Fostamatinib (disodium hexahydrate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.25908
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.159246
GOLGA4 golgin A4 0.130638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.114977
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.112081
ADAM10 ADAM metallopeptidase domain 10 0.111157
VCL vinculin 0.093402
ZNF292 zinc finger protein 292 0.0925664
PDE4B phosphodiesterase 4B, cAMP-specific 0.0850958
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0849735
TMSB4X thymosin beta 4, X-linked 0.0838063
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0815535
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0770568
PGK1 phosphoglycerate kinase 1 0.0764284
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0760277
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0737586
DSCAM Down syndrome cell adhesion molecule 0.0726152
EVI5 ecotropic viral integration site 5 0.0711389
NAMPT nicotinamide phosphoribosyltransferase 0.0684407
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0677105
RBM39 RNA binding motif protein 39 0.0653526
NAP1L1 nucleosome assembly protein 1-like 1 0.0636484
TXNIP thioredoxin interacting protein 0.060334
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0587465
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0581803
DLG1 discs, large homolog 1 (Drosophila) 0.0580981
KDM3A lysine (K)-specific demethylase 3A 0.0577694
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0568827
SET SET nuclear proto-oncogene 0.0553398
KMT2E lysine (K)-specific methyltransferase 2E 0.0541288
ZEB1 zinc finger E-box binding homeobox 1 0.0526144
WSB1 WD repeat and SOCS box containing 1 0.052361
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0510777
OGA O-GlcNAcase 0.0500708
XPO1 exportin 1 0.049926
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0494617
CAMTA1 calmodulin binding transcription activator 1 0.0486749
CDC73 cell division cycle 73 0.0483641
RPS2 ribosomal protein S2 0.047434
WAC WW domain containing adaptor with coiled-coil 0.0472029
NUP58 nucleoporin 58 0.0470945
RAB6A RAB6A, member RAS oncogene family 0.0468908
EML4 echinoderm microtubule associated protein like 4 0.0465542
FLNB filamin B, beta 0.0463751
SSBP2 single-stranded DNA binding protein 2 0.046329
RTN4 reticulon 4 0.0459177
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0457447
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0454464
RNF145 ring finger protein 145 0.0449999
BIRC6 baculoviral IAP repeat containing 6 0.0448802
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0448696
NCKAP1 NCK-associated protein 1 0.04436
PNISR PNN-interacting serine/arginine-rich protein 0.0437497
SMNDC1 survival motor neuron domain containing 1 0.0437136
QKI QKI, KH domain containing, RNA binding 0.0435382
NBAS neuroblastoma amplified sequence 0.0434711
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0434616
LPP LIM domain containing preferred translocation partner in lipoma 0.0432746
PUM2 pumilio RNA-binding family member 2 0.043102
MATR3 matrin 3 0.0428112
LDHA lactate dehydrogenase A 0.042308
COG5 component of oligomeric golgi complex 5 0.0420353
YME1L1 YME1-like 1 ATPase 0.0419775
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0414529
GARS1 glycyl-tRNA synthetase 1 0.0412124
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0409342
SETD5 SET domain containing 5 0.0408337
HDAC9 histone deacetylase 9 0.0408271
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0407483
NFIA nuclear factor I/A 0.0404839
UBA6 ubiquitin-like modifier activating enzyme 6 0.0404825
TGFBR3 transforming growth factor, beta receptor III 0.040216
JMJD1C jumonji domain containing 1C 0.0396156
TMEM65 transmembrane protein 65 0.0394321
EIF4A2 eukaryotic translation initiation factor 4A2 0.0392886
ZMYM2 zinc finger, MYM-type 2 0.0391536
TJP1 tight junction protein 1 0.0387891
TOP2B topoisomerase (DNA) II beta 180kDa 0.0385775
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0382514
SBF2 SET binding factor 2 0.0379401
TMEM41B transmembrane protein 41B 0.0375781
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0369704
AHNAK AHNAK nucleoprotein 0.0369365
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0365472
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0363819
BRWD1 bromodomain and WD repeat domain containing 1 0.035907
RLF rearranged L-myc fusion 0.0358856
FAM13A family with sequence similarity 13, member A 0.0354179
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0354088
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0352295
PDIA3 protein disulfide isomerase family A, member 3 0.0351517
MXI1 MAX interactor 1, dimerization protein 0.0349181
CSDE1 cold shock domain containing E1, RNA-binding 0.0348129
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0346006
GPBP1 GC-rich promoter binding protein 1 0.0345093
ELP2 elongator acetyltransferase complex subunit 2 0.0339341
FXR1 fragile X mental retardation, autosomal homolog 1 0.0339303
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0339188
RAD21 RAD21 homolog (S. pombe) 0.0337528
ZFAND3 zinc finger, AN1-type domain 3 0.0335194

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.118587
PDE4D phosphodiesterase 4D, cAMP-specific -0.0527718
BMP10 bone morphogenetic protein 10 -0.0518842
GLI3 GLI family zinc finger 3 -0.0432038
TMSB10 thymosin beta 10 -0.0394609
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0355803
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0340805
ZMYND8 zinc finger, MYND-type containing 8 -0.0329769
GSE1 Gse1 coiled-coil protein -0.0326186
GLI2 GLI family zinc finger 2 -0.0319548
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.03184
CCND1 cyclin D1 -0.0314024
ENO2 enolase 2 (gamma, neuronal) -0.0309319
PKM pyruvate kinase, muscle -0.0305139
EGFR epidermal growth factor receptor -0.0291311
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0277043
NAV2 neuron navigator 2 -0.0245376
PRUNE2 prune homolog 2 (Drosophila) -0.0242138
RPS13 ribosomal protein S13 -0.0238593
HEG1 heart development protein with EGF-like domains 1 -0.0235256
INTS6 integrator complex subunit 6 -0.0234692
TUBB4B tubulin, beta 4B class IVb -0.0227625
IFI16 interferon, gamma-inducible protein 16 -0.0225875
SPRY4 sprouty homolog 4 (Drosophila) -0.0223489
RPL35A ribosomal protein L35a -0.0211468
ARHGAP25 Rho GTPase activating protein 25 -0.0211144
FER1L6 fer-1-like family member 6 -0.0210867
MYO5C myosin VC -0.0209781
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0205971
PDE7B phosphodiesterase 7B -0.020409
PKP4 plakophilin 4 -0.0199395
PRH1 proline-rich protein HaeIII subfamily 1 -0.0194071
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0190293
BRD2 bromodomain containing 2 -0.0187917
RPL38 ribosomal protein L38 -0.0186772
ZNF438 zinc finger protein 438 -0.0184862
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0183672
PFN1 profilin 1 -0.0183033
RPL28 ribosomal protein L28 -0.0182074
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0174322
TBCA tubulin folding cofactor A -0.0173525
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0170709
RPS15 ribosomal protein S15 -0.0169904
BICD1 bicaudal D homolog 1 (Drosophila) -0.016945
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -0.0168611
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0167339
GCLM glutamate-cysteine ligase, modifier subunit -0.0166595
LENG8 leukocyte receptor cluster (LRC) member 8 -0.0165936
RPS19 ribosomal protein S19 -0.0165717
RPS23 ribosomal protein S23 -0.0164708
EEF2 eukaryotic translation elongation factor 2 -0.0163875
RPLP1 ribosomal protein, large, P1 -0.0163795
PRDX2 peroxiredoxin 2 -0.0160184
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0159678
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0159285
LOC112694756 uncharaterized LOC112694756 -0.0157819
SP100 SP100 nuclear antigen -0.0157421
FBLN2 fibulin 2 -0.0156779
ACTG1 actin gamma 1 -0.0152657
DUSP4 dual specificity phosphatase 4 -0.0152622
STAU2 staufen double-stranded RNA binding protein 2 -0.0151322
RPS21 ribosomal protein S21 -0.0150333
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0148926
CEP112 centrosomal protein 112kDa -0.0145896
RPS11 ribosomal protein S11 -0.0145232
COMMD10 COMM domain containing 10 -0.0141608
SOGA1 suppressor of glucose, autophagy associated 1 -0.014068
RPL13A ribosomal protein L13a -0.0138555
PRDX1 peroxiredoxin 1 -0.0138273
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0137421
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0136313
RPL36 ribosomal protein L36 -0.013584
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.013497
RPL8 ribosomal protein L8 -0.0133258
RPL23 ribosomal protein L23 -0.0131866
LRP10 low density lipoprotein receptor-related protein 10 -0.0131657
S100A9 S100 calcium binding protein A9 -0.0130837
TAPBP TAP binding protein (tapasin) -0.0130481
PHACTR2 phosphatase and actin regulator 2 -0.0130024
APLF aprataxin and PNKP like factor -0.0128801
NKD1 naked cuticle homolog 1 (Drosophila) -0.0127963
SEPTIN9 septin 9 -0.0127784
CMIP c-Maf inducing protein -0.0125666
PLSCR1 phospholipid scramblase 1 -0.0124793
BSG basigin (Ok blood group) -0.0124314
DHFR dihydrofolate reductase -0.0124196
IARS1 isoleucyl-tRNA synthetase 1 -0.012384
SSBP3 single stranded DNA binding protein 3 -0.0122314
ACYP2 acylphosphatase 2, muscle type -0.012225
TUBA1B tubulin, alpha 1b -0.0122246
WNK1 WNK lysine deficient protein kinase 1 -0.0122074
MLIP muscular LMNA-interacting protein -0.0120669
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0120082
RPS16 ribosomal protein S16 -0.011856
ATG7 autophagy related 7 -0.0117919
YLPM1 YLP motif containing 1 -0.0117646
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0117457
IFITM3 interferon induced transmembrane protein 3 -0.0116488
RPL32 ribosomal protein L32 -0.0115654
MYO9A myosin IXA -0.0114158