Fostamatinib (disodium hexahydrate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.106016
LAMB3 laminin, beta 3 0.0602165
MT2A metallothionein 2A 0.0532367
RPL7A ribosomal protein L7a 0.049531
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0465027
ELL2 elongation factor, RNA polymerase II, 2 0.0460308
NAP1L1 nucleosome assembly protein 1-like 1 0.0452202
RPS3 ribosomal protein S3 0.0432515
RPS8 ribosomal protein S8 0.0408851
PTMA prothymosin, alpha 0.0407742
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0399608
FLNB filamin B, beta 0.0396452
ZNF292 zinc finger protein 292 0.0389896
GOLGA4 golgin A4 0.0388085
KDM3A lysine (K)-specific demethylase 3A 0.0373398
RPS12 ribosomal protein S12 0.0360219
TPD52 tumor protein D52 0.0356673
UBA6 ubiquitin-like modifier activating enzyme 6 0.0351772
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0350706
FMNL2 formin-like 2 0.0348885
USP3 ubiquitin specific peptidase 3 0.0342941
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0338059
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0326187
MXI1 MAX interactor 1, dimerization protein 0.0318669
NCKAP1 NCK-associated protein 1 0.0317969
PNISR PNN-interacting serine/arginine-rich protein 0.031328
STC1 stanniocalcin 1 0.0307925
RPL37A ribosomal protein L37a 0.0305181
TPT1 tumor protein, translationally-controlled 1 0.0303831
RNF24 ring finger protein 24 0.0301761
DSCAM Down syndrome cell adhesion molecule 0.0295268
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.028545
RLF rearranged L-myc fusion 0.028515
MTDH metadherin 0.028026
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0272449
RPS19 ribosomal protein S19 0.0265142
TTR transthyretin 0.0262656
PRELID2 PRELI domain containing 2 0.0260751
PGK1 phosphoglycerate kinase 1 0.0260585
H1-4 H1.4 linker histone, cluster member 0.025926
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0258846
ARFGEF3 ARFGEF family member 3 0.0255335
ARL5B ADP-ribosylation factor-like 5B 0.0246511
YEATS2 YEATS domain containing 2 0.0246282
RPS27A ribosomal protein S27a 0.0240701
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0239787
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0238631
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0237919
BBX bobby sox homolog (Drosophila) 0.0237648
KMT2C lysine (K)-specific methyltransferase 2C 0.0237123
RNMT RNA (guanine-7-) methyltransferase 0.0234975
SFXN1 sideroflexin 1 0.0233166
MAP2K1 mitogen-activated protein kinase kinase 1 0.0231364
RNF145 ring finger protein 145 0.0231347
RACK1 receptor for activated C kinase 1 0.0230185
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0229793
FTL ferritin, light polypeptide 0.0229018
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0228951
OGA O-GlcNAcase 0.0226635
ENO1 enolase 1, (alpha) 0.0226201
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0226083
TRIO trio Rho guanine nucleotide exchange factor 0.0224168
BHLHE40 basic helix-loop-helix family, member e40 0.0224085
LRRC8C leucine rich repeat containing 8 family, member C 0.0222239
C1ORF52 chromosome 1 open reading frame 52 0.0221829
B2M beta-2-microglobulin 0.0220276
SETD5 SET domain containing 5 0.0218755
CTTN cortactin 0.0215516
RB1CC1 RB1-inducible coiled-coil 1 0.0215041
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0213914
RPL8 ribosomal protein L8 0.0209126
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0208984
MARCHF6 membrane associated ring-CH-type finger 6 0.0207557
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0206729
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0205567
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0204204
RPL6 ribosomal protein L6 0.0203761
RO60 Ro60, Y RNA binding protein 0.0202953
RPL7 ribosomal protein L7 0.0202197
BRWD3 bromodomain and WD repeat domain containing 3 0.0200473
FOXO3 forkhead box O3 0.0200219
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0198898
ADAM17 ADAM metallopeptidase domain 17 0.0198694
MACF1 microtubule-actin crosslinking factor 1 0.0198641
SBF2 SET binding factor 2 0.0196558
PHIP pleckstrin homology domain interacting protein 0.0195851
RPL18 ribosomal protein L18 0.0195161
WSB1 WD repeat and SOCS box containing 1 0.0194987
TMEM123 transmembrane protein 123 0.0192197
NEMF nuclear export mediator factor 0.0192001
GOLM1 golgi membrane protein 1 0.0189423
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0188122
TMF1 TATA element modulatory factor 1 0.0187396
RPL32 ribosomal protein L32 0.0186872
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0185828
PUM2 pumilio RNA-binding family member 2 0.0185258
XPO1 exportin 1 0.0184558
ZNF106 zinc finger protein 106 0.018313
ZNF706 zinc finger protein 706 0.0182293
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0177983

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.127148
NAV3 neuron navigator 3 -0.0898977
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0876978
ZNF438 zinc finger protein 438 -0.0816187
FRMD6 FERM domain containing 6 -0.0803315
EGR1 early growth response 1 -0.0751502
ZEB1 zinc finger E-box binding homeobox 1 -0.0655178
IARS1 isoleucyl-tRNA synthetase 1 -0.0624315
POTEF POTE ankyrin domain family, member F -0.0616893
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0574473
EXT1 exostosin glycosyltransferase 1 -0.055282
ANKRD17 ankyrin repeat domain 17 -0.0505751
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0464326
AGO2 argonaute RISC catalytic component 2 -0.0444291
INTS6 integrator complex subunit 6 -0.0419006
JMJD1C jumonji domain containing 1C -0.041725
NABP1 nucleic acid binding protein 1 -0.0411452
RAB7A RAB7A, member RAS oncogene family -0.0409793
HMGA1 high mobility group AT-hook 1 -0.0403113
SGMS2 sphingomyelin synthase 2 -0.0400575
ERBIN erbb2 interacting protein -0.0396928
LOC112694756 uncharaterized LOC112694756 -0.0396103
SETX senataxin -0.0378111
SPRY4 sprouty homolog 4 (Drosophila) -0.0359705
PKM pyruvate kinase, muscle -0.0343174
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0324962
SP100 SP100 nuclear antigen -0.0324021
SFPQ splicing factor proline/glutamine-rich -0.0306609
TXNRD1 thioredoxin reductase 1 -0.0304417
PRRC2B proline-rich coiled-coil 2B -0.028338
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0282478
TRIP12 thyroid hormone receptor interactor 12 -0.0282278
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0278933
GDI2 GDP dissociation inhibitor 2 -0.0278043
GPATCH2L G patch domain containing 2-like -0.0273085
RIGI RNA sensor RIG-I -0.0270418
WNT2B wingless-type MMTV integration site family, member 2B -0.0269979
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0262309
ARHGAP22 Rho GTPase activating protein 22 -0.0260845
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0258579
RCOR1 REST corepressor 1 -0.0256531
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0249356
LDHA lactate dehydrogenase A -0.0247685
HDAC9 histone deacetylase 9 -0.0246185
EFNB2 ephrin-B2 -0.0245343
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0241465
ZNF121 zinc finger protein 121 -0.023858
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0237145
RPL35A ribosomal protein L35a -0.0235581
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0235527
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.023435
BNC2 basonuclin 2 -0.0232391
FUBP3 far upstream element (FUSE) binding protein 3 -0.0232391
SLC38A2 solute carrier family 38, member 2 -0.0231499
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0225013
RBM25 RNA binding motif protein 25 -0.0217383
PLSCR1 phospholipid scramblase 1 -0.0215782
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0215122
LOC102724023 ES1 protein homolog, mitochondrial -0.0211307
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0208182
TMSB10 thymosin beta 10 -0.0205913
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0203011
GATAD2A GATA zinc finger domain containing 2A -0.020211
EFL1 elongation factor like GTPase 1 -0.0198009
TUBB4B tubulin, beta 4B class IVb -0.0196195
MORF4L2 mortality factor 4 like 2 -0.019308
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.019287
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0191891
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.019174
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0190333
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0188141
SRCAP Snf2-related CREBBP activator protein -0.0187824
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0187543
SRSF3 serine/arginine-rich splicing factor 3 -0.0182783
TCF12 transcription factor 12 -0.0182303
DGKH diacylglycerol kinase, eta -0.0179912
ATAD2 ATPase family, AAA domain containing 2 -0.017894
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0177941
SPIDR scaffolding protein involved in DNA repair -0.0177709
EEF1G eukaryotic translation elongation factor 1 gamma -0.0177177
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0175655
PCNX4 pecanex 4 -0.0175054
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.017406
RNF169 ring finger protein 169 -0.0172472
SRRM2 serine/arginine repetitive matrix 2 -0.0171335
BPTF bromodomain PHD finger transcription factor -0.0169188
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0168675
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.01686
DLC1 DLC1 Rho GTPase activating protein -0.0163452
UBAP2 ubiquitin associated protein 2 -0.0162552
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0161979
BLZF1 basic leucine zipper nuclear factor 1 -0.01598
PUM1 pumilio RNA-binding family member 1 -0.015761
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0156764
LARP4B La ribonucleoprotein domain family, member 4B -0.0156376
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0156235
MCL1 myeloid cell leukemia 1 -0.0155852
DIAPH3 diaphanous-related formin 3 -0.0155749
TRIB1 tribbles pseudokinase 1 -0.0154281
ZBTB38 zinc finger and BTB domain containing 38 -0.0154049