| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fulvestrant perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Fulvestrant_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.423349 |
| APOB | apolipoprotein B | 0.217768 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.216103 |
| C3 | complement component 3 | 0.152802 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.12052 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0766982 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.075625 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0662018 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0639594 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0589981 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0589793 |
| SDC4 | syndecan 4 | 0.0564578 |
| GPC3 | glypican 3 | 0.0545096 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0531732 |
| TRIM26 | tripartite motif containing 26 | 0.0529407 |
| RPS6 | ribosomal protein S6 | 0.0505866 |
| RPS12 | ribosomal protein S12 | 0.0459566 |
| RPL4 | ribosomal protein L4 | 0.0457977 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0439033 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0438454 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0435482 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0413639 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0412656 |
| DSPP | dentin sialophosphoprotein | 0.0393299 |
| UBC | ubiquitin C | 0.0389941 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0378765 |
| CPE | carboxypeptidase E | 0.0350511 |
| ITGAV | integrin, alpha V | 0.033842 |
| JMJD1C | jumonji domain containing 1C | 0.0333016 |
| MT2A | metallothionein 2A | 0.0327761 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0327631 |
| RPS8 | ribosomal protein S8 | 0.0325889 |
| FAT1 | FAT atypical cadherin 1 | 0.0325406 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0323056 |
| LYZ | lysozyme | 0.0317854 |
| A2M | alpha-2-macroglobulin | 0.0311654 |
| CFB | complement factor B | 0.0305739 |
| MBNL3 | muscleblind-like splicing regulator 3 | 0.029592 |
| EGR1 | early growth response 1 | 0.0295034 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0286912 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0283506 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0275462 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0269278 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0268853 |
| RRBP1 | ribosome binding protein 1 | 0.0267857 |
| PEG3 | paternally expressed 3 | 0.0255394 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0251366 |
| AHSG | alpha-2-HS-glycoprotein | 0.0250837 |
| ENO1 | enolase 1, (alpha) | 0.0250617 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0249101 |
| SVIL | supervillin | 0.0247227 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0243735 |
| RPL5 | ribosomal protein L5 | 0.024204 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0241918 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.02361 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0232986 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0231934 |
| PDGFB | platelet-derived growth factor beta polypeptide | 0.0230917 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0222353 |
| ENAH | enabled homolog (Drosophila) | 0.0222089 |
| RPLP0 | ribosomal protein, large, P0 | 0.0220934 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0216941 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0213989 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0213329 |
| FTL | ferritin, light polypeptide | 0.0211372 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.021037 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0208313 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0204564 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0204547 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.020269 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0202415 |
| RPL12 | ribosomal protein L12 | 0.0196941 |
| TCIM | transcriptional and immune response regulator | 0.0196554 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.0196421 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0196398 |
| SEPTIN9 | septin 9 | 0.0195862 |
| RPS23 | ribosomal protein S23 | 0.0195856 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0192333 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0191894 |
| SELENOP | selenoprotein P | 0.0191174 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0189209 |
| BPIFB2 | BPI fold containing family B, member 2 | 0.0188634 |
| GDF15 | growth differentiation factor 15 | 0.0188351 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0187885 |
| RPL11 | ribosomal protein L11 | 0.0187681 |
| RPL10A | ribosomal protein L10a | 0.0187444 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0186783 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.0186488 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0186283 |
| VMP1 | vacuole membrane protein 1 | 0.0186146 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0185911 |
| TF | transferrin | 0.0185319 |
| RPL30 | ribosomal protein L30 | 0.0183463 |
| RELL1 | RELT-like 1 | 0.0182719 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0182197 |
| RACK1 | receptor for activated C kinase 1 | 0.0181969 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0181224 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0180865 |
| ITGB5 | integrin, beta 5 | 0.018025 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0177149 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.363775 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0952672 |
| ASPH | aspartate beta-hydroxylase | -0.0905368 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.085875 |
| NDRG1 | N-myc downstream regulated 1 | -0.0631912 |
| DTNA | dystrobrevin, alpha | -0.060928 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0469862 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.046054 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0434189 |
| ATP10A | ATPase, class V, type 10A | -0.0395515 |
| ATXN1 | ataxin 1 | -0.0377386 |
| RUNX1 | runt-related transcription factor 1 | -0.0375385 |
| TMSB10 | thymosin beta 10 | -0.0331802 |
| FAM13A | family with sequence similarity 13, member A | -0.0300752 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0300573 |
| HMGA1 | high mobility group AT-hook 1 | -0.0288724 |
| TNS1 | tensin 1 | -0.0281704 |
| RIGI | RNA sensor RIG-I | -0.0277125 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0273318 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.027265 |
| NABP1 | nucleic acid binding protein 1 | -0.0266836 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0265705 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0264494 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0257507 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0246853 |
| CP | ceruloplasmin (ferroxidase) | -0.0244908 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0244768 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0243906 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.024352 |
| FMNL2 | formin-like 2 | -0.0239597 |
| FBXO11 | F-box protein 11 | -0.023949 |
| NGLY1 | N-glycanase 1 | -0.0237796 |
| SPAG9 | sperm associated antigen 9 | -0.0236279 |
| FLNB | filamin B, beta | -0.0234701 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0234349 |
| RNF213 | ring finger protein 213 | -0.0233272 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.0231148 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0225587 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0224191 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.021981 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0216619 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0203835 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0203704 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0200149 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0199252 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0198551 |
| STC2 | stanniocalcin 2 | -0.019797 |
| KIAA1217 | KIAA1217 | -0.0197626 |
| INTS6 | integrator complex subunit 6 | -0.0197015 |
| HELZ | helicase with zinc finger | -0.0193724 |
| RYBP | RING1 and YY1 binding protein | -0.019024 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0188856 |
| HPCAL1 | hippocalcin-like 1 | -0.0186524 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0186519 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0186405 |
| FOXO3 | forkhead box O3 | -0.0184982 |
| INSIG2 | insulin induced gene 2 | -0.0183464 |
| NUP58 | nucleoporin 58 | -0.0183338 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0183016 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0181216 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0181012 |
| MYO1B | myosin IB | -0.0180152 |
| BBX | bobby sox homolog (Drosophila) | -0.0180087 |
| USP53 | ubiquitin specific peptidase 53 | -0.0179183 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0179084 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0174668 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0173827 |
| BRD4 | bromodomain containing 4 | -0.0173279 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0173076 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0172409 |
| FBXO42 | F-box protein 42 | -0.0171081 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0165729 |
| PTK2 | protein tyrosine kinase 2 | -0.0165176 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.016439 |
| RAD51B | RAD51 paralog B | -0.0163969 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0163428 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0161577 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0160845 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0159964 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0158979 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0158876 |
| VCL | vinculin | -0.0158264 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0155458 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0155134 |
| VEGFA | vascular endothelial growth factor A | -0.0153804 |
| PRELID2 | PRELI domain containing 2 | -0.0152227 |
| COPA | coatomer protein complex, subunit alpha | -0.0151903 |
| NPAS2 | neuronal PAS domain protein 2 | -0.015143 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0150672 |
| HDAC4 | histone deacetylase 4 | -0.0148986 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0147635 |
| RBM39 | RNA binding motif protein 39 | -0.0147606 |
| ZNF804A | zinc finger protein 804A | -0.0147207 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.014702 |
| HDLBP | high density lipoprotein binding protein | -0.0145603 |
| ARFGEF3 | ARFGEF family member 3 | -0.0144589 |
| PUM2 | pumilio RNA-binding family member 2 | -0.014364 |
| ABHD3 | abhydrolase domain containing 3 | -0.0141679 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0140291 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0139236 |
