| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.115917 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0761921 |
| TPM3 | tropomyosin 3 | 0.0756659 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0638577 |
| CAVIN1 | caveolae associated protein 1 | 0.0632188 |
| TPD52 | tumor protein D52 | 0.06069 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.058738 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0559841 |
| USP3 | ubiquitin specific peptidase 3 | 0.054003 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0511762 |
| SRGN | serglycin | 0.0474176 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0465643 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0459584 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0459068 |
| FMNL2 | formin-like 2 | 0.0454641 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0434252 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0426364 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0423346 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0418135 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0391689 |
| RTN4 | reticulon 4 | 0.0387428 |
| LMNA | lamin A/C | 0.0382689 |
| STC1 | stanniocalcin 1 | 0.0378209 |
| ANXA2 | annexin A2 | 0.0369812 |
| B2M | beta-2-microglobulin | 0.036464 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.035565 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0348477 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0347056 |
| CFDP1 | craniofacial development protein 1 | 0.0346209 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0339254 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.033615 |
| RPS12 | ribosomal protein S12 | 0.0334697 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0323685 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0316095 |
| RNF145 | ring finger protein 145 | 0.0314054 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0313058 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.031265 |
| WDR43 | WD repeat domain 43 | 0.0311558 |
| ZNF292 | zinc finger protein 292 | 0.0309929 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0300489 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0295272 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.0291659 |
| NCKAP1 | NCK-associated protein 1 | 0.0291041 |
| WBP11 | WW domain binding protein 11 | 0.0289999 |
| RPS2 | ribosomal protein S2 | 0.0288924 |
| SEPTIN7 | septin 7 | 0.0287839 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0283049 |
| FAM168A | family with sequence similarity 168, member A | 0.0281935 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0276714 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0272572 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.026906 |
| VGLL4 | vestigial-like family member 4 | 0.026888 |
| RPL3 | ribosomal protein L3 | 0.0266704 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0266026 |
| RPS7 | ribosomal protein S7 | 0.0265911 |
| CCNL1 | cyclin L1 | 0.0264948 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0264268 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0263432 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0262676 |
| ENO1 | enolase 1, (alpha) | 0.0261306 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0255723 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.025304 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.025155 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 0.0244216 |
| FDPS | farnesyl diphosphate synthase | 0.0242769 |
| CHN1 | chimerin 1 | 0.024195 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | 0.0241813 |
| RPL4 | ribosomal protein L4 | 0.0241309 |
| YBX3 | Y box binding protein 3 | 0.0241235 |
| KLF6 | Kruppel-like factor 6 | 0.0239627 |
| ANXA1 | annexin A1 | 0.0237809 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0234057 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0233512 |
| ABI1 | abl-interactor 1 | 0.0232382 |
| STMN1 | stathmin 1 | 0.0231965 |
| RPL6 | ribosomal protein L6 | 0.0230132 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0228717 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0228005 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0227858 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0227643 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0225707 |
| RPS3 | ribosomal protein S3 | 0.0224994 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0224303 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0224156 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0222848 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0222315 |
| ZFR | zinc finger RNA binding protein | 0.0220817 |
| H1-4 | H1.4 linker histone, cluster member | 0.0219832 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.021883 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0217812 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0217534 |
| CCNY | cyclin Y | 0.0216416 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0215862 |
| LYPLA1 | lysophospholipase I | 0.0215741 |
| SNX14 | sorting nexin 14 | 0.0214406 |
| GOLT1B | golgi transport 1B | 0.0213252 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0212868 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0212228 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0210377 |
| TFAM | transcription factor A, mitochondrial | 0.0205177 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | -0.16305 |
| TMSB10 | thymosin beta 10 | -0.163033 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.13501 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.128015 |
| TXNRD1 | thioredoxin reductase 1 | -0.123612 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.120039 |
| GRAMD1B | GRAM domain containing 1B | -0.114003 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.106999 |
| EGR1 | early growth response 1 | -0.0864685 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0792835 |
| HDAC9 | histone deacetylase 9 | -0.0775095 |
| KYNU | kynureninase | -0.0758379 |
| OSMR | oncostatin M receptor | -0.0729878 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0707463 |
| RPL35A | ribosomal protein L35a | -0.0691242 |
| POTEF | POTE ankyrin domain family, member F | -0.0659602 |
| LDHA | lactate dehydrogenase A | -0.0651174 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0638975 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.063106 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0622738 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0615974 |
| SVIL | supervillin | -0.0574375 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0563462 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0553364 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0547695 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0546415 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0546361 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0527812 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0523296 |
| RBM39 | RNA binding motif protein 39 | -0.0501674 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0499417 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0478697 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.047168 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.046819 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0453673 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0444552 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0442486 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0441701 |
| RAB10 | RAB10, member RAS oncogene family | -0.0433321 |
| NTN4 | netrin 4 | -0.042244 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0422086 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0420747 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0411031 |
| DST | dystonin | -0.0410277 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0407375 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0401795 |
| MCL1 | myeloid cell leukemia 1 | -0.0400381 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0391224 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0385698 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0381684 |
| RPL31 | ribosomal protein L31 | -0.0371798 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0371365 |
| BICC1 | BicC family RNA binding protein 1 | -0.03707 |
| MORF4L2 | mortality factor 4 like 2 | -0.0366589 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0364743 |
| USP36 | ubiquitin specific peptidase 36 | -0.0362425 |
| NABP1 | nucleic acid binding protein 1 | -0.0352145 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0351372 |
| MED13 | mediator complex subunit 13 | -0.0345411 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0344455 |
| COPA | coatomer protein complex, subunit alpha | -0.0342843 |
| USP34 | ubiquitin specific peptidase 34 | -0.0339139 |
| MT2A | metallothionein 2A | -0.0338659 |
| TOP1 | topoisomerase (DNA) I | -0.0338327 |
| PSEN1 | presenilin 1 | -0.0337171 |
| GPATCH2L | G patch domain containing 2-like | -0.0335733 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0335041 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0332947 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0332759 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0330128 |
| TPM4 | tropomyosin 4 | -0.0329526 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0326917 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0322629 |
| JMJD1C | jumonji domain containing 1C | -0.0317882 |
| HLA-B | major histocompatibility complex, class I, B | -0.030722 |
| SQSTM1 | sequestosome 1 | -0.0305751 |
| DENND4A | DENN/MADD domain containing 4A | -0.0305336 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0304786 |
| GLIS3 | GLIS family zinc finger 3 | -0.030189 |
| MT1X | metallothionein 1X | -0.0299928 |
| INO80 | INO80 complex subunit | -0.0298507 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0296539 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0295887 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0293635 |
| ZNF804A | zinc finger protein 804A | -0.0292157 |
| TMEM87A | transmembrane protein 87A | -0.0287974 |
| NF1 | neurofibromin 1 | -0.0286793 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.028324 |
| MYOF | myoferlin | -0.0283033 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0281511 |
| PKM | pyruvate kinase, muscle | -0.0281173 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0279424 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0278586 |
| HDLBP | high density lipoprotein binding protein | -0.0278209 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0277068 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0274081 |
| RAB31 | RAB31, member RAS oncogene family | -0.0273317 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0271859 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.027169 |
| PFN1 | profilin 1 | -0.0271602 |
