Fostamatinib (disodium hexahydrate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.188323
PTMA prothymosin, alpha 0.14789
HILPDA hypoxia inducible lipid droplet-associated 0.117128
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.115157
RBM39 RNA binding motif protein 39 0.111387
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.105509
WAC WW domain containing adaptor with coiled-coil 0.102029
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0875393
GOLGA4 golgin A4 0.0842752
CANX calnexin 0.0835817
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0763925
NUP58 nucleoporin 58 0.0715558
TPT1 tumor protein, translationally-controlled 1 0.068343
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0678744
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0674479
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0614288
FMNL2 formin-like 2 0.0611979
RPS12 ribosomal protein S12 0.0582252
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0552457
DERA deoxyribose-phosphate aldolase (putative) 0.0537682
RPL37A ribosomal protein L37a 0.0524201
NAP1L1 nucleosome assembly protein 1-like 1 0.0519125
SETD5 SET domain containing 5 0.0518759
RPS6 ribosomal protein S6 0.0511135
EIF1 eukaryotic translation initiation factor 1 0.050953
PHF20 PHD finger protein 20 0.0508721
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0508275
YAP1 Yes-associated protein 1 0.0508226
PUM2 pumilio RNA-binding family member 2 0.0501601
PHIP pleckstrin homology domain interacting protein 0.0501128
NKTR natural killer cell triggering receptor 0.0495129
RPL9 ribosomal protein L9 0.0492758
RPL26 ribosomal protein L26 0.0486683
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.048296
RPS23 ribosomal protein S23 0.0479459
ITSN2 intersectin 2 0.0462543
TPD52 tumor protein D52 0.046215
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.046147
FAM13A family with sequence similarity 13, member A 0.0458545
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0457141
ZNF292 zinc finger protein 292 0.0447048
DTNA dystrobrevin, alpha 0.0443735
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0440229
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0439783
RPL7A ribosomal protein L7a 0.0436935
PRRC2C proline-rich coiled-coil 2C 0.0434332
ZFR zinc finger RNA binding protein 0.0433898
ESYT2 extended synaptotagmin-like protein 2 0.043118
BIRC2 baculoviral IAP repeat containing 2 0.0431019
PNISR PNN-interacting serine/arginine-rich protein 0.0428612
KTN1 kinectin 1 (kinesin receptor) 0.0427188
SEPTIN7 septin 7 0.0426239
RAB5A RAB5A, member RAS oncogene family 0.0425421
RDX radixin 0.0424503
RPS17 ribosomal protein S17 0.0422436
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0421465
TPR translocated promoter region, nuclear basket protein 0.042092
RPL23 ribosomal protein L23 0.0420774
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0418871
SNX3 sorting nexin 3 0.0416132
SRP54 signal recognition particle 54kDa 0.0415085
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0409348
DLG1 discs, large homolog 1 (Drosophila) 0.0405912
RRBP1 ribosome binding protein 1 0.0405439
RPLP0 ribosomal protein, large, P0 0.0405156
SNX14 sorting nexin 14 0.0402436
RPS27A ribosomal protein S27a 0.0401154
SEC24A SEC24 family member A 0.0400719
MT2A metallothionein 2A 0.0399224
RPLP1 ribosomal protein, large, P1 0.0393168
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0388163
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0387487
OGA O-GlcNAcase 0.0386042
MARCHF6 membrane associated ring-CH-type finger 6 0.0379597
B2M beta-2-microglobulin 0.0377947
RPL12 ribosomal protein L12 0.0376713
ZFAND3 zinc finger, AN1-type domain 3 0.0376075
PGK1 phosphoglycerate kinase 1 0.0374817
LDHA lactate dehydrogenase A 0.0374796
WSB1 WD repeat and SOCS box containing 1 0.0374131
RPS8 ribosomal protein S8 0.0372849
RPS3 ribosomal protein S3 0.0370974
NIPBL Nipped-B homolog (Drosophila) 0.036868
NAMPT nicotinamide phosphoribosyltransferase 0.0363013
GNAS GNAS complex locus 0.0362774
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0358446
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0358244
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0356574
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.035468
RPL32 ribosomal protein L32 0.0352959
RAB1A RAB1A, member RAS oncogene family 0.0350948
RPS29 ribosomal protein S29 0.0347498
ANKRD17 ankyrin repeat domain 17 0.0347164
KMT2E lysine (K)-specific methyltransferase 2E 0.0339853
NBAS neuroblastoma amplified sequence 0.0337745
CCNI cyclin I 0.033556
MAP2K1 mitogen-activated protein kinase kinase 1 0.0335068
HIPK2 homeodomain interacting protein kinase 2 0.0334121
RPL34 ribosomal protein L34 0.0333882
UBAC2 UBA domain containing 2 0.0329592

decreased expression

Symbol Name Standardized Value
OSMR oncostatin M receptor -0.0907352
NCEH1 neutral cholesterol ester hydrolase 1 -0.072233
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0710076
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0528345
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0524865
DNER delta/notch-like EGF repeat containing -0.0524719
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0494857
VCL vinculin -0.0490638
FBXL7 F-box and leucine-rich repeat protein 7 -0.0485864
SIK2 salt-inducible kinase 2 -0.0465985
LOC112694756 uncharaterized LOC112694756 -0.0419071
EGR1 early growth response 1 -0.0404657
BPTF bromodomain PHD finger transcription factor -0.0370421
SETX senataxin -0.036686
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0364118
BICD1 bicaudal D homolog 1 (Drosophila) -0.0363327
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0342817
MBNL1 muscleblind-like splicing regulator 1 -0.0341779
HJURP Holliday junction recognition protein -0.03417
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0338997
WWC1 WW and C2 domain containing 1 -0.0333039
NALCN sodium leak channel, non selective -0.0325625
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.032047
VMP1 vacuole membrane protein 1 -0.0319653
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0317186
MACF1 microtubule-actin crosslinking factor 1 -0.0315079
PCNX4 pecanex 4 -0.0307772
EFL1 elongation factor like GTPase 1 -0.0306
THSD4 thrombospondin, type I, domain containing 4 -0.0299825
HMGA2 high mobility group AT-hook 2 -0.029875
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0297958
PRH1 proline-rich protein HaeIII subfamily 1 -0.0290581
BCAR3 breast cancer anti-estrogen resistance 3 -0.0288892
WNK1 WNK lysine deficient protein kinase 1 -0.0287605
MCL1 myeloid cell leukemia 1 -0.0285592
RAB28 RAB28, member RAS oncogene family -0.0285383
BCAS3 breast carcinoma amplified sequence 3 -0.02737
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0271946
SMAD3 SMAD family member 3 -0.0271789
ATN1 atrophin 1 -0.0270341
TRAPPC9 trafficking protein particle complex 9 -0.0268618
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0267977
ELL2 elongation factor, RNA polymerase II, 2 -0.0267027
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0264401
SMAD2 SMAD family member 2 -0.0262863
MKI67 marker of proliferation Ki-67 -0.0260687
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0260186
GLCCI1 glucocorticoid induced 1 -0.026017
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.025992
CD163L1 CD163 molecule-like 1 -0.0259483
FAM120B family with sequence similarity 120B -0.0257132
SLC35F3 solute carrier family 35, member F3 -0.02565
NLK nemo-like kinase -0.0255775
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0254109
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0249217
ETV6 ets variant 6 -0.0248948
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0244848
SPRY4 sprouty homolog 4 (Drosophila) -0.0242517
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0242507
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0242288
MCC mutated in colorectal cancers -0.0240566
GOLGB1 golgin B1 -0.0240094
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0237094
IL31RA interleukin 31 receptor A -0.0233788
VRK1 vaccinia related kinase 1 -0.0233557
MBNL2 muscleblind-like splicing regulator 2 -0.0230628
FER fer (fps/fes related) tyrosine kinase -0.0227484
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0227237
COMMD10 COMM domain containing 10 -0.0225411
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0225242
INTS6 integrator complex subunit 6 -0.0225028
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.022414
SVIL supervillin -0.022401
TAPBP TAP binding protein (tapasin) -0.0223096
AOPEP aminopeptidase O (putative) -0.0222791
FBXL17 F-box and leucine-rich repeat protein 17 -0.0222058
STK38L serine/threonine kinase 38 like -0.0222032
DOCK1 dedicator of cytokinesis 1 -0.0221083
RIN2 Ras and Rab interactor 2 -0.0220763
STRN3 striatin, calmodulin binding protein 3 -0.0220497
BBX bobby sox homolog (Drosophila) -0.0219551
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0218252
ANKRD28 ankyrin repeat domain 28 -0.0215544
ZFP91 ZFP91 zinc finger protein -0.0213454
ATXN7L1 ataxin 7-like 1 -0.0211468
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0211407
ARHGAP18 Rho GTPase activating protein 18 -0.021088
RHEB Ras homolog enriched in brain -0.0210865
TNRC18 trinucleotide repeat containing 18 -0.0207779
DOCK9 dedicator of cytokinesis 9 -0.020685
NCOR2 nuclear receptor corepressor 2 -0.0206616
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.020613
TAOK3 TAO kinase 3 -0.0205624
HIPK3 homeodomain interacting protein kinase 3 -0.0205602
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -0.0204718
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.0204195
RNF169 ring finger protein 169 -0.0203541
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0202727
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0200447
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0200004