| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fostamatinib (disodium hexahydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.164432 |
| PTMA | prothymosin, alpha | 0.163373 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.089551 |
| PEG10 | paternally expressed 10 | 0.0707786 |
| CENPF | centromere protein F, 350/400kDa | 0.0699907 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0639216 |
| ZNF292 | zinc finger protein 292 | 0.0602519 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0508901 |
| CALCA | calcitonin-related polypeptide alpha | 0.0493441 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0481171 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.046152 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0457401 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0453613 |
| MIS18BP1 | MIS18 binding protein 1 | 0.04485 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0436554 |
| TENM1 | teneurin transmembrane protein 1 | 0.0431871 |
| NFIA | nuclear factor I/A | 0.0405526 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0395497 |
| RTN4 | reticulon 4 | 0.0394665 |
| H1-0 | H1.0 linker histone | 0.0393916 |
| XPO1 | exportin 1 | 0.0385784 |
| FTL | ferritin, light polypeptide | 0.0373007 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0372578 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0370442 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0360955 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.035482 |
| NUF2 | NUF2, NDC80 kinetochore complex component | 0.0351258 |
| MKI67 | marker of proliferation Ki-67 | 0.0340358 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.033442 |
| ENO1 | enolase 1, (alpha) | 0.0327271 |
| MATR3 | matrin 3 | 0.0320684 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0317722 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0316781 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0311728 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0309 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0308672 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0306163 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0304515 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0301987 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0296844 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0294805 |
| IRS2 | insulin receptor substrate 2 | 0.0294702 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0291513 |
| TPX2 | TPX2, microtubule-associated | 0.0283169 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0279475 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0273403 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0271183 |
| FAM13A | family with sequence similarity 13, member A | 0.0270817 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0270531 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0270095 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0269289 |
| ECT2 | epithelial cell transforming 2 | 0.0266477 |
| STMN1 | stathmin 1 | 0.0265838 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0260434 |
| RPS21 | ribosomal protein S21 | 0.0258923 |
| TPD52 | tumor protein D52 | 0.025677 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0255158 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0254595 |
| KANTR | KDM5C adjacent non-coding transcript | 0.0253553 |
| FOXN3 | forkhead box N3 | 0.0252898 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0250154 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0245602 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0238114 |
| CCDC88A | coiled-coil domain containing 88A | 0.0237023 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0236523 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0235561 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0235554 |
| MTMR7 | myotubularin related protein 7 | 0.0229924 |
| NCKAP1 | NCK-associated protein 1 | 0.0229606 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0228419 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0227161 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.022657 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | 0.0225116 |
| JAM3 | junctional adhesion molecule 3 | 0.0224712 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0223499 |
| PCM1 | pericentriolar material 1 | 0.022217 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0221132 |
| RPL6 | ribosomal protein L6 | 0.0219498 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.02188 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0217671 |
| RPS3 | ribosomal protein S3 | 0.0217491 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0216699 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0216359 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0215172 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0214813 |
| USP3 | ubiquitin specific peptidase 3 | 0.0214646 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0213189 |
| VGF | VGF nerve growth factor inducible | 0.0210278 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0209144 |
| PBK | PDZ binding kinase | 0.0209089 |
| KNL1 | kinetochore scaffold 1 | 0.0206445 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.0205752 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0203961 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0202411 |
| BBX | bobby sox homolog (Drosophila) | 0.0201907 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0201765 |
| RPL37A | ribosomal protein L37a | 0.02017 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0201295 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0200895 |
| CCNY | cyclin Y | 0.0198949 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.153857 |
| GPC6 | glypican 6 | -0.130083 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.125406 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.120659 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0897621 |
| RORA | RAR-related orphan receptor A | -0.0858379 |
| SNTG1 | syntrophin, gamma 1 | -0.0841949 |
| MCL1 | myeloid cell leukemia 1 | -0.0766644 |
| EGR1 | early growth response 1 | -0.0718149 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0710125 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0672184 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0667095 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0658172 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0649983 |
| EFNA5 | ephrin-A5 | -0.062188 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0606141 |
| KIF26B | kinesin family member 26B | -0.060166 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0600069 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0586342 |
| PTCHD4 | patched domain containing 4 | -0.0561389 |
| NBEA | neurobeachin | -0.0554817 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0553045 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0531887 |
| GPC5 | glypican 5 | -0.0509943 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0506631 |
| STC1 | stanniocalcin 1 | -0.0491575 |
| ESRRG | estrogen-related receptor gamma | -0.0488579 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0487606 |
| SMYD3 | SET and MYND domain containing 3 | -0.0475737 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0464341 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0460277 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0449807 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0449254 |
| SETX | senataxin | -0.0435451 |
| EPHA6 | EPH receptor A6 | -0.042789 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0419782 |
| KLHL29 | kelch-like family member 29 | -0.0415598 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0413298 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.0397889 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0395984 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0379458 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0378521 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0363974 |
| MYT1L | myelin transcription factor 1-like | -0.0361596 |
| NCKAP5 | NCK-associated protein 5 | -0.0361266 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0359565 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0347644 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0343752 |
| MAP1B | microtubule-associated protein 1B | -0.0341984 |
| NDRG1 | N-myc downstream regulated 1 | -0.0340413 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0329826 |
| TOP1 | topoisomerase (DNA) I | -0.0328615 |
| CNKSR3 | CNKSR family member 3 | -0.0325778 |
| SVIL | supervillin | -0.0322992 |
| TUSC3 | tumor suppressor candidate 3 | -0.0322778 |
| NELL1 | NEL-like 1 (chicken) | -0.0316263 |
| CDK13 | cyclin-dependent kinase 13 | -0.0315729 |
| NAV2 | neuron navigator 2 | -0.0312148 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0310741 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.03101 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0294502 |
| FGF14 | fibroblast growth factor 14 | -0.0287001 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.027433 |
| HM13 | histocompatibility (minor) 13 | -0.0272097 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0269321 |
| ZFHX3 | zinc finger homeobox 3 | -0.0268917 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0268646 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.026625 |
| ASPH | aspartate beta-hydroxylase | -0.0266188 |
| CHGB | chromogranin B | -0.0266153 |
| SCFD2 | sec1 family domain containing 2 | -0.0264663 |
| EGFR | epidermal growth factor receptor | -0.0261706 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0256594 |
| HOMER1 | homer scaffolding protein 1 | -0.025581 |
| GOLGB1 | golgin B1 | -0.0255794 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0254606 |
| CNTNAP2 | contactin associated protein-like 2 | -0.0250847 |
| GPATCH2L | G patch domain containing 2-like | -0.0249602 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0239327 |
| LSAMP | limbic system-associated membrane protein | -0.023914 |
| TOX | thymocyte selection-associated high mobility group box | -0.0237582 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0236697 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0236156 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0234279 |
| APP | amyloid beta (A4) precursor protein | -0.0234222 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0233586 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.0233168 |
| ATF6 | activating transcription factor 6 | -0.0232333 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0230296 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.022789 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0227541 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0224664 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0223398 |
| ZNF804A | zinc finger protein 804A | -0.0221421 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | -0.0214687 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0212645 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0212424 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -0.0208528 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0207918 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.020784 |
