Fulvestrant_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fulvestrant perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fulvestrant_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.182764
AKAP12 A kinase (PRKA) anchor protein 12 0.148705
PLAT plasminogen activator, tissue 0.138964
TRIO trio Rho guanine nucleotide exchange factor 0.128921
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.116926
IGFBP3 insulin-like growth factor binding protein 3 0.102401
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0834217
NDRG1 N-myc downstream regulated 1 0.078542
UBC ubiquitin C 0.0783209
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0716438
LOXL2 lysyl oxidase-like 2 0.0659823
PODXL podocalyxin-like 0.0638188
DLG1 discs, large homolog 1 (Drosophila) 0.0610278
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0582274
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0577012
MYADM myeloid-associated differentiation marker 0.0559169
BHLHE40 basic helix-loop-helix family, member e40 0.0528594
SRRM2 serine/arginine repetitive matrix 2 0.0511786
ELL2 elongation factor, RNA polymerase II, 2 0.0486978
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0481228
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0466223
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0459597
MSN moesin 0.043383
SLC39A11 solute carrier family 39, member 11 0.0424112
COL8A1 collagen, type VIII, alpha 1 0.0409782
DST dystonin 0.0402598
DCAF6 DDB1 and CUL4 associated factor 6 0.0393479
NFE2L1 nuclear factor, erythroid 2-like 1 0.0390505
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0380484
CD109 CD109 molecule 0.0379916
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0367058
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0347789
SETD5 SET domain containing 5 0.0343535
TENM3 teneurin transmembrane protein 3 0.0342086
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0341854
ADAM17 ADAM metallopeptidase domain 17 0.034095
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0340051
AVL9 AVL9 homolog (S. cerevisiase) 0.0336098
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0330064
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0329764
SPIRE1 spire-type actin nucleation factor 1 0.0327671
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.032398
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0321351
TIMP2 TIMP metallopeptidase inhibitor 2 0.0317367
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0315281
SH3PXD2B SH3 and PX domains 2B 0.0314458
FNIP1 folliculin interacting protein 1 0.0311459
TPM3 tropomyosin 3 0.03095
TM4SF1 transmembrane 4 L six family member 1 0.0306352
ITCH itchy E3 ubiquitin protein ligase 0.0305634
FNDC3B fibronectin type III domain containing 3B 0.0305464
TAOK1 TAO kinase 1 0.0305293
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0304174
STC1 stanniocalcin 1 0.0302774
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0302008
KDM6A lysine (K)-specific demethylase 6A 0.0298357
ZEB1 zinc finger E-box binding homeobox 1 0.0297929
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0288873
TNIP1 TNFAIP3 interacting protein 1 0.0285933
SEPTIN9 septin 9 0.0283152
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0279837
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0275938
PBX3 pre-B-cell leukemia homeobox 3 0.0275408
SLC22A23 solute carrier family 22, member 23 0.0273871
CLU clusterin 0.0270286
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0270232
TENT5A terminal nucleotidyltransferase 5A 0.0265815
KMT2E lysine (K)-specific methyltransferase 2E 0.0264211
SFTPA2 surfactant protein A2 0.0261934
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0259155
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0255088
ATP13A3 ATPase type 13A3 0.0254191
RHOA ras homolog family member A 0.0253327
CD99 CD99 molecule 0.0253213
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0253077
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0249566
ADAM19 ADAM metallopeptidase domain 19 0.024932
ZBTB7C zinc finger and BTB domain containing 7C 0.0248297
COPA coatomer protein complex, subunit alpha 0.024777
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0245399
SDC4 syndecan 4 0.0244076
ZNF638 zinc finger protein 638 0.0243565
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0241826
HILPDA hypoxia inducible lipid droplet-associated 0.0241805
APP amyloid beta (A4) precursor protein 0.0239751
COL6A1 collagen, type VI, alpha 1 0.0237157
HIP1 huntingtin interacting protein 1 0.0236399
FNIP2 folliculin interacting protein 2 0.0234858
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0234497
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0232867
BSG basigin (Ok blood group) 0.0232506
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0232377
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0231765
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.0231247
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.023117
MSI2 musashi RNA-binding protein 2 0.0227534
SECISBP2L SECIS binding protein 2-like 0.0226785
CAMSAP1 calmodulin regulated spectrin-associated protein 1 0.0226671
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0225293
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0225231

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.21167
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.203615
VIM vimentin -0.159233
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152731
S100A10 S100 calcium binding protein A10 -0.0927593
TPT1 tumor protein, translationally-controlled 1 -0.0832014
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0792074
MT2A metallothionein 2A -0.0721921
MEIS2 Meis homeobox 2 -0.0715882
CENPF centromere protein F, 350/400kDa -0.0666327
RPL35A ribosomal protein L35a -0.065225
MX2 MX dynamin-like GTPase 2 -0.0618117
PTMA prothymosin, alpha -0.0611949
IFI16 interferon, gamma-inducible protein 16 -0.0593272
HLA-B major histocompatibility complex, class I, B -0.0537426
PDE4D phosphodiesterase 4D, cAMP-specific -0.0471692
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0461294
IFITM3 interferon induced transmembrane protein 3 -0.0455013
SAMD9 sterile alpha motif domain containing 9 -0.0451512
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0437456
RPLP1 ribosomal protein, large, P1 -0.0422777
CDH13 cadherin 13 -0.0417518
RPL23 ribosomal protein L23 -0.0416145
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0415653
PRRC2C proline-rich coiled-coil 2C -0.0403363
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0386412
KLF6 Kruppel-like factor 6 -0.038585
RPL34 ribosomal protein L34 -0.0379416
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.037655
RNF213 ring finger protein 213 -0.0367851
SMC4 structural maintenance of chromosomes 4 -0.0366449
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0359913
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0354117
RRBP1 ribosome binding protein 1 -0.034727
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0344878
GARS1 glycyl-tRNA synthetase 1 -0.0342075
RPS8 ribosomal protein S8 -0.0339652
RPS6 ribosomal protein S6 -0.0338418
RPL12 ribosomal protein L12 -0.0334967
AHNAK AHNAK nucleoprotein -0.0333995
PARD3 par-3 family cell polarity regulator -0.0333451
TMSB4X thymosin beta 4, X-linked -0.0327051
NAP1L1 nucleosome assembly protein 1-like 1 -0.0321333
PTK2 protein tyrosine kinase 2 -0.0320825
RPLP0 ribosomal protein, large, P0 -0.0316615
LMNA lamin A/C -0.031077
THBS2 thrombospondin 2 -0.0303205
LGALS1 lectin, galactoside-binding, soluble, 1 -0.030167
RPL37A ribosomal protein L37a -0.0299422
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0299043
RPS19 ribosomal protein S19 -0.0295911
SYT1 synaptotagmin I -0.0294325
ZBTB20 zinc finger and BTB domain containing 20 -0.0294017
ACTG1 actin gamma 1 -0.0290206
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0288645
SON SON DNA binding protein -0.0285927
S100A6 S100 calcium binding protein A6 -0.0284773
RPS24 ribosomal protein S24 -0.0283565
RPL28 ribosomal protein L28 -0.0282232
NAMPT nicotinamide phosphoribosyltransferase -0.0282042
IFITM1 interferon induced transmembrane protein 1 -0.0281856
LOX lysyl oxidase -0.0278079
VCL vinculin -0.027377
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0270965
IER3 immediate early response 3 -0.0266493
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0264095
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0261162
BTG1 B-cell translocation gene 1, anti-proliferative -0.0260453
CCND1 cyclin D1 -0.0259084
RIGI RNA sensor RIG-I -0.0256278
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0253641
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0250971
CEP112 centrosomal protein 112kDa -0.0249307
FBXL7 F-box and leucine-rich repeat protein 7 -0.0249245
HSPB1 heat shock 27kDa protein 1 -0.0249232
B2M beta-2-microglobulin -0.0249019
WDR45B WD repeat domain 45B -0.0244467
IFI6 interferon, alpha-inducible protein 6 -0.0242969
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0241438
LOC112694756 uncharaterized LOC112694756 -0.0238996
FTL ferritin, light polypeptide -0.0238983
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.023805
VDAC1 voltage-dependent anion channel 1 -0.0237856
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0237119
LMO7 LIM domain 7 -0.0236494
MATR3 matrin 3 -0.0236087
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0234342
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0232614
ANLN anillin, actin binding protein -0.0229472
RPL36 ribosomal protein L36 -0.022882
NALF1 NALCN channel auxiliary factor 1 -0.022812
RPLP2 ribosomal protein, large, P2 -0.0227097
SP100 SP100 nuclear antigen -0.0226843
IFIH1 interferon induced with helicase C domain 1 -0.0225915
HMGB2 high mobility group box 2 -0.0225471
MKI67 marker of proliferation Ki-67 -0.0224763
CXCL8 chemokine (C-X-C motif) ligand 8 -0.022351
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0222576
SH3BP2 SH3-domain binding protein 2 -0.0222409
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0222211