Fostamatinib (disodium hexahydrate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.230639
AREG amphiregulin 0.157438
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.104411
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.103818
ANXA1 annexin A1 0.0863317
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0823646
CD36 CD36 molecule (thrombospondin receptor) 0.0784642
RPS12 ribosomal protein S12 0.0759512
RPS6 ribosomal protein S6 0.0755153
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0706535
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0673346
EIF1 eukaryotic translation initiation factor 1 0.0666605
NAP1L1 nucleosome assembly protein 1-like 1 0.0652433
RPS3 ribosomal protein S3 0.0609392
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0603697
RPL12 ribosomal protein L12 0.0601876
FLOT1 flotillin 1 0.0599575
IER3 immediate early response 3 0.0581812
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0548504
EREG epiregulin 0.0540834
RPS2 ribosomal protein S2 0.0535091
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0530789
RPLP1 ribosomal protein, large, P1 0.0504327
TPT1 tumor protein, translationally-controlled 1 0.0503042
OXR1 oxidation resistance 1 0.0496507
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0489302
GOLGA4 golgin A4 0.0488302
RPL26 ribosomal protein L26 0.0486163
DDIT4 DNA-damage-inducible transcript 4 0.0486026
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.047365
TMSB10 thymosin beta 10 0.0471064
RPL18 ribosomal protein L18 0.0464913
RAB1A RAB1A, member RAS oncogene family 0.0459826
RPS8 ribosomal protein S8 0.0459208
ZFP36L1 ZFP36 ring finger protein-like 1 0.0439769
PDE4B phosphodiesterase 4B, cAMP-specific 0.0390941
RPS29 ribosomal protein S29 0.0390408
HILPDA hypoxia inducible lipid droplet-associated 0.0389058
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.0386778
PNISR PNN-interacting serine/arginine-rich protein 0.0383839
RPL11 ribosomal protein L11 0.0378618
PRRC2C proline-rich coiled-coil 2C 0.0366459
PGK1 phosphoglycerate kinase 1 0.0364213
OGA O-GlcNAcase 0.0359411
SLMAP sarcolemma associated protein 0.0358546
KTN1 kinectin 1 (kinesin receptor) 0.0357421
RPS19 ribosomal protein S19 0.0348691
RPS13 ribosomal protein S13 0.0340279
SQSTM1 sequestosome 1 0.0337323
KDM3A lysine (K)-specific demethylase 3A 0.0330638
RSRC2 arginine/serine-rich coiled-coil 2 0.0329885
KMT2E lysine (K)-specific methyltransferase 2E 0.0329273
RPL31 ribosomal protein L31 0.032564
NAMPT nicotinamide phosphoribosyltransferase 0.032463
RPL37A ribosomal protein L37a 0.0318244
SFXN1 sideroflexin 1 0.0314431
GDF15 growth differentiation factor 15 0.031122
RPL34 ribosomal protein L34 0.0309057
RNF145 ring finger protein 145 0.0307509
GARS1 glycyl-tRNA synthetase 1 0.0307364
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0304725
MXI1 MAX interactor 1, dimerization protein 0.0301692
BRWD1 bromodomain and WD repeat domain containing 1 0.0301555
KMT2C lysine (K)-specific methyltransferase 2C 0.0298947
ARRDC3 arrestin domain containing 3 0.0297948
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0297227
CDC73 cell division cycle 73 0.0297155
MT2A metallothionein 2A 0.0294622
RPL19 ribosomal protein L19 0.0294186
USP53 ubiquitin specific peptidase 53 0.0293619
LDHA lactate dehydrogenase A 0.0291897
RPL32 ribosomal protein L32 0.0291262
ACBD3 acyl-CoA binding domain containing 3 0.0288367
ELP2 elongator acetyltransferase complex subunit 2 0.0286752
MIS18BP1 MIS18 binding protein 1 0.0283875
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0282891
FXR1 fragile X mental retardation, autosomal homolog 1 0.0282377
MTDH metadherin 0.0280771
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0276902
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0273975
SET SET nuclear proto-oncogene 0.0272598
TRA2A transformer 2 alpha homolog (Drosophila) 0.027225
RPS27A ribosomal protein S27a 0.026695
BIRC3 baculoviral IAP repeat containing 3 0.0266721
KLF5 Kruppel-like factor 5 (intestinal) 0.026215
ZNF292 zinc finger protein 292 0.026208
RPL37 ribosomal protein L37 0.0259898
PUM2 pumilio RNA-binding family member 2 0.0256758
RAB6A RAB6A, member RAS oncogene family 0.0256482
RACK1 receptor for activated C kinase 1 0.0256456
RPS17 ribosomal protein S17 0.0255882
ENO1 enolase 1, (alpha) 0.0255858
RPS25 ribosomal protein S25 0.025343
RPL36 ribosomal protein L36 0.0250999
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0247413
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0246763
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0242903
RPL9 ribosomal protein L9 0.0241368
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0240881
SNX6 sorting nexin 6 0.0239017

decreased expression

Symbol Name Standardized Value
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.149135
EGR1 early growth response 1 -0.131598
HMGA2 high mobility group AT-hook 2 -0.119334
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0936868
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.09368
RAD51B RAD51 paralog B -0.0892716
EGFR epidermal growth factor receptor -0.0837315
LAMA4 laminin, alpha 4 -0.0705078
RCOR1 REST corepressor 1 -0.0643414
LMO7 LIM domain 7 -0.0608516
VCL vinculin -0.0519385
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0508551
ITPKC inositol-trisphosphate 3-kinase C -0.0494049
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0481521
LAMC2 laminin, gamma 2 -0.0475386
AKAP13 A kinase (PRKA) anchor protein 13 -0.0472232
JARID2 jumonji, AT rich interactive domain 2 -0.0464335
HMGA1 high mobility group AT-hook 1 -0.045563
NTSR1 neurotensin receptor 1 (high affinity) -0.0421108
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0419205
YAP1 Yes-associated protein 1 -0.0409439
BCL2L1 BCL2-like 1 -0.0404121
DOCK5 dedicator of cytokinesis 5 -0.0395927
LOC112694756 uncharaterized LOC112694756 -0.0387827
SPATA13 spermatogenesis associated 13 -0.0386624
ZNRF3 zinc and ring finger 3 -0.0374883
FERMT1 fermitin family member 1 -0.0366595
ATXN1 ataxin 1 -0.0363134
FHL2 four and a half LIM domains 2 -0.0358418
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0358217
MPRIP myosin phosphatase Rho interacting protein -0.0355357
FHIT fragile histidine triad -0.0350607
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0334946
ITGB4 integrin, beta 4 -0.0334146
TNS3 tensin 3 -0.033163
FAT1 FAT atypical cadherin 1 -0.0331252
EPHA2 EPH receptor A2 -0.0327451
EEF2 eukaryotic translation elongation factor 2 -0.0325616
ACTN4 actinin, alpha 4 -0.0323838
SEPTIN9 septin 9 -0.0308375
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0301302
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0300146
CMIP c-Maf inducing protein -0.0295593
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.029541
PRRC2B proline-rich coiled-coil 2B -0.029434
HDAC4 histone deacetylase 4 -0.0287836
KRT8 keratin 8, type II -0.0286892
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0286433
PATJ PATJ crumbs cell polarity complex component -0.0284809
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0279656
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0278804
NIBAN2 niban apoptosis regulator 2 -0.0278572
SKAP1 src kinase associated phosphoprotein 1 -0.0276116
ZBTB7C zinc finger and BTB domain containing 7C -0.0275272
OSBPL10 oxysterol binding protein-like 10 -0.0270497
FAF1 Fas (TNFRSF6) associated factor 1 -0.0270296
DUSP4 dual specificity phosphatase 4 -0.0269141
ANXA11 annexin A11 -0.0267373
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0267142
MKI67 marker of proliferation Ki-67 -0.0263987
GATAD2A GATA zinc finger domain containing 2A -0.0263445
EXOC4 exocyst complex component 4 -0.0254528
LOC102724023 ES1 protein homolog, mitochondrial -0.0252958
SRRM2 serine/arginine repetitive matrix 2 -0.024892
EVA1C eva-1 homolog C (C. elegans) -0.0248031
GPHN gephyrin -0.0247699
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0247099
FTH1 ferritin, heavy polypeptide 1 -0.0245385
IGSF9B immunoglobulin superfamily, member 9B -0.024419
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0243025
SMAD3 SMAD family member 3 -0.0242375
KRT18 keratin 18, type I -0.0241609
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0238993
THSD4 thrombospondin, type I, domain containing 4 -0.0237248
WARS1 tryptophanyl-tRNA synthetase 1 -0.0236846
BICD1 bicaudal D homolog 1 (Drosophila) -0.0235815
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0235015
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0233828
AGO2 argonaute RISC catalytic component 2 -0.023131
NCEH1 neutral cholesterol ester hydrolase 1 -0.0230654
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.023049
IARS1 isoleucyl-tRNA synthetase 1 -0.022945
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0227404
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0225266
PTEN phosphatase and tensin homolog -0.0221538
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0216957
TRRAP transformation/transcription domain-associated protein -0.0216781
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0216075
EFNB2 ephrin-B2 -0.0215474
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0213394
SNX9 sorting nexin 9 -0.0209655
KIAA0040 KIAA0040 -0.0209442
MAML3 mastermind-like 3 (Drosophila) -0.0208931
PARD3B par-3 family cell polarity regulator beta -0.0207973
MTUS1 microtubule associated tumor suppressor 1 -0.0206277
TXNRD1 thioredoxin reductase 1 -0.0204421
PTPRG protein tyrosine phosphatase, receptor type, G -0.0203629
SH3RF2 SH3 domain containing ring finger 2 -0.0203558
ABR active BCR-related -0.0203268
TENM3 teneurin transmembrane protein 3 -0.0203156