF292 | zinc finger protein 292 | 0.0584467 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0580323 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0577812 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0566423 |
| SMAD3 | SMAD family member 3 | 0.0555824 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0550053 |
| B2M | beta-2-microglobulin | 0.053725 |
| OGA | O-GlcNAcase | 0.0524913 |
| CA12 | carbonic anhydrase XII | 0.0507722 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0480028 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0474798 |
| GOLGA4 | golgin A4 | 0.0468554 |
| NGLY1 | N-glycanase 1 | 0.0464008 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0453196 |
| RPS8 | ribosomal protein S8 | 0.0453172 |
| FLNB | filamin B, beta | 0.0451794 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0449844 |
| ENO1 | enolase 1, (alpha) | 0.0447921 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0445348 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0443701 |
| RPLP1 | ribosomal protein, large, P1 | 0.0429486 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0427466 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0422554 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0420257 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0417574 |
| RPS19 | ribosomal protein S19 | 0.0415225 |
| NDRG1 | N-myc downstream regulated 1 | 0.0414535 |
| ANGPTL4 | angiopoietin-like 4 | 0.041284 |
| RIOK3 | RIO kinase 3 | 0.0401008 |
| RUNX1 | runt-related transcription factor 1 | 0.0394859 |
| PFKP | phosphofructokinase, platelet | 0.0394457 |
| STC1 | stanniocalcin 1 | 0.0388497 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0386265 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 0.0386144 |
| RPL32 | ribosomal protein L32 | 0.0372286 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0364657 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0360955 |
| RPS12 | ribosomal protein S12 | 0.0357513 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0356476 |
| HELZ | helicase with zinc finger | 0.0354902 |
| RPS6 | ribosomal protein S6 | 0.0353841 |
| RPL37A | ribosomal protein L37a | 0.0352932 |
| RPL4 | ribosomal protein L4 | 0.0352046 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0345403 |
| USP3 | ubiquitin specific peptidase 3 | 0.0338488 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0337988 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0335923 |
| CANX | calnexin | 0.0335534 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0335352 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0329945 |
| RPS3 | ribosomal protein S3 | 0.0321186 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0317926 |
| RPS21 | ribosomal protein S21 | 0.0312978 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0312938 |
| SRGN | serglycin | 0.0311222 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0310758 |
| RPLP2 | ribosomal protein, large, P2 | 0.0310266 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0306636 |
| RPS29 | ribosomal protein S29 | 0.0305373 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0304658 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0299721 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0298435 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0296389 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0293522 |
| GNAS | GNAS complex locus | 0.0292414 |
| PGK1 | phosphoglycerate kinase 1 | 0.0292147 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0292125 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0291065 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0288814 |
| WDR45B | WD repeat domain 45B | 0.0282791 |
| RPL11 | ribosomal protein L11 | 0.0282591 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0280448 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0280395 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0280381 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0278801 |
| CALR | calreticulin | 0.0276066 |
| ZFR | zinc finger RNA binding protein | 0.0275665 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0275208 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0273832 |
| ANXA1 | annexin A1 | 0.0273503 |
| MYOF | myoferlin | 0.0273148 |
| CLEC1B | C-type lectin domain family 1, member B | 0.027218 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.124078 |
| GLCCI1 | glucocorticoid induced 1 | -0.123046 |
| CD44 | CD44 molecule (Indian blood group) | -0.110986 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0951173 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0805361 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0778823 |
| OSMR | oncostatin M receptor | -0.0746727 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0746355 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0704928 |
| LOX | lysyl oxidase | -0.0658199 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0648792 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0635287 |
| EGR1 | early growth response 1 | -0.0604727 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.059939 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0595549 |
| NTN4 | netrin 4 | -0.0594805 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0582202 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0577006 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0556335 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0553697 |
| AADAC | arylacetamide deacetylase | -0.0523089 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0519209 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0505113 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0501914 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.049225 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0480966 |
| HMGA2 | high mobility group AT-hook 2 | -0.0479769 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0475052 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0460787 |
| FN1 | fibronectin 1 | -0.0457871 |
| TNNC1 | troponin C type 1 (slow) | -0.0452863 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0425106 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.040285 |
| KSR1 | kinase suppressor of ras 1 | -0.0392777 |
| CDH13 | cadherin 13 | -0.0391129 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0380089 |
| VMP1 | vacuole membrane protein 1 | -0.0378124 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0377253 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0376315 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0376102 |
| NRP1 | neuropilin 1 | -0.0372208 |
| GLIS3 | GLIS family zinc finger 3 | -0.0365354 |
| IL1R1 | interleukin 1 receptor, type I | -0.0361868 |
| NRG1 | neuregulin 1 | -0.0356671 |
| STK38L | serine/threonine kinase 38 like | -0.0355154 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0351602 |
| VRK2 | vaccinia related kinase 2 | -0.0343652 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0333593 |
| RASAL2 | RAS protein activator like 2 | -0.0333236 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0332322 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0321327 |
| WLS | wntless Wnt ligand secretion mediator | -0.0309667 |
| VEGFA | vascular endothelial growth factor A | -0.0299311 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0296386 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0289193 |
| VCL | vinculin | -0.028877 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0286729 |
| EGFR | epidermal growth factor receptor | -0.0283548 |
| NLK | nemo-like kinase | -0.0283072 |
| COPA | coatomer protein complex, subunit alpha | -0.0282266 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0278963 |
| SIK3 | SIK family kinase 3 | -0.0273659 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0268735 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0265504 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.026247 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.0261889 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0259423 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.0258433 |
| CLMP | CXADR-like membrane protein | -0.025427 |
| NABP1 | nucleic acid binding protein 1 | -0.025404 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0249002 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0247934 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0247707 |
| ZNF804A | zinc finger protein 804A | -0.024646 |
| CLIC4 | chloride intracellular channel 4 | -0.0245131 |
| ZNF407 | zinc finger protein 407 | -0.0245098 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0243482 |
| NPC1 | Niemann-Pick disease, type C1 | -0.024336 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0240561 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.023921 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0236099 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0235767 |
| FBXO11 | F-box protein 11 | -0.0232356 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0230874 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | -0.0230095 |
| TUT7 | terminal uridylyl transferase 7 | -0.0229567 |
| KYNU | kynureninase | -0.0228382 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0227897 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0224374 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.02243 |
| DUSP16 | dual specificity phosphatase 16 | -0.0224265 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0222876 |
| EXOC6B | exocyst complex component 6B | -0.0221147 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0219973 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0217042 |
| GPATCH2L | G patch domain containing 2-like | -0.0213178 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0210753 |
| NUMB | numb homolog (Drosophila) | -0.0210464 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.020975 |
| TJP1 | tight junction protein 1 | -0.0204966 |
