| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0672072 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0428153 |
| EFNA5 | ephrin-A5 | 0.034941 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0322391 |
| FAM13A | family with sequence similarity 13, member A | 0.0320127 |
| RTN4 | reticulon 4 | 0.0318501 |
| FLNB | filamin B, beta | 0.0313309 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0308299 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0290912 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0275904 |
| OGA | O-GlcNAcase | 0.0269248 |
| ZNF292 | zinc finger protein 292 | 0.0247958 |
| NEK7 | NIMA-related kinase 7 | 0.0243392 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0240246 |
| HELZ | helicase with zinc finger | 0.02285 |
| GRAMD1B | GRAM domain containing 1B | 0.0223669 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0215106 |
| NDRG1 | N-myc downstream regulated 1 | 0.0207292 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0201016 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0200717 |
| MYOF | myoferlin | 0.0188528 |
| TBXT | T-box transcription factor T | 0.0186002 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0185404 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0184657 |
| NGLY1 | N-glycanase 1 | 0.0184656 |
| RUNX1 | runt-related transcription factor 1 | 0.0184528 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0180043 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0176542 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0174937 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0173959 |
| NUP58 | nucleoporin 58 | 0.0168513 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0167869 |
| NCKAP1 | NCK-associated protein 1 | 0.0166329 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0165079 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0164815 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0160224 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0155219 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0154431 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0150472 |
| SUCO | SUN domain containing ossification factor | 0.014591 |
| NBAS | neuroblastoma amplified sequence | 0.014577 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0143284 |
| WDR43 | WD repeat domain 43 | 0.0142917 |
| USP3 | ubiquitin specific peptidase 3 | 0.0142319 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0138824 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.013573 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0134251 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0132247 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0131991 |
| SRP54 | signal recognition particle 54kDa | 0.0131642 |
| PHIP | pleckstrin homology domain interacting protein | 0.0130616 |
| SEC24D | SEC24 family member D | 0.0130374 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0129516 |
| WDR26 | WD repeat domain 26 | 0.0129026 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0127987 |
| ARRDC3 | arrestin domain containing 3 | 0.0126003 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0125703 |
| H1-4 | H1.4 linker histone, cluster member | 0.0125097 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0124311 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0124195 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0123876 |
| MCL1 | myeloid cell leukemia 1 | 0.0122736 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0122184 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.012004 |
| METTL15 | methyltransferase like 15 | 0.0119346 |
| GOLGA4 | golgin A4 | 0.0118899 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0116964 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0116352 |
| ATP13A3 | ATPase type 13A3 | 0.0113493 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0111825 |
| ANLN | anillin, actin binding protein | 0.0110928 |
| RNF145 | ring finger protein 145 | 0.0110763 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0110182 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0110169 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0109792 |
| ZFR | zinc finger RNA binding protein | 0.0109425 |
| ECT2 | epithelial cell transforming 2 | 0.0109379 |
| RAI1 | retinoic acid induced 1 | 0.0108501 |
| COPA | coatomer protein complex, subunit alpha | 0.0108266 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0108118 |
| TCERG1 | transcription elongation regulator 1 | 0.0107297 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0106138 |
| RNF24 | ring finger protein 24 | 0.0105404 |
| KIF14 | kinesin family member 14 | 0.0103584 |
| SPAG9 | sperm associated antigen 9 | 0.0103338 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0103273 |
| POM121 | POM121 transmembrane nucleoporin | 0.0102932 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0101535 |
| WDR45B | WD repeat domain 45B | 0.00993675 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.00993357 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.00987395 |
| ANKRD28 | ankyrin repeat domain 28 | 0.00986369 |
| BDNF | brain-derived neurotrophic factor | 0.00985603 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.00967749 |
| CTSC | cathepsin C | 0.00956607 |
| RAB1A | RAB1A, member RAS oncogene family | 0.00952452 |
| ANXA1 | annexin A1 | 0.00950165 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.00939896 |
| MSN | moesin | 0.00936595 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.00930834 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.367485 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.353047 |
| FN1 | fibronectin 1 | -0.176188 |
| VIM | vimentin | -0.139497 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.128397 |
| COL5A2 | collagen, type V, alpha 2 | -0.119881 |
| CDH13 | cadherin 13 | -0.115508 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.110046 |
| TMSB10 | thymosin beta 10 | -0.10942 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0989531 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0958062 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0943646 |
| RPS6 | ribosomal protein S6 | -0.089658 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0890878 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0870666 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0753893 |
| RPLP1 | ribosomal protein, large, P1 | -0.0725876 |
| PDE10A | phosphodiesterase 10A | -0.0721622 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0705767 |
| SMYD3 | SET and MYND domain containing 3 | -0.0651403 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0608664 |
| RPL35A | ribosomal protein L35a | -0.0602617 |
| RPL31 | ribosomal protein L31 | -0.0601362 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0593742 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0578613 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0569754 |
| DST | dystonin | -0.0556982 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0546196 |
| LSAMP | limbic system-associated membrane protein | -0.0489717 |
| RPS8 | ribosomal protein S8 | -0.0486834 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0481951 |
| CTSL | cathepsin L | -0.0456356 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.045628 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0455151 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0452897 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0448881 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0443733 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0443228 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0439565 |
| PTMA | prothymosin, alpha | -0.0437822 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0437003 |
| RPS24 | ribosomal protein S24 | -0.0435713 |
| RPS19 | ribosomal protein S19 | -0.0432816 |
| RPL26 | ribosomal protein L26 | -0.0422075 |
| AUTS2 | autism susceptibility candidate 2 | -0.0422046 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0401246 |
| RPL12 | ribosomal protein L12 | -0.0400093 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0385433 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0385143 |
| CANX | calnexin | -0.0382161 |
| HLA-B | major histocompatibility complex, class I, B | -0.0378094 |
| DOCK5 | dedicator of cytokinesis 5 | -0.037039 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0365771 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0361437 |
| MAP7 | microtubule-associated protein 7 | -0.0360828 |
| RPL23 | ribosomal protein L23 | -0.0359899 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0358564 |
| RPL37A | ribosomal protein L37a | -0.0353938 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0353181 |
| GDA | guanine deaminase | -0.0351557 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0351419 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0349176 |
| ENO1 | enolase 1, (alpha) | -0.0346691 |
| RPS23 | ribosomal protein S23 | -0.0346193 |
| LDHA | lactate dehydrogenase A | -0.0345752 |
| RPL34 | ribosomal protein L34 | -0.0344003 |
| TENM3 | teneurin transmembrane protein 3 | -0.034327 |
| RPS27 | ribosomal protein S27 | -0.0342948 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0341638 |
| RPS12 | ribosomal protein S12 | -0.0341359 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0336144 |
| FTL | ferritin, light polypeptide | -0.033277 |
| RPL36A | ribosomal protein L36a | -0.0331449 |
| RPS14 | ribosomal protein S14 | -0.0330606 |
| CUX1 | cut-like homeobox 1 | -0.0328375 |
| RPL19 | ribosomal protein L19 | -0.0322196 |
| SMAD2 | SMAD family member 2 | -0.0321338 |
| NCKAP5 | NCK-associated protein 5 | -0.0319444 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0318217 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0318094 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0317247 |
| TPM4 | tropomyosin 4 | -0.0314739 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0311486 |
| KIAA0825 | KIAA0825 | -0.0311082 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0298867 |
| RPLP2 | ribosomal protein, large, P2 | -0.0285995 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0285756 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0283411 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0281731 |
| S100A6 | S100 calcium binding protein A6 | -0.0281131 |
| PKM | pyruvate kinase, muscle | -0.0278966 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0277513 |
| RPLP0 | ribosomal protein, large, P0 | -0.0274725 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0274541 |
| CADM2 | cell adhesion molecule 2 | -0.0272373 |
| RAD51B | RAD51 paralog B | -0.0270377 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0269182 |
| RAB31 | RAB31, member RAS oncogene family | -0.0268884 |
| RPS27A | ribosomal protein S27a | -0.0268614 |
| CHL1 | cell adhesion molecule L1-like | -0.0268009 |
