Fostamatinib (disodium hexahydrate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0938173
ERRFI1 ERBB receptor feedback inhibitor 1 0.0899951
GRAMD1B GRAM domain containing 1B 0.0758402
TPM3 tropomyosin 3 0.0664056
CTTN cortactin 0.0638933
RAD51B RAD51 paralog B 0.0621402
TRIO trio Rho guanine nucleotide exchange factor 0.0607979
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0595607
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0540422
ADAR adenosine deaminase, RNA-specific 0.046232
CSDE1 cold shock domain containing E1, RNA-binding 0.041471
ZFR zinc finger RNA binding protein 0.0397697
SINHCAF SIN3-HDAC complex associated factor 0.0397667
ANKRD36 ankyrin repeat domain 36 0.0396145
RPL6 ribosomal protein L6 0.0387287
BRWD3 bromodomain and WD repeat domain containing 3 0.0375637
PTMA prothymosin, alpha 0.0366957
BBX bobby sox homolog (Drosophila) 0.0363345
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0359004
OGA O-GlcNAcase 0.0344299
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0342956
PUM2 pumilio RNA-binding family member 2 0.0322794
THSD4 thrombospondin, type I, domain containing 4 0.0319545
XPO1 exportin 1 0.0318829
DENND5B DENN/MADD domain containing 5B 0.0313986
BIRC2 baculoviral IAP repeat containing 2 0.030978
PTPRF protein tyrosine phosphatase, receptor type, F 0.0304231
EXOC4 exocyst complex component 4 0.0301751
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0301368
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0297807
CSNK1A1 casein kinase 1, alpha 1 0.0296877
KDM2A lysine (K)-specific demethylase 2A 0.0296329
KDM3A lysine (K)-specific demethylase 3A 0.0295534
SMAD3 SMAD family member 3 0.0295051
MARCHF4 membrane associated ring-CH-type finger 4 0.0290412
NCKAP1 NCK-associated protein 1 0.0288239
EIF4B eukaryotic translation initiation factor 4B 0.028186
MED13L mediator complex subunit 13-like 0.027786
KRT18 keratin 18, type I 0.0275301
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0270832
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0267593
ETNK1 ethanolamine kinase 1 0.025989
MACF1 microtubule-actin crosslinking factor 1 0.0259802
FAM13A family with sequence similarity 13, member A 0.0258412
PHIP pleckstrin homology domain interacting protein 0.0257288
AK4 adenylate kinase 4 0.0252947
PHF20 PHD finger protein 20 0.024944
ANO6 anoctamin 6 0.0248219
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0247467
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0247057
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0246169
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0244589
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0240817
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0240642
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.023975
DARS1 aspartyl-tRNA synthetase 1 0.0236248
H1-4 H1.4 linker histone, cluster member 0.0234941
MMP12 matrix metallopeptidase 12 0.0231202
ZNF462 zinc finger protein 462 0.0231175
TMEM165 transmembrane protein 165 0.023105
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0230473
ATP11A ATPase, class VI, type 11A 0.0230234
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0230064
PRPF8 pre-mRNA processing factor 8 0.0228943
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.0226834
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0225417
RFX7 regulatory factor X, 7 0.0224438
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0224133
NBPF15 neuroblastoma breakpoint family, member 15 0.0224027
PREPL prolyl endopeptidase-like 0.0222755
COPA coatomer protein complex, subunit alpha 0.02216
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0221172
SRPK1 SRSF protein kinase 1 0.0216098
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0215856
MXI1 MAX interactor 1, dimerization protein 0.0215009
NEK7 NIMA-related kinase 7 0.0214977
GIGYF2 GRB10 interacting GYF protein 2 0.0214776
BCAS3 breast carcinoma amplified sequence 3 0.0214712
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0214643
MKI67 marker of proliferation Ki-67 0.021464
STK4 serine/threonine kinase 4 0.021453
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0211457
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0207106
ZNF292 zinc finger protein 292 0.0206879
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.02061
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0205791
TOP2B topoisomerase (DNA) II beta 180kDa 0.0205461
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0204917
SEPTIN10 septin 10 0.0201958
LARS1 leucyl-tRNA synthetase 1 0.0201515
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0199722
ANKIB1 ankyrin repeat and IBR domain containing 1 0.019951
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0199343
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.0198711
HELZ helicase with zinc finger 0.0197942
AHNAK AHNAK nucleoprotein 0.01977
RPL3 ribosomal protein L3 0.0197284
BRWD1 bromodomain and WD repeat domain containing 1 0.0196961
ZMYM2 zinc finger, MYM-type 2 0.0195768
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0195741

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.216567
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.214244
EGR1 early growth response 1 -0.155901
TFPI2 tissue factor pathway inhibitor 2 -0.0836408
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0802802
RPL35A ribosomal protein L35a -0.0773145
RPLP1 ribosomal protein, large, P1 -0.0742572
YBX3 Y box binding protein 3 -0.071838
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.068655
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0626046
RPL23 ribosomal protein L23 -0.0577328
YBX1 Y box binding protein 1 -0.0571978
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0538062
RPL12 ribosomal protein L12 -0.0517633
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0496601
RPL38 ribosomal protein L38 -0.0491112
FTL ferritin, light polypeptide -0.0481045
MT2A metallothionein 2A -0.0474244
RPL5 ribosomal protein L5 -0.046942
MORF4L2 mortality factor 4 like 2 -0.046498
RPS19 ribosomal protein S19 -0.0452068
RPL31 ribosomal protein L31 -0.0435874
RPL34 ribosomal protein L34 -0.0414067
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0397632
PFN1 profilin 1 -0.0389746
RPS6 ribosomal protein S6 -0.0389159
LOC112694756 uncharaterized LOC112694756 -0.0371209
MYL12B myosin, light chain 12B, regulatory -0.0369751
S100A11 S100 calcium binding protein A11 -0.0367974
RPLP2 ribosomal protein, large, P2 -0.036582
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0360657
RIMS2 regulating synaptic membrane exocytosis 2 -0.0360415
ATP5F1E ATP synthase F1 subunit epsilon -0.0351667
RPL26 ribosomal protein L26 -0.0347995
PKM pyruvate kinase, muscle -0.0347744
HLA-B major histocompatibility complex, class I, B -0.0343602
SEPTIN7 septin 7 -0.0343572
NACA nascent polypeptide-associated complex alpha subunit -0.0335348
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0334919
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0331209
PRH1 proline-rich protein HaeIII subfamily 1 -0.0330191
RPS4X ribosomal protein S4, X-linked -0.0327098
TPI1 triosephosphate isomerase 1 -0.0323902
BRD2 bromodomain containing 2 -0.0318604
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0315185
RPS27 ribosomal protein S27 -0.0312996
RPS21 ribosomal protein S21 -0.0312837
OSMR oncostatin M receptor -0.0305472
RPS29 ribosomal protein S29 -0.0305215
RAB7A RAB7A, member RAS oncogene family -0.0303008
RPL35 ribosomal protein L35 -0.0301652
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0301418
RPL36 ribosomal protein L36 -0.0298771
RPL19 ribosomal protein L19 -0.0297384
RPL9 ribosomal protein L9 -0.0294215
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0290003
HMGB1 high mobility group box 1 -0.0289572
HMGA1 high mobility group AT-hook 1 -0.0289262
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0287539
RPS20 ribosomal protein S20 -0.0280047
VDAC1 voltage-dependent anion channel 1 -0.0279391
PCBP2 poly(rC) binding protein 2 -0.0275829
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0274237
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0274174
RPL32 ribosomal protein L32 -0.0272519
RPS10 ribosomal protein S10 -0.0271487
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0269886
RPS15 ribosomal protein S15 -0.0269835
TXNRD1 thioredoxin reductase 1 -0.0267451
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0265776
INTS6 integrator complex subunit 6 -0.0263322
LOC102724023 ES1 protein homolog, mitochondrial -0.0260759
TPM2 tropomyosin 2 (beta) -0.0258738
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0258514
LDHB lactate dehydrogenase B -0.0256363
SRSF3 serine/arginine-rich splicing factor 3 -0.0252598
SMC4 structural maintenance of chromosomes 4 -0.0252483
RPL28 ribosomal protein L28 -0.0250684
RPL8 ribosomal protein L8 -0.024732
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0246628
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0244114
MATR3 matrin 3 -0.0242089
RPS14 ribosomal protein S14 -0.0241279
TPT1 tumor protein, translationally-controlled 1 -0.0241032
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0238089
RPL30 ribosomal protein L30 -0.0231013
RPL27 ribosomal protein L27 -0.0229208
RPS3 ribosomal protein S3 -0.0228984
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0228733
SEC61G Sec61 gamma subunit -0.0228343
PRRC2C proline-rich coiled-coil 2C -0.0226951
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0226467
PTMS parathymosin -0.0225625
RPS23 ribosomal protein S23 -0.0224849
PDLIM5 PDZ and LIM domain 5 -0.0223914
WNT2B wingless-type MMTV integration site family, member 2B -0.0222261
RPS8 ribosomal protein S8 -0.0221698
RPL27A ribosomal protein L27a -0.0217668
EEF1G eukaryotic translation elongation factor 1 gamma -0.021711
AEBP2 AE binding protein 2 -0.0214758