Fostamatinib (disodium hexahydrate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fostamatinib (disodium hexahydrate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fostamatinib (disodium hexahydrate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DIAPH3 diaphanous-related formin 3 0.0434446
ESYT2 extended synaptotagmin-like protein 2 0.0404943
BRWD3 bromodomain and WD repeat domain containing 3 0.0404122
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0367846
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0364893
ETNK1 ethanolamine kinase 1 0.0348265
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0346151
CD46 CD46 molecule, complement regulatory protein 0.0344024
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0339945
H1-4 H1.4 linker histone, cluster member 0.0338617
ABHD2 abhydrolase domain containing 2 0.0337135
ZNF292 zinc finger protein 292 0.0332277
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0326954
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0319013
HELZ helicase with zinc finger 0.0296359
SBF2 SET binding factor 2 0.0282964
FANCI Fanconi anemia, complementation group I 0.0278523
PRELID2 PRELI domain containing 2 0.0278288
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0275854
RUNX1 runt-related transcription factor 1 0.025948
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0255502
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.025178
AOPEP aminopeptidase O (putative) 0.0251379
WDFY2 WD repeat and FYVE domain containing 2 0.0248585
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0245021
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.024486
KIZ kizuna centrosomal protein 0.024176
OGA O-GlcNAcase 0.0234441
OXR1 oxidation resistance 1 0.0219459
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0215153
SETD5 SET domain containing 5 0.021141
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0209569
MBD5 methyl-CpG binding domain protein 5 0.0207028
PCLO piccolo presynaptic cytomatrix protein 0.0203907
RBM26 RNA binding motif protein 26 0.0203475
VGLL4 vestigial-like family member 4 0.0202866
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0199464
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0199222
ANKRD36 ankyrin repeat domain 36 0.01946
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0193225
CCDC82 coiled-coil domain containing 82 0.0192297
PDE8A phosphodiesterase 8A 0.019174
CTTN cortactin 0.0190975
THOC2 THO complex 2 0.0187959
UBA6 ubiquitin-like modifier activating enzyme 6 0.0185234
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0184847
USP3 ubiquitin specific peptidase 3 0.018367
MIS18BP1 MIS18 binding protein 1 0.0182125
YEATS2 YEATS domain containing 2 0.0179825
PCBP2 poly(rC) binding protein 2 0.017808
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.0176598
TMF1 TATA element modulatory factor 1 0.0176049
BRWD1 bromodomain and WD repeat domain containing 1 0.0176039
GCC2 GRIP and coiled-coil domain containing 2 0.0172464
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0170761
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0170618
ZFR zinc finger RNA binding protein 0.0169899
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0169296
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.01689
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0167874
RICTOR RPTOR independent companion of MTOR, complex 2 0.0166325
EXOC1 exocyst complex component 1 0.0165937
AFDN afadin, adherens junction formation factor 0.0163225
RFWD3 ring finger and WD repeat domain 3 0.016259
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.016204
FKBP9 FK506 binding protein 9, 63 kDa 0.0161716
FANCL Fanconi anemia, complementation group L 0.015887
KIF18A kinesin family member 18A 0.0158757
HP1BP3 heterochromatin protein 1, binding protein 3 0.0158693
SFXN1 sideroflexin 1 0.0158135
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0157474
APOLD1 apolipoprotein L domain containing 1 0.0157194
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0156709
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0156522
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0153486
SKAP2 src kinase associated phosphoprotein 2 0.0150435
TOX3 TOX high mobility group box family member 3 0.0150155
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0149738
UBAC2 UBA domain containing 2 0.0149091
MAPK14 mitogen-activated protein kinase 14 0.0148907
KMT2C lysine (K)-specific methyltransferase 2C 0.0147809
STK38 serine/threonine kinase 38 0.0146344
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0145023
POM121 POM121 transmembrane nucleoporin 0.014494
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0144861
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0143223
CEMIP cell migration inducing protein, hyaluronan binding 0.0142659
MYH10 myosin, heavy chain 10, non-muscle 0.0141692
SRP54 signal recognition particle 54kDa 0.0140701
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0140597
METTL15 methyltransferase like 15 0.0140398
CEP95 centrosomal protein 95kDa 0.0139824
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0139769
SPRED2 sprouty-related, EVH1 domain containing 2 0.0139334
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0139301
PTBP2 polypyrimidine tract binding protein 2 0.0138897
CEMIP2 cell migration inducing hyaluronidase 2 0.0138016
LRP5 low density lipoprotein receptor-related protein 5 0.0136334
KIF4A kinesin family member 4A 0.0135906
NDE1 nudE neurodevelopment protein 1 0.0134027

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.228856
TPT1 tumor protein, translationally-controlled 1 -0.141788
RPL35A ribosomal protein L35a -0.13854
NKD1 naked cuticle homolog 1 (Drosophila) -0.132945
VCL vinculin -0.130167
TMSB10 thymosin beta 10 -0.114608
RPS6 ribosomal protein S6 -0.112858
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111651
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.109914
LDHA lactate dehydrogenase A -0.109523
PTMA prothymosin, alpha -0.105463
CCND1 cyclin D1 -0.103394
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.101016
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0925377
EZR ezrin -0.0924534
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0891346
RPL23 ribosomal protein L23 -0.0817589
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0810785
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0802365
INTS6 integrator complex subunit 6 -0.0729191
RPS24 ribosomal protein S24 -0.0721183
AHNAK AHNAK nucleoprotein -0.0690927
CDH13 cadherin 13 -0.0686716
EGR1 early growth response 1 -0.0686405
SLC38A2 solute carrier family 38, member 2 -0.0661627
AKAP12 A kinase (PRKA) anchor protein 12 -0.0659146
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0646778
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0643139
ANXA2 annexin A2 -0.0592439
RPLP1 ribosomal protein, large, P1 -0.058859
TPM4 tropomyosin 4 -0.0586089
MRPS6 mitochondrial ribosomal protein S6 -0.0577719
RPL31 ribosomal protein L31 -0.0570357
RPS8 ribosomal protein S8 -0.0566864
KRT18 keratin 18, type I -0.0565255
CDK6 cyclin-dependent kinase 6 -0.0553402
RPL26 ribosomal protein L26 -0.0546015
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0535266
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0533551
FTL ferritin, light polypeptide -0.0501889
PKM pyruvate kinase, muscle -0.0498153
ANO1 anoctamin 1, calcium activated chloride channel -0.0489817
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0487179
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0485049
RPLP0 ribosomal protein, large, P0 -0.0474923
S100A10 S100 calcium binding protein A10 -0.0473254
LOC102724023 ES1 protein homolog, mitochondrial -0.0469708
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.046939
HMGA1 high mobility group AT-hook 1 -0.0468626
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0466211
YBX1 Y box binding protein 1 -0.0463863
TMSB4X thymosin beta 4, X-linked -0.045041
RPS19 ribosomal protein S19 -0.0447875
RPL12 ribosomal protein L12 -0.0443358
CANX calnexin -0.044255
KRT8 keratin 8, type II -0.0434885
MT2A metallothionein 2A -0.0426763
SDK1 sidekick cell adhesion molecule 1 -0.0423619
VIM vimentin -0.0422091
ENO1 enolase 1, (alpha) -0.0415917
UBAP2 ubiquitin associated protein 2 -0.0415439
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.040999
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0409543
RPL27A ribosomal protein L27a -0.0406943
RBP1 retinol binding protein 1, cellular -0.0399384
RPS13 ribosomal protein S13 -0.0399074
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0393847
LOC112694756 uncharaterized LOC112694756 -0.0393548
ASPH aspartate beta-hydroxylase -0.039199
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0377645
RPL11 ribosomal protein L11 -0.0373353
RPS25 ribosomal protein S25 -0.0370842
RPL38 ribosomal protein L38 -0.0369242
RPL5 ribosomal protein L5 -0.0364776
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0364311
TUBA1B tubulin, alpha 1b -0.0362707
CBX3 chromobox homolog 3 -0.0362438
HSPA8 heat shock 70kDa protein 8 -0.0361885
SPDYA speedy/RINGO cell cycle regulator family member A -0.0359627
KPNB1 karyopherin (importin) beta 1 -0.0355602
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0354189
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0353887
POTEF POTE ankyrin domain family, member F -0.0352615
EMP1 epithelial membrane protein 1 -0.0352212
EIF1 eukaryotic translation initiation factor 1 -0.0351622
RPL37 ribosomal protein L37 -0.0351474
S100A6 S100 calcium binding protein A6 -0.0348591
ANXA3 annexin A3 -0.0348382
RPL19 ribosomal protein L19 -0.03481
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0347152
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0340815
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0338758
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0338749
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0338143
TPI1 triosephosphate isomerase 1 -0.0336307
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0334631
IARS1 isoleucyl-tRNA synthetase 1 -0.0330966
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0328145
SQSTM1 sequestosome 1 -0.0327635
GMDS GDP-mannose 4,6-dehydratase -0.0325223