| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.194803 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.110665 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0950263 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0943882 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0616867 |
| LAMC2 | laminin, gamma 2 | 0.0549458 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0543348 |
| RPL4 | ribosomal protein L4 | 0.053236 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.042537 |
| RACK1 | receptor for activated C kinase 1 | 0.0419134 |
| AHNAK | AHNAK nucleoprotein | 0.041876 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.037435 |
| DSPP | dentin sialophosphoprotein | 0.0373743 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0361312 |
| FHIT | fragile histidine triad | 0.0357729 |
| RPLP0 | ribosomal protein, large, P0 | 0.0339032 |
| FAM13A | family with sequence similarity 13, member A | 0.0298473 |
| RPS2 | ribosomal protein S2 | 0.0294195 |
| DSG2 | desmoglein 2 | 0.0294109 |
| RPL6 | ribosomal protein L6 | 0.0290926 |
| H1-4 | H1.4 linker histone, cluster member | 0.0289419 |
| NCKAP1 | NCK-associated protein 1 | 0.0278428 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0267498 |
| UPP1 | uridine phosphorylase 1 | 0.0256706 |
| ACTG1 | actin gamma 1 | 0.02549 |
| FN1 | fibronectin 1 | 0.0254142 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0252745 |
| HSPA8 | heat shock 70kDa protein 8 | 0.023813 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0237419 |
| H1-0 | H1.0 linker histone | 0.0232375 |
| RPL3 | ribosomal protein L3 | 0.0227797 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0225911 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0224826 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.02185 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0217653 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0216443 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0214948 |
| RPL12 | ribosomal protein L12 | 0.0207654 |
| RPS6 | ribosomal protein S6 | 0.0202389 |
| TKT | transketolase | 0.0201158 |
| STEAP4 | STEAP family member 4 | 0.020021 |
| ZNF706 | zinc finger protein 706 | 0.0197981 |
| LAMB3 | laminin, beta 3 | 0.0188138 |
| MT2A | metallothionein 2A | 0.0185487 |
| PEG10 | paternally expressed 10 | 0.0176546 |
| ENO1 | enolase 1, (alpha) | 0.0173956 |
| RPL18 | ribosomal protein L18 | 0.017378 |
| KIAA1217 | KIAA1217 | 0.0170837 |
| MAP1B | microtubule-associated protein 1B | 0.0167724 |
| RPL23A | ribosomal protein L23a | 0.0167716 |
| TPM3 | tropomyosin 3 | 0.0167543 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0165839 |
| USP3 | ubiquitin specific peptidase 3 | 0.0165198 |
| S100A10 | S100 calcium binding protein A10 | 0.016513 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.016347 |
| KRT18 | keratin 18, type I | 0.0160293 |
| EMB | embigin | 0.0158331 |
| RPL32 | ribosomal protein L32 | 0.0157879 |
| SQSTM1 | sequestosome 1 | 0.0157159 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0155738 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0155555 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0154301 |
| MSN | moesin | 0.0151805 |
| RPS17 | ribosomal protein S17 | 0.0150961 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0150743 |
| ANXA5 | annexin A5 | 0.0149795 |
| RPS3A | ribosomal protein S3A | 0.0148661 |
| RPL7 | ribosomal protein L7 | 0.0148549 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0147995 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 0.0144179 |
| GPX4 | glutathione peroxidase 4 | 0.0143359 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0142511 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0141002 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0138932 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0138051 |
| RPL5 | ribosomal protein L5 | 0.0137466 |
| RPS7 | ribosomal protein S7 | 0.0136572 |
| RPL35 | ribosomal protein L35 | 0.0136165 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0135599 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0134737 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0134235 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0134013 |
| PLEC | plectin | 0.0133606 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0133316 |
| KLF6 | Kruppel-like factor 6 | 0.0132052 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.0131792 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.013065 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.0130373 |
| DUSP6 | dual specificity phosphatase 6 | 0.0130325 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.0130067 |
| ARRDC3 | arrestin domain containing 3 | 0.0128892 |
| RPS12 | ribosomal protein S12 | 0.0127657 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0123264 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | 0.0121898 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0121699 |
| HPCAL1 | hippocalcin-like 1 | 0.0121501 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0121431 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.0120519 |
| MKI67 | marker of proliferation Ki-67 | 0.0120045 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0119847 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.149032 |
| POTEF | POTE ankyrin domain family, member F | -0.144462 |
| TMSB10 | thymosin beta 10 | -0.127675 |
| ERBIN | erbb2 interacting protein | -0.0957444 |
| MYO6 | myosin VI | -0.0929734 |
| FTL | ferritin, light polypeptide | -0.0922057 |
| RPL35A | ribosomal protein L35a | -0.0902076 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0835353 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0767964 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0734357 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0710331 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0706107 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0700798 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0698562 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0697563 |
| LMO7 | LIM domain 7 | -0.0659334 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0655053 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0640179 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0636745 |
| RBM25 | RNA binding motif protein 25 | -0.0632824 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0628537 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0623449 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0619548 |
| COPA | coatomer protein complex, subunit alpha | -0.0609855 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0607088 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0603811 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0598628 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0591255 |
| RBM39 | RNA binding motif protein 39 | -0.0581157 |
| LDHA | lactate dehydrogenase A | -0.0581093 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0577112 |
| HLA-B | major histocompatibility complex, class I, B | -0.0550481 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0539548 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0532659 |
| NDRG1 | N-myc downstream regulated 1 | -0.0527093 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0519758 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0518898 |
| RCOR1 | REST corepressor 1 | -0.0511666 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0509033 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0501698 |
| PTK2 | protein tyrosine kinase 2 | -0.0499386 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0497878 |
| CD2AP | CD2-associated protein | -0.049625 |
| PDLIM5 | PDZ and LIM domain 5 | -0.048943 |
| PKM | pyruvate kinase, muscle | -0.0484858 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0476575 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0466752 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.046577 |
| WASF2 | WAS protein family, member 2 | -0.0460393 |
| VEGFA | vascular endothelial growth factor A | -0.0454331 |
| JMJD1C | jumonji domain containing 1C | -0.0453854 |
| FBXO11 | F-box protein 11 | -0.044942 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0439689 |
| RBM47 | RNA binding motif protein 47 | -0.0435073 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0434934 |
| MCU | mitochondrial calcium uniporter | -0.0428866 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0424495 |
| GRB10 | growth factor receptor-bound protein 10 | -0.042271 |
| RASAL2 | RAS protein activator like 2 | -0.0421306 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.04204 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0414496 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.041061 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0408499 |
| HLA-A | major histocompatibility complex, class I, A | -0.0407082 |
| MYO1E | myosin IE | -0.0406389 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0404729 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0403693 |
| CERT1 | ceramide transporter 1 | -0.0401938 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0398626 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0395516 |
| ARF4 | ADP-ribosylation factor 4 | -0.0394532 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0393817 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0392166 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0390816 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0383758 |
| ZNF207 | zinc finger protein 207 | -0.0383355 |
| MXD1 | MAX dimerization protein 1 | -0.0382158 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0377334 |
| TMEM165 | transmembrane protein 165 | -0.0377076 |
| FAM3C | family with sequence similarity 3, member C | -0.0370837 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0369413 |
| SPAG9 | sperm associated antigen 9 | -0.0367983 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0364914 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0361494 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0360547 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0360093 |
| MCL1 | myeloid cell leukemia 1 | -0.0357772 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0357205 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0356251 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0355189 |
| TPM4 | tropomyosin 4 | -0.0352699 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0352252 |
| CCND1 | cyclin D1 | -0.0351223 |
| FBXO32 | F-box protein 32 | -0.0349029 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0346914 |
| EGR1 | early growth response 1 | -0.0345948 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0345925 |
| HMGA1 | high mobility group AT-hook 1 | -0.0345869 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0343847 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0342964 |
