| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | 0.262376 |
| VIM | vimentin | 0.177014 |
| NDRG1 | N-myc downstream regulated 1 | 0.144781 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.141366 |
| B2M | beta-2-microglobulin | 0.126403 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.115241 |
| MT2A | metallothionein 2A | 0.105152 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.099339 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0987432 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0958753 |
| FAM13A | family with sequence similarity 13, member A | 0.0876148 |
| COL1A2 | collagen, type I, alpha 2 | 0.0830691 |
| PTMA | prothymosin, alpha | 0.0829852 |
| ZNF292 | zinc finger protein 292 | 0.0724634 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0672571 |
| CD109 | CD109 molecule | 0.0657726 |
| PGK1 | phosphoglycerate kinase 1 | 0.064138 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0625169 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.062256 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0605301 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0571035 |
| POTEF | POTE ankyrin domain family, member F | 0.0550773 |
| FNDC3B | fibronectin type III domain containing 3B | 0.054478 |
| MMP12 | matrix metallopeptidase 12 | 0.051065 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0508232 |
| ENO1 | enolase 1, (alpha) | 0.0504821 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0487803 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.046973 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0468905 |
| GOLGA4 | golgin A4 | 0.0458914 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0453047 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0445178 |
| SETD5 | SET domain containing 5 | 0.0444589 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.044266 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0438022 |
| VEGFA | vascular endothelial growth factor A | 0.0437158 |
| MEF2A | myocyte enhancer factor 2A | 0.0425141 |
| INSIG2 | insulin induced gene 2 | 0.0421035 |
| MSN | moesin | 0.0419388 |
| XPO1 | exportin 1 | 0.0419264 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0413075 |
| NGLY1 | N-glycanase 1 | 0.0411886 |
| RNF24 | ring finger protein 24 | 0.039643 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0395104 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0393788 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0381963 |
| PFKP | phosphofructokinase, platelet | 0.0378982 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0377558 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0369731 |
| FBXO32 | F-box protein 32 | 0.0368639 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0368431 |
| INHBA | inhibin, beta A | 0.0366078 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0359709 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0357494 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0355762 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0354549 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0348395 |
| FAM162A | family with sequence similarity 162, member A | 0.0348178 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0343684 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0343497 |
| ZNF395 | zinc finger protein 395 | 0.0343177 |
| FOSL1 | FOS-like antigen 1 | 0.0342669 |
| SRP54 | signal recognition particle 54kDa | 0.0340757 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0336809 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0335804 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.033407 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.033223 |
| YEATS2 | YEATS domain containing 2 | 0.0331602 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0327999 |
| CDK19 | cyclin-dependent kinase 19 | 0.0326171 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0325923 |
| TPM1 | tropomyosin 1 (alpha) | 0.0322798 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0321547 |
| ATP13A3 | ATPase type 13A3 | 0.0319506 |
| ZNF148 | zinc finger protein 148 | 0.0314002 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.031109 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0310517 |
| TMF1 | TATA element modulatory factor 1 | 0.030861 |
| SEPTIN7 | septin 7 | 0.0308512 |
| TGM2 | transglutaminase 2 | 0.0307167 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0305671 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0305348 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0304915 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0303089 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0302393 |
| MYO1B | myosin IB | 0.0302119 |
| PKM | pyruvate kinase, muscle | 0.0301905 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.030079 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0300067 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0299976 |
| PCBP2 | poly(rC) binding protein 2 | 0.0297396 |
| RNF145 | ring finger protein 145 | 0.0294144 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0289716 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0287866 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0287281 |
| DOCK7 | dedicator of cytokinesis 7 | 0.0286815 |
| ARRDC3 | arrestin domain containing 3 | 0.0286371 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0285802 |
| MTSS1 | metastasis suppressor 1 | 0.0285276 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0284878 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.158242 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0829379 |
| FRMD4A | FERM domain containing 4A | -0.0703521 |
| VCL | vinculin | -0.0660205 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0629137 |
| EGR1 | early growth response 1 | -0.0608327 |
| HPCAL1 | hippocalcin-like 1 | -0.0606401 |
| CD44 | CD44 molecule (Indian blood group) | -0.0566601 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0543364 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0522373 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0504028 |
| TNNC1 | troponin C type 1 (slow) | -0.0499126 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0468604 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0448567 |
| FBXO11 | F-box protein 11 | -0.0443024 |
| HLA-B | major histocompatibility complex, class I, B | -0.0440363 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0433586 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0419492 |
| GLIS3 | GLIS family zinc finger 3 | -0.0404349 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0384085 |
| INTS6 | integrator complex subunit 6 | -0.0377325 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0369105 |
| COL5A3 | collagen, type V, alpha 3 | -0.0360304 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.03594 |
| HMGA2 | high mobility group AT-hook 2 | -0.0355085 |
| NF1 | neurofibromin 1 | -0.0345914 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0345392 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0336752 |
| ACTN1 | actinin, alpha 1 | -0.03342 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0333527 |
| SVIL | supervillin | -0.0333398 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.032881 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.032485 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0323569 |
| SMAD3 | SMAD family member 3 | -0.0323072 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0318448 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0310888 |
| ERBIN | erbb2 interacting protein | -0.0307486 |
| CCDC138 | coiled-coil domain containing 138 | -0.0302008 |
| SHISA5 | shisa family member 5 | -0.0293102 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0281892 |
| PAX3 | paired box 3 | -0.0281248 |
| TOP1 | topoisomerase (DNA) I | -0.0280493 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0277616 |
| HDLBP | high density lipoprotein binding protein | -0.0274963 |
| PHF14 | PHD finger protein 14 | -0.027266 |
| ZNF644 | zinc finger protein 644 | -0.0271916 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0271509 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.026735 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0264976 |
| GOLGB1 | golgin B1 | -0.0264637 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0264185 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0263069 |
| CDK13 | cyclin-dependent kinase 13 | -0.0261274 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0259075 |
| ARF1 | ADP-ribosylation factor 1 | -0.0257201 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.025597 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0255075 |
| FTL | ferritin, light polypeptide | -0.0251267 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0251025 |
| RSU1 | Ras suppressor protein 1 | -0.0250847 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0250806 |
| ATG7 | autophagy related 7 | -0.0249841 |
| FAM20C | family with sequence similarity 20, member C | -0.0245933 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0242473 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0240706 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0239054 |
| SETX | senataxin | -0.0236959 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0236341 |
| BPTF | bromodomain PHD finger transcription factor | -0.0232243 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0232171 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0230067 |
| FHL2 | four and a half LIM domains 2 | -0.0229919 |
| MAP1B | microtubule-associated protein 1B | -0.0228832 |
| HLA-C | major histocompatibility complex, class I, C | -0.0228572 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0227232 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0224264 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0223683 |
| AOPEP | aminopeptidase O (putative) | -0.0222614 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.022257 |
| PCBP3 | poly(rC) binding protein 3 | -0.0221143 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0220132 |
| GOLGA3 | golgin A3 | -0.0219807 |
| SCFD2 | sec1 family domain containing 2 | -0.0218748 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0218624 |
| NABP1 | nucleic acid binding protein 1 | -0.0215786 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0209577 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | -0.0208814 |
| GPATCH2L | G patch domain containing 2-like | -0.0206388 |
| RASA3 | RAS p21 protein activator 3 | -0.0203803 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0203633 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0203277 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0203179 |
| CCDC102B | coiled-coil domain containing 102B | -0.0202213 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0201962 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0201508 |
| COMMD10 | COMM domain containing 10 | -0.0201073 |
| KYNU | kynureninase | -0.0199825 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.019847 |
| AEBP2 | AE binding protein 2 | -0.0196894 |
