Fostamatinib (disodium hexahydrate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

167 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.153685
FAM13A family with sequence similarity 13, member A 0.144611
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.140885
DSCAM Down syndrome cell adhesion molecule 0.128274
KDM2A lysine (K)-specific demethylase 2A 0.128157
EFNA5 ephrin-A5 0.126044
RAB7A RAB7A, member RAS oncogene family 0.125975
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.12194
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.103412
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.100934
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0897678
RUNX1 runt-related transcription factor 1 0.0857867
ENO1 enolase 1, (alpha) 0.0841544
SRPK2 SRSF protein kinase 2 0.0830096
RPLP2 ribosomal protein, large, P2 0.0771127
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0756509
ASPH aspartate beta-hydroxylase 0.0738474
ADAM10 ADAM metallopeptidase domain 10 0.0711093
SPAG9 sperm associated antigen 9 0.068349
FMN1 formin 1 0.0633196
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0572504
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0545135
LAMA4 laminin, alpha 4 0.0529677
MAP4 microtubule-associated protein 4 0.0504027
NUP58 nucleoporin 58 0.0500196
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0498917
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0487657
RTN4 reticulon 4 0.0486632
NAMPT nicotinamide phosphoribosyltransferase 0.0484484
RICTOR RPTOR independent companion of MTOR, complex 2 0.04822
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0480641
AKAP12 A kinase (PRKA) anchor protein 12 0.0474502
LPP LIM domain containing preferred translocation partner in lipoma 0.047437
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0470137
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0465577
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0449143
RPS3 ribosomal protein S3 0.0448605
NDRG1 N-myc downstream regulated 1 0.0447933
COL6A3 collagen, type VI, alpha 3 0.0446544
KMT2E lysine (K)-specific methyltransferase 2E 0.0442428
NCOA3 nuclear receptor coactivator 3 0.0440164
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0430525
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0417675
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0395562
ACTG1 actin gamma 1 0.0392635
FNDC3B fibronectin type III domain containing 3B 0.039143
CSDE1 cold shock domain containing E1, RNA-binding 0.0382424
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0380745
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0372957
GPC6 glypican 6 0.0372889
SMAD3 SMAD family member 3 0.0363413
FTL ferritin, light polypeptide 0.0362829
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0359798
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0359164
AHNAK AHNAK nucleoprotein 0.0355302
EEF2 eukaryotic translation elongation factor 2 0.0355131
LDHA lactate dehydrogenase A 0.0353597
RLF rearranged L-myc fusion 0.0347956
RPL37A ribosomal protein L37a 0.034191
ANKRD12 ankyrin repeat domain 12 0.0337007
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0333123
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.033201
MORF4L2 mortality factor 4 like 2 0.0325915
FMNL2 formin-like 2 0.0321003
WAC WW domain containing adaptor with coiled-coil 0.0305947
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0284188
RPL31 ribosomal protein L31 0.0283884
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0274317
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.027058
EPS8 epidermal growth factor receptor pathway substrate 8 0.0270445
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0255641
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.025278
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0248958
PDE4D phosphodiesterase 4D, cAMP-specific 0.0243732
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0241612
AKAP13 A kinase (PRKA) anchor protein 13 0.0229143
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0224666
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0215203
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0207289
ZFAND3 zinc finger, AN1-type domain 3 0.0198898
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0198773
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0191595
RPS6 ribosomal protein S6 0.0189158
KMT2C lysine (K)-specific methyltransferase 2C 0.0184267
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0181113
GLS2 glutaminase 2 (liver, mitochondrial) 0.016414
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0150117
PGK1 phosphoglycerate kinase 1 0.014593
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.014434
KTN1 kinectin 1 (kinesin receptor) 0.0143968
CTNND1 catenin (cadherin-associated protein), delta 1 0.0140888
ZNF292 zinc finger protein 292 0.0136038
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0099725
P4HB prolyl 4-hydroxylase, beta polypeptide 0.00876611
COG5 component of oligomeric golgi complex 5 0.00800058
TIMP3 TIMP metallopeptidase inhibitor 3 0.00715629
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00606022
TPI1 triosephosphate isomerase 1 0.00602946
SRRM2 serine/arginine repetitive matrix 2 0.0054155
EGFR epidermal growth factor receptor 0.00512387

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.243922
EXT1 exostosin glycosyltransferase 1 -0.185193
HMGA2 high mobility group AT-hook 2 -0.183303
CXCL8 chemokine (C-X-C motif) ligand 8 -0.177579
CADM2 cell adhesion molecule 2 -0.162745
PEG10 paternally expressed 10 -0.150867
VIM vimentin -0.150573
NALF1 NALCN channel auxiliary factor 1 -0.14009
ATP11A ATPase, class VI, type 11A -0.126008
TRIO trio Rho guanine nucleotide exchange factor -0.122936
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.107031
MYO1E myosin IE -0.104848
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.104364
ZBTB20 zinc finger and BTB domain containing 20 -0.102267
GOLGB1 golgin B1 -0.101331
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0988831
ARRDC3 arrestin domain containing 3 -0.0962489
ANKRD17 ankyrin repeat domain 17 -0.0891377
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0842191
ANXA2 annexin A2 -0.0804385
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0785042
GSK3B glycogen synthase kinase 3 beta -0.0744986
JMJD1C jumonji domain containing 1C -0.0739701
ATXN1 ataxin 1 -0.0704544
PTMA prothymosin, alpha -0.0648806
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0640181
RORA RAR-related orphan receptor A -0.0632166
IGF2 insulin-like growth factor 2 -0.0611352
RNF213 ring finger protein 213 -0.0605131
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0589746
CANX calnexin -0.0567468
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0560808
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.048442
FN1 fibronectin 1 -0.0467506
TXNRD1 thioredoxin reductase 1 -0.0466039
DST dystonin -0.0459041
RPS27A ribosomal protein S27a -0.0447758
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0396687
BPTF bromodomain PHD finger transcription factor -0.0342697
PARD3 par-3 family cell polarity regulator -0.0336119
TMSB10 thymosin beta 10 -0.0310142
TPT1 tumor protein, translationally-controlled 1 -0.0308948
PDIA3 protein disulfide isomerase family A, member 3 -0.0273859
ACTN4 actinin, alpha 4 -0.0265527
GOLGA4 golgin A4 -0.0242346
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0237915
PTK2 protein tyrosine kinase 2 -0.0223376
VCL vinculin -0.022104
MYO6 myosin VI -0.0204144
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0188214
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0179862
RAD51B RAD51 paralog B -0.0174102
SMYD3 SET and MYND domain containing 3 -0.0162182
CCNI cyclin I -0.0158872
MED13L mediator complex subunit 13-like -0.0151623
SETD5 SET domain containing 5 -0.0149378
PDE10A phosphodiesterase 10A -0.0116706
SLC38A1 solute carrier family 38, member 1 -0.010478
NF1 neurofibromin 1 -0.00899015
KDM3A lysine (K)-specific demethylase 3A -0.00876813
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.00856355
MYH9 myosin, heavy chain 9, non-muscle -0.00853118
UBC ubiquitin C -0.00270726
PKM pyruvate kinase, muscle -0.00199333
GPHN gephyrin -0.00139699
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.00105796
PABPC1 poly(A) binding protein, cytoplasmic 1 -9.61486E-4